ATE508134T1 - Amorphe form das natriumsalzes der ibandronsäure - Google Patents
Amorphe form das natriumsalzes der ibandronsäureInfo
- Publication number
- ATE508134T1 ATE508134T1 AT04804152T AT04804152T ATE508134T1 AT E508134 T1 ATE508134 T1 AT E508134T1 AT 04804152 T AT04804152 T AT 04804152T AT 04804152 T AT04804152 T AT 04804152T AT E508134 T1 ATE508134 T1 AT E508134T1
- Authority
- AT
- Austria
- Prior art keywords
- amorphous form
- sodium salt
- ibandronic acid
- acid
- relates
- Prior art date
Links
- 229960005236 ibandronic acid Drugs 0.000 title abstract 2
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 title 1
- NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 title 1
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- -1 ibandronic acid monosodium salt Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI20032582 ITMI20032582A1 (it) | 2003-12-23 | 2003-12-23 | Ibandronato monosodico amorfo |
| ITMI20040080 ITMI20040080A1 (it) | 2004-01-22 | 2004-01-22 | Processo per la produzione di acidi alchil-e aril-difosfonici |
| PCT/EP2004/014556 WO2005063779A2 (en) | 2003-12-23 | 2004-12-22 | A process for the preparation of alkyl- and aryl-diphosphonic acids and salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE508134T1 true ATE508134T1 (de) | 2011-05-15 |
Family
ID=34740786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04804152T ATE508134T1 (de) | 2003-12-23 | 2004-12-22 | Amorphe form das natriumsalzes der ibandronsäure |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7723542B2 (de) |
| EP (2) | EP1716161B1 (de) |
| AT (1) | ATE508134T1 (de) |
| CA (1) | CA2551230A1 (de) |
| DE (1) | DE602004032577D1 (de) |
| IL (2) | IL176487A (de) |
| WO (1) | WO2005063779A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003233569A1 (en) * | 2002-05-17 | 2003-12-02 | Teva Pharmaceutical Industries Ltd. | Use of certain diluents for making bisphosphonic acids |
| WO2006002348A2 (en) * | 2004-06-23 | 2006-01-05 | Teva Pharmaceutical Industies Ltd. | Solid and crystalline ibandronic acid |
| EP1713489B1 (de) * | 2004-08-23 | 2011-01-19 | Teva Pharmaceutical Industries Ltd | Kristalline form des ibandronat-natriums und herstellungsverfahren dafür |
| PL199215B1 (pl) * | 2004-12-28 | 2008-08-29 | Politechnika Gdanska | Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej |
| US8071574B2 (en) | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| AR054673A1 (es) * | 2005-07-28 | 2007-07-11 | Gador Sa | Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende |
| WO2007069049A2 (en) * | 2005-12-16 | 2007-06-21 | Wockhardt Ltd | Processes for the preparation of pure zoledronic acid |
| MX2008000139A (es) * | 2006-04-25 | 2009-02-23 | Teva Pharma | Formas cristalinas de acido inbandronico y procesos para la preparacion de ellas. |
| WO2007125521A2 (en) * | 2006-05-02 | 2007-11-08 | Ranbaxy Laboratories Limited | Polymorphic form of zoledronic acid and processes for their preparation |
| JP5354858B2 (ja) * | 2006-05-09 | 2013-11-27 | 株式会社Ａｄｅｋａ | スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物 |
| WO2007132478A2 (en) | 2006-05-11 | 2007-11-22 | Ind-Swift Laboratories Limited | Process for the preparation of pure risedronic acid or salts |
| ATE473990T1 (de) | 2006-06-23 | 2010-07-15 | Cipla Ltd | Verfahren zur synthese von ibandronat-natrium |
| WO2008014510A2 (en) * | 2006-07-28 | 2008-01-31 | Dr. Reddy's Laboratories Limited | Crystalline form a of ibandronic acid and process for the preparation |
| CA2570949A1 (en) | 2006-12-12 | 2008-06-12 | Apotex Pharmachem Inc. | Ibandronate sodium propylene glycol solvate and processes for the preparation thereof |
| SI2144919T1 (sl) * | 2007-04-11 | 2016-02-29 | F. Hoffmann-La Roche Ag | Večstopenjska sinteza ibandronata |
| WO2009061336A1 (en) * | 2007-11-05 | 2009-05-14 | Teva Pharmaceutical Industries Ltd. | Amorphous and crystalline forms of ibandronate disodium |
| EP2180003A1 (de) | 2008-10-21 | 2010-04-28 | Zentiva, k.s. | Herstellung von Trinatriumbandronat |
| PL213599B1 (pl) * | 2008-10-31 | 2013-03-29 | Politechnika Gdanska | Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego |
| WO2011016738A1 (en) | 2009-08-05 | 2011-02-10 | Zaklady Farmaceutyczne Polpharma Sa | A process for the synthesis of 1-hydroxy-3-(n-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate |
| US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
| TR201110524A2 (tr) * | 2011-01-06 | 2012-07-23 | Bi̇lgi̇ç Mahmut | Kemik hastalıklarının tedavisinde kullanılmak üzere suda çözünebilir yeni formülasyonlar. |
| CN106699809A (zh) * | 2016-12-07 | 2017-05-24 | 河北仁合益康药业有限公司 | 一种唑来膦酸的合成工艺 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2658961C3 (de) * | 1976-12-24 | 1981-09-24 | Joh. A. Benckiser Gmbh, 6700 Ludwigshafen | Verfahren zur Herstellung von 1-Hydroxy-3-amino-propan-1,1-diphosphonsäuren |
| DE2702631A1 (de) * | 1977-01-22 | 1978-07-27 | Henkel Kgaa | Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren |
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| IL77243A (en) | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| ES2038692T4 (es) | 1986-11-21 | 2012-02-10 | Novartis Ag | Procedimiento para la obtencion de acidos alcanodifosfonicos substituidos. |
| IT1230503B (it) | 1988-09-23 | 1991-10-25 | Gentili Ist Spa | Acido 8 amino 1 idrossiottan 1,1difosfonico, suoi sali o derivati e relative composizioni farmaceutiche |
| PL194770B1 (pl) | 2001-03-19 | 2007-07-31 | Adamed Sp Z Oo | Sposób wytwarzania kwasu rizedronowego |
| AU2003233569A1 (en) * | 2002-05-17 | 2003-12-02 | Teva Pharmaceutical Industries Ltd. | Use of certain diluents for making bisphosphonic acids |
-
2004
- 2004-12-22 AT AT04804152T patent/ATE508134T1/de not_active IP Right Cessation
- 2004-12-22 EP EP04804152A patent/EP1716161B1/de not_active Expired - Lifetime
- 2004-12-22 DE DE602004032577T patent/DE602004032577D1/de not_active Expired - Lifetime
- 2004-12-22 EP EP10158130A patent/EP2206717B1/de not_active Expired - Lifetime
- 2004-12-22 US US10/584,022 patent/US7723542B2/en not_active Expired - Fee Related
- 2004-12-22 WO PCT/EP2004/014556 patent/WO2005063779A2/en not_active Ceased
- 2004-12-22 CA CA002551230A patent/CA2551230A1/en not_active Abandoned
-
2006
- 2006-06-22 IL IL176487A patent/IL176487A/en active IP Right Grant
-
2010
- 2010-04-29 IL IL205426A patent/IL205426A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004032577D1 (de) | 2011-06-16 |
| WO2005063779A2 (en) | 2005-07-14 |
| IL176487A (en) | 2012-06-28 |
| EP2206717A1 (de) | 2010-07-14 |
| IL176487A0 (en) | 2008-02-09 |
| EP1716161B1 (de) | 2011-05-04 |
| US7723542B2 (en) | 2010-05-25 |
| WO2005063779A3 (en) | 2005-09-29 |
| EP1716161A2 (de) | 2006-11-02 |
| IL205426A (en) | 2015-09-24 |
| IL205426A0 (en) | 2011-07-31 |
| EP2206717B1 (de) | 2013-03-27 |
| CA2551230A1 (en) | 2005-07-14 |
| US20070112197A1 (en) | 2007-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |