KR101461376B1 - 통증 치료를 위한 ｔｒｐｖｌ의 모듈레이터로서의 6,7,8,9-테트라하이드로-5ｈ-피리미도[4,5-ｄ]아제핀-4-일]-아민 유도체 - Google Patents

통증 치료를 위한 ｔｒｐｖｌ의 모듈레이터로서의 6,7,8,9-테트라하이드로-5ｈ-피리미도[4,5-ｄ]아제핀-4-일]-아민 유도체 Download PDF

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KR101461376B1
KR101461376B1 KR1020087025462A KR20087025462A KR101461376B1 KR 101461376 B1 KR101461376 B1 KR 101461376B1 KR 1020087025462 A KR1020087025462 A KR 1020087025462A KR 20087025462 A KR20087025462 A KR 20087025462A KR 101461376 B1 KR101461376 B1 KR 101461376B1
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trifluoromethyl
tetrahydro
pyrimido
pyridin
azepin
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KR20090006098A (ko
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브레트 디. 알리손
브라이언 제임스 브랜스테터
제임스 가이 브라이텐부처
마이클 디. 하크
나탈리 에이. 호우리룩
알렉 디. 레브사크
켈리 제이. 맥클루어
제프리 이. 메리트
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얀센 파마슈티카 엔.브이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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KR1020087025462A 2006-03-21 2007-03-21 통증 치료를 위한 ｔｒｐｖｌ의 모듈레이터로서의 6,7,8,9-테트라하이드로-5ｈ-피리미도[4,5-ｄ]아제핀-4-일]-아민 유도체 Expired - Fee Related KR101461376B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78541506P 2006-03-21 2006-03-21
US60/785,415 2006-03-21
PCT/US2007/007166 WO2007109355A2 (en) 2006-03-21 2007-03-21 6,7,8, 9 -tetrahydro- 5h- pyrimido [4, 5-d] azepin-4-yl] -amine derivatives as modulators of trpvl for the treatment of pain

Publications (2)

Publication Number Publication Date
KR20090006098A KR20090006098A (ko) 2009-01-14
KR101461376B1 true KR101461376B1 (ko) 2014-11-26

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US (3) US8673895B2 (https=)
EP (1) EP2024368B1 (https=)
JP (1) JP5232768B2 (https=)
KR (1) KR101461376B1 (https=)
CN (1) CN101448835B (https=)
AR (1) AR059985A1 (https=)
AU (1) AU2007227203B2 (https=)
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CN102712642B (zh) * 2009-11-12 2015-08-12 霍夫曼-拉罗奇有限公司 N-7取代的嘌呤和吡唑并嘧啶化合物、组合物和使用方法
WO2011058027A2 (en) * 2009-11-12 2011-05-19 F. Hoffmann-La Roche Ag N-9-substituted purine compounds, compositions and methods of use
EP2585216B1 (en) * 2010-06-23 2019-11-20 Johnson Matthey PLC Pi-allylpalladium and pi-allylnickel complexes for use as catalysts in carbon-carbon and carbon-nitrogen coupling reactions
CN102154494B (zh) * 2011-03-14 2013-01-02 中国人民解放军军事医学科学院基础医学研究所 一种用于儿童哮喘检测的标志物
WO2014129796A1 (en) 2013-02-20 2014-08-28 Lg Life Sciences Ltd. Sphingosine-1-phosphate receptor agonists, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent
CN103641762A (zh) * 2013-12-18 2014-03-19 中国药科大学 一类trpv1/cox-2双重抑制剂、其制备方法及其制备镇痛药物的用途
CN113727758A (zh) * 2019-03-01 2021-11-30 锐新医药公司 双环杂环基化合物及其用途
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