KR101226787B1 - 포스파티딜세린의 안정화된 제제 - Google Patents

포스파티딜세린의 안정화된 제제 Download PDF

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Publication number
KR101226787B1
KR101226787B1 KR1020067005677A KR20067005677A KR101226787B1 KR 101226787 B1 KR101226787 B1 KR 101226787B1 KR 1020067005677 A KR1020067005677 A KR 1020067005677A KR 20067005677 A KR20067005677 A KR 20067005677A KR 101226787 B1 KR101226787 B1 KR 101226787B1
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South Korea
Prior art keywords
phosphatidylserine
composition
delete delete
present
oil
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Expired - Lifetime
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KR1020067005677A
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English (en)
Korean (ko)
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KR20060123100A (ko
Inventor
도리트 플래트
아비도르 슐만
가이 벤 드로어
네타 쉐인맨
요니 트위토
라싼 주아비
Original Assignee
엔지모테크 리미티드
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/103—Extraction or purification by physical or chemical treatment of natural phosphatides; Preparation of compositions containing phosphatides of unknown structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
KR1020067005677A 2003-09-25 2004-09-26 포스파티딜세린의 안정화된 제제 Expired - Lifetime KR101226787B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL158139 2003-09-25
IL15813903A IL158139A0 (en) 2003-09-25 2003-09-25 Stabilized formulations of phosphatidyl serine
PCT/IL2004/000895 WO2005027822A2 (en) 2003-09-25 2004-09-26 Stabilized formulations of phosphatidylserine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020127005527A Division KR20120039752A (ko) 2003-09-25 2004-09-26 포스파티딜세린의 안정화된 제제

Publications (2)

Publication Number Publication Date
KR20060123100A KR20060123100A (ko) 2006-12-01
KR101226787B1 true KR101226787B1 (ko) 2013-01-25

Family

ID=34073789

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020067005677A Expired - Lifetime KR101226787B1 (ko) 2003-09-25 2004-09-26 포스파티딜세린의 안정화된 제제
KR1020127005527A Ceased KR20120039752A (ko) 2003-09-25 2004-09-26 포스파티딜세린의 안정화된 제제

Family Applications After (1)

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KR1020127005527A Ceased KR20120039752A (ko) 2003-09-25 2004-09-26 포스파티딜세린의 안정화된 제제

Country Status (11)

Country Link
US (1) US8324187B2 (enExample)
EP (1) EP1663157B1 (enExample)
JP (1) JP5077841B2 (enExample)
KR (2) KR101226787B1 (enExample)
CN (1) CN1897919A (enExample)
AU (1) AU2004273700C1 (enExample)
BR (1) BRPI0414721A (enExample)
CA (1) CA2540170C (enExample)
ES (1) ES2399049T3 (enExample)
IL (2) IL158139A0 (enExample)
WO (1) WO2005027822A2 (enExample)

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US7935365B2 (en) * 2003-10-22 2011-05-03 Enzymotec, Ltd. Glycerophospholipids for the improvement of cognitive functions
US20050130937A1 (en) 2003-10-22 2005-06-16 Enzymotec Ltd. Lipids containing omega-3 and omega-6 fatty acids
US8052992B2 (en) * 2003-10-22 2011-11-08 Enzymotec Ltd. Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions
CA2611121C (en) 2005-05-31 2014-01-28 Arla Foods Amba Phosphatidylserine enriched milk fractions for the formulation of functional foods
HUE037129T2 (hu) * 2005-12-15 2018-08-28 Nestec Sa Kompozíciók és eljárások agyi funkció megõrzésére
US8877239B2 (en) * 2010-08-12 2014-11-04 Nutritional Therapeutics, Inc. Lipid supplements for maintaining health and treatment of acute and chronic disorders
DE102007042557A1 (de) 2007-09-07 2009-03-19 Membramed Gmbh Neuartige Formulierung von Phospholipiden
JP5432563B2 (ja) * 2009-03-31 2014-03-05 株式会社ファンケル ホスファチジルセリン含有カプセル及びカプセル充填用ホスファチジルセリン組成物
EP2464350B1 (en) * 2009-09-11 2016-08-24 Nestec S.A. Compositions and methods for enhancing cognitive and related functions in animals
US8399432B2 (en) * 2009-10-27 2013-03-19 Lipogen Ltd. Compositions and methods of treatment for alleviating premenstrual syndrome symptoms
WO2012143860A1 (en) * 2011-04-18 2012-10-26 Jian Guan Ameliorating cognitive decline
CN102908336B (zh) * 2011-08-05 2015-10-28 深圳市华正实业有限公司 磷脂酰丝氨酸的稳定制剂、其制备方法、应用和应用产物
ITPD20120021A1 (it) 2012-01-26 2013-07-27 Fidia Farmaceutici "nuove composizioni farmaceutiche contenenti fosfatidilserina e curcumina".
ITMI20121784A1 (it) * 2012-10-22 2014-04-23 Velleja Res Srl Composizioni galattogeniche a base di fosfatidilserina
US9101580B2 (en) * 2012-12-18 2015-08-11 Matthew Bennett Compositions and methods for treating traumatic brain injury
DK2769725T3 (en) * 2013-02-22 2016-08-22 Lipogen Ltd PREPARATIONS FOR USE AT relief of symptoms associated with premenstrual syndrome and premenstrual dysphoric disorder
EP3171706B2 (en) * 2014-07-25 2024-10-16 Frutarom Limited Nutritional compositions containing phosphatidylserine powder
CN104327114A (zh) * 2014-11-06 2015-02-04 江南大学 一种磷脂酰丝氨酸的制备方法
WO2017125816A1 (en) * 2016-01-21 2017-07-27 Enzymotec Ltd. Methods using phosphatidylserine powder
CN110283803B (zh) * 2016-06-02 2021-08-03 天津科技大学 一种磷脂酶d及其制备磷脂酸、磷脂酰丝氨酸的方法
CN107125752B (zh) * 2017-06-14 2020-06-30 安徽省芬格欣生物药业有限公司 一种增进记忆功能的磷脂酰丝氨酸口服液及制备方法
CN107034248A (zh) * 2017-06-19 2017-08-11 成都新柯力化工科技有限公司 一种连续高效酶转化合成食品用磷脂酰丝氨酸的方法
CN107722051B (zh) * 2017-08-24 2020-08-14 南通励成生物工程有限公司 制备磷脂酰丝氨酸盐的方法
GB201821049D0 (en) * 2018-12-21 2019-02-06 Ge Healthcare As Ultrasound contrast agent and methods for use therof
US20220249455A1 (en) * 2019-07-15 2022-08-11 R.P. Scherer Technologies, Llc Enteric proton pump inhibitor softgel capsule
CN110938090A (zh) * 2019-12-24 2020-03-31 南通励成生物工程有限公司 一种磷脂酰丝氨酸的纯化方法
CN112314949A (zh) * 2020-11-04 2021-02-05 上海欧睿生物科技有限公司 一种磷脂酰丝氨酸液体配制方法
KR102754261B1 (ko) * 2022-05-12 2025-01-10 주식회사 한국인삼공사 붕해성이 개선된 포스파티딜세린 함유 연질캡슐
WO2026014835A1 (ko) * 2024-07-12 2026-01-15 주식회사 아스트로젠 L-세린의 리포좀 제형 및 이의 제조 방법

Citations (2)

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US5700668A (en) * 1995-12-08 1997-12-23 Italfarmaco Sud S.P.A. Process for the industrial preparation of phosphatidylserine
US6514973B1 (en) * 1998-10-30 2003-02-04 Merck Patent Geseilschaft Mit Beschrankter Haftung Compositions for the treatment and prevention of neurological and pathopsychological diseases

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JP2001354680A (ja) * 2000-06-08 2001-12-25 Nof Corp 高安定性酸性リン脂質および製造方法
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JP4009066B2 (ja) * 2001-02-15 2007-11-14 株式会社ヤクルト本社 ホスファチジルセリンの分画法
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JP4599604B2 (ja) 2002-04-19 2010-12-15 カーギル テクスチュアライジング ソリューションズ ドイチュラント ゲゼルシャフト ミット ベシュレクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト 生体活性のリン脂質含有成分を含有するマトリックス
CN1306736C (zh) 2003-06-13 2007-03-21 松下电器产业株式会社 用于射频光学传输的系统和方法
US20050130937A1 (en) * 2003-10-22 2005-06-16 Enzymotec Ltd. Lipids containing omega-3 and omega-6 fatty acids
US7935365B2 (en) * 2003-10-22 2011-05-03 Enzymotec, Ltd. Glycerophospholipids for the improvement of cognitive functions
EP1898722B1 (en) * 2005-04-28 2013-04-10 Enzymotec Ltd. Polar lipid mixtures, their preparation and uses

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700668A (en) * 1995-12-08 1997-12-23 Italfarmaco Sud S.P.A. Process for the industrial preparation of phosphatidylserine
US6514973B1 (en) * 1998-10-30 2003-02-04 Merck Patent Geseilschaft Mit Beschrankter Haftung Compositions for the treatment and prevention of neurological and pathopsychological diseases

Also Published As

Publication number Publication date
KR20060123100A (ko) 2006-12-01
AU2004273700C1 (en) 2010-03-11
US8324187B2 (en) 2012-12-04
ES2399049T3 (es) 2013-03-25
KR20120039752A (ko) 2012-04-25
EP1663157B1 (en) 2012-11-28
HK1092703A1 (en) 2007-02-16
AU2004273700A1 (en) 2005-03-31
WO2005027822A3 (en) 2005-10-06
JP2007506733A (ja) 2007-03-22
AU2004273700B2 (en) 2009-10-29
JP5077841B2 (ja) 2012-11-21
CA2540170C (en) 2012-02-21
CN102160651A (zh) 2011-08-24
CN1897919A (zh) 2007-01-17
BRPI0414721A (pt) 2006-11-21
US20070160659A1 (en) 2007-07-12
CA2540170A1 (en) 2005-03-31
IL158139A0 (en) 2004-09-27
IL174420A0 (en) 2006-08-01
WO2005027822A2 (en) 2005-03-31
EP1663157A2 (en) 2006-06-07
EP1663157A4 (en) 2010-02-24
IL174420A (en) 2015-02-26

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