BRPI0818978B8 - novos análogos não-seletivos da somatostatina - Google Patents
novos análogos não-seletivos da somatostatinaInfo
- Publication number
- BRPI0818978B8 BRPI0818978B8 BRPI0818978A BRPI0818978A BRPI0818978B8 BR PI0818978 B8 BRPI0818978 B8 BR PI0818978B8 BR PI0818978 A BRPI0818978 A BR PI0818978A BR PI0818978 A BRPI0818978 A BR PI0818978A BR PI0818978 B8 BRPI0818978 B8 BR PI0818978B8
- Authority
- BR
- Brazil
- Prior art keywords
- new non
- somatostatin analogues
- selective
- selective somatostatin
- analogues
- Prior art date
Links
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 4
- 229940075620 somatostatin analogue Drugs 0.000 title abstract 3
- 102000001189 Cyclic Peptides Human genes 0.000 abstract 1
- 108010069514 Cyclic Peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI20072266 ITMI20072266A1 (it) | 2007-12-03 | 2007-12-03 | Nuovi analoghi non selettivi di somatostatina |
| EP07425778A EP2067786A1 (en) | 2007-12-07 | 2007-12-07 | Novel non selective analogs of somatostatin |
| PCT/EP2008/066081 WO2009071460A2 (en) | 2007-12-03 | 2008-11-24 | New non-selective somatostatin analogues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0818978A2 BRPI0818978A2 (pt) | 2016-05-03 |
| BRPI0818978B1 BRPI0818978B1 (pt) | 2019-09-10 |
| BRPI0818978B8 true BRPI0818978B8 (pt) | 2021-05-25 |
Family
ID=40667736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0818978A BRPI0818978B8 (pt) | 2007-12-03 | 2008-11-24 | novos análogos não-seletivos da somatostatina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8937152B2 (https=) |
| EP (1) | EP2225271B1 (https=) |
| JP (1) | JP5331817B2 (https=) |
| KR (1) | KR101500528B1 (https=) |
| CN (1) | CN101883785B (https=) |
| BR (1) | BRPI0818978B8 (https=) |
| CA (1) | CA2702940C (https=) |
| CY (1) | CY1114490T1 (https=) |
| DK (1) | DK2225271T3 (https=) |
| ES (1) | ES2431573T3 (https=) |
| HR (1) | HRP20130948T1 (https=) |
| PL (1) | PL2225271T3 (https=) |
| PT (1) | PT2225271E (https=) |
| SI (1) | SI2225271T1 (https=) |
| WO (1) | WO2009071460A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
| US8937152B2 (en) * | 2007-12-03 | 2015-01-20 | Italfarmaco Spa | Non-selective somatostatin analogues |
| ES2711526T3 (es) | 2010-08-13 | 2019-05-06 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
| BR112014004936A2 (pt) * | 2011-09-04 | 2017-04-04 | Glytech Inc | polipeptídeo glicosilado e composição de drogas contendo referido polipeptídeo |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES |
| BR112014020103A2 (pt) | 2012-02-15 | 2018-10-09 | Aileron Therapeutics, Inc. | macrociclos peptidomiméticos |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| JP6869720B2 (ja) * | 2013-06-13 | 2021-05-12 | アンチセンス セラピューティクス リミテッド | 併用療法 |
| CN103467575B (zh) * | 2013-08-22 | 2016-03-02 | 深圳翰宇药业股份有限公司 | 一种帕西瑞肽的制备方法 |
| CN103641894B (zh) * | 2013-12-06 | 2015-10-28 | 深圳翰宇药业股份有限公司 | 一种治疗库欣病的多肽药物的制备方法 |
| EP3197478A4 (en) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN104447962B (zh) * | 2014-12-29 | 2018-07-17 | 成都圣诺生物科技股份有限公司 | 一种合成帕瑞肽的方法 |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2020064693A1 (en) * | 2018-09-25 | 2020-04-02 | Advanced Accelerator Applications (Italy) Srl | Combination therapy |
| GB201816637D0 (en) * | 2018-10-12 | 2018-11-28 | Heptares Therapeutics Ltd | Selective somatostatin receptor agonists |
| IL305248A (en) * | 2021-03-04 | 2023-10-01 | Starget Pharma Ltd | Structurally constrained peptide ligands for the somatostatin-3 receptor, their derivatives, and their uses |
| IT202100032615A1 (it) | 2021-12-24 | 2023-06-24 | Italfarmaco Spa | Uso di un agonista della somatostatina nel trattamento di tumori che esprimono SSTR3 |
| CN119708199A (zh) * | 2023-09-27 | 2025-03-28 | 钱杭江医药科技(嘉兴)有限公司 | 生长抑素肽类类似物、螯合物及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY147327A (en) * | 1995-06-29 | 2012-11-30 | Novartis Ag | Somatostatin peptides |
| GB0018891D0 (en) * | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| US6365380B2 (en) * | 2000-02-23 | 2002-04-02 | Pcbu Services, Inc. | Method for stereoselectively inverting a chiral center of a chemical compound using an enzyme and a metal catalyst |
| CA2476324A1 (en) * | 2002-03-12 | 2003-09-25 | The Procter & Gamble Company | Cosmetic composition comprising double coated pigment and a gelling agent |
| GB0206415D0 (en) | 2002-03-19 | 2002-05-01 | Glaxo Group Ltd | Deracemisation of amines |
| GB0300095D0 (en) * | 2003-01-03 | 2003-02-05 | Novartis Ag | Organic compounds |
| AR044852A1 (es) * | 2003-06-24 | 2005-10-05 | Novartis Ag | Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina |
| JP2007501775A (ja) * | 2003-08-07 | 2007-02-01 | ノバルティス アクチエンゲゼルシャフト | 免疫抑制剤としてのヒストンデアセチラーゼ阻害剤 |
| GB0318682D0 (en) | 2003-08-08 | 2003-09-10 | Novartis Ag | Organic compounds |
| EP1522311A1 (fr) * | 2003-10-10 | 2005-04-13 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Utilisation de la somatostine ou d'un de ses analogues pour préparer un médicament destiné à réguler la réserve folliculaire ovarienne chez la femme non ménopausée |
| JP2007518702A (ja) * | 2003-11-25 | 2007-07-12 | ノバルティス アクチエンゲゼルシャフト | ソマトスタチン類似体処置の効力についてのバイオマーカー |
| ITFI20040057A1 (it) * | 2004-03-10 | 2004-06-10 | Mauro Giuntini | Analoghi della somatostatina |
| GB0428151D0 (en) | 2004-12-22 | 2005-01-26 | Novartis Ag | Organic compounds |
| US7824663B2 (en) * | 2005-03-10 | 2010-11-02 | Kokyu Alcohol Kogyo Co., Ltd. | Lip gloss composition |
| ES2383303T3 (es) * | 2005-11-10 | 2012-06-20 | Chemi S.P.A. | Formulaciones de inhibidores de la liberación prolongada de la hormona del crecimiento análogos de la somatostatina |
| US8937152B2 (en) * | 2007-12-03 | 2015-01-20 | Italfarmaco Spa | Non-selective somatostatin analogues |
-
2008
- 2008-11-24 US US12/734,475 patent/US8937152B2/en active Active
- 2008-11-24 DK DK08856519.7T patent/DK2225271T3/da active
- 2008-11-24 EP EP08856519.7A patent/EP2225271B1/en active Active
- 2008-11-24 CA CA2702940A patent/CA2702940C/en active Active
- 2008-11-24 KR KR1020107010880A patent/KR101500528B1/ko active Active
- 2008-11-24 CN CN200880118937.1A patent/CN101883785B/zh active Active
- 2008-11-24 PL PL08856519T patent/PL2225271T3/pl unknown
- 2008-11-24 ES ES08856519T patent/ES2431573T3/es active Active
- 2008-11-24 SI SI200831046T patent/SI2225271T1/sl unknown
- 2008-11-24 WO PCT/EP2008/066081 patent/WO2009071460A2/en not_active Ceased
- 2008-11-24 PT PT88565197T patent/PT2225271E/pt unknown
- 2008-11-24 BR BRPI0818978A patent/BRPI0818978B8/pt active IP Right Grant
- 2008-11-24 HR HRP20130948AT patent/HRP20130948T1/hr unknown
- 2008-11-24 JP JP2010535349A patent/JP5331817B2/ja active Active
-
2013
- 2013-10-10 CY CY20131100895T patent/CY1114490T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20100323964A1 (en) | 2010-12-23 |
| SI2225271T1 (sl) | 2013-10-30 |
| HRP20130948T1 (hr) | 2013-11-08 |
| ES2431573T3 (es) | 2013-11-27 |
| EP2225271A2 (en) | 2010-09-08 |
| WO2009071460A2 (en) | 2009-06-11 |
| CN101883785B (zh) | 2014-01-15 |
| KR20100103464A (ko) | 2010-09-27 |
| DK2225271T3 (da) | 2013-10-07 |
| PT2225271E (pt) | 2013-09-27 |
| EP2225271B1 (en) | 2013-07-31 |
| JP5331817B2 (ja) | 2013-10-30 |
| JP2011505345A (ja) | 2011-02-24 |
| CA2702940A1 (en) | 2009-06-11 |
| PL2225271T3 (pl) | 2013-12-31 |
| BRPI0818978A2 (pt) | 2016-05-03 |
| US8937152B2 (en) | 2015-01-20 |
| WO2009071460A3 (en) | 2009-12-17 |
| CY1114490T1 (el) | 2016-10-05 |
| KR101500528B1 (ko) | 2015-03-09 |
| CN101883785A (zh) | 2010-11-10 |
| BRPI0818978B1 (pt) | 2019-09-10 |
| CA2702940C (en) | 2016-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06A | Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette] | ||
| B06A | Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/09/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/09/2019, OBSERVADAS AS CONDICOES LEGAIS |
|
| B16C | Correction of notification of the grant |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/11/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |