IL158139A0 - Stabilized formulations of phosphatidyl serine - Google Patents

Stabilized formulations of phosphatidyl serine

Info

Publication number
IL158139A0
IL158139A0 IL15813903A IL15813903A IL158139A0 IL 158139 A0 IL158139 A0 IL 158139A0 IL 15813903 A IL15813903 A IL 15813903A IL 15813903 A IL15813903 A IL 15813903A IL 158139 A0 IL158139 A0 IL 158139A0
Authority
IL
Israel
Prior art keywords
phosphatidyl serine
stabilized formulations
formulations
stabilized
phosphatidyl
Prior art date
Application number
IL15813903A
Other languages
English (en)
Original Assignee
Enzymotec Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzymotec Ltd filed Critical Enzymotec Ltd
Priority to IL15813903A priority Critical patent/IL158139A0/xx
Priority to CNA2004800348781A priority patent/CN1897919A/zh
Priority to CN201110043969.3A priority patent/CN102160651B/zh
Priority to AU2004273700A priority patent/AU2004273700C1/en
Priority to EP04770566A priority patent/EP1663157B1/en
Priority to KR1020067005677A priority patent/KR101226787B1/ko
Priority to ES04770566T priority patent/ES2399049T3/es
Priority to BRPI0414721-9A priority patent/BRPI0414721A/pt
Priority to US10/572,782 priority patent/US8324187B2/en
Priority to PCT/IL2004/000895 priority patent/WO2005027822A2/en
Priority to KR1020127005527A priority patent/KR20120039752A/ko
Priority to CA2540170A priority patent/CA2540170C/en
Priority to JP2006527572A priority patent/JP5077841B2/ja
Publication of IL158139A0 publication Critical patent/IL158139A0/xx
Priority to IL174420A priority patent/IL174420A/en
Priority to HK06113400.1A priority patent/HK1092703A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/103—Extraction or purification by physical or chemical treatment of natural phosphatides; Preparation of compositions containing phosphatides of unknown structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
IL15813903A 2003-09-25 2003-09-25 Stabilized formulations of phosphatidyl serine IL158139A0 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IL15813903A IL158139A0 (en) 2003-09-25 2003-09-25 Stabilized formulations of phosphatidyl serine
BRPI0414721-9A BRPI0414721A (pt) 2003-09-25 2004-09-26 formulações estabilizadas de fosfatidilserina
US10/572,782 US8324187B2 (en) 2003-09-25 2004-09-26 Stabilized formulations of phosphatidylserine
AU2004273700A AU2004273700C1 (en) 2003-09-25 2004-09-26 Stabilized formulations of phosphatidylserine
EP04770566A EP1663157B1 (en) 2003-09-25 2004-09-26 Stabilized formulations of phosphatidylserine
KR1020067005677A KR101226787B1 (ko) 2003-09-25 2004-09-26 포스파티딜세린의 안정화된 제제
ES04770566T ES2399049T3 (es) 2003-09-25 2004-09-26 Formulaciones estabilizadas de fosfatidilserina
CNA2004800348781A CN1897919A (zh) 2003-09-25 2004-09-26 稳定的磷脂酰丝氨酸制剂
CN201110043969.3A CN102160651B (zh) 2003-09-25 2004-09-26 稳定的磷脂酰丝氨酸制剂
PCT/IL2004/000895 WO2005027822A2 (en) 2003-09-25 2004-09-26 Stabilized formulations of phosphatidylserine
KR1020127005527A KR20120039752A (ko) 2003-09-25 2004-09-26 포스파티딜세린의 안정화된 제제
CA2540170A CA2540170C (en) 2003-09-25 2004-09-26 Stabilized formulations of phosphatidylserine
JP2006527572A JP5077841B2 (ja) 2003-09-25 2004-09-26 ホスファチジルセリンの安定化された配合物
IL174420A IL174420A (en) 2003-09-25 2006-03-20 Phosphatidylsarin preparations are stabilized
HK06113400.1A HK1092703A1 (en) 2003-09-25 2006-12-06 Stabilized formulations of phosphatidylserine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL15813903A IL158139A0 (en) 2003-09-25 2003-09-25 Stabilized formulations of phosphatidyl serine

Publications (1)

Publication Number Publication Date
IL158139A0 true IL158139A0 (en) 2004-09-27

Family

ID=34073789

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15813903A IL158139A0 (en) 2003-09-25 2003-09-25 Stabilized formulations of phosphatidyl serine
IL174420A IL174420A (en) 2003-09-25 2006-03-20 Phosphatidylsarin preparations are stabilized

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL174420A IL174420A (en) 2003-09-25 2006-03-20 Phosphatidylsarin preparations are stabilized

Country Status (12)

Country Link
US (1) US8324187B2 (xx)
EP (1) EP1663157B1 (xx)
JP (1) JP5077841B2 (xx)
KR (2) KR101226787B1 (xx)
CN (1) CN1897919A (xx)
AU (1) AU2004273700C1 (xx)
BR (1) BRPI0414721A (xx)
CA (1) CA2540170C (xx)
ES (1) ES2399049T3 (xx)
HK (1) HK1092703A1 (xx)
IL (2) IL158139A0 (xx)
WO (1) WO2005027822A2 (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8052992B2 (en) * 2003-10-22 2011-11-08 Enzymotec Ltd. Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions
US20050130937A1 (en) * 2003-10-22 2005-06-16 Enzymotec Ltd. Lipids containing omega-3 and omega-6 fatty acids
US7935365B2 (en) * 2003-10-22 2011-05-03 Enzymotec, Ltd. Glycerophospholipids for the improvement of cognitive functions
KR101352288B1 (ko) 2005-05-31 2014-01-16 아를라 푸즈 에이엠비에이 기능성 식품의 제제화를 위한 포스파티딜세린이 풍부한우유 분획물
HUE037129T2 (hu) * 2005-12-15 2018-08-28 Nestec Sa Kompozíciók és eljárások agyi funkció megõrzésére
US8877239B2 (en) * 2010-08-12 2014-11-04 Nutritional Therapeutics, Inc. Lipid supplements for maintaining health and treatment of acute and chronic disorders
DE102007042557A1 (de) 2007-09-07 2009-03-19 Membramed Gmbh Neuartige Formulierung von Phospholipiden
JP5432563B2 (ja) * 2009-03-31 2014-03-05 株式会社ファンケル ホスファチジルセリン含有カプセル及びカプセル充填用ホスファチジルセリン組成物
US20120171303A1 (en) * 2009-09-11 2012-07-05 Nestec S.A. Compositions and methods for ehnancing cognitive and related functions in animals
US8399432B2 (en) * 2009-10-27 2013-03-19 Lipogen Ltd. Compositions and methods of treatment for alleviating premenstrual syndrome symptoms
WO2012143860A1 (en) * 2011-04-18 2012-10-26 Jian Guan Ameliorating cognitive decline
CN102908336B (zh) * 2011-08-05 2015-10-28 深圳市华正实业有限公司 磷脂酰丝氨酸的稳定制剂、其制备方法、应用和应用产物
ITPD20120021A1 (it) 2012-01-26 2013-07-27 Fidia Farmaceutici "nuove composizioni farmaceutiche contenenti fosfatidilserina e curcumina".
ITMI20121784A1 (it) * 2012-10-22 2014-04-23 Velleja Res Srl Composizioni galattogeniche a base di fosfatidilserina
US9101580B2 (en) * 2012-12-18 2015-08-11 Matthew Bennett Compositions and methods for treating traumatic brain injury
DK2769725T3 (en) * 2013-02-22 2016-08-22 Lipogen Ltd PREPARATIONS FOR USE AT relief of symptoms associated with premenstrual syndrome and premenstrual dysphoric disorder
CN106714569A (zh) * 2014-07-25 2017-05-24 恩兹莫特克有限公司 含有磷脂酰丝氨酸粉末的营养组合物
CN104327114A (zh) * 2014-11-06 2015-02-04 江南大学 一种磷脂酰丝氨酸的制备方法
US20190015435A1 (en) * 2016-01-21 2019-01-17 Enzymotec Ltd. Methods using phosphatidylserine powder
CN110129299B (zh) * 2016-06-02 2021-08-03 天津科技大学 磷脂酶d及其应用
CN107125752B (zh) * 2017-06-14 2020-06-30 安徽省芬格欣生物药业有限公司 一种增进记忆功能的磷脂酰丝氨酸口服液及制备方法
CN107034248A (zh) * 2017-06-19 2017-08-11 成都新柯力化工科技有限公司 一种连续高效酶转化合成食品用磷脂酰丝氨酸的方法
CN107722051B (zh) * 2017-08-24 2020-08-14 南通励成生物工程有限公司 制备磷脂酰丝氨酸盐的方法
CN110938090A (zh) * 2019-12-24 2020-03-31 南通励成生物工程有限公司 一种磷脂酰丝氨酸的纯化方法
CN112314949A (zh) * 2020-11-04 2021-02-05 上海欧睿生物科技有限公司 一种磷脂酰丝氨酸液体配制方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3357918A (en) 1964-05-27 1967-12-12 Central Soya Co Fluidized lecithin composition and method
US5015483A (en) * 1989-02-09 1991-05-14 Nabisco Brands, Inc. Liposome composition for the stabilization of oxidizable substances
US5700668A (en) 1995-12-08 1997-12-23 Italfarmaco Sud S.P.A. Process for the industrial preparation of phosphatidylserine
IL129086A0 (en) 1999-03-22 2000-02-17 Enzymotec Ltd Surfactant-lipase complex immobilized on insoluble matrix
US6514973B1 (en) * 1998-10-30 2003-02-04 Merck Patent Geseilschaft Mit Beschrankter Haftung Compositions for the treatment and prevention of neurological and pathopsychological diseases
DE19917249C2 (de) 1999-02-26 2001-09-27 Meyer Lucas Gmbh & Co Verfahren zur Herstellung von Phosphatidylserin-Produkten
US6323060B1 (en) * 1999-05-05 2001-11-27 Dense-Pac Microsystems, Inc. Stackable flex circuit IC package and method of making same
JP4306899B2 (ja) 1999-10-26 2009-08-05 株式会社ヤクルト本社 ホスファチジルセリン含有油溶組成物の製造法
AU2001259295A1 (en) * 2000-04-28 2001-11-12 Zengen, Inc. Method and composition for rapid delivery of bioactive compounds to the systemiccirculation via the nasal membrane
US7226916B1 (en) * 2000-05-08 2007-06-05 N.V. Nutricia Preparation for the prevention and/or treatment of vascular disorders
JP2001354680A (ja) 2000-06-08 2001-12-25 Nof Corp 高安定性酸性リン脂質および製造方法
IT1319679B1 (it) * 2000-12-05 2003-10-23 Chemi Spa Processo di purificazione di fosfatidilserina.
JP4009066B2 (ja) 2001-02-15 2007-11-14 株式会社ヤクルト本社 ホスファチジルセリンの分画法
ES2227479T3 (es) * 2001-03-26 2005-04-01 Giventis Gmbh Alimento destinado a aumentar la capacidad cognitiva.
JP4599604B2 (ja) 2002-04-19 2010-12-15 カーギル テクスチュアライジング ソリューションズ ドイチュラント ゲゼルシャフト ミット ベシュレクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト 生体活性のリン脂質含有成分を含有するマトリックス
US20050286907A1 (en) 2003-06-13 2005-12-29 Matsushita Electric Industrial Co., Ltd System, device, and method for radio frequency optical transmission
US7935365B2 (en) * 2003-10-22 2011-05-03 Enzymotec, Ltd. Glycerophospholipids for the improvement of cognitive functions
US20050130937A1 (en) * 2003-10-22 2005-06-16 Enzymotec Ltd. Lipids containing omega-3 and omega-6 fatty acids
EP2382872A1 (en) * 2005-04-28 2011-11-02 Enzymotec Ltd. Polar lipid mixtures, their preparation and uses

Also Published As

Publication number Publication date
CA2540170C (en) 2012-02-21
EP1663157A4 (en) 2010-02-24
EP1663157B1 (en) 2012-11-28
BRPI0414721A (pt) 2006-11-21
AU2004273700C1 (en) 2010-03-11
IL174420A (en) 2015-02-26
JP2007506733A (ja) 2007-03-22
KR20060123100A (ko) 2006-12-01
AU2004273700B2 (en) 2009-10-29
EP1663157A2 (en) 2006-06-07
WO2005027822A2 (en) 2005-03-31
KR20120039752A (ko) 2012-04-25
HK1092703A1 (en) 2007-02-16
CN102160651A (zh) 2011-08-24
CA2540170A1 (en) 2005-03-31
IL174420A0 (en) 2006-08-01
JP5077841B2 (ja) 2012-11-21
US20070160659A1 (en) 2007-07-12
KR101226787B1 (ko) 2013-01-25
ES2399049T3 (es) 2013-03-25
AU2004273700A1 (en) 2005-03-31
WO2005027822A3 (en) 2005-10-06
US8324187B2 (en) 2012-12-04
CN1897919A (zh) 2007-01-17

Similar Documents

Publication Publication Date Title
IL158139A0 (en) Stabilized formulations of phosphatidyl serine
IL162404A0 (en) Stabilized formulations of adenovirus
ZA200605348B (en) Solid forms of anti-EGFR-antibodies
HK1063179A1 (en) Production of fluorine compounds
IL174863A0 (en) Compounds that inhibit serine proteases and pharmaceutical compositions containing the same
IL175844A0 (en) Improved stability of progestogen formulations
MX294225B (en) Stabilized compositions comprising probiotics
IL163863A0 (en) Form of presentation for3-Ä(2-äÄ4-(hexyloxycarbonylamino-imino-methyl)-phenylaminoÜmethylü-1-methyl-1H-benzimidaz
ZA200407609B (en) Use of vitamin d compounds
EP1713326A4 (en) STABILIZED PREPARATION OF A SOLUTION READY FOR IVERMERCTINE FOOD USE
GB0202900D0 (en) Novel formulations of drugs
GB0324147D0 (en) Functionilisation of particles
AU2001278488A1 (en) Regulation of human matriptase-like serine protease
AU2002311147A1 (en) Preparation of d-(-) -1-substituted phenyl-2-dichloro-acetoamino-3fluoro-1-propanol from l type substituted phenyl serine ester
AU2001281967A1 (en) Regulation of human desc1-like serine protease
PT1576951E (pt) Formulações para administração rectal de agentes com acção trombolitica
AU2003250830A8 (en) Regulation of human subtilase-like serine protease
GB0317128D0 (en) Use of antitumoral compounds
EP1385846A4 (en) PROCESS FOR THE SYNTHESIS OF PANCRATISTATIN PRODUCTS
AU2002213949A1 (en) Regulation of human serine protease
TW466911U (en) Improved structure of insole
GB0306268D0 (en) Statue of remembrance
GB0115361D0 (en) Process for the manufacture of solid formulations
TW560260U (en) Structure improvement of insole
TW567754U (en) Improved structure of slippers