ES2431573T3 - Nuevos análogos no selectivos de somatostatina - Google Patents

Nuevos análogos no selectivos de somatostatina Download PDF

Info

Publication number
ES2431573T3
ES2431573T3 ES08856519T ES08856519T ES2431573T3 ES 2431573 T3 ES2431573 T3 ES 2431573T3 ES 08856519 T ES08856519 T ES 08856519T ES 08856519 T ES08856519 T ES 08856519T ES 2431573 T3 ES2431573 T3 ES 2431573T3
Authority
ES
Spain
Prior art keywords
phe
group
cycle
tyr
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08856519T
Other languages
English (en)
Spanish (es)
Inventor
Andrea Vitali
Massimo Pinori
Paolo Mascagni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Italfarmaco SpA
Original Assignee
Italfarmaco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20072266 external-priority patent/ITMI20072266A1/it
Priority claimed from EP07425778A external-priority patent/EP2067786A1/en
Application filed by Italfarmaco SpA filed Critical Italfarmaco SpA
Application granted granted Critical
Publication of ES2431573T3 publication Critical patent/ES2431573T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ES08856519T 2007-12-03 2008-11-24 Nuevos análogos no selectivos de somatostatina Active ES2431573T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ITMI20072266 2007-12-03
ITMI20072266 ITMI20072266A1 (it) 2007-12-03 2007-12-03 Nuovi analoghi non selettivi di somatostatina
EP07425778A EP2067786A1 (en) 2007-12-07 2007-12-07 Novel non selective analogs of somatostatin
EP07425778 2007-12-07
PCT/EP2008/066081 WO2009071460A2 (en) 2007-12-03 2008-11-24 New non-selective somatostatin analogues

Publications (1)

Publication Number Publication Date
ES2431573T3 true ES2431573T3 (es) 2013-11-27

Family

ID=40667736

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08856519T Active ES2431573T3 (es) 2007-12-03 2008-11-24 Nuevos análogos no selectivos de somatostatina

Country Status (15)

Country Link
US (1) US8937152B2 (https=)
EP (1) EP2225271B1 (https=)
JP (1) JP5331817B2 (https=)
KR (1) KR101500528B1 (https=)
CN (1) CN101883785B (https=)
BR (1) BRPI0818978B8 (https=)
CA (1) CA2702940C (https=)
CY (1) CY1114490T1 (https=)
DK (1) DK2225271T3 (https=)
ES (1) ES2431573T3 (https=)
HR (1) HRP20130948T1 (https=)
PL (1) PL2225271T3 (https=)
PT (1) PT2225271E (https=)
SI (1) SI2225271T1 (https=)
WO (1) WO2009071460A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
US8937152B2 (en) * 2007-12-03 2015-01-20 Italfarmaco Spa Non-selective somatostatin analogues
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
BR112014004936A2 (pt) * 2011-09-04 2017-04-04 Glytech Inc polipeptídeo glicosilado e composição de drogas contendo referido polipeptídeo
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
JP6869720B2 (ja) * 2013-06-13 2021-05-12 アンチセンス セラピューティクス リミテッド 併用療法
CN103467575B (zh) * 2013-08-22 2016-03-02 深圳翰宇药业股份有限公司 一种帕西瑞肽的制备方法
CN103641894B (zh) * 2013-12-06 2015-10-28 深圳翰宇药业股份有限公司 一种治疗库欣病的多肽药物的制备方法
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN104447962B (zh) * 2014-12-29 2018-07-17 成都圣诺生物科技股份有限公司 一种合成帕瑞肽的方法
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2020064693A1 (en) * 2018-09-25 2020-04-02 Advanced Accelerator Applications (Italy) Srl Combination therapy
GB201816637D0 (en) * 2018-10-12 2018-11-28 Heptares Therapeutics Ltd Selective somatostatin receptor agonists
IL305248A (en) * 2021-03-04 2023-10-01 Starget Pharma Ltd Structurally constrained peptide ligands for the somatostatin-3 receptor, their derivatives, and their uses
IT202100032615A1 (it) 2021-12-24 2023-06-24 Italfarmaco Spa Uso di un agonista della somatostatina nel trattamento di tumori che esprimono SSTR3
CN119708199A (zh) * 2023-09-27 2025-03-28 钱杭江医药科技(嘉兴)有限公司 生长抑素肽类类似物、螯合物及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY147327A (en) * 1995-06-29 2012-11-30 Novartis Ag Somatostatin peptides
GB0018891D0 (en) * 2000-08-01 2000-09-20 Novartis Ag Organic compounds
US6365380B2 (en) * 2000-02-23 2002-04-02 Pcbu Services, Inc. Method for stereoselectively inverting a chiral center of a chemical compound using an enzyme and a metal catalyst
CA2476324A1 (en) * 2002-03-12 2003-09-25 The Procter & Gamble Company Cosmetic composition comprising double coated pigment and a gelling agent
GB0206415D0 (en) 2002-03-19 2002-05-01 Glaxo Group Ltd Deracemisation of amines
GB0300095D0 (en) * 2003-01-03 2003-02-05 Novartis Ag Organic compounds
AR044852A1 (es) * 2003-06-24 2005-10-05 Novartis Ag Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina
JP2007501775A (ja) * 2003-08-07 2007-02-01 ノバルティス アクチエンゲゼルシャフト 免疫抑制剤としてのヒストンデアセチラーゼ阻害剤
GB0318682D0 (en) 2003-08-08 2003-09-10 Novartis Ag Organic compounds
EP1522311A1 (fr) * 2003-10-10 2005-04-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Utilisation de la somatostine ou d'un de ses analogues pour préparer un médicament destiné à réguler la réserve folliculaire ovarienne chez la femme non ménopausée
JP2007518702A (ja) * 2003-11-25 2007-07-12 ノバルティス アクチエンゲゼルシャフト ソマトスタチン類似体処置の効力についてのバイオマーカー
ITFI20040057A1 (it) * 2004-03-10 2004-06-10 Mauro Giuntini Analoghi della somatostatina
GB0428151D0 (en) 2004-12-22 2005-01-26 Novartis Ag Organic compounds
US7824663B2 (en) * 2005-03-10 2010-11-02 Kokyu Alcohol Kogyo Co., Ltd. Lip gloss composition
ES2383303T3 (es) * 2005-11-10 2012-06-20 Chemi S.P.A. Formulaciones de inhibidores de la liberación prolongada de la hormona del crecimiento análogos de la somatostatina
US8937152B2 (en) * 2007-12-03 2015-01-20 Italfarmaco Spa Non-selective somatostatin analogues

Also Published As

Publication number Publication date
US20100323964A1 (en) 2010-12-23
SI2225271T1 (sl) 2013-10-30
HRP20130948T1 (hr) 2013-11-08
EP2225271A2 (en) 2010-09-08
BRPI0818978B8 (pt) 2021-05-25
WO2009071460A2 (en) 2009-06-11
CN101883785B (zh) 2014-01-15
KR20100103464A (ko) 2010-09-27
DK2225271T3 (da) 2013-10-07
PT2225271E (pt) 2013-09-27
EP2225271B1 (en) 2013-07-31
JP5331817B2 (ja) 2013-10-30
JP2011505345A (ja) 2011-02-24
CA2702940A1 (en) 2009-06-11
PL2225271T3 (pl) 2013-12-31
BRPI0818978A2 (pt) 2016-05-03
US8937152B2 (en) 2015-01-20
WO2009071460A3 (en) 2009-12-17
CY1114490T1 (el) 2016-10-05
KR101500528B1 (ko) 2015-03-09
CN101883785A (zh) 2010-11-10
BRPI0818978B1 (pt) 2019-09-10
CA2702940C (en) 2016-09-13

Similar Documents

Publication Publication Date Title
ES2431573T3 (es) Nuevos análogos no selectivos de somatostatina
ES2646192T3 (es) Antagonistas del receptor 2 de somatostatina
ES2288029T3 (es) Analogos de somatostatina con esqueleto ciclado de conformacion restringida.
ES2325880T3 (es) Analogos quimericos de somatostatina-dopamina.
RU2329273C2 (ru) Химерные аналоги лигандов соматостатиновых и допаминовых рецепторов, фармацевтические композиции на их основе и способы воздействия на рецепторы соматостатина и/или допамина
SK211290A3 (en) Octapeptide and therapeutical agent containing the same
US20130035286A1 (en) Pharmaceutical Composition Comprising Cyclic Somatostatin Analogues
JP2949129B2 (ja) 胃腸運動刺激活性を有するモチリン類似ポリペプチド
EP2067786A1 (en) Novel non selective analogs of somatostatin
CN1812997B (zh) 包含促生长素抑制素类似物的胃肠外药物组合物
ITMI20072266A1 (it) Nuovi analoghi non selettivi di somatostatina
AU2008200693B2 (en) Treatment of disease or condition with somatostatin-dopamine chimeric analogs