EG20551A - A process for the preparation of alkylphosphacholines and the production thereof in pure form - Google Patents

A process for the preparation of alkylphosphacholines and the production thereof in pure form

Info

Publication number
EG20551A
EG20551A EG34492A EG34492A EG20551A EG 20551 A EG20551 A EG 20551A EG 34492 A EG34492 A EG 34492A EG 34492 A EG34492 A EG 34492A EG 20551 A EG20551 A EG 20551A
Authority
EG
Egypt
Prior art keywords
ion exchanger
preparation
alkylphosphacholines
production
reaction
Prior art date
Application number
EG34492A
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Application granted granted Critical
Publication of EG20551A publication Critical patent/EG20551A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Steroid Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

Process for the preparation of C14-C18-alkylphosphocholines in a one-pot process by reaction of an n-alkanol having a chain length of C14-C18 with phosphorus oxychloride in an inert solvent or else without solvent in the presence or absence of a basic substance, and further reaction of the reaction product in an inert solvent with a choline salt in the presence of a basic substance to give the phosphoric acid diester chloride, followed by hydrolysis and isolation of alkylphosphocholine, and, if appropriate, purification by means of a mixed-bed ion exchanger or in succession with an acidic ion exchanger and a basic ion exchanger.
EG34492A 1991-07-04 1992-07-01 A process for the preparation of alkylphosphacholines and the production thereof in pure form EG20551A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4122127 1991-07-04

Publications (1)

Publication Number Publication Date
EG20551A true EG20551A (en) 1999-07-31

Family

ID=6435410

Family Applications (1)

Application Number Title Priority Date Filing Date
EG34492A EG20551A (en) 1991-07-04 1992-07-01 A process for the preparation of alkylphosphacholines and the production thereof in pure form

Country Status (19)

Country Link
EP (1) EP0521297B1 (en)
JP (1) JP3171279B2 (en)
CN (1) CN1034941C (en)
AT (1) ATE158295T1 (en)
AU (2) AU652646B2 (en)
CA (1) CA2073126C (en)
DE (2) DE59208905D1 (en)
DK (1) DK0521297T3 (en)
EG (1) EG20551A (en)
ES (1) ES2108715T3 (en)
FI (1) FI107260B (en)
GR (1) GR3025490T3 (en)
HU (1) HU219243B (en)
IE (1) IE80555B1 (en)
IL (1) IL102379A (en)
NO (2) NO304232B1 (en)
PL (1) PL169571B1 (en)
SG (1) SG47844A1 (en)
ZA (1) ZA924980B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0521353T3 (en) * 1991-07-04 1996-05-13 Asta Medica Ag Antineoplastic drug containing octadecyl (2- (N-methylpiperidino) ethyl) phosphate as an active ingredient and process for its preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3164332D1 (en) * 1980-10-21 1984-07-26 Boehringer Mannheim Gmbh Phospholipids that contain sulphur, process for their preparation and medicines containing these compounds
JPS60184092A (en) * 1984-03-01 1985-09-19 Kao Corp Phosphoric ester and its preparation
IE59778B1 (en) * 1985-12-04 1994-04-06 Max Planck Gesellschaft Medicament with anti-tumour action containing hexadecylphosphocholine
EP0336142A3 (en) * 1988-04-04 1991-04-24 American Cyanamid Company Novel antagonists of platelet activating factor
IT1229238B (en) * 1989-05-08 1991-07-26 Istituto Chemioterapico PROCEDURE FOR THE PREPARATION OF L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE AND ALPHA-GLYCERYLPHOSPHORYLETHANOLAMINE.

Also Published As

Publication number Publication date
EP0521297A1 (en) 1993-01-07
DE59208905D1 (en) 1997-10-23
FI107260B (en) 2001-06-29
ES2108715T3 (en) 1998-01-01
NO922612L (en) 1993-01-05
IL102379A0 (en) 1993-01-14
DE4220852A1 (en) 1993-01-14
NO981742D0 (en) 1998-04-17
IL102379A (en) 1996-10-31
GR3025490T3 (en) 1998-02-27
SG47844A1 (en) 1998-04-17
FI923087A (en) 1993-01-05
JP3171279B2 (en) 2001-05-28
ZA924980B (en) 1993-04-28
CN1034941C (en) 1997-05-21
FI923087A0 (en) 1992-07-03
PL169571B1 (en) 1996-08-30
EP0521297B1 (en) 1997-09-17
CN1068331A (en) 1993-01-27
IE80555B1 (en) 1998-09-23
CA2073126C (en) 2001-09-04
AU652646B2 (en) 1994-09-01
CA2073126A1 (en) 1993-01-05
AU6605994A (en) 1994-09-22
NO304316B1 (en) 1998-11-30
DE4220852C2 (en) 2000-10-19
HUT61560A (en) 1993-01-28
DK0521297T3 (en) 1998-05-04
AU1944192A (en) 1993-01-07
HU9202233D0 (en) 1992-10-28
NO981742L (en) 1993-01-05
HU219243B (en) 2001-03-28
PL295129A1 (en) 1993-06-28
IE922182A1 (en) 1993-01-13
JPH05186483A (en) 1993-07-27
NO304232B1 (en) 1998-11-16
AU663259B2 (en) 1995-09-28
ATE158295T1 (en) 1997-10-15
NO922612D0 (en) 1992-07-02

Similar Documents

Publication Publication Date Title
ES2080116T3 (en) CRYSTALLINE MONOSODIC SALT CRYSTALLINE ACID 4-AMINO-1-HYDROXYBUTYLIDENE-1,1-BISPHOSPHONIC, PROCEDURE FOR PRODUCING AND COMPOSITIONS AND USE OF THE SAME.
DE602004032577D1 (en) Amorphous form the sodium salt of ibandronic acid
FR2492358B1 (en) PROCESS FOR THE MANUFACTURE OF WET PHOSPHORIC ACID FROM PHOSPHATE ROCK
EG20551A (en) A process for the preparation of alkylphosphacholines and the production thereof in pure form
BE852230A (en) PROCESS FOR THE PREPARATION OF PHOSPHORIC ACID FROM PHOSPHATE ORES
MA19682A1 (en) PROCESS FOR PRODUCING PHOSPHORIC ACID AND SUPPLEMENTAL PRODUCTS FROM PHOSPHATE ORE
IE830156L (en) Phosphorus-containing antibiotic compounds
YU42958B (en) Process for phosphoric acid purifying
PT87916A (en) PROCESS FOR THE PREPARATION OF PHOSPHONUM-ALKYL-PHOSPHINATES OF AMINYMETHYLENE
IL116601A0 (en) 4, 5, 6, 7 tetrahydro-2-saccharinylmethyl phosphates phosphonates and phosphinates and pharmaceutical compositions containing them
GB1516440A (en) Production of 0,0-dialkyl thiono phosphoric acid chloride
BE890350A (en) PROCESS FOR PRODUCING 0- (2,6-DICHLORANILINO) PHENYLACETIC ACID
EP0230355A3 (en) Process for production of dialkali metal phosphates by ion exchange
RO70908A (en) PROCESS FOR THE PREPARATION OF ESTERAMIDES OF O- (1-FLUORE-2-HALOGENETHYL) (THIONO) PHOSPHORIC (PHOSPHONIC) ACID
EP0281311A3 (en) Phosphine oxide process
PT79998A (en) PROCESS FOR THE PREPARATION OF PHOSPHONIC DIESTERS
MA20927A1 (en) Method for producing highly concentrated phosphoric acid
YU24396A (en) Process for preparation 1-hydroxybisphosphonates
JPS51131831A (en) Neutralization process for 2*33dibromopropanol acidic phosphoric acid ester contained in tris*2*33dibromoo11propyl* phosphate
ZA861099B (en) Process for making wet-process phosphoric acid
ZA821208B (en) Process for purifying phosphoric acid gypsum
ZA874108B (en) New process for the production of l-2-amino-4-(hydroxymethylphosphinyl)-butyric acid
IE871472L (en) New process for the production of¹l-2-amino-4-(hydroxymethylphosphinyl)-butyric acid
RO94341A2 (en) PROCESS FOR PURIFYING PLANT LECITHIN