KR101563939B1 - 4―데메톡시다우노루비신의 제조방법 - Google Patents

4―데메톡시다우노루비신의 제조방법 Download PDF

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KR101563939B1
KR101563939B1 KR1020120028353A KR20120028353A KR101563939B1 KR 101563939 B1 KR101563939 B1 KR 101563939B1 KR 1020120028353 A KR1020120028353 A KR 1020120028353A KR 20120028353 A KR20120028353 A KR 20120028353A KR 101563939 B1 KR101563939 B1 KR 101563939B1
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formula
compound
prot
daunorubicin
group
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KR20120122886A (ko
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자부드킨 알렉산더
마트비엔코 빅터
마트비예이에프 알렉세이
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신바이어스 파마 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020120028353A 2011-04-29 2012-03-20 4―데메톡시다우노루비신의 제조방법 Active KR101563939B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/097,131 US8846882B2 (en) 2011-04-29 2011-04-29 Method of producing 4-demethoxydaunorubicin
US13/097,131 2011-04-29

Publications (2)

Publication Number Publication Date
KR20120122886A KR20120122886A (ko) 2012-11-07
KR101563939B1 true KR101563939B1 (ko) 2015-10-29

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ID=45894256

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KR1020120028353A Active KR101563939B1 (ko) 2011-04-29 2012-03-20 4―데메톡시다우노루비신의 제조방법

Country Status (9)

Country Link
US (1) US8846882B2 (enExample)
EP (1) EP2518077B1 (enExample)
JP (1) JP5524262B2 (enExample)
KR (1) KR101563939B1 (enExample)
CN (1) CN102757470B (enExample)
DK (1) DK2518077T3 (enExample)
ES (1) ES2562328T3 (enExample)
PL (1) PL2518077T3 (enExample)
RU (1) RU2540968C2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107698634B (zh) * 2017-09-22 2020-03-10 南京正大天晴制药有限公司 一种盐酸伊达比星的制备方法
CN107669693B (zh) * 2017-09-22 2020-03-31 南京正大天晴制药有限公司 一种稳定安全的伊达比星药物组合物及其制备方法
CN112010913B (zh) * 2019-05-31 2022-06-21 南京正大天晴制药有限公司 4-脱氧柔红霉素的制备方法
CN115785168B (zh) * 2022-08-22 2023-11-07 浙江亚瑟医药有限公司 一种制备4-脱甲氧柔红霉素盐酸盐的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188377A (en) 1977-02-01 1980-02-12 Farmitalia Carlo Erba S.P.A. Carminomycin derivatives, their preparation and use
US20070135624A1 (en) 2005-12-13 2007-06-14 Zabudkin Alexander F Method for preparing 4-demethyldaunorubicin
US9053181B2 (en) 2003-11-03 2015-06-09 James W. Wieder Adaptive personalized playback or presentation using count

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012284A (en) 1962-11-16 1977-03-15 Societa' Farmaceutici Italia, S.p.A. Process of preparation of antibiotic F.I. 1762 derivatives
GB1461190A (en) 1974-09-20 1977-01-13 Farmaceutici Italia Anthracycline preparation
GB1551334A (en) 1976-02-21 1979-08-30 Newalls Insulation Co Ltd Manufacture of insulation products
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
US4116981A (en) 1977-05-02 1978-09-26 Yuh-Geng Tsay 5,12-epoxy-naphthacene-6,11-dione derivatives
US4161480A (en) 1978-06-05 1979-07-17 G. D. Searle & Co. Intermediates for the synthesis of 4-demethoxydaunorubicin
IT1130074B (it) 1979-04-20 1986-06-11 Hoffmann La Roche Composti policiclici e procedimento per la loro preparazione
US4471052A (en) 1982-01-18 1984-09-11 Adria Laboratories, Inc. Biosynthesis of simplified anthracyclines
US5162512A (en) 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
US4448724A (en) 1982-12-20 1984-05-15 The Trustees Of The University Of Pennsylvania Synthesis of 4-demethoxydaunomycinone
US4489206A (en) 1983-05-13 1984-12-18 Adria Laboratories, Inc. Synthesis of (+)-4-demethoxydaunomycinone
US4564674A (en) 1983-10-31 1986-01-14 Sagami Chemical Research Center Process for an anthracycline derivative, and an anthracyclinone derivative useful for the process
US4496485A (en) 1983-11-25 1985-01-29 G. D. Searle & Co. Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
US4697005A (en) 1985-03-20 1987-09-29 Ohio State University Research Foundation 1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics
GB8708927D0 (en) 1987-04-14 1987-05-20 Erba Farmitalia Chiral synthesis of anthracyclines
NZ224252A (en) 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
GB8803301D0 (en) 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
GB8818167D0 (en) 1988-07-29 1988-09-01 Erba Carlo Spa Novel 4-substituted anthracyclinones & process for their preparation
GB8824947D0 (en) 1988-10-25 1988-11-30 Erba Carlo Spa New 4-substituted anthracyclinones & process for preparing them
GB8904794D0 (en) 1989-03-02 1989-04-12 Erba Carlo Spa Process for preparing anthracyclinones
MA21995A1 (fr) 1989-11-13 1991-07-01 Menarini Farma Ind Nouvelles fluoronaphthacenediones,leurs derives glycozyles et leurs procedes de fabrication .
GB9019934D0 (en) 1990-09-12 1990-10-24 Erba Carlo Spa 2-hydroxy-and 2-acyloxy-4-morpholinyl anthracyclines
US5776458A (en) 1990-12-05 1998-07-07 Pharmacia & Upjohn S.P.A. Anthracycline-conjugates
GB9416007D0 (en) 1994-08-08 1994-09-28 Erba Carlo Spa Anthracyclinone derivatives
IT1275953B1 (it) 1995-03-22 1997-10-24 Sicor Spa Procedimento per la preparazione di antibiotici della classe delle antracicline
GB9516349D0 (en) 1995-08-09 1995-10-11 Pharmacia Spa Aza-anthracyclinone derivatives
DK0871490T3 (da) 1995-12-22 2003-07-07 Bristol Myers Squibb Co Forgrenede hydrazonlinkere
CA2249593A1 (en) 1996-03-22 1997-09-25 Waldemar Priebe Bis-anthracyclines with high activity against doxorubicin resistant tumors
US6218519B1 (en) 1996-04-12 2001-04-17 Pro-Neuron, Inc. Compounds and methods for the selective treatment of cancer and bacterial infections
GB9701628D0 (en) 1997-01-27 1997-03-19 Pharmacia & Upjohn Spa Imino-aza-anthracyclinone derivatives
AUPQ319799A0 (en) 1999-10-01 1999-10-28 Institute Of Drug Technology Australia Limited Chemical methods
IT1318532B1 (it) 2000-05-19 2003-08-27 Antibioticos Spa Procedimento di sintesi di derivati antraciclinici.
JP4688315B2 (ja) * 2001-02-28 2011-05-25 メルシャン株式会社 ４−デメトキシダウノマイシノンの製造
US7053191B2 (en) 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
RU2260011C1 (ru) * 2004-02-27 2005-09-10 ОЛСУФЬЕВА Евгения Николаевна Способ получения антибиотика карминомицина или его гидрохлорида
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
JP5634862B2 (ja) * 2007-05-16 2014-12-03 カーテーベー トゥモーアフォルシュングス ゲゼルシャフト ミット ベシュレンクテル ハフツング 低粘度アントラサイクリン製剤
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188377A (en) 1977-02-01 1980-02-12 Farmitalia Carlo Erba S.P.A. Carminomycin derivatives, their preparation and use
US9053181B2 (en) 2003-11-03 2015-06-09 James W. Wieder Adaptive personalized playback or presentation using count
US20070135624A1 (en) 2005-12-13 2007-06-14 Zabudkin Alexander F Method for preparing 4-demethyldaunorubicin

Also Published As

Publication number Publication date
US8846882B2 (en) 2014-09-30
EP2518077B1 (en) 2016-01-06
RU2012110492A (ru) 2013-09-27
RU2540968C2 (ru) 2015-02-10
CN102757470A (zh) 2012-10-31
ES2562328T3 (es) 2016-03-03
DK2518077T3 (en) 2016-01-18
JP2012232971A (ja) 2012-11-29
KR20120122886A (ko) 2012-11-07
CN102757470B (zh) 2015-07-29
JP5524262B2 (ja) 2014-06-18
HK1178170A1 (en) 2013-09-06
PL2518077T3 (pl) 2016-05-31
EP2518077A1 (en) 2012-10-31
US20120277415A1 (en) 2012-11-01

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