JP2007506733A5 - - Google Patents
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- Publication number
- JP2007506733A5 JP2007506733A5 JP2006527572A JP2006527572A JP2007506733A5 JP 2007506733 A5 JP2007506733 A5 JP 2007506733A5 JP 2006527572 A JP2006527572 A JP 2006527572A JP 2006527572 A JP2006527572 A JP 2006527572A JP 2007506733 A5 JP2007506733 A5 JP 2007506733A5
- Authority
- JP
- Japan
- Prior art keywords
- phosphatidylserine
- composition
- liquid
- matter
- dispersion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 60
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 59
- 239000000203 mixture Substances 0.000 claims 23
- 239000007788 liquid Substances 0.000 claims 16
- 239000006185 dispersion Substances 0.000 claims 14
- 238000002360 preparation method Methods 0.000 claims 12
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 235000015872 dietary supplement Nutrition 0.000 claims 6
- 206010027175 memory impairment Diseases 0.000 claims 6
- 239000003921 oil Substances 0.000 claims 5
- 235000019198 oils Nutrition 0.000 claims 5
- 150000003904 phospholipids Chemical class 0.000 claims 5
- 229960001153 serine Drugs 0.000 claims 5
- -1 sterol ester Chemical class 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 229930182558 Sterol Natural products 0.000 claims 4
- 239000004615 ingredient Substances 0.000 claims 4
- 235000016709 nutrition Nutrition 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 235000003702 sterols Nutrition 0.000 claims 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 3
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 claims 3
- 125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 claims 3
- 102000015439 Phospholipases Human genes 0.000 claims 3
- 108010064785 Phospholipases Proteins 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000006114 decarboxylation reaction Methods 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 230000007071 enzymatic hydrolysis Effects 0.000 claims 3
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 125000005456 glyceride group Chemical group 0.000 claims 3
- 230000007062 hydrolysis Effects 0.000 claims 3
- 238000006460 hydrolysis reaction Methods 0.000 claims 3
- 229940067606 lecithin Drugs 0.000 claims 3
- 235000010445 lecithin Nutrition 0.000 claims 3
- 239000000787 lecithin Substances 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 229940057917 medium chain triglycerides Drugs 0.000 claims 3
- 230000003647 oxidation Effects 0.000 claims 3
- 238000007254 oxidation reaction Methods 0.000 claims 3
- 230000037361 pathway Effects 0.000 claims 3
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 150000003141 primary amines Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 150000003432 sterols Chemical class 0.000 claims 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
- 102000011420 Phospholipase D Human genes 0.000 claims 2
- 108090000553 Phospholipase D Proteins 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 230000001149 cognitive effect Effects 0.000 claims 2
- 238000000855 fermentation Methods 0.000 claims 2
- 230000004151 fermentation Effects 0.000 claims 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000011707 mineral Substances 0.000 claims 2
- 235000010755 mineral Nutrition 0.000 claims 2
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 2
- 229940067631 phospholipid Drugs 0.000 claims 2
- 239000000419 plant extract Substances 0.000 claims 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000003860 storage Methods 0.000 claims 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 2
- 239000008158 vegetable oil Substances 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 159000000007 calcium salts Chemical class 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 230000003930 cognitive ability Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000008157 edible vegetable oil Substances 0.000 claims 1
- 238000011049 filling Methods 0.000 claims 1
- 235000021323 fish oil Nutrition 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- GKTNLYAAZKKMTQ-UHFFFAOYSA-N n-[bis(dimethylamino)phosphinimyl]-n-methylmethanamine Chemical compound CN(C)P(=N)(N(C)C)N(C)C GKTNLYAAZKKMTQ-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001095 phosphatidyl group Chemical group 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL158139 | 2003-09-25 | ||
| IL15813903A IL158139A0 (en) | 2003-09-25 | 2003-09-25 | Stabilized formulations of phosphatidyl serine |
| PCT/IL2004/000895 WO2005027822A2 (en) | 2003-09-25 | 2004-09-26 | Stabilized formulations of phosphatidylserine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007506733A JP2007506733A (ja) | 2007-03-22 |
| JP2007506733A5 true JP2007506733A5 (enExample) | 2007-07-19 |
| JP5077841B2 JP5077841B2 (ja) | 2012-11-21 |
Family
ID=34073789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006527572A Expired - Lifetime JP5077841B2 (ja) | 2003-09-25 | 2004-09-26 | ホスファチジルセリンの安定化された配合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8324187B2 (enExample) |
| EP (1) | EP1663157B1 (enExample) |
| JP (1) | JP5077841B2 (enExample) |
| KR (2) | KR101226787B1 (enExample) |
| CN (1) | CN1897919A (enExample) |
| AU (1) | AU2004273700C1 (enExample) |
| BR (1) | BRPI0414721A (enExample) |
| CA (1) | CA2540170C (enExample) |
| ES (1) | ES2399049T3 (enExample) |
| IL (2) | IL158139A0 (enExample) |
| WO (1) | WO2005027822A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935365B2 (en) * | 2003-10-22 | 2011-05-03 | Enzymotec, Ltd. | Glycerophospholipids for the improvement of cognitive functions |
| US20050130937A1 (en) | 2003-10-22 | 2005-06-16 | Enzymotec Ltd. | Lipids containing omega-3 and omega-6 fatty acids |
| US8052992B2 (en) * | 2003-10-22 | 2011-11-08 | Enzymotec Ltd. | Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions |
| CA2611121C (en) | 2005-05-31 | 2014-01-28 | Arla Foods Amba | Phosphatidylserine enriched milk fractions for the formulation of functional foods |
| HUE037129T2 (hu) * | 2005-12-15 | 2018-08-28 | Nestec Sa | Kompozíciók és eljárások agyi funkció megõrzésére |
| US8877239B2 (en) * | 2010-08-12 | 2014-11-04 | Nutritional Therapeutics, Inc. | Lipid supplements for maintaining health and treatment of acute and chronic disorders |
| DE102007042557A1 (de) | 2007-09-07 | 2009-03-19 | Membramed Gmbh | Neuartige Formulierung von Phospholipiden |
| JP5432563B2 (ja) * | 2009-03-31 | 2014-03-05 | 株式会社ファンケル | ホスファチジルセリン含有カプセル及びカプセル充填用ホスファチジルセリン組成物 |
| EP2464350B1 (en) * | 2009-09-11 | 2016-08-24 | Nestec S.A. | Compositions and methods for enhancing cognitive and related functions in animals |
| US8399432B2 (en) * | 2009-10-27 | 2013-03-19 | Lipogen Ltd. | Compositions and methods of treatment for alleviating premenstrual syndrome symptoms |
| WO2012143860A1 (en) * | 2011-04-18 | 2012-10-26 | Jian Guan | Ameliorating cognitive decline |
| CN102908336B (zh) * | 2011-08-05 | 2015-10-28 | 深圳市华正实业有限公司 | 磷脂酰丝氨酸的稳定制剂、其制备方法、应用和应用产物 |
| ITPD20120021A1 (it) | 2012-01-26 | 2013-07-27 | Fidia Farmaceutici | "nuove composizioni farmaceutiche contenenti fosfatidilserina e curcumina". |
| ITMI20121784A1 (it) * | 2012-10-22 | 2014-04-23 | Velleja Res Srl | Composizioni galattogeniche a base di fosfatidilserina |
| US9101580B2 (en) * | 2012-12-18 | 2015-08-11 | Matthew Bennett | Compositions and methods for treating traumatic brain injury |
| DK2769725T3 (en) * | 2013-02-22 | 2016-08-22 | Lipogen Ltd | PREPARATIONS FOR USE AT relief of symptoms associated with premenstrual syndrome and premenstrual dysphoric disorder |
| EP3171706B2 (en) * | 2014-07-25 | 2024-10-16 | Frutarom Limited | Nutritional compositions containing phosphatidylserine powder |
| CN104327114A (zh) * | 2014-11-06 | 2015-02-04 | 江南大学 | 一种磷脂酰丝氨酸的制备方法 |
| WO2017125816A1 (en) * | 2016-01-21 | 2017-07-27 | Enzymotec Ltd. | Methods using phosphatidylserine powder |
| CN110283803B (zh) * | 2016-06-02 | 2021-08-03 | 天津科技大学 | 一种磷脂酶d及其制备磷脂酸、磷脂酰丝氨酸的方法 |
| CN107125752B (zh) * | 2017-06-14 | 2020-06-30 | 安徽省芬格欣生物药业有限公司 | 一种增进记忆功能的磷脂酰丝氨酸口服液及制备方法 |
| CN107034248A (zh) * | 2017-06-19 | 2017-08-11 | 成都新柯力化工科技有限公司 | 一种连续高效酶转化合成食品用磷脂酰丝氨酸的方法 |
| CN107722051B (zh) * | 2017-08-24 | 2020-08-14 | 南通励成生物工程有限公司 | 制备磷脂酰丝氨酸盐的方法 |
| GB201821049D0 (en) * | 2018-12-21 | 2019-02-06 | Ge Healthcare As | Ultrasound contrast agent and methods for use therof |
| US20220249455A1 (en) * | 2019-07-15 | 2022-08-11 | R.P. Scherer Technologies, Llc | Enteric proton pump inhibitor softgel capsule |
| CN110938090A (zh) * | 2019-12-24 | 2020-03-31 | 南通励成生物工程有限公司 | 一种磷脂酰丝氨酸的纯化方法 |
| CN112314949A (zh) * | 2020-11-04 | 2021-02-05 | 上海欧睿生物科技有限公司 | 一种磷脂酰丝氨酸液体配制方法 |
| KR102754261B1 (ko) * | 2022-05-12 | 2025-01-10 | 주식회사 한국인삼공사 | 붕해성이 개선된 포스파티딜세린 함유 연질캡슐 |
| WO2026014835A1 (ko) * | 2024-07-12 | 2026-01-15 | 주식회사 아스트로젠 | L-세린의 리포좀 제형 및 이의 제조 방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3357918A (en) * | 1964-05-27 | 1967-12-12 | Central Soya Co | Fluidized lecithin composition and method |
| US5015483A (en) * | 1989-02-09 | 1991-05-14 | Nabisco Brands, Inc. | Liposome composition for the stabilization of oxidizable substances |
| US5700668A (en) * | 1995-12-08 | 1997-12-23 | Italfarmaco Sud S.P.A. | Process for the industrial preparation of phosphatidylserine |
| IL129086A0 (en) | 1999-03-22 | 2000-02-17 | Enzymotec Ltd | Surfactant-lipase complex immobilized on insoluble matrix |
| JP2002528507A (ja) * | 1998-10-30 | 2002-09-03 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 神経疾患および病態心理学的疾患の治療および予防用の組成物 |
| DE19917249C2 (de) | 1999-02-26 | 2001-09-27 | Meyer Lucas Gmbh & Co | Verfahren zur Herstellung von Phosphatidylserin-Produkten |
| US6323060B1 (en) * | 1999-05-05 | 2001-11-27 | Dense-Pac Microsystems, Inc. | Stackable flex circuit IC package and method of making same |
| JP4306899B2 (ja) * | 1999-10-26 | 2009-08-05 | 株式会社ヤクルト本社 | ホスファチジルセリン含有油溶組成物の製造法 |
| AU2001259295A1 (en) * | 2000-04-28 | 2001-11-12 | Zengen, Inc. | Method and composition for rapid delivery of bioactive compounds to the systemiccirculation via the nasal membrane |
| US7226916B1 (en) * | 2000-05-08 | 2007-06-05 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
| JP2001354680A (ja) * | 2000-06-08 | 2001-12-25 | Nof Corp | 高安定性酸性リン脂質および製造方法 |
| IT1319679B1 (it) * | 2000-12-05 | 2003-10-23 | Chemi Spa | Processo di purificazione di fosfatidilserina. |
| JP4009066B2 (ja) * | 2001-02-15 | 2007-11-14 | 株式会社ヤクルト本社 | ホスファチジルセリンの分画法 |
| AU2002338230A1 (en) * | 2001-03-26 | 2002-10-15 | Giventis Gmbh | Food item for increasing cognitive capacity |
| JP4599604B2 (ja) | 2002-04-19 | 2010-12-15 | カーギル テクスチュアライジング ソリューションズ ドイチュラント ゲゼルシャフト ミット ベシュレクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト | 生体活性のリン脂質含有成分を含有するマトリックス |
| CN1306736C (zh) | 2003-06-13 | 2007-03-21 | 松下电器产业株式会社 | 用于射频光学传输的系统和方法 |
| US20050130937A1 (en) * | 2003-10-22 | 2005-06-16 | Enzymotec Ltd. | Lipids containing omega-3 and omega-6 fatty acids |
| US7935365B2 (en) * | 2003-10-22 | 2011-05-03 | Enzymotec, Ltd. | Glycerophospholipids for the improvement of cognitive functions |
| EP1898722B1 (en) * | 2005-04-28 | 2013-04-10 | Enzymotec Ltd. | Polar lipid mixtures, their preparation and uses |
-
2003
- 2003-09-25 IL IL15813903A patent/IL158139A0/xx unknown
-
2004
- 2004-09-26 EP EP04770566A patent/EP1663157B1/en not_active Expired - Lifetime
- 2004-09-26 ES ES04770566T patent/ES2399049T3/es not_active Expired - Lifetime
- 2004-09-26 KR KR1020067005677A patent/KR101226787B1/ko not_active Expired - Lifetime
- 2004-09-26 JP JP2006527572A patent/JP5077841B2/ja not_active Expired - Lifetime
- 2004-09-26 KR KR1020127005527A patent/KR20120039752A/ko not_active Ceased
- 2004-09-26 US US10/572,782 patent/US8324187B2/en active Active
- 2004-09-26 CN CNA2004800348781A patent/CN1897919A/zh active Pending
- 2004-09-26 CA CA2540170A patent/CA2540170C/en not_active Expired - Fee Related
- 2004-09-26 AU AU2004273700A patent/AU2004273700C1/en not_active Expired
- 2004-09-26 BR BRPI0414721-9A patent/BRPI0414721A/pt active IP Right Grant
- 2004-09-26 WO PCT/IL2004/000895 patent/WO2005027822A2/en not_active Ceased
-
2006
- 2006-03-20 IL IL174420A patent/IL174420A/en active IP Right Grant
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