KR100953483B1 - 세포독성 화학요법의 독성효과 감소에 유용한 아미노산 및리보플라빈 조성물 - Google Patents

세포독성 화학요법의 독성효과 감소에 유용한 아미노산 및리보플라빈 조성물 Download PDF

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Publication number
KR100953483B1
KR100953483B1 KR1020047007754A KR20047007754A KR100953483B1 KR 100953483 B1 KR100953483 B1 KR 100953483B1 KR 1020047007754 A KR1020047007754 A KR 1020047007754A KR 20047007754 A KR20047007754 A KR 20047007754A KR 100953483 B1 KR100953483 B1 KR 100953483B1
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South Korea
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riboflavin
pharmaceutical composition
concentration
composition
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Expired - Fee Related
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English (en)
Korean (ko)
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KR20040065565A (ko
Inventor
스탠니슬로우 알. 벌진스키
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벌진스키, 스탠니슬로우, 알
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020047007754A 2001-11-27 2002-11-21 세포독성 화학요법의 독성효과 감소에 유용한 아미노산 및리보플라빈 조성물 Expired - Fee Related KR100953483B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/995,010 US20030105104A1 (en) 2001-11-27 2001-11-27 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
US09/995,010 2001-11-27
PCT/US2002/037354 WO2003045372A1 (en) 2001-11-27 2002-11-21 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy

Publications (2)

Publication Number Publication Date
KR20040065565A KR20040065565A (ko) 2004-07-22
KR100953483B1 true KR100953483B1 (ko) 2010-04-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047007754A Expired - Fee Related KR100953483B1 (ko) 2001-11-27 2002-11-21 세포독성 화학요법의 독성효과 감소에 유용한 아미노산 및리보플라빈 조성물

Country Status (21)

Country Link
US (2) US20030105104A1 (enExample)
EP (1) EP1450781B1 (enExample)
JP (1) JP4614660B2 (enExample)
KR (1) KR100953483B1 (enExample)
CN (1) CN100358527C (enExample)
AT (1) ATE330595T1 (enExample)
BR (1) BR0214430A (enExample)
CA (1) CA2468133C (enExample)
DE (1) DE60212693T2 (enExample)
EA (1) EA009516B1 (enExample)
HU (1) HU230986B1 (enExample)
IL (2) IL162141A0 (enExample)
MX (1) MXPA04004994A (enExample)
NO (1) NO332858B1 (enExample)
NZ (1) NZ532833A (enExample)
PL (1) PL353656A1 (enExample)
RO (1) RO121173B1 (enExample)
SI (1) SI21542A (enExample)
UA (1) UA78977C2 (enExample)
WO (1) WO2003045372A1 (enExample)
ZA (1) ZA200404115B (enExample)

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WO2008105384A1 (ja) * 2007-02-26 2008-09-04 Kyowa Hakko Bio Co., Ltd. シトルリン含有錠剤
US9609884B2 (en) 2007-03-15 2017-04-04 Suntory Holdings Limited Anti-fatigue agent
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EP3011843A1 (en) 2008-09-19 2016-04-27 Nestec S.A. Nutritional support of the immune system during anti-cancer treatment
AU2014200578B2 (en) * 2008-09-19 2016-08-11 Société des Produits Nestlé S.A. Nutritional support to prevent or moderate bone marrow paralysis or neutropenia during anti-cancer treatment
SMT201700601T1 (it) 2009-04-03 2018-03-08 Ocera Therapeutics Inc L-ornitina fenilacetato e metodi per la sua fabbricazione
EP2799067B1 (en) 2009-06-08 2019-04-03 UCL Business PLC Treatment of brain inflammation using L-Ornithine Phenylacetate
US8449512B2 (en) 2010-04-09 2013-05-28 Davinci Biomedical Research Products Inc. Stoma stabilitating device and method
EP2397458A1 (en) * 2010-06-21 2011-12-21 Lunamed AG Organic salts and co-crystals of phenylbutyric acid
CN108420827A (zh) 2010-07-22 2018-08-21 雷文制药有限公司 包含磁偶极子稳定化溶液的组合物及其用途
MX2013003282A (es) * 2010-09-24 2013-05-09 Univ Florida Materiales y metodos para mejorar la funcion gastrointestinal.
NZ609191A (en) 2010-10-06 2015-06-26 Ocera Therapeutics Inc Methods of making l-ornithine phenyl acetate
CN103429234B (zh) 2010-12-10 2016-10-05 布罗迪健康科学有限公司 茉莉酮酸酯治疗膀胱功能障碍的用途
TWI551288B (zh) * 2011-02-17 2016-10-01 Ea Pharma Co Ltd Antimicrobial activity enhancer for chemotherapeutic agents
US20130011488A1 (en) * 2011-07-07 2013-01-10 Nezami Md Mohammad Systems, Methods, and Formulations for Treating Cancer
CN110522744B (zh) 2013-03-11 2023-04-07 佛罗里达大学研究基金会有限公司 用于改善肺功能和用于预防和/或治疗辐射诱发的肺并发症的材料和方法
PL3065751T3 (pl) * 2013-11-08 2020-07-13 Legacy Healthcare Ltd Sposób leczenia raka i chorób współistniejących
JP6598425B2 (ja) * 2014-02-27 2019-10-30 花王株式会社 疲労の評価方法
KR20230018526A (ko) 2014-11-24 2023-02-07 유씨엘 비즈니스 리미티드 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료
HK1249434A1 (zh) 2015-08-18 2018-11-02 Ocera Therapeutics, Inc. 使用与苯乙酸盐和苯丁酸盐中的至少一种组合的l-鸟氨酸治疗和预防肌肉损失
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
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Also Published As

Publication number Publication date
WO2003045372A1 (en) 2003-06-05
CN1596109A (zh) 2005-03-16
KR20040065565A (ko) 2004-07-22
EA009516B1 (ru) 2008-02-28
BR0214430A (pt) 2004-11-03
IL162141A (en) 2009-05-04
SI21542A (sl) 2005-02-28
ZA200404115B (en) 2005-11-30
HUP0402240A2 (hu) 2005-02-28
EP1450781B1 (en) 2006-06-21
DE60212693T2 (de) 2007-07-05
DE60212693D1 (de) 2006-08-03
CN100358527C (zh) 2008-01-02
EA200400737A1 (ru) 2004-12-30
MXPA04004994A (es) 2005-04-08
US20030105104A1 (en) 2003-06-05
NO332858B1 (no) 2013-01-21
CA2468133C (en) 2011-02-22
US20050182064A1 (en) 2005-08-18
PL353656A1 (en) 2003-06-02
NZ532833A (en) 2006-12-22
HUP0402240A3 (en) 2012-09-28
JP2005518361A (ja) 2005-06-23
HU230986B1 (hu) 2019-08-28
JP4614660B2 (ja) 2011-01-19
CA2468133A1 (en) 2003-06-05
RO121173B1 (ro) 2007-01-30
ATE330595T1 (de) 2006-07-15
UA78977C2 (en) 2007-05-10
NO20042364L (no) 2004-06-07
IL162141A0 (en) 2005-11-20
US7427619B2 (en) 2008-09-23
AU2002352843A1 (en) 2003-06-10
EP1450781A1 (en) 2004-09-01

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