KR101639772B1 - 항암 화합물 - Google Patents

항암 화합물 Download PDF

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Publication number
KR101639772B1
KR101639772B1 KR1020157016575A KR20157016575A KR101639772B1 KR 101639772 B1 KR101639772 B1 KR 101639772B1 KR 1020157016575 A KR1020157016575 A KR 1020157016575A KR 20157016575 A KR20157016575 A KR 20157016575A KR 101639772 B1 KR101639772 B1 KR 101639772B1
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KR
South Korea
Prior art keywords
unsubstituted
substituted
mmol
hydrogen
alkyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020157016575A
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English (en)
Korean (ko)
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KR20150076265A (ko
Inventor
비센테 알베르토 로드리게즈
가르시아-이바롤라 마리아 가란조
페레즈 카르멘 무르시아
산초 프란시스코 산체스
마르산테 마리아 델 카르멘 쿠에바스
우르바노 크리스티나 마테오
후아레즈 이사벨 디곤
Original Assignee
파르마 마르 에스.에이.
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Publication of KR20150076265A publication Critical patent/KR20150076265A/ko
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Publication of KR101639772B1 publication Critical patent/KR101639772B1/ko
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
KR1020157016575A 2007-12-20 2008-12-19 항암 화합물 Expired - Fee Related KR101639772B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07123882 2007-12-20
EP07123882.8 2007-12-20
PCT/EP2008/068049 WO2009080761A1 (en) 2007-12-20 2008-12-19 Antitumoral compounds

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020107015968A Division KR101579553B1 (ko) 2007-12-20 2008-12-19 항암 화합물

Publications (2)

Publication Number Publication Date
KR20150076265A KR20150076265A (ko) 2015-07-06
KR101639772B1 true KR101639772B1 (ko) 2016-07-15

Family

ID=40580474

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020157016575A Expired - Fee Related KR101639772B1 (ko) 2007-12-20 2008-12-19 항암 화합물
KR1020107015965A Expired - Fee Related KR101541436B1 (ko) 2007-12-20 2008-12-19 항암 화합물
KR1020107015968A Expired - Fee Related KR101579553B1 (ko) 2007-12-20 2008-12-19 항암 화합물

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020107015965A Expired - Fee Related KR101541436B1 (ko) 2007-12-20 2008-12-19 항암 화합물
KR1020107015968A Expired - Fee Related KR101579553B1 (ko) 2007-12-20 2008-12-19 항암 화합물

Country Status (26)

Country Link
US (4) US8710264B2 (cg-RX-API-DMAC7.html)
EP (3) EP2231633B1 (cg-RX-API-DMAC7.html)
JP (3) JP5529038B2 (cg-RX-API-DMAC7.html)
KR (3) KR101639772B1 (cg-RX-API-DMAC7.html)
CN (4) CN102190643B (cg-RX-API-DMAC7.html)
AT (1) ATE549313T1 (cg-RX-API-DMAC7.html)
AU (2) AU2008341671B2 (cg-RX-API-DMAC7.html)
BR (2) BRPI0821116B8 (cg-RX-API-DMAC7.html)
CA (2) CA2715203C (cg-RX-API-DMAC7.html)
CY (1) CY1117245T1 (cg-RX-API-DMAC7.html)
DK (2) DK2231590T3 (cg-RX-API-DMAC7.html)
ES (3) ES2384420T3 (cg-RX-API-DMAC7.html)
HR (2) HRP20140015T1 (cg-RX-API-DMAC7.html)
IL (3) IL206396A (cg-RX-API-DMAC7.html)
MX (2) MX2010006795A (cg-RX-API-DMAC7.html)
MY (3) MY148651A (cg-RX-API-DMAC7.html)
NZ (3) NZ597526A (cg-RX-API-DMAC7.html)
PL (2) PL2231590T3 (cg-RX-API-DMAC7.html)
PT (2) PT2231590E (cg-RX-API-DMAC7.html)
RS (2) RS53140B (cg-RX-API-DMAC7.html)
RU (3) RU2493147C2 (cg-RX-API-DMAC7.html)
SG (2) SG170778A1 (cg-RX-API-DMAC7.html)
SI (2) SI2231590T1 (cg-RX-API-DMAC7.html)
UA (3) UA106967C2 (cg-RX-API-DMAC7.html)
WO (2) WO2009080769A1 (cg-RX-API-DMAC7.html)
ZA (3) ZA201004017B (cg-RX-API-DMAC7.html)

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Publication number Priority date Publication date Assignee Title
HRP20140015T1 (hr) 2007-12-20 2014-02-14 Pharma Mar, S.A. Antitumorski spojevi
WO2013103155A1 (en) * 2012-01-05 2013-07-11 Kao Corporation Agent for reduction of sensory irritation
MA38588B1 (fr) 2013-04-16 2018-04-30 Idorsia Pharmaceuticals Ltd Dérivés bi-aromatiques antibactériens
GB201309807D0 (en) * 2013-05-31 2013-07-17 Pharma Mar Sau Antibody drug conjugates
CN108467378A (zh) * 2017-02-23 2018-08-31 复旦大学 一种二氢吡喃酮类化合物及其制备方法和用途
LT3615544T (lt) 2017-04-27 2023-05-10 Pharma Mar S.A. Priešnavikiniai junginiai
TWI824043B (zh) 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物

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WO2005117894A1 (en) 2004-06-03 2005-12-15 Kosan Biosciences Incorporated Leptomycin compounds

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Also Published As

Publication number Publication date
NZ586012A (en) 2011-11-25
US20100280108A1 (en) 2010-11-04
BRPI0821114B1 (pt) 2021-09-08
JP2014133752A (ja) 2014-07-24
EP2231590B1 (en) 2012-03-14
HK1147990A1 (en) 2011-08-26
MY155342A (en) 2015-10-15
BRPI0821114B8 (pt) 2021-11-09
RU2493147C2 (ru) 2013-09-20
IL206397A (en) 2014-01-30
JP5529038B2 (ja) 2014-06-25
JP5860088B2 (ja) 2016-02-16
CN101903367A (zh) 2010-12-01
IL206396A (en) 2014-05-28
CN102174058A (zh) 2011-09-07
US9187445B2 (en) 2015-11-17
HK1180678A1 (en) 2013-10-25
IL206396A0 (en) 2010-12-30
US20120041063A2 (en) 2012-02-16
EP2231633B1 (en) 2013-10-30
JP5727228B2 (ja) 2015-06-03
IL206397A0 (en) 2010-12-30
MX2010006796A (es) 2010-10-26
UA106967C2 (uk) 2014-11-10
MY164533A (en) 2017-12-29
RU2013112003A (ru) 2014-08-20
DK2231590T3 (da) 2012-07-09
US20150344454A1 (en) 2015-12-03
ES2442140T3 (es) 2014-02-25
JP2011506575A (ja) 2011-03-03
CN102190643A (zh) 2011-09-21
PL2231633T3 (pl) 2014-03-31
SI2231590T1 (sl) 2012-10-30
RU2528393C9 (ru) 2015-01-10
EP2231633A1 (en) 2010-09-29
EP2597091A1 (en) 2013-05-29
IL229594A (en) 2016-02-29
AU2008341670B2 (en) 2012-04-19
PT2231590E (pt) 2012-06-25
UA104281C2 (ru) 2014-01-27
RU2528393C1 (ru) 2014-09-20
ZA201106371B (en) 2013-05-29
CN101903367B (zh) 2015-08-05
BRPI0821116B1 (pt) 2020-02-18
JP2011506578A (ja) 2011-03-03
CN101903337A (zh) 2010-12-01
HK1147998A1 (en) 2011-08-26
RS52343B (sr) 2012-12-31
SI2231633T1 (sl) 2014-02-28
ES2384420T3 (es) 2012-07-04
AU2008341671B2 (en) 2012-07-26
KR20150076265A (ko) 2015-07-06
SG170779A1 (en) 2011-05-30
HRP20120464T1 (hr) 2012-07-31
ZA201004018B (en) 2011-12-28
US9827257B2 (en) 2017-11-28
CA2710087A1 (en) 2009-07-02
BRPI0821116A2 (pt) 2015-08-11
MX2010006795A (es) 2010-10-26
AU2008341670A1 (en) 2009-07-02
CN101903337B (zh) 2013-12-18
KR101541436B1 (ko) 2015-08-03
IL229594A0 (en) 2014-01-30
US8710264B2 (en) 2014-04-29
RS53140B (sr) 2014-06-30
CN102190643B (zh) 2015-02-25
RU2010130180A (ru) 2012-01-27
KR101579553B1 (ko) 2015-12-22
RU2489429C2 (ru) 2013-08-10
WO2009080761A1 (en) 2009-07-02
BRPI0821116B8 (pt) 2021-05-25
SG170778A1 (en) 2011-05-30
CA2710087C (en) 2015-06-02
US20150342972A1 (en) 2015-12-03
MY148651A (en) 2013-05-15
UA119963C2 (uk) 2019-09-10
US9750759B2 (en) 2017-09-05
PT2231633E (pt) 2014-01-20
WO2009080769A1 (en) 2009-07-02
EP2231590B9 (en) 2012-08-15
DK2231633T3 (da) 2014-01-20
HRP20140015T1 (hr) 2014-02-14
CA2715203C (en) 2015-09-08
BRPI0821114A2 (pt) 2015-06-16
EP2597091B1 (en) 2016-04-20
AU2008341671A1 (en) 2009-07-02
ATE549313T1 (de) 2012-03-15
KR20100125226A (ko) 2010-11-30
ES2578606T3 (es) 2016-07-28
EP2231590A1 (en) 2010-09-29
PL2231590T3 (pl) 2012-09-28
US20110034549A1 (en) 2011-02-10
ZA201004017B (en) 2011-12-28
RU2010130253A (ru) 2012-01-27
NZ586013A (en) 2012-02-24
KR20100100979A (ko) 2010-09-15
NZ597526A (en) 2012-06-29
CY1117245T1 (el) 2017-04-05
CA2715203A1 (en) 2009-07-02

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