KR101141985B1 - 각막 상피 형성용 세포 시트, 그들의 제조 방법 및 그들의이용 방법 - Google Patents
각막 상피 형성용 세포 시트, 그들의 제조 방법 및 그들의이용 방법 Download PDFInfo
- Publication number
- KR101141985B1 KR101141985B1 KR1020057014284A KR20057014284A KR101141985B1 KR 101141985 B1 KR101141985 B1 KR 101141985B1 KR 1020057014284 A KR1020057014284 A KR 1020057014284A KR 20057014284 A KR20057014284 A KR 20057014284A KR 101141985 B1 KR101141985 B1 KR 101141985B1
- Authority
- KR
- South Korea
- Prior art keywords
- cell sheet
- corneal
- cell
- corneal epithelial
- sheet
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
- A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2539/00—Supports and/or coatings for cell culture characterised by properties
- C12N2539/10—Coating allowing for selective detachment of cells, e.g. thermoreactive coating
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Developmental Biology & Embryology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003068899A JP3935093B2 (ja) | 2003-02-06 | 2003-02-06 | 高生着性再生角膜上皮細胞シート、製造方法及びその利用方法 |
JPJP-P-2003-00068899 | 2003-02-06 | ||
JP2003079100A JP3935096B2 (ja) | 2003-02-14 | 2003-02-14 | 高生着性角膜上皮代替細胞シート、製造方法及びその利用方法 |
JPJP-P-2003-00079100 | 2003-02-14 | ||
PCT/JP2004/001274 WO2004069295A1 (ja) | 2003-02-06 | 2004-02-06 | 角膜上皮形成用細胞シート、それらの製造方法及びそれらの利用方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20050118670A KR20050118670A (ko) | 2005-12-19 |
KR101141985B1 true KR101141985B1 (ko) | 2012-05-17 |
Family
ID=32852737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020057014284A KR101141985B1 (ko) | 2003-02-06 | 2004-02-06 | 각막 상피 형성용 세포 시트, 그들의 제조 방법 및 그들의이용 방법 |
Country Status (6)
Country | Link |
---|---|
US (2) | US20060234377A1 (zh) |
EP (2) | EP1602383B1 (zh) |
KR (1) | KR101141985B1 (zh) |
CN (1) | CN1747753B (zh) |
ES (1) | ES2538696T3 (zh) |
WO (1) | WO2004069295A1 (zh) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2538696T3 (es) | 2003-02-06 | 2015-06-23 | Cellseed Inc. | Láminas de células para la formación de la ectocórnea, método para producir las mismas y método para usar las mismas |
AU2003207288A1 (en) * | 2003-02-06 | 2004-08-30 | Cellseed Inc. | Anterior ocular-associated cell sheet, three-dimensional construct and process for producing the same |
EP1600177B1 (en) * | 2003-02-20 | 2016-05-25 | Cellseed Inc. | Endothelial cell sheet for cornea regeneration, method of producing the same and method of using the same |
JP4834802B2 (ja) | 2004-02-18 | 2011-12-14 | 聡 山上 | ヒト角膜内皮細胞の培養物層積層体及びその作製方法 |
US9114192B2 (en) * | 2004-04-25 | 2015-08-25 | Cellseed Inc. | Cultured periodontal ligament cell sheet, process for producing the same and method of use thereof |
WO2006093153A1 (ja) | 2005-02-28 | 2006-09-08 | Cellseed Inc. | 培養細胞シート、製造方法及びその利用した組織修復方法 |
US10533158B2 (en) * | 2005-02-28 | 2020-01-14 | Tokai University Educational System | Cultured cell sheet, production method thereof, and application method thereof |
CN1883438A (zh) * | 2005-06-21 | 2006-12-27 | 香港理工大学 | 温度响应性智能面膜及其制备方法 |
JP4919464B2 (ja) | 2006-03-02 | 2012-04-18 | 国立大学法人大阪大学 | 三次元組織の製造方法およびそれに用いる細胞外マトリックスの製造方法。 |
JP4934360B2 (ja) * | 2006-07-05 | 2012-05-16 | 学校法人東京女子医科大学 | 細胞培養支持体 |
US9102916B2 (en) | 2007-02-27 | 2015-08-11 | Trustees Of Tufts College | Tissue-engineered silk organs |
US8557583B2 (en) * | 2007-03-15 | 2013-10-15 | Dai Nippon Printing Co., Ltd. | Cell culture support and manufacture thereof |
US9598668B2 (en) * | 2008-10-14 | 2017-03-21 | Cellseed Inc. | Temperature-responsive cell culture substrate and method for producing the same |
JP4483994B1 (ja) * | 2009-02-26 | 2010-06-16 | 株式会社豊田中央研究所 | 細胞培養担体及びその利用 |
EP2682458B1 (en) * | 2011-02-28 | 2019-10-23 | CellSeed Inc. | Cell sheet having hyaluronic acid production ability and method for preparing the same |
CN103892938A (zh) * | 2014-04-01 | 2014-07-02 | 薛春燕 | 一种角膜板层片及其制备方法 |
CN106661537B (zh) * | 2014-08-13 | 2019-06-25 | 三井化学株式会社 | 医疗器具、细胞培养方法、含氟环状烯烃聚合物、含氟环状烯烃聚合物组合物及培养细胞 |
US20180127700A1 (en) * | 2015-05-21 | 2018-05-10 | University Of South Florida | Cell Culture Substrate for Rapid Release and Re-Plating |
CN108567995A (zh) * | 2017-03-10 | 2018-09-25 | 上海睿泰生物科技股份有限公司 | 一种用于角膜疾病治疗的上皮细胞片的制备方法及其应用 |
CN110229783A (zh) * | 2019-05-22 | 2019-09-13 | 中国人民解放军总医院 | 一种基于温皿制备干细胞膜片的方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4304866A (en) | 1979-11-14 | 1981-12-08 | Massachusetts Institute Of Technology | Transplantable sheets of living keratinous tissue |
US4718420A (en) * | 1986-03-06 | 1988-01-12 | Lemp Michael A | Method and apparatus for trephining corneal tissue in preparation for keratoplasty |
US4772283A (en) * | 1986-05-16 | 1988-09-20 | White Thomas C | Corneal implant |
US5284766A (en) * | 1989-02-10 | 1994-02-08 | Kao Corporation | Bed material for cell culture |
JPH06104061B2 (ja) | 1989-02-10 | 1994-12-21 | 花王株式会社 | 細胞培養支持体材料 |
GB9400163D0 (en) * | 1994-01-06 | 1994-03-02 | Geistlich Soehne Ag | Membrane |
AU6242298A (en) | 1997-01-17 | 1998-08-07 | Celadon Science, Llc | Methods for promoting healing of corneal resurfacing wounds |
CA2227827A1 (en) | 1998-01-23 | 1999-07-23 | Unknown | In vitro artificial cornea and sclera |
ATE301679T1 (de) * | 1999-01-29 | 2005-08-15 | Amersham Biosciences Kk | Temperatursensitives polymer und verfahren zu seiner herstellung |
JP4397082B2 (ja) | 1999-12-09 | 2010-01-13 | 有限会社ジャパン・オフサルミック・コンサルタンツ | 移植用細胞片及びその作成方法 |
JP4556269B2 (ja) | 2000-02-17 | 2010-10-06 | 積水ハウス株式会社 | 夾雑物含有積層泡ガラスの製造方法 |
EP2298858A1 (en) | 2000-03-16 | 2011-03-23 | Cellseed Inc. | Bed material for cell culture, method for co-culture of cell and co-cultured cell sheet obtainable therefrom |
AU5380201A (en) * | 2000-04-27 | 2001-11-07 | Ray Jui Fang Tsai | Method for expansion of epithelial stem cells |
US8889417B2 (en) * | 2000-07-21 | 2014-11-18 | Cellseed Inc. | Epidermal cultured cell sheet, multi-layered cultured skin sheet and processes for producing those sheets |
US20040009566A1 (en) * | 2000-07-21 | 2004-01-15 | Teruo Okano | Heart muscle-like cell sheet, three-dimensional construct, heart muscle-like tissue and process for producing the same |
JP4745525B2 (ja) * | 2001-05-09 | 2011-08-10 | 実 上田 | 角膜治療用培養上皮細胞シート及びその製造方法 |
EP1428871B1 (en) * | 2001-07-26 | 2008-08-27 | Transparent Inc. | Cultured cell construct containing spheroids of cultured animal cells and utilization thereof |
JP4475847B2 (ja) * | 2001-07-26 | 2010-06-09 | 株式会社セルシード | 前眼部関連細胞シート、3次元構造体、及びそれらの製造法 |
DE10221034A1 (de) * | 2002-05-03 | 2003-11-20 | Schering Ag | 17alpha-Fluoralkyl-11ß-benzaldoxim-Steroide, Verfahren zu deren Herstellung, diese Steroide enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
AU2003207288A1 (en) | 2003-02-06 | 2004-08-30 | Cellseed Inc. | Anterior ocular-associated cell sheet, three-dimensional construct and process for producing the same |
ES2538696T3 (es) | 2003-02-06 | 2015-06-23 | Cellseed Inc. | Láminas de células para la formación de la ectocórnea, método para producir las mismas y método para usar las mismas |
EP1600177B1 (en) | 2003-02-20 | 2016-05-25 | Cellseed Inc. | Endothelial cell sheet for cornea regeneration, method of producing the same and method of using the same |
JP4781999B2 (ja) * | 2004-03-04 | 2011-09-28 | 株式会社セルシード | 癌細胞移植動物の製造方法 |
US9114192B2 (en) * | 2004-04-25 | 2015-08-25 | Cellseed Inc. | Cultured periodontal ligament cell sheet, process for producing the same and method of use thereof |
WO2006093153A1 (ja) * | 2005-02-28 | 2006-09-08 | Cellseed Inc. | 培養細胞シート、製造方法及びその利用した組織修復方法 |
US10533158B2 (en) * | 2005-02-28 | 2020-01-14 | Tokai University Educational System | Cultured cell sheet, production method thereof, and application method thereof |
US9598668B2 (en) * | 2008-10-14 | 2017-03-21 | Cellseed Inc. | Temperature-responsive cell culture substrate and method for producing the same |
-
2004
- 2004-02-06 ES ES04708896.8T patent/ES2538696T3/es not_active Expired - Lifetime
- 2004-02-06 KR KR1020057014284A patent/KR101141985B1/ko active IP Right Grant
- 2004-02-06 US US10/544,541 patent/US20060234377A1/en not_active Abandoned
- 2004-02-06 CN CN2004800036987A patent/CN1747753B/zh not_active Expired - Lifetime
- 2004-02-06 EP EP04708896.8A patent/EP1602383B1/en not_active Expired - Lifetime
- 2004-02-06 WO PCT/JP2004/001274 patent/WO2004069295A1/ja active Application Filing
- 2004-02-06 EP EP11192961.8A patent/EP2450065B1/en not_active Expired - Lifetime
-
2017
- 2017-12-29 US US15/859,304 patent/US10434219B2/en not_active Expired - Lifetime
Non-Patent Citations (5)
Title |
---|
ARCH OPHTHALMOL, Vol.119, FEB 2001, pages 298-303 * |
IOVS, Vol.44, No.1, pages 106-116 * |
Ophthalmology, Vol.108, No.9, SEP 2001, pages 1569-1574 * |
The New England Journal of Medicine, Vol.343, No.2, July 13, 2000. pages 86-93 * |
Tissue Engineering, Vol.7, No.4, 2001, pages 473-480 * |
Also Published As
Publication number | Publication date |
---|---|
EP1602383B1 (en) | 2015-05-27 |
EP2450065B1 (en) | 2017-08-23 |
CN1747753A (zh) | 2006-03-15 |
EP1602383A1 (en) | 2005-12-07 |
US20180126040A1 (en) | 2018-05-10 |
KR20050118670A (ko) | 2005-12-19 |
US20060234377A1 (en) | 2006-10-19 |
CN1747753B (zh) | 2010-11-10 |
US10434219B2 (en) | 2019-10-08 |
WO2004069295A1 (ja) | 2004-08-19 |
EP1602383A4 (en) | 2009-07-22 |
EP2450065A1 (en) | 2012-05-09 |
ES2538696T3 (es) | 2015-06-23 |
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