KR101423344B1 - 올리고펩티드-무함유 세포 배양 배지를 이용하여 단백질을 발현시키는 방법 - Google Patents
올리고펩티드-무함유 세포 배양 배지를 이용하여 단백질을 발현시키는 방법 Download PDFInfo
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- KR101423344B1 KR101423344B1 KR1020087018889A KR20087018889A KR101423344B1 KR 101423344 B1 KR101423344 B1 KR 101423344B1 KR 1020087018889 A KR1020087018889 A KR 1020087018889A KR 20087018889 A KR20087018889 A KR 20087018889A KR 101423344 B1 KR101423344 B1 KR 101423344B1
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/50—Soluble polymers, e.g. polyethyleneglycol [PEG]
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24151—Methods of production or purification of viral material
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75641906P | 2006-01-04 | 2006-01-04 | |
| US60/756,419 | 2006-01-04 | ||
| PCT/EP2007/000027 WO2007077217A2 (en) | 2006-01-04 | 2007-01-03 | Oligopeptide-free cell culture media |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137022322A Division KR101422435B1 (ko) | 2006-01-04 | 2007-01-03 | 올리고펩티드-무함유 세포 배양 배지 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20080083197A KR20080083197A (ko) | 2008-09-16 |
| KR101423344B1 true KR101423344B1 (ko) | 2014-07-30 |
Family
ID=37942126
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087018889A Active KR101423344B1 (ko) | 2006-01-04 | 2007-01-03 | 올리고펩티드-무함유 세포 배양 배지를 이용하여 단백질을 발현시키는 방법 |
| KR1020137022322A Active KR101422435B1 (ko) | 2006-01-04 | 2007-01-03 | 올리고펩티드-무함유 세포 배양 배지 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137022322A Active KR101422435B1 (ko) | 2006-01-04 | 2007-01-03 | 올리고펩티드-무함유 세포 배양 배지 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US20070212770A1 (enExample) |
| EP (4) | EP3121266B8 (enExample) |
| JP (6) | JP5259418B2 (enExample) |
| KR (2) | KR101423344B1 (enExample) |
| CN (2) | CN101360820A (enExample) |
| AU (1) | AU2007204044B2 (enExample) |
| CA (1) | CA2633306A1 (enExample) |
| CY (1) | CY1119046T1 (enExample) |
| DK (3) | DK1974014T3 (enExample) |
| ES (3) | ES2474573T3 (enExample) |
| HU (1) | HUE032744T2 (enExample) |
| LT (1) | LT1974014T (enExample) |
| PL (3) | PL3121266T3 (enExample) |
| PT (3) | PT3121266T (enExample) |
| RU (3) | RU2486236C2 (enExample) |
| SI (1) | SI2522717T1 (enExample) |
| WO (1) | WO2007077217A2 (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101423344B1 (ko) | 2006-01-04 | 2014-07-30 | 백스터 인터내셔널 인코포레이티드 | 올리고펩티드-무함유 세포 배양 배지를 이용하여 단백질을 발현시키는 방법 |
| SI2235197T1 (sl) | 2007-12-27 | 2017-10-30 | Baxalta GmbH | Procesi celične kulture |
| MX2010007344A (es) * | 2007-12-31 | 2010-11-09 | Baxter Int | Furina recombinante substancialmente libre de proteina animal y metodos para la produccion de la misma. |
| DK2250251T3 (en) | 2008-01-09 | 2018-01-22 | Sartorius Stedim Cellca Gmbh | Improved culture medium additive and method of using it |
| EP2257622B1 (en) * | 2008-02-25 | 2017-03-22 | Nanotherapeutics, Inc. | Method for producing continuous cell lines |
| HRP20151054T4 (hr) * | 2008-11-12 | 2019-11-15 | Baxalta Inc | Postupak proizvodnje faktora vii bez seruma, bez inzulina |
| US8580554B2 (en) | 2009-07-31 | 2013-11-12 | Baxter International Inc. | Method of producing a polypeptide or virus of interest in a continuous cell culture |
| WO2011014838A1 (en) | 2009-07-31 | 2011-02-03 | Baxter International Inc. | Cell culture medium for adamts protein expression |
| PL4218797T3 (pl) | 2009-09-21 | 2025-02-10 | Takeda Pharmaceutical Company Limited | Stabilizowane płynne i liofilizowane preparaty adamts13 |
| US8986957B2 (en) | 2010-04-26 | 2015-03-24 | Novartis Ag | Cell culture medium |
| CN103097522A (zh) * | 2010-07-08 | 2013-05-08 | 巴克斯特国际公司 | 在细胞培养物中生产重组adamts13的方法 |
| TWI621625B (zh) | 2010-09-17 | 2018-04-21 | 巴克斯歐塔公司 | 在弱酸性至中性ph中經由具有組胺酸的水性調配物穩定免疫球蛋白 |
| TWI580430B (zh) | 2010-10-27 | 2017-05-01 | 巴克斯歐塔公司 | 用於免疫耐受誘導及免疫診斷之fviii胜肽 |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| EP3858375B1 (en) | 2011-06-10 | 2024-03-20 | Takeda Pharmaceutical Company Limited | Treatment of coagulation disease by administration of recombinant vwf |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| EP2906683B1 (en) | 2012-10-15 | 2017-05-31 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
| HK1207960A1 (en) | 2013-03-12 | 2016-02-19 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| AR095196A1 (es) * | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| KR101641655B1 (ko) * | 2014-01-08 | 2016-07-21 | 서울대학교산학협력단 | 스퍼미딘 또는 스퍼민을 이용함으로써 생육 저해제에 대한 내성이 증진된 효모의 배양방법 |
| JP6801930B2 (ja) * | 2015-03-17 | 2020-12-16 | ディーエスエム アイピー アセッツ ビー.ブイ.Dsm Ip Assets B.V. | ジアミノブタンの調製のためのプロセス |
| JP6624985B2 (ja) * | 2015-03-27 | 2019-12-25 | 日清ファルマ株式会社 | ポリアミン高含有酵母 |
| TW202440903A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法(一) |
| US12209261B2 (en) | 2015-12-02 | 2025-01-28 | CSL Behring Lengnau AG | Media for the expression of recombinant vitamin K-dependent proteins |
| CN106635953B (zh) * | 2016-12-13 | 2021-02-19 | 昆明润什生物科技有限公司 | 无血清无蛋白细胞培养基 |
| EP3967765A1 (en) * | 2017-07-06 | 2022-03-16 | FrieslandCampina Nederland B.V. | Cell culture process for making a glycoprotein |
| FI3648787T3 (fi) | 2017-07-07 | 2025-01-20 | Takeda Pharmaceuticals Co | Elektiiviseen leikkaustoimenpiteeseen osallistuvien vaikeaa von willebrandin tautia sairastavien potilaiden hoito antamalla rekombinanttia vwf:ää |
| AU2018298233B2 (en) | 2017-07-07 | 2025-04-24 | Takeda Pharmaceutical Company Limited | Treatment of gastrointestinal bleeding in patients with severe von willebrand disease by administration of recombinant VWF |
| JP2021519280A (ja) | 2018-03-21 | 2021-08-10 | バクスアルタ インコーポレイテッド | クロマトグラフィー法によるvwfとvwfプロペプチドの分離 |
| LT3781943T (lt) | 2018-04-20 | 2022-07-11 | Janssen Biotech, Inc. | Chromatografinės kolonos kvalifikavimas gamybinių metodų, skirtų pagaminti anti-il-12/il-23 antikūnų kompozicijas, metu |
| CN108872758B (zh) * | 2018-05-10 | 2019-06-28 | 江苏大学 | 一种电子元器件寿命检测装置 |
| EP3880824B1 (en) | 2018-11-13 | 2024-07-24 | Janssen Biotech, Inc. | Control of trace metals during production of anti-cd38 antibodies |
| WO2020150411A1 (en) | 2019-01-17 | 2020-07-23 | Boehringer Ingelheim Animal Health USA Inc. | Serum-free medium for avian vaccine production and uses thereof |
| CA3128498A1 (en) | 2019-02-01 | 2020-08-06 | Bjorn Mellgard | Methods of prophylactic treatment using recombinant vwf (rvwf) |
| CA3133381A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-tnf antibody compositions |
| WO2020183271A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Methods for producing anti-tnf antibody compositions |
| CN113825769A (zh) | 2019-03-14 | 2021-12-21 | 詹森生物科技公司 | 用于产生抗tnf抗体组合物的方法 |
| CN113825765A (zh) | 2019-03-14 | 2021-12-21 | 詹森生物科技公司 | 用于制备抗il12/il23抗体组合物的制造方法 |
| WO2020201296A1 (en) | 2019-04-01 | 2020-10-08 | The Automation Partnership (Cambridge) Ltd. | Operation process for a cell cultivation system |
| EP4028046B1 (en) | 2019-09-11 | 2024-02-14 | Takeda Pharmaceutical Company Limited | Methods of treatment related to complexes of von willebrand factor and complement c1q |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| JP7513034B2 (ja) * | 2019-11-05 | 2024-07-09 | 味の素株式会社 | タンパク質の製造方法 |
| KR20230152810A (ko) | 2019-12-06 | 2023-11-03 | 리제너론 파아마슈티컬스, 인크. | 항-vegf 단백질 조성물 및 이를 생산하는 방법 |
| WO2021158777A1 (en) | 2020-02-04 | 2021-08-12 | Baxalta Incorporated | Treatment of menorrhagia in patients with severe von willebrand disease by administration of recombinant vwf |
| US20230203469A1 (en) | 2020-04-02 | 2023-06-29 | Takeda Pharmaceutical Company Limited | Adamts13 variant, compositions, and uses thereof |
| JP2023525034A (ja) | 2020-05-08 | 2023-06-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Vegfトラップおよびミニトラップならびに眼障害およびがんの治療方法 |
| US12031151B2 (en) | 2021-01-20 | 2024-07-09 | Regeneron Pharmaceuticals, Inc. | Methods of improving protein titer in cell culture |
| CN113151183A (zh) * | 2021-04-21 | 2021-07-23 | 赵峻岭 | 一种促进蛋白表达的培养基添加物及其应用 |
| US20230042465A1 (en) | 2021-07-09 | 2023-02-09 | Janssen Biotech, Inc. | Manufacturing Methods for Producing Anti-TNF Antibody Compositions |
| CN117916260A (zh) | 2021-07-09 | 2024-04-19 | 詹森生物科技公司 | 用于制备抗il12/il23抗体组合物的制造方法 |
| KR20240167717A (ko) | 2022-03-02 | 2024-11-27 | 리제너론 파아마슈티컬스, 인크. | 항체 생산을 위한 세포 배양 방법 |
| CA3266599A1 (en) | 2022-09-07 | 2024-11-07 | Quantitative Biosciences, Inc. | UNIQUE VARIABLE DOMAIN ANTIBODIES SPECIFIC TO FENTANYL AND USE IN A CONTINUOUS AGGLUTINATION TEST |
| WO2025053166A1 (ja) * | 2023-09-05 | 2025-03-13 | 味の素株式会社 | 培地組成物 |
| WO2025128343A1 (en) | 2023-12-11 | 2025-06-19 | Just-Evotec Biologics, Inc. | Protein expression using trans-splicing and split selectable markers |
| WO2025210223A1 (en) * | 2024-04-04 | 2025-10-09 | Sartorius Xell GmbH | Methods for viral vector production with reduced host cell aggregation and methods for dissolving host cell aggregates |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0659880A1 (en) * | 1993-12-24 | 1995-06-28 | Eiken Chemical Co., Ltd. | Medium for culturing animal cells or antibody-producing cells |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT165999B (de) | 1947-06-26 | 1950-05-25 | Delle Atel Const Electr | Einirchtung zum Schutz von Drehstrommotoren gegen Überstrom |
| US4443540A (en) * | 1980-05-09 | 1984-04-17 | University Of Illinois Foundation | Protein hydrolysis |
| DK207980A (da) * | 1980-05-13 | 1981-11-14 | Novo Industri As | Fremgangsmaade til fremstilling af et skumnings- eller emulgeringsmiddel paa sojaproteinbasis |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| FR2543158B1 (fr) | 1983-03-24 | 1985-11-15 | Inst Nat Sante Rech Med | Milieu de culture de cellules animales sans serum, sans hormones et sans facteurs de croissance et procedes de culture primaire et d'obtention de lignees cellulaires utilisant ce milieu |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| FI86885C (fi) | 1984-04-20 | 1992-10-26 | Genentech Inc | Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill |
| DE3688418T2 (de) | 1985-02-13 | 1993-08-26 | Scios Nova Inc | Menschlicher metallothionein ii-promotor in saeugetierexpressionssystemen. |
| US4978616A (en) * | 1985-02-28 | 1990-12-18 | Verax Corporation | Fluidized cell cultivation process |
| DE3787805T2 (de) | 1986-08-04 | 1994-02-10 | Garvan Inst Med Res | Serumfreies gewebekulturmedium, das ein polymerzellenschutzmittel enthält. |
| US5045468A (en) | 1986-12-12 | 1991-09-03 | Cell Enterprises, Inc. | Protein-free culture medium which promotes hybridoma growth |
| JPH01503679A (ja) | 1987-06-30 | 1989-12-14 | アムジエン・インコーポレーテツド | カリクレインの生産 |
| JP2507882B2 (ja) | 1988-02-17 | 1996-06-19 | 工業技術院長 | 外部増殖因子非依存性増殖良好細胞株の製造法 |
| US6048728A (en) * | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
| US5573937A (en) * | 1989-12-07 | 1996-11-12 | Snow Brand Milk Products Co., Ltd. | Serum free culture medium |
| SE465222C5 (sv) | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
| JPH0789954B2 (ja) | 1990-01-22 | 1995-10-04 | アメリカ合衆国 | 細胞の保存と増殖のための二酸化炭素―非依存性増殖培地 |
| JP2844484B2 (ja) | 1990-02-22 | 1999-01-06 | 味の素株式会社 | 組換え蛋白質の生産方法 |
| JP2859679B2 (ja) | 1990-03-01 | 1999-02-17 | 協和醗酵工業株式会社 | 新規細胞株 |
| US5378612A (en) * | 1990-05-11 | 1995-01-03 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Culture medium for production of recombinant protein |
| JP2696001B2 (ja) | 1991-04-15 | 1998-01-14 | 財団法人化学及血清療法研究所 | 組換え蛋白質産生用培地 |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| AU643077B2 (en) | 1990-10-19 | 1993-11-04 | Unilever Plc | Detergent compositions |
| JPH04228066A (ja) | 1990-10-23 | 1992-08-18 | Rikagaku Kenkyusho | 外来遺伝子発現用培養細胞 |
| EP0531562A1 (de) * | 1991-09-11 | 1993-03-17 | Doerr, Hans-Wilhelm, Prof. Dr. med. | Kultivierung von Säugetierzellen |
| CA2078721A1 (en) | 1991-09-24 | 1993-03-25 | Hiroshi Yonemura | Process for preparing human coagulation factor viii protein complex |
| JPH05123178A (ja) | 1991-11-01 | 1993-05-21 | Ajinomoto Co Inc | L−フエニルアラニンの製造法 |
| AU7895898A (en) | 1993-04-26 | 1998-10-08 | Hans Wolf | Mammal cell lines and method of obtaining glycoproteins |
| DE4313620A1 (de) | 1993-04-26 | 1994-10-27 | Biotechnolog Forschung Gmbh | Hamsterzellinien und Verfahren zur Glykoproteingewinnung |
| GB9311132D0 (en) * | 1993-05-28 | 1993-07-14 | Eisai London Res Lab Ltd | Control of cell death |
| US5405637A (en) | 1993-06-30 | 1995-04-11 | Bristol-Myers Squibb Company | Milk protein partial hydrolysate and infant formula containing same |
| JP2766165B2 (ja) | 1993-08-02 | 1998-06-18 | 株式会社バイオポリマー・リサーチ | バクテリアセルロースの製造方法 |
| US5445956A (en) * | 1993-08-13 | 1995-08-29 | The Regents Of The University Of California | Recombinant soluble epoxide hydrolase |
| EP0653487A1 (de) | 1993-11-07 | 1995-05-17 | Ferruccio Dr. Messi | Serum- und proteinfrei wachsende Zellen |
| US5498599A (en) * | 1994-01-21 | 1996-03-12 | Amgen Inc. | Methods for stimulating platelet production |
| EP0666312A1 (en) | 1994-02-08 | 1995-08-09 | Wolfgang A. Renner | Process for the improvement of mammalian cell growth |
| US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
| US5789247A (en) * | 1994-04-01 | 1998-08-04 | Ballay; Annick | Expression in non-tumoral human lymphoblastoid lines with an integrative vector |
| WO1996007730A2 (de) | 1994-09-09 | 1996-03-14 | Renner Wolfgang A | Chemisches verfahren zur förderung der proliferation von tierischen zellen |
| ES2323490T3 (es) | 1994-11-10 | 2009-07-17 | Baxter Healthcare Sa | Procedimiento de produccion de agentes biologicos en un medio de cultivo sin proteinas. |
| AT403167B (de) | 1994-11-14 | 1997-11-25 | Immuno Ag | Selektion und expression von fremdproteinen mittels eines selektions-amplifikations-systems |
| EP0799310A1 (en) | 1994-12-16 | 1997-10-08 | Novartis AG | Production of recombinant secretory component |
| DE69608668T2 (de) | 1995-02-23 | 2001-02-01 | Quest International B.V., Naarden | Peptide für gewebe- und zellkulturmedien |
| US5741705A (en) * | 1995-02-23 | 1998-04-21 | Quest International Flavors & Food Ingredients Company, Division Of Indopco, Inc. | Method for in vitro cell growth of eucaryotic cells using low molecular weight peptides |
| AU6125396A (en) | 1995-06-07 | 1996-12-30 | Novartis Ag | Serum-free media for primitive hematopoietic cells and metho ds of use thereof |
| AUPN442295A0 (en) | 1995-07-26 | 1995-08-17 | Commonwealth Scientific And Industrial Research Organisation | Regulated autocrine growth of mammalian cells |
| US5851800A (en) * | 1996-05-14 | 1998-12-22 | Pharmacia & Upjohn Ab | Process for producing a protein |
| EP0953041A4 (en) | 1996-08-30 | 2003-01-29 | Life Technologies Inc | SERUM-FREE CULTURAL MEDIUM FOR MAMMAL CELLS AND THEIR USE |
| WO1998008935A1 (en) | 1996-08-30 | 1998-03-05 | The University Of North Carolina At Chapel Hill | Immortalized human hepatic cell line |
| US6103529A (en) | 1996-10-10 | 2000-08-15 | Life Technologies, Inc. | Animal cell culture media comprising peptides derived from rice |
| US5804420A (en) * | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| WO1998054296A1 (en) | 1997-05-28 | 1998-12-03 | Chiron S.P.A. | Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin |
| AT407255B (de) * | 1997-06-20 | 2001-02-26 | Immuno Ag | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
| US6475725B1 (en) * | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| JP4541539B2 (ja) | 1997-07-23 | 2010-09-08 | ロシュ ダイアグノスティックス ゲーエムベーハー | 内因性遺伝子活性化によるエリスロポエチンの製造 |
| CA2309258C (en) | 1997-11-20 | 2012-05-01 | Weyerhaeuser Company | Nutritive media and manufactured seeds comprising same |
| WO1999035255A2 (en) * | 1998-01-12 | 1999-07-15 | Betagene, Inc. | Compositions and methods for regulated secretion from neuroendocrine cell lines |
| FR2775983B1 (fr) | 1998-03-13 | 2000-11-10 | Pasteur Merieux Serums Vacc | Milieu et procede de propagation et de multiplication virales |
| WO1999057246A1 (en) | 1998-05-01 | 1999-11-11 | Life Technologies, Inc. | Animal cell culture media comprising non-animal or plant-derived nutrients |
| US6537782B1 (en) * | 1998-06-01 | 2003-03-25 | Chugai Seiyaku Kabushiki Kaisha | Media for culturing animal cells and process for producing protein by using the same |
| US6406909B1 (en) | 1998-07-10 | 2002-06-18 | Chugai Seiyaku Kabushiki Kaisha | Serum-free medium for culturing animal cells |
| JP4266055B2 (ja) | 1999-03-04 | 2009-05-20 | 雪印乳業株式会社 | ポリアミン組成物の製造法 |
| AT409379B (de) * | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| EP1200561B1 (de) | 1999-08-05 | 2006-06-14 | Baxter Aktiengesellschaft | Rekombinanter stabiler zellklon, seine herstellung und verwendung |
| NZ517215A (en) | 1999-08-25 | 2004-01-30 | Immunex Corp | Compositions and methods for improved cell culture |
| US6596526B1 (en) * | 2000-06-09 | 2003-07-22 | Baxter Aktiengesellschaft | Furin polypeptides with improved characteristics |
| EP1358319B1 (en) | 2000-09-25 | 2009-06-17 | Polymun Scientific Immunbiologische Forschung GmbH | Live influenza vaccine and method of manufacture |
| EP1208966A1 (en) | 2000-11-27 | 2002-05-29 | Cheng-Kun Liao | Manufacturing process of patio tabletop glass with broken protection |
| DE10059175A1 (de) | 2000-11-29 | 2002-06-20 | Siemens Ag | Verfahren und Vorrichtung zur Anrufumleitung mittels eines Stellvertreters in einem Kommunikationssystem |
| US20030096414A1 (en) | 2001-03-27 | 2003-05-22 | Invitrogen Corporation | Culture medium for cell growth and transfection |
| US6734289B2 (en) * | 2001-03-29 | 2004-05-11 | The University Of Chicago | Gastrokines and derived peptides including inhibitors |
| AU2002316230A1 (en) | 2001-06-13 | 2002-12-23 | Genentech, Inc. | Methods of culturing animal cells and polypeptide production in animal cells |
| US7037658B2 (en) * | 2001-08-16 | 2006-05-02 | Regents Of University Of Michigan | Methods and compositions for detecting variant ADAMTS13 genes |
| WO2003029442A1 (en) | 2001-10-02 | 2003-04-10 | Novo Nordisk Health Care Ag | Method for production of recombinant proteins in eukaryote cells |
| US20030104527A1 (en) * | 2001-12-03 | 2003-06-05 | National Research Council Of Canada | Methylotrophic bacterium for the production of recombinant proteins and other products |
| DE10161412A1 (de) * | 2001-12-13 | 2003-07-03 | Aventis Pharma Gmbh | Verfahren zur Bestimmung der Aktivität der Ornithin-Decarboxylase sowie zur Identifizierung von Effektoren der Ornithin-Decarboxylase-Aktivität |
| JP2005532057A (ja) | 2002-07-09 | 2005-10-27 | バクスター・インターナショナル・インコーポレイテッド | 細胞を培養するための動物性タンパク質非含有培地 |
| FR2846004B1 (fr) | 2002-10-16 | 2006-06-23 | Maco Pharma Sa | Composition pour culture de cellules notamment animales ou de tissus, comprenant du polyethylene glycol |
| FR2846005B1 (fr) | 2002-10-16 | 2006-06-23 | Maco Pharma Sa | Composition pour milieu biologique comprenant de l'erythorbate de sodium |
| DE10333675A1 (de) | 2003-07-24 | 2005-03-03 | Aventis Pharma Deutschland Gmbh | Perfusionsverfahren für die Produktion von Erythropoietin |
| WO2005035748A1 (en) | 2003-10-10 | 2005-04-21 | Novo Nordisk Health Care Ag | Method for large-scale production of a polypeptide in eukaryote cells and a culture vessel suitable therefor |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| US20060094104A1 (en) * | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| AU2005302516A1 (en) | 2004-10-29 | 2006-05-11 | Centocor, Inc. | Chemically defined media compositions |
| KR101423344B1 (ko) | 2006-01-04 | 2014-07-30 | 백스터 인터내셔널 인코포레이티드 | 올리고펩티드-무함유 세포 배양 배지를 이용하여 단백질을 발현시키는 방법 |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0659880A1 (en) * | 1993-12-24 | 1995-06-28 | Eiken Chemical Co., Ltd. | Medium for culturing animal cells or antibody-producing cells |
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