KR101570252B1 - 글리피칸-3에 대한 단클론 항체 - Google Patents

글리피칸-3에 대한 단클론 항체 Download PDF

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KR101570252B1
KR101570252B1 KR1020107003345A KR20107003345A KR101570252B1 KR 101570252 B1 KR101570252 B1 KR 101570252B1 KR 1020107003345 A KR1020107003345 A KR 1020107003345A KR 20107003345 A KR20107003345 A KR 20107003345A KR 101570252 B1 KR101570252 B1 KR 101570252B1
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antibody
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seq
ser
antibodies
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KR20100056467A (ko
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조나선 알렉산더 테렛
리-솅 루
하이춘 후앙
다펭 야오
친 판
하이디 르블랑
티모시 스프롤
마크 야마나카
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메다렉스, 엘.엘.시.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
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KR1020107003345A 2007-07-17 2008-07-17 글리피칸-3에 대한 단클론 항체 Expired - Fee Related KR101570252B1 (ko)

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US95984507P 2007-07-17 2007-07-17
US60/959,845 2007-07-17

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KR20100056467A KR20100056467A (ko) 2010-05-27
KR101570252B1 true KR101570252B1 (ko) 2015-11-19

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KR1020157007446A Expired - Fee Related KR101527342B1 (ko) 2007-07-17 2008-07-17 글리피칸-3에 대한 단클론 항체

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US (2) US8680247B2 (OSRAM)
EP (1) EP2178921B1 (OSRAM)
JP (2) JP5868593B2 (OSRAM)
KR (2) KR101570252B1 (OSRAM)
CN (1) CN101815726B (OSRAM)
AU (1) AU2008275985B2 (OSRAM)
CY (1) CY1117236T1 (OSRAM)
DK (1) DK2178921T3 (OSRAM)
ES (1) ES2562790T3 (OSRAM)
HR (1) HRP20160270T1 (OSRAM)
HU (1) HUE028737T2 (OSRAM)
ME (1) ME02345B (OSRAM)
MX (1) MX2010000537A (OSRAM)
PL (1) PL2178921T3 (OSRAM)
PT (1) PT2178921E (OSRAM)
RS (1) RS54624B1 (OSRAM)
SI (1) SI2178921T1 (OSRAM)
WO (1) WO2009012394A1 (OSRAM)

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SI2178921T1 (sl) 2016-05-31
JP5868593B2 (ja) 2016-02-24
KR20150038732A (ko) 2015-04-08
JP2010533498A (ja) 2010-10-28
EP2178921A1 (en) 2010-04-28
DK2178921T3 (en) 2016-04-04
CN101815726B (zh) 2013-04-03
HRP20160270T1 (hr) 2016-05-06
KR101527342B1 (ko) 2015-06-09
AU2008275985A1 (en) 2009-01-22
US9217033B2 (en) 2015-12-22
US8680247B2 (en) 2014-03-25
PT2178921E (pt) 2016-03-23
CN101815726A (zh) 2010-08-25
EP2178921B1 (en) 2016-01-06
US20140186892A1 (en) 2014-07-03
PL2178921T3 (pl) 2016-06-30
CY1117236T1 (el) 2017-04-05
ES2562790T3 (es) 2016-03-08
MX2010000537A (es) 2010-03-25
RS54624B1 (sr) 2016-08-31
US20100209432A1 (en) 2010-08-19
ME02345B (me) 2016-08-31
JP2014236734A (ja) 2014-12-18
KR20100056467A (ko) 2010-05-27
AU2008275985B2 (en) 2013-09-19
WO2009012394A1 (en) 2009-01-22
HUE028737T2 (en) 2017-01-30

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