EG20551A - A process for the preparation of alkylphosphacholines and the production thereof in pure form - Google Patents

A process for the preparation of alkylphosphacholines and the production thereof in pure form

Info

Publication number
EG20551A
EG20551A EG34492A EG34492A EG20551A EG 20551 A EG20551 A EG 20551A EG 34492 A EG34492 A EG 34492A EG 34492 A EG34492 A EG 34492A EG 20551 A EG20551 A EG 20551A
Authority
EG
Egypt
Prior art keywords
ion exchanger
preparation
alkylphosphacholines
production
reaction
Prior art date
Application number
EG34492A
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Application granted granted Critical
Publication of EG20551A publication Critical patent/EG20551A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

Process for the preparation of C14-C18-alkylphosphocholines in a one-pot process by reaction of an n-alkanol having a chain length of C14-C18 with phosphorus oxychloride in an inert solvent or else without solvent in the presence or absence of a basic substance, and further reaction of the reaction product in an inert solvent with a choline salt in the presence of a basic substance to give the phosphoric acid diester chloride, followed by hydrolysis and isolation of alkylphosphocholine, and, if appropriate, purification by means of a mixed-bed ion exchanger or in succession with an acidic ion exchanger and a basic ion exchanger.
EG34492A 1991-07-04 1992-07-01 A process for the preparation of alkylphosphacholines and the production thereof in pure form EG20551A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4122127 1991-07-04

Publications (1)

Publication Number Publication Date
EG20551A true EG20551A (en) 1999-07-31

Family

ID=6435410

Family Applications (1)

Application Number Title Priority Date Filing Date
EG34492A EG20551A (en) 1991-07-04 1992-07-01 A process for the preparation of alkylphosphacholines and the production thereof in pure form

Country Status (19)

Country Link
EP (1) EP0521297B1 (en)
JP (1) JP3171279B2 (en)
CN (1) CN1034941C (en)
AT (1) ATE158295T1 (en)
AU (2) AU652646B2 (en)
CA (1) CA2073126C (en)
DE (2) DE59208905D1 (en)
DK (1) DK0521297T3 (en)
EG (1) EG20551A (en)
ES (1) ES2108715T3 (en)
FI (1) FI107260B (en)
GR (1) GR3025490T3 (en)
HU (1) HU219243B (en)
IE (1) IE80555B1 (en)
IL (1) IL102379A (en)
NO (2) NO304232B1 (en)
PL (1) PL169571B1 (en)
SG (1) SG47844A1 (en)
ZA (1) ZA924980B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59205998D1 (en) * 1991-07-04 1996-05-23 Asta Medica Ag Medicament with antineoplastic activity containing octadecyl- [2- (N-methylpiperidino) ethyl] phosphate as active ingredient and process for its preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3164332D1 (en) * 1980-10-21 1984-07-26 Boehringer Mannheim Gmbh Phospholipids that contain sulphur, process for their preparation and medicines containing these compounds
JPS60184092A (en) * 1984-03-01 1985-09-19 Kao Corp Phosphoric ester and its preparation
CA1338627C (en) * 1985-12-04 1996-10-01 Hansjorg Eibl Pharmaceuticals based on phosphoric acid esters for use in tumor therapy, and process for their preparation
EP0336142A3 (en) * 1988-04-04 1991-04-24 American Cyanamid Company Novel antagonists of platelet activating factor
IT1229238B (en) * 1989-05-08 1991-07-26 Istituto Chemioterapico PROCEDURE FOR THE PREPARATION OF L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE AND ALPHA-GLYCERYLPHOSPHORYLETHANOLAMINE.

Also Published As

Publication number Publication date
ZA924980B (en) 1993-04-28
NO981742L (en) 1993-01-05
FI107260B (en) 2001-06-29
AU6605994A (en) 1994-09-22
NO304316B1 (en) 1998-11-30
AU663259B2 (en) 1995-09-28
AU652646B2 (en) 1994-09-01
IL102379A (en) 1996-10-31
HU9202233D0 (en) 1992-10-28
NO981742D0 (en) 1998-04-17
DE59208905D1 (en) 1997-10-23
DK0521297T3 (en) 1998-05-04
CN1068331A (en) 1993-01-27
HU219243B (en) 2001-03-28
EP0521297B1 (en) 1997-09-17
CA2073126A1 (en) 1993-01-05
CN1034941C (en) 1997-05-21
IE80555B1 (en) 1998-09-23
IE922182A1 (en) 1993-01-13
JPH05186483A (en) 1993-07-27
DE4220852C2 (en) 2000-10-19
JP3171279B2 (en) 2001-05-28
CA2073126C (en) 2001-09-04
DE4220852A1 (en) 1993-01-14
IL102379A0 (en) 1993-01-14
HUT61560A (en) 1993-01-28
GR3025490T3 (en) 1998-02-27
PL169571B1 (en) 1996-08-30
NO922612L (en) 1993-01-05
FI923087A (en) 1993-01-05
SG47844A1 (en) 1998-04-17
EP0521297A1 (en) 1993-01-07
ES2108715T3 (en) 1998-01-01
AU1944192A (en) 1993-01-07
NO922612D0 (en) 1992-07-02
FI923087A0 (en) 1992-07-03
ATE158295T1 (en) 1997-10-15
NO304232B1 (en) 1998-11-16
PL295129A1 (en) 1993-06-28

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