AU2001265939A1 - A process for the preparation of anthracycline derivatives - Google Patents

A process for the preparation of anthracycline derivatives

Info

Publication number
AU2001265939A1
AU2001265939A1 AU2001265939A AU6593901A AU2001265939A1 AU 2001265939 A1 AU2001265939 A1 AU 2001265939A1 AU 2001265939 A AU2001265939 A AU 2001265939A AU 6593901 A AU6593901 A AU 6593901A AU 2001265939 A1 AU2001265939 A1 AU 2001265939A1
Authority
AU
Australia
Prior art keywords
preparation
anthracycline derivatives
anthracycline
derivatives
demethoxydaunomycinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001265939A
Inventor
Walter Cabri
Elio Mapelli
Valentina Pizzamiglio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olon SpA
Original Assignee
Antibioticos SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos SpA filed Critical Antibioticos SpA
Publication of AU2001265939A1 publication Critical patent/AU2001265939A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes

Abstract

The present invention discloses a process for the semi-synthesis of 4-demethoxydaunomycinone, (8s-cis)-acetyl-10-hydroxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-5,12-naphthacenedione, of formula (I).
AU2001265939A 2000-05-19 2001-05-10 A process for the preparation of anthracycline derivatives Abandoned AU2001265939A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000MI001122A IT1318532B1 (en) 2000-05-19 2000-05-19 ANTHRACYCLINIC DERIVATIVES SYNTHESIS PROCEDURE.
ITMI200A001122 2000-05-19
PCT/EP2001/005304 WO2001087814A2 (en) 2000-05-19 2001-05-10 A process for the preparation of anthracycline derivatives

Publications (1)

Publication Number Publication Date
AU2001265939A1 true AU2001265939A1 (en) 2001-11-26

Family

ID=11445091

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001265939A Abandoned AU2001265939A1 (en) 2000-05-19 2001-05-10 A process for the preparation of anthracycline derivatives

Country Status (7)

Country Link
US (1) US6844455B2 (en)
EP (1) EP1282590B1 (en)
AT (1) ATE308499T1 (en)
AU (1) AU2001265939A1 (en)
DE (1) DE60114608T2 (en)
IT (1) IT1318532B1 (en)
WO (1) WO2001087814A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053191B2 (en) 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
FR2871156B1 (en) * 2004-06-04 2006-08-25 Archemis Sa PROCESS FOR THE PREPARATION OF RHODOMYCINONE DERIVATIVES
ATE464280T1 (en) * 2004-08-23 2010-04-15 Sicor Inc SYNTHESIS OF IDARUBIN-AGLYCONE
US8357785B2 (en) 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
CA2760271A1 (en) * 2009-04-28 2010-11-04 Tbd-Biodiscovery Methods for the synthesis of amrubicin
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8804429D0 (en) 1988-02-25 1988-03-23 Erba Carlo Spa New 4-demethyl-4-0-(fluorobenzensulfonyl)anthracycline glycosides
GB8808475D0 (en) 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone

Also Published As

Publication number Publication date
ITMI20001122A1 (en) 2001-11-19
WO2001087814A2 (en) 2001-11-22
US6844455B2 (en) 2005-01-18
WO2001087814A3 (en) 2002-05-02
EP1282590B1 (en) 2005-11-02
DE60114608D1 (en) 2005-12-08
ITMI20001122A0 (en) 2000-05-19
EP1282590A2 (en) 2003-02-12
ATE308499T1 (en) 2005-11-15
US20040044189A1 (en) 2004-03-04
DE60114608T2 (en) 2006-06-01
IT1318532B1 (en) 2003-08-27

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