KR101425429B1 - 이반드로네이트 나트륨 합성을 위한 향상된 공정 - Google Patents

이반드로네이트 나트륨 합성을 위한 향상된 공정 Download PDF

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Publication number
KR101425429B1
KR101425429B1 KR1020087030889A KR20087030889A KR101425429B1 KR 101425429 B1 KR101425429 B1 KR 101425429B1 KR 1020087030889 A KR1020087030889 A KR 1020087030889A KR 20087030889 A KR20087030889 A KR 20087030889A KR 101425429 B1 KR101425429 B1 KR 101425429B1
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KR
South Korea
Prior art keywords
methyl
amino
methylpentyl
iii
formula
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Expired - Fee Related
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KR1020087030889A
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English (en)
Korean (ko)
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KR20090023394A (ko
Inventor
다라마라 람찬드라 라오
라젠드라 나라얀라오 칸칸
마루티 간파티 가게어
Original Assignee
씨아이피엘에이 엘티디.
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/04—Sodium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
KR1020087030889A 2006-06-23 2007-06-22 이반드로네이트 나트륨 합성을 위한 향상된 공정 Expired - Fee Related KR101425429B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN994/MUM/2006 2006-06-23
IN994MU2006 2006-06-23
PCT/IN2007/000255 WO2008035367A2 (en) 2006-06-23 2007-06-22 Process for the synthesis of ibandronate sodium

Publications (2)

Publication Number Publication Date
KR20090023394A KR20090023394A (ko) 2009-03-04
KR101425429B1 true KR101425429B1 (ko) 2014-08-01

Family

ID=39144580

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087030889A Expired - Fee Related KR101425429B1 (ko) 2006-06-23 2007-06-22 이반드로네이트 나트륨 합성을 위한 향상된 공정

Country Status (11)

Country Link
US (1) US8178712B2 (cg-RX-API-DMAC7.html)
EP (1) EP2038291B1 (cg-RX-API-DMAC7.html)
JP (1) JP5571378B2 (cg-RX-API-DMAC7.html)
KR (1) KR101425429B1 (cg-RX-API-DMAC7.html)
AT (1) ATE473990T1 (cg-RX-API-DMAC7.html)
AU (1) AU2007298508B2 (cg-RX-API-DMAC7.html)
CA (1) CA2652420C (cg-RX-API-DMAC7.html)
DE (1) DE602007007773D1 (cg-RX-API-DMAC7.html)
NZ (1) NZ573137A (cg-RX-API-DMAC7.html)
WO (1) WO2008035367A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200810024B (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007270897A1 (en) * 2006-07-03 2008-01-10 Generics [Uk] Limited Novel process for the preparation of bisphosphonic acids
CN102093416B (zh) * 2011-03-17 2013-07-24 南京恒生制药有限公司 一种合成伊班膦酸钠的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006045578A2 (en) 2004-10-29 2006-05-04 F. Hoffmann-La Roche Ag Process for the preparation of ibandronate

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
JPS5414931A (en) * 1977-07-05 1979-02-03 Seitetsu Kagaku Co Ltd Preparation of n-benzylglycine
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JPS63190868A (ja) * 1986-08-21 1988-08-08 Kanegafuchi Chem Ind Co Ltd 光学活性スルホニルオキシ化合物及びその化合物を用いる光学活性アミンの製造方法
JPH11322687A (ja) * 1998-05-12 1999-11-24 Koei Chem Co Ltd ホルムアミド類の製造方法
JPH11349494A (ja) * 1998-06-03 1999-12-21 Toray Ind Inc 光学分割用分離剤および光学異性体の吸着分離方法
JP2001294558A (ja) * 2000-04-12 2001-10-23 Honshu Chem Ind Co Ltd ノルボルネンー２−カルボン酸エステル類及びその製造方法
CA2536229C (en) * 2003-08-21 2012-09-25 Sun Pharmaceutical Industries Limited A process for preparation of bisphosphonic acid compounds
JP4191008B2 (ja) * 2003-11-04 2008-12-03 花王株式会社 アミノカルボン酸エステルの製造法
US7723542B2 (en) 2003-12-23 2010-05-25 Trifarma S.P.A. Process for the preparation of alkyl- and aryl-diphosphonic acids and salts thereof
MX2007000087A (es) * 2004-06-23 2007-11-06 Teva Pharma Acido ibandronico solido y cristalino.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006045578A2 (en) 2004-10-29 2006-05-04 F. Hoffmann-La Roche Ag Process for the preparation of ibandronate

Also Published As

Publication number Publication date
EP2038291A2 (en) 2009-03-25
WO2008035367A3 (en) 2008-05-22
KR20090023394A (ko) 2009-03-04
DE602007007773D1 (de) 2010-08-26
EP2038291B1 (en) 2010-07-14
CA2652420A1 (en) 2008-03-27
CA2652420C (en) 2014-01-14
ZA200810024B (en) 2009-10-28
AU2007298508B2 (en) 2012-02-09
US20100228052A1 (en) 2010-09-09
US8178712B2 (en) 2012-05-15
NZ573137A (en) 2011-03-31
WO2008035367A2 (en) 2008-03-27
AU2007298508A1 (en) 2008-03-27
ATE473990T1 (de) 2010-07-15
WO2008035367B1 (en) 2008-08-07
JP5571378B2 (ja) 2014-08-13
JP2009541305A (ja) 2009-11-26

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