KR101500528B1 - 새로운 비-선택적 소마토스타틴 유사체 - Google Patents

새로운 비-선택적 소마토스타틴 유사체 Download PDF

Info

Publication number
KR101500528B1
KR101500528B1 KR1020107010880A KR20107010880A KR101500528B1 KR 101500528 B1 KR101500528 B1 KR 101500528B1 KR 1020107010880 A KR1020107010880 A KR 1020107010880A KR 20107010880 A KR20107010880 A KR 20107010880A KR 101500528 B1 KR101500528 B1 KR 101500528B1
Authority
KR
South Korea
Prior art keywords
phe
delete delete
tyr
pro
cyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020107010880A
Other languages
English (en)
Korean (ko)
Other versions
KR20100103464A (ko
Inventor
안드레아 비탈리
마시모 피노리
파올로 마스카니
Original Assignee
이탈파마코 에스.피.에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20072266 external-priority patent/ITMI20072266A1/it
Priority claimed from EP07425778A external-priority patent/EP2067786A1/en
Application filed by 이탈파마코 에스.피.에이. filed Critical 이탈파마코 에스.피.에이.
Publication of KR20100103464A publication Critical patent/KR20100103464A/ko
Application granted granted Critical
Publication of KR101500528B1 publication Critical patent/KR101500528B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/655Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/655Somatostatins
    • C07K14/6555Somatostatins at least 1 amino acid in D-form

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020107010880A 2007-12-03 2008-11-24 새로운 비-선택적 소마토스타틴 유사체 Active KR101500528B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ITMI2007A002266 2007-12-03
ITMI20072266 ITMI20072266A1 (it) 2007-12-03 2007-12-03 Nuovi analoghi non selettivi di somatostatina
EP07425778A EP2067786A1 (en) 2007-12-07 2007-12-07 Novel non selective analogs of somatostatin
EP07425778.3 2007-12-07
PCT/EP2008/066081 WO2009071460A2 (en) 2007-12-03 2008-11-24 New non-selective somatostatin analogues

Publications (2)

Publication Number Publication Date
KR20100103464A KR20100103464A (ko) 2010-09-27
KR101500528B1 true KR101500528B1 (ko) 2015-03-09

Family

ID=40667736

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107010880A Active KR101500528B1 (ko) 2007-12-03 2008-11-24 새로운 비-선택적 소마토스타틴 유사체

Country Status (15)

Country Link
US (1) US8937152B2 (https=)
EP (1) EP2225271B1 (https=)
JP (1) JP5331817B2 (https=)
KR (1) KR101500528B1 (https=)
CN (1) CN101883785B (https=)
BR (1) BRPI0818978B8 (https=)
CA (1) CA2702940C (https=)
CY (1) CY1114490T1 (https=)
DK (1) DK2225271T3 (https=)
ES (1) ES2431573T3 (https=)
HR (1) HRP20130948T1 (https=)
PL (1) PL2225271T3 (https=)
PT (1) PT2225271E (https=)
SI (1) SI2225271T1 (https=)
WO (1) WO2009071460A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
US8937152B2 (en) * 2007-12-03 2015-01-20 Italfarmaco Spa Non-selective somatostatin analogues
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
BR112014004936A2 (pt) * 2011-09-04 2017-04-04 Glytech Inc polipeptídeo glicosilado e composição de drogas contendo referido polipeptídeo
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
JP6869720B2 (ja) * 2013-06-13 2021-05-12 アンチセンス セラピューティクス リミテッド 併用療法
CN103467575B (zh) * 2013-08-22 2016-03-02 深圳翰宇药业股份有限公司 一种帕西瑞肽的制备方法
CN103641894B (zh) * 2013-12-06 2015-10-28 深圳翰宇药业股份有限公司 一种治疗库欣病的多肽药物的制备方法
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN104447962B (zh) * 2014-12-29 2018-07-17 成都圣诺生物科技股份有限公司 一种合成帕瑞肽的方法
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2020064693A1 (en) * 2018-09-25 2020-04-02 Advanced Accelerator Applications (Italy) Srl Combination therapy
GB201816637D0 (en) * 2018-10-12 2018-11-28 Heptares Therapeutics Ltd Selective somatostatin receptor agonists
IL305248A (en) * 2021-03-04 2023-10-01 Starget Pharma Ltd Structurally constrained peptide ligands for the somatostatin-3 receptor, their derivatives, and their uses
IT202100032615A1 (it) 2021-12-24 2023-06-24 Italfarmaco Spa Uso di un agonista della somatostatina nel trattamento di tumori che esprimono SSTR3
CN119708199A (zh) * 2023-09-27 2025-03-28 钱杭江医药科技(嘉兴)有限公司 生长抑素肽类类似物、螯合物及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001579A2 (en) * 1995-06-29 1997-01-16 Novartis Ag Somatostatin peptides
EP1598366A1 (en) * 2004-03-10 2005-11-23 GIUNTINI, Mauro Somatostatin analogues

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0018891D0 (en) * 2000-08-01 2000-09-20 Novartis Ag Organic compounds
US6365380B2 (en) * 2000-02-23 2002-04-02 Pcbu Services, Inc. Method for stereoselectively inverting a chiral center of a chemical compound using an enzyme and a metal catalyst
CA2476324A1 (en) * 2002-03-12 2003-09-25 The Procter & Gamble Company Cosmetic composition comprising double coated pigment and a gelling agent
GB0206415D0 (en) 2002-03-19 2002-05-01 Glaxo Group Ltd Deracemisation of amines
GB0300095D0 (en) * 2003-01-03 2003-02-05 Novartis Ag Organic compounds
AR044852A1 (es) * 2003-06-24 2005-10-05 Novartis Ag Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina
JP2007501775A (ja) * 2003-08-07 2007-02-01 ノバルティス アクチエンゲゼルシャフト 免疫抑制剤としてのヒストンデアセチラーゼ阻害剤
GB0318682D0 (en) 2003-08-08 2003-09-10 Novartis Ag Organic compounds
EP1522311A1 (fr) * 2003-10-10 2005-04-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Utilisation de la somatostine ou d'un de ses analogues pour préparer un médicament destiné à réguler la réserve folliculaire ovarienne chez la femme non ménopausée
JP2007518702A (ja) * 2003-11-25 2007-07-12 ノバルティス アクチエンゲゼルシャフト ソマトスタチン類似体処置の効力についてのバイオマーカー
GB0428151D0 (en) 2004-12-22 2005-01-26 Novartis Ag Organic compounds
US7824663B2 (en) * 2005-03-10 2010-11-02 Kokyu Alcohol Kogyo Co., Ltd. Lip gloss composition
ES2383303T3 (es) * 2005-11-10 2012-06-20 Chemi S.P.A. Formulaciones de inhibidores de la liberación prolongada de la hormona del crecimiento análogos de la somatostatina
US8937152B2 (en) * 2007-12-03 2015-01-20 Italfarmaco Spa Non-selective somatostatin analogues

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001579A2 (en) * 1995-06-29 1997-01-16 Novartis Ag Somatostatin peptides
EP1598366A1 (en) * 2004-03-10 2005-11-23 GIUNTINI, Mauro Somatostatin analogues

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Lung Cancer Vol.50(3):319-328 (2005. 12. 01.) *
New Journal of Chemistry Vol.27(2):251-256 (2003) *

Also Published As

Publication number Publication date
US20100323964A1 (en) 2010-12-23
SI2225271T1 (sl) 2013-10-30
HRP20130948T1 (hr) 2013-11-08
ES2431573T3 (es) 2013-11-27
EP2225271A2 (en) 2010-09-08
BRPI0818978B8 (pt) 2021-05-25
WO2009071460A2 (en) 2009-06-11
CN101883785B (zh) 2014-01-15
KR20100103464A (ko) 2010-09-27
DK2225271T3 (da) 2013-10-07
PT2225271E (pt) 2013-09-27
EP2225271B1 (en) 2013-07-31
JP5331817B2 (ja) 2013-10-30
JP2011505345A (ja) 2011-02-24
CA2702940A1 (en) 2009-06-11
PL2225271T3 (pl) 2013-12-31
BRPI0818978A2 (pt) 2016-05-03
US8937152B2 (en) 2015-01-20
WO2009071460A3 (en) 2009-12-17
CY1114490T1 (el) 2016-10-05
CN101883785A (zh) 2010-11-10
BRPI0818978B1 (pt) 2019-09-10
CA2702940C (en) 2016-09-13

Similar Documents

Publication Publication Date Title
KR101500528B1 (ko) 새로운 비-선택적 소마토스타틴 유사체
CA2222524C (en) Somatostatin peptides
US7084244B2 (en) Conformationally constrained backbone cyclized peptide analogs
JP4181203B2 (ja) ソマトスタチン−ドーパミンキメラ類似体
JP4637352B2 (ja) コンフォメーション的に拘束された主鎖環化ソマトスタチン類似体
JP5254868B2 (ja) ソマトスタチン−ドーパミンキメラ類似体
AU2002333396B2 (en) Somatostatin analogues and their use somatostatin analogues binding to all somatostatin receptor and their use
WO2001044273A2 (en) Receptor-selective somatostatin analogs
WO2010065572A1 (en) Sstr1-selective analogs
JP5908184B2 (ja) ソマトスタチン−ドーパミンのキメラ類似体
JP2003503369A (ja) ソマトスタチンアゴニスト
AU2004251866B2 (en) Pharmaceutical composition comprising cyclic somatostatin analogues
EP2067786A1 (en) Novel non selective analogs of somatostatin
ITMI20072266A1 (it) Nuovi analoghi non selettivi di somatostatina
EP4656654A1 (en) Somatostatin peptide analogue, chelate and use thereof
AU2008200693B2 (en) Treatment of disease or condition with somatostatin-dopamine chimeric analogs

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20100518

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20130529

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20141121

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20150223

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20150303

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20150304

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20180226

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20180226

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20190222

Year of fee payment: 5

PR1001 Payment of annual fee

Payment date: 20190222

Start annual number: 5

End annual number: 5

FPAY Annual fee payment

Payment date: 20200225

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20200225

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 20210223

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 20220222

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20230222

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20250219

Start annual number: 11

End annual number: 11