IT1318532B1 - Procedimento di sintesi di derivati antraciclinici. - Google Patents

Procedimento di sintesi di derivati antraciclinici.

Info

Publication number
IT1318532B1
IT1318532B1 IT2000MI001122A ITMI20001122A IT1318532B1 IT 1318532 B1 IT1318532 B1 IT 1318532B1 IT 2000MI001122 A IT2000MI001122 A IT 2000MI001122A IT MI20001122 A ITMI20001122 A IT MI20001122A IT 1318532 B1 IT1318532 B1 IT 1318532B1
Authority
IT
Italy
Prior art keywords
anthracyclinic
synthesis procedure
derivatives synthesis
derivatives
procedure
Prior art date
Application number
IT2000MI001122A
Other languages
English (en)
Inventor
Valentina Pizzamiglio
Walter Cabri
Elio Mapelli
Original Assignee
Antibioticos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos Spa filed Critical Antibioticos Spa
Priority to IT2000MI001122A priority Critical patent/IT1318532B1/it
Publication of ITMI20001122A0 publication Critical patent/ITMI20001122A0/it
Priority to DE60114608T priority patent/DE60114608T2/de
Priority to US10/276,823 priority patent/US6844455B2/en
Priority to AU2001265939A priority patent/AU2001265939A1/en
Priority to PCT/EP2001/005304 priority patent/WO2001087814A2/en
Priority to EP01943338A priority patent/EP1282590B1/en
Priority to AT01943338T priority patent/ATE308499T1/de
Publication of ITMI20001122A1 publication Critical patent/ITMI20001122A1/it
Application granted granted Critical
Publication of IT1318532B1 publication Critical patent/IT1318532B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
IT2000MI001122A 2000-05-19 2000-05-19 Procedimento di sintesi di derivati antraciclinici. IT1318532B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT2000MI001122A IT1318532B1 (it) 2000-05-19 2000-05-19 Procedimento di sintesi di derivati antraciclinici.
DE60114608T DE60114608T2 (de) 2000-05-19 2001-05-10 Verfahren zur herstellung von anthracyclinederivaten
US10/276,823 US6844455B2 (en) 2000-05-19 2001-05-10 Process for the preparation of anthracycline derivatives
AU2001265939A AU2001265939A1 (en) 2000-05-19 2001-05-10 A process for the preparation of anthracycline derivatives
PCT/EP2001/005304 WO2001087814A2 (en) 2000-05-19 2001-05-10 A process for the preparation of anthracycline derivatives
EP01943338A EP1282590B1 (en) 2000-05-19 2001-05-10 A process for the preparation of anthracycline derivatives
AT01943338T ATE308499T1 (de) 2000-05-19 2001-05-10 Verfahren zur herstellung von anthracyclinederivaten

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI001122A IT1318532B1 (it) 2000-05-19 2000-05-19 Procedimento di sintesi di derivati antraciclinici.

Publications (3)

Publication Number Publication Date
ITMI20001122A0 ITMI20001122A0 (it) 2000-05-19
ITMI20001122A1 ITMI20001122A1 (it) 2001-11-19
IT1318532B1 true IT1318532B1 (it) 2003-08-27

Family

ID=11445091

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI001122A IT1318532B1 (it) 2000-05-19 2000-05-19 Procedimento di sintesi di derivati antraciclinici.

Country Status (7)

Country Link
US (1) US6844455B2 (it)
EP (1) EP1282590B1 (it)
AT (1) ATE308499T1 (it)
AU (1) AU2001265939A1 (it)
DE (1) DE60114608T2 (it)
IT (1) IT1318532B1 (it)
WO (1) WO2001087814A2 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053191B2 (en) 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
FR2871156B1 (fr) * 2004-06-04 2006-08-25 Archemis Sa Procede de preparation de derives de la rhodomycinone
WO2006024016A2 (en) * 2004-08-23 2006-03-02 Sicor, Inc. Synthesis of idarubin aglycone
US8357785B2 (en) 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
WO2010125466A1 (en) * 2009-04-28 2010-11-04 Tbd-Biodiscovery Methods for the synthesis of amrubicin
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8804429D0 (en) * 1988-02-25 1988-03-23 Erba Carlo Spa New 4-demethyl-4-0-(fluorobenzensulfonyl)anthracycline glycosides
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone

Also Published As

Publication number Publication date
EP1282590A2 (en) 2003-02-12
WO2001087814A2 (en) 2001-11-22
DE60114608D1 (de) 2005-12-08
EP1282590B1 (en) 2005-11-02
US20040044189A1 (en) 2004-03-04
ITMI20001122A0 (it) 2000-05-19
ATE308499T1 (de) 2005-11-15
AU2001265939A1 (en) 2001-11-26
DE60114608T2 (de) 2006-06-01
WO2001087814A3 (en) 2002-05-02
US6844455B2 (en) 2005-01-18
ITMI20001122A1 (it) 2001-11-19

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