PL2518077T3 - Sposób wytwarzania 4-demetoksydaunorubicyny - Google Patents

Sposób wytwarzania 4-demetoksydaunorubicyny

Info

Publication number
PL2518077T3
PL2518077T3 PL12160375T PL12160375T PL2518077T3 PL 2518077 T3 PL2518077 T3 PL 2518077T3 PL 12160375 T PL12160375 T PL 12160375T PL 12160375 T PL12160375 T PL 12160375T PL 2518077 T3 PL2518077 T3 PL 2518077T3
Authority
PL
Poland
Prior art keywords
demethoxydaunorubicin
producing
Prior art date
Application number
PL12160375T
Other languages
English (en)
Inventor
Alexander Zabudkin
Victor Matvienko
Alexey Matvyeyev
Original Assignee
Synbias Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45894256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2518077(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synbias Pharma Ag filed Critical Synbias Pharma Ag
Publication of PL2518077T3 publication Critical patent/PL2518077T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL12160375T 2011-04-29 2012-03-20 Sposób wytwarzania 4-demetoksydaunorubicyny PL2518077T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/097,131 US8846882B2 (en) 2011-04-29 2011-04-29 Method of producing 4-demethoxydaunorubicin
EP12160375.7A EP2518077B1 (en) 2011-04-29 2012-03-20 Method of producing 4-demethoxydaunorubicin

Publications (1)

Publication Number Publication Date
PL2518077T3 true PL2518077T3 (pl) 2016-05-31

Family

ID=45894256

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12160375T PL2518077T3 (pl) 2011-04-29 2012-03-20 Sposób wytwarzania 4-demetoksydaunorubicyny

Country Status (10)

Country Link
US (1) US8846882B2 (pl)
EP (1) EP2518077B1 (pl)
JP (1) JP5524262B2 (pl)
KR (1) KR101563939B1 (pl)
CN (1) CN102757470B (pl)
DK (1) DK2518077T3 (pl)
ES (1) ES2562328T3 (pl)
HK (1) HK1178170A1 (pl)
PL (1) PL2518077T3 (pl)
RU (1) RU2540968C2 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107698634B (zh) * 2017-09-22 2020-03-10 南京正大天晴制药有限公司 一种盐酸伊达比星的制备方法
CN107669693B (zh) * 2017-09-22 2020-03-31 南京正大天晴制药有限公司 一种稳定安全的伊达比星药物组合物及其制备方法
CN112010913B (zh) * 2019-05-31 2022-06-21 南京正大天晴制药有限公司 4-脱氧柔红霉素的制备方法
CN115785168B (zh) * 2022-08-22 2023-11-07 浙江亚瑟医药有限公司 一种制备4-脱甲氧柔红霉素盐酸盐的方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012284A (en) 1962-11-16 1977-03-15 Societa' Farmaceutici Italia, S.p.A. Process of preparation of antibiotic F.I. 1762 derivatives
GB1461190A (en) 1974-09-20 1977-01-13 Farmaceutici Italia Anthracycline preparation
GB1551334A (en) 1976-02-21 1979-08-30 Newalls Insulation Co Ltd Manufacture of insulation products
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
GB1555401A (en) 1977-02-01 1979-11-07 Farmaceutici Italia Carminomycin derivatives
US4116981A (en) 1977-05-02 1978-09-26 Yuh-Geng Tsay 5,12-epoxy-naphthacene-6,11-dione derivatives
US4161480A (en) 1978-06-05 1979-07-17 G. D. Searle & Co. Intermediates for the synthesis of 4-demethoxydaunorubicin
IT1130074B (it) 1979-04-20 1986-06-11 Hoffmann La Roche Composti policiclici e procedimento per la loro preparazione
US4471052A (en) 1982-01-18 1984-09-11 Adria Laboratories, Inc. Biosynthesis of simplified anthracyclines
US5162512A (en) 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
US4448724A (en) 1982-12-20 1984-05-15 The Trustees Of The University Of Pennsylvania Synthesis of 4-demethoxydaunomycinone
US4489206A (en) 1983-05-13 1984-12-18 Adria Laboratories, Inc. Synthesis of (+)-4-demethoxydaunomycinone
US4564674A (en) 1983-10-31 1986-01-14 Sagami Chemical Research Center Process for an anthracycline derivative, and an anthracyclinone derivative useful for the process
US4496485A (en) 1983-11-25 1985-01-29 G. D. Searle & Co. Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
US4697005A (en) 1985-03-20 1987-09-29 Ohio State University Research Foundation 1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics
GB8708927D0 (en) 1987-04-14 1987-05-20 Erba Farmitalia Chiral synthesis of anthracyclines
NZ224252A (en) 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
GB8803301D0 (en) 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
GB8818167D0 (en) 1988-07-29 1988-09-01 Erba Carlo Spa Novel 4-substituted anthracyclinones & process for their preparation
GB8824947D0 (en) 1988-10-25 1988-11-30 Erba Carlo Spa New 4-substituted anthracyclinones & process for preparing them
GB8904794D0 (en) 1989-03-02 1989-04-12 Erba Carlo Spa Process for preparing anthracyclinones
MA21995A1 (fr) 1989-11-13 1991-07-01 Menarini Farma Ind Nouvelles fluoronaphthacenediones,leurs derives glycozyles et leurs procedes de fabrication .
GB9019934D0 (en) 1990-09-12 1990-10-24 Erba Carlo Spa 2-hydroxy-and 2-acyloxy-4-morpholinyl anthracyclines
US5776458A (en) 1990-12-05 1998-07-07 Pharmacia & Upjohn S.P.A. Anthracycline-conjugates
GB9416007D0 (en) 1994-08-08 1994-09-28 Erba Carlo Spa Anthracyclinone derivatives
IT1275953B1 (it) 1995-03-22 1997-10-24 Sicor Spa Procedimento per la preparazione di antibiotici della classe delle antracicline
GB9516349D0 (en) 1995-08-09 1995-10-11 Pharmacia Spa Aza-anthracyclinone derivatives
EP0871490B1 (en) 1995-12-22 2003-03-19 Bristol-Myers Squibb Company Branched hydrazone linkers
EP0971716A1 (en) 1996-03-22 2000-01-19 Waldemar Priebe Bis-anthracyclines with high activity against doxorubicin resistant tumors
US6218519B1 (en) 1996-04-12 2001-04-17 Pro-Neuron, Inc. Compounds and methods for the selective treatment of cancer and bacterial infections
GB9701628D0 (en) 1997-01-27 1997-03-19 Pharmacia & Upjohn Spa Imino-aza-anthracyclinone derivatives
AUPQ319799A0 (en) 1999-10-01 1999-10-28 Institute Of Drug Technology Australia Limited Chemical methods
IT1318532B1 (it) 2000-05-19 2003-08-27 Antibioticos Spa Procedimento di sintesi di derivati antraciclinici.
JP4688315B2 (ja) * 2001-02-28 2011-05-25 メルシャン株式会社 ４−デメトキシダウノマイシノンの製造
US7053191B2 (en) * 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US9053181B2 (en) 2003-11-03 2015-06-09 James W. Wieder Adaptive personalized playback or presentation using count
RU2260011C1 (ru) * 2004-02-27 2005-09-10 ОЛСУФЬЕВА Евгения Николаевна Способ получения антибиотика карминомицина или его гидрохлорида
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin
JP5634862B2 (ja) * 2007-05-16 2014-12-03 カーテーベー トゥモーアフォルシュングス ゲゼルシャフト ミット ベシュレンクテル ハフツング 低粘度アントラサイクリン製剤
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins

Also Published As

Publication number Publication date
ES2562328T3 (es) 2016-03-03
DK2518077T3 (en) 2016-01-18
US20120277415A1 (en) 2012-11-01
HK1178170A1 (zh) 2013-09-06
KR101563939B1 (ko) 2015-10-29
CN102757470A (zh) 2012-10-31
CN102757470B (zh) 2015-07-29
RU2012110492A (ru) 2013-09-27
KR20120122886A (ko) 2012-11-07
JP2012232971A (ja) 2012-11-29
US8846882B2 (en) 2014-09-30
RU2540968C2 (ru) 2015-02-10
JP5524262B2 (ja) 2014-06-18
EP2518077A1 (en) 2012-10-31
EP2518077B1 (en) 2016-01-06

Similar Documents

Publication Publication Date Title
IL263389B (en) A method for the production of modified 5-fluoro-1h-pyrazolopyridines
ZA201401133B (en) Method for producing ternesite
ZA201400196B (en) Method of producing nanoparticles
IL248217B (en) A method for the production of inganol-3-englate
HUE037048T2 (hu) Eljárások 4-cikloalkiloxibenzolszulfonamidok elõállítására
EP2699534A4 (en) PROCESS FOR PRODUCING TRANS-1233zd
EP2721017A4 (en) PROCESS FOR PREPARING BERAPROST
HK1188090A1 (en) Method for producing instant noodles
AP3748A (en) Method of producing hydrocarbons
EP2796487A4 (en) METHOD FOR PRODUCING MASTERBATCHES
PL2931937T3 (pl) Sposób wytwarzania układów nanocząstek metali
PL2755493T3 (pl) Sposób wytwarzania czekolady
GB201400544D0 (en) Method of calculating formation characteristics
PL2760619T3 (pl) Sposób wytwarzania struktury
EP2740719A4 (en) PROCESS FOR THE PREPARATION OF A-FLUOROALDEHYDE
GB201404539D0 (en) Method for producing graphene
HK1178170A1 (zh) 生產 -脫甲氧柔紅霉素的方法
IL231877A0 (en) A method for the production of dithiene tetracarboximides
IL231878A0 (en) A method for the production of dithiene tetracarboximides
IL232678A (en) METHOD FOR PRODUCING SYNACLETZ
GB201116033D0 (en) Method of producing tantalum
GB201119607D0 (en) Method of manufacture
EP2744994A4 (en) PROCESS FOR GENERATING ENERGY
AU2012900312A0 (en) Method of producing biosurfactants
PL396113A1 (pl) Metoda wytwarzania probiotyków