WO2008105384A1 - シトルリン含有錠剤 - Google Patents

シトルリン含有錠剤 Download PDF

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Publication number
WO2008105384A1
WO2008105384A1 PCT/JP2008/053233 JP2008053233W WO2008105384A1 WO 2008105384 A1 WO2008105384 A1 WO 2008105384A1 JP 2008053233 W JP2008053233 W JP 2008053233W WO 2008105384 A1 WO2008105384 A1 WO 2008105384A1
Authority
WO
WIPO (PCT)
Prior art keywords
citrulline
salt
tablet
active ingredient
containing tablet
Prior art date
Application number
PCT/JP2008/053233
Other languages
English (en)
French (fr)
Inventor
Yasushi Sakai
Masao Kimura
Ayako Kamimura
Original Assignee
Kyowa Hakko Bio Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Bio Co., Ltd. filed Critical Kyowa Hakko Bio Co., Ltd.
Priority to JP2009501235A priority Critical patent/JPWO2008105384A1/ja
Publication of WO2008105384A1 publication Critical patent/WO2008105384A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

　アルギニンや配合される他の成分が有する種々の有用な機能を体内で発揮させることができ、かつ打錠性や保存安定性に優れた錠剤の開発が望まれている。 　シトルリンまたはその塩と他の有効成分とを含有する錠剤。他の有効成分が、アミノ酸（但し、シトルリンを除く）またはその塩、有機酸またはその塩および動植物粉末からなる群から選ばれる１以上の成分である前記錠剤。
PCT/JP2008/053233 2007-02-26 2008-02-26 シトルリン含有錠剤 WO2008105384A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009501235A JPWO2008105384A1 (ja) 2007-02-26 2008-02-26 シトルリン含有錠剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-044954 2007-02-26
JP2007044954 2007-02-26

Publications (1)

Publication Number Publication Date
WO2008105384A1 true WO2008105384A1 (ja) 2008-09-04

Family

ID=39721216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053233 WO2008105384A1 (ja) 2007-02-26 2008-02-26 シトルリン含有錠剤

Country Status (2)

Country Link
JP (1) JPWO2008105384A1 (ja)
WO (1) WO2008105384A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010270111A (ja) * 2009-04-21 2010-12-02 Taisho Pharmaceutical Co Ltd アルギニン含有錠剤
JP2012139124A (ja) * 2010-12-28 2012-07-26 House Foods Corp ニンニク成分含有飲料及びニンニク成分による風味の調整を行う方法
CN102885311A (zh) * 2012-10-19 2013-01-23 中科乐仁（北京）科技发展有限公司 一种缓解体力疲劳的保健食品组合物及其制备方法
JP2013509395A (ja) * 2009-10-28 2013-03-14 モデュテック エス．エー． アミノ酸および植物を含む調製物およびアルコール解毒におけるその活性
JP2013060406A (ja) * 2011-09-15 2013-04-04 Kyowa Hakko Bio Co Ltd 脳疲労改善用経口剤
EP2637505A4 (en) * 2010-10-19 2014-04-09 K L R M Llc COMPOSITIONS AND METHOD FOR TREATING EFFECTIVE DYSFUNCTION
CN103734724A (zh) * 2013-12-31 2014-04-23 勾大卉 玛咖山楂咀嚼片
CN104435536A (zh) * 2014-11-11 2015-03-25 武汉名实生物医药科技有限责任公司 能延缓衰老、改善性功能、抗疲劳的复方制剂的制备方法
JPWO2013122188A1 (ja) * 2012-02-15 2015-05-18 協和発酵バイオ株式会社 血管内皮機能低下の予防または改善剤
JP2016121194A (ja) * 2016-04-05 2016-07-07 協和発酵バイオ株式会社 脳疲労改善用経口剤
WO2019022216A1 (ja) * 2017-07-28 2019-01-31 株式会社明治 筋力向上用アミノ酸組成物

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01180823A (ja) * 1988-01-13 1989-07-18 Sawai Seiyaku Kk 脳障害処置剤
US6028107A (en) * 1997-02-27 2000-02-22 Waugh; William Howard Orthomolecular medical use of L-citrulline for vasoprotection, relaxative smooth muscle tone and cell protection
US20010056068A1 (en) * 1998-03-04 2001-12-27 Kristof Chwalisz Method of treatment and prevention of nitric oxide deficiency-related disorders with citrulline and citrulline derivatives
JP2005518361A (ja) * 2001-11-27 2005-06-23 ブルジンスキー，スタニスロー・アール 細胞傷害的化学療法の毒性作用を軽減するために有用な、アミノ酸およびリボフラビンの配合物
WO2005077349A1 (ja) * 2004-02-17 2005-08-25 Otsuka Pharmaceutical Co., Ltd. ヒトβディフェンシン産生促進剤
WO2006002096A2 (en) * 2004-06-18 2006-01-05 Vivo Therapeutics, Inc. Low doses of l-citrulline for treating diseases
US20060046982A1 (en) * 2004-08-26 2006-03-02 Waugh William H Orthomolecular medical use of L-citrulline for capillary endothelial protection and adjacent cell protection in neurodegenerative disease
JP2006089487A (ja) * 2005-10-03 2006-04-06 Nara Institute Of Science & Technology シトルリンを含有するｄｎａ切断防止剤、活性酸素障害に起因する疾患の治療薬または予防薬、抗酸化食品添加物
US20060247315A1 (en) * 2003-07-08 2006-11-02 Biocodex Method of treating intestinal disorders with citrulline
WO2007000985A1 (ja) * 2005-06-27 2007-01-04 Kyowa Hakko Kogyo Co., Ltd. ヘモグロビン尿症またはミオグロビン尿症の予防または治療用組成物
WO2007023931A1 (ja) * 2005-08-25 2007-03-01 Kyowa Hakko Kogyo Co., Ltd. 血中アルコール濃度上昇抑制用組成物
WO2007066642A1 (ja) * 2005-12-05 2007-06-14 Kyowa Hakko Kogyo Co., Ltd. 皮膚の乾燥予防または改善用経口剤
JP2008050352A (ja) * 2006-07-27 2008-03-06 Ezaki Glico Co Ltd 睡眠改善剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5124913B2 (ja) * 2005-06-27 2013-01-23 パナソニック株式会社 覚醒装置

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01180823A (ja) * 1988-01-13 1989-07-18 Sawai Seiyaku Kk 脳障害処置剤
US6028107A (en) * 1997-02-27 2000-02-22 Waugh; William Howard Orthomolecular medical use of L-citrulline for vasoprotection, relaxative smooth muscle tone and cell protection
US20010056068A1 (en) * 1998-03-04 2001-12-27 Kristof Chwalisz Method of treatment and prevention of nitric oxide deficiency-related disorders with citrulline and citrulline derivatives
JP2005518361A (ja) * 2001-11-27 2005-06-23 ブルジンスキー，スタニスロー・アール 細胞傷害的化学療法の毒性作用を軽減するために有用な、アミノ酸およびリボフラビンの配合物
US20060247315A1 (en) * 2003-07-08 2006-11-02 Biocodex Method of treating intestinal disorders with citrulline
WO2005077349A1 (ja) * 2004-02-17 2005-08-25 Otsuka Pharmaceutical Co., Ltd. ヒトβディフェンシン産生促進剤
WO2006002096A2 (en) * 2004-06-18 2006-01-05 Vivo Therapeutics, Inc. Low doses of l-citrulline for treating diseases
US20060046982A1 (en) * 2004-08-26 2006-03-02 Waugh William H Orthomolecular medical use of L-citrulline for capillary endothelial protection and adjacent cell protection in neurodegenerative disease
WO2007000985A1 (ja) * 2005-06-27 2007-01-04 Kyowa Hakko Kogyo Co., Ltd. ヘモグロビン尿症またはミオグロビン尿症の予防または治療用組成物
WO2007023931A1 (ja) * 2005-08-25 2007-03-01 Kyowa Hakko Kogyo Co., Ltd. 血中アルコール濃度上昇抑制用組成物
JP2006089487A (ja) * 2005-10-03 2006-04-06 Nara Institute Of Science & Technology シトルリンを含有するｄｎａ切断防止剤、活性酸素障害に起因する疾患の治療薬または予防薬、抗酸化食品添加物
WO2007066642A1 (ja) * 2005-12-05 2007-06-14 Kyowa Hakko Kogyo Co., Ltd. 皮膚の乾燥予防または改善用経口剤
JP2008050352A (ja) * 2006-07-27 2008-03-06 Ezaki Glico Co Ltd 睡眠改善剤

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010270111A (ja) * 2009-04-21 2010-12-02 Taisho Pharmaceutical Co Ltd アルギニン含有錠剤
JP2013509395A (ja) * 2009-10-28 2013-03-14 モデュテック エス．エー． アミノ酸および植物を含む調製物およびアルコール解毒におけるその活性
EP2637505A4 (en) * 2010-10-19 2014-04-09 K L R M Llc COMPOSITIONS AND METHOD FOR TREATING EFFECTIVE DYSFUNCTION
US10406196B2 (en) 2010-10-19 2019-09-10 K.L.R.M., Llc Compositions and methods for treating, inhibiting the onset, and slowing the progression of erectile dysfunction including naturally occurring age related erectile dysfunction
JP2012139124A (ja) * 2010-12-28 2012-07-26 House Foods Corp ニンニク成分含有飲料及びニンニク成分による風味の調整を行う方法
JP2013060406A (ja) * 2011-09-15 2013-04-04 Kyowa Hakko Bio Co Ltd 脳疲労改善用経口剤
JPWO2013122188A1 (ja) * 2012-02-15 2015-05-18 協和発酵バイオ株式会社 血管内皮機能低下の予防または改善剤
CN102885311A (zh) * 2012-10-19 2013-01-23 中科乐仁（北京）科技发展有限公司 一种缓解体力疲劳的保健食品组合物及其制备方法
CN103734724A (zh) * 2013-12-31 2014-04-23 勾大卉 玛咖山楂咀嚼片
CN104435536A (zh) * 2014-11-11 2015-03-25 武汉名实生物医药科技有限责任公司 能延缓衰老、改善性功能、抗疲劳的复方制剂的制备方法
JP2016121194A (ja) * 2016-04-05 2016-07-07 協和発酵バイオ株式会社 脳疲労改善用経口剤
WO2019022216A1 (ja) * 2017-07-28 2019-01-31 株式会社明治 筋力向上用アミノ酸組成物

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