PL353656A1 - Preparation containing amino acids and riboflavin, useful in reducing toxic effects of a treatment by means of cytotoxic drugs - Google Patents
Preparation containing amino acids and riboflavin, useful in reducing toxic effects of a treatment by means of cytotoxic drugsInfo
- Publication number
- PL353656A1 PL353656A1 PL02353656A PL35365602A PL353656A1 PL 353656 A1 PL353656 A1 PL 353656A1 PL 02353656 A PL02353656 A PL 02353656A PL 35365602 A PL35365602 A PL 35365602A PL 353656 A1 PL353656 A1 PL 353656A1
- Authority
- PL
- Poland
- Prior art keywords
- amino acids
- riboflavin
- useful
- treatment
- preparation containing
- Prior art date
Links
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 title abstract 4
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 title abstract 2
- 229960002477 riboflavin Drugs 0.000 title abstract 2
- 235000019192 riboflavin Nutrition 0.000 title abstract 2
- 239000002151 riboflavin Substances 0.000 title abstract 2
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 231100000331 toxic Toxicity 0.000 title 1
- 230000002588 toxic effect Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 201000011510 cancer Diseases 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 238000002512 chemotherapy Methods 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 235000020776 essential amino acid Nutrition 0.000 abstract 1
- 239000003797 essential amino acid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000004143 urea cycle Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/995,010 US20030105104A1 (en) | 2001-11-27 | 2001-11-27 | Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL353656A1 true PL353656A1 (en) | 2003-06-02 |
Family
ID=25541300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL02353656A PL353656A1 (en) | 2001-11-27 | 2002-04-26 | Preparation containing amino acids and riboflavin, useful in reducing toxic effects of a treatment by means of cytotoxic drugs |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20030105104A1 (enExample) |
| EP (1) | EP1450781B1 (enExample) |
| JP (1) | JP4614660B2 (enExample) |
| KR (1) | KR100953483B1 (enExample) |
| CN (1) | CN100358527C (enExample) |
| AT (1) | ATE330595T1 (enExample) |
| BR (1) | BR0214430A (enExample) |
| CA (1) | CA2468133C (enExample) |
| DE (1) | DE60212693T2 (enExample) |
| EA (1) | EA009516B1 (enExample) |
| HU (1) | HU230986B1 (enExample) |
| IL (2) | IL162141A0 (enExample) |
| MX (1) | MXPA04004994A (enExample) |
| NO (1) | NO332858B1 (enExample) |
| NZ (1) | NZ532833A (enExample) |
| PL (1) | PL353656A1 (enExample) |
| RO (1) | RO121173B1 (enExample) |
| SI (1) | SI21542A (enExample) |
| UA (1) | UA78977C2 (enExample) |
| WO (1) | WO2003045372A1 (enExample) |
| ZA (1) | ZA200404115B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1553099A4 (en) * | 2002-08-02 | 2006-06-28 | Inst Radiation Med Amms Pla | RIBOFLAVIN DERIVATIVE AND ITS MANUFACTURE AND USES |
| US20060035981A1 (en) * | 2003-08-02 | 2006-02-16 | Mazzio Elizabeth A | Inhibition of anaerobic glucose metabolism and corresponding composition as a natural non-toxic approach to cancer treatment |
| US20070248693A1 (en) * | 2003-08-02 | 2007-10-25 | Elizabeth Mazzio | Nutraceutical composition and method of use for treatment / prevention of cancer |
| RU2240788C1 (ru) * | 2003-09-09 | 2004-11-27 | Воронежская государственная медицинская академия им. Н.Н. Бурденко | Детоксикационное средство |
| PT2319581E (pt) * | 2004-11-26 | 2015-06-30 | Ucl Business Plc | Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática |
| WO2008008084A2 (en) * | 2005-09-19 | 2008-01-17 | Cdm Optics, Inc. | Task-based imaging systems |
| KR101451438B1 (ko) | 2006-03-15 | 2014-10-15 | 산토리 홀딩스 가부시키가이샤 | 리보플라빈과 세사민류를 함유하는 조성물 |
| WO2008050836A1 (en) * | 2006-10-25 | 2008-05-02 | Ajinomoto Co., Inc. | Agent for ameliorating adverse side-effect of chemotherapeutic agent |
| JPWO2008105384A1 (ja) * | 2007-02-26 | 2010-06-03 | 協和発酵バイオ株式会社 | シトルリン含有錠剤 |
| EP3342409A1 (en) | 2007-03-15 | 2018-07-04 | Suntory Holdings Limited | Anti-fatigue agent |
| US9101537B2 (en) | 2008-07-25 | 2015-08-11 | Reven Pharmaceuticals, Inc. | Compositions and methods for the prevention and treatment of cardiovascular diseases |
| AU2014200578B2 (en) * | 2008-09-19 | 2016-08-11 | Société des Produits Nestlé S.A. | Nutritional support to prevent or moderate bone marrow paralysis or neutropenia during anti-cancer treatment |
| CN103355668A (zh) | 2008-09-19 | 2013-10-23 | 雀巢产品技术援助有限公司 | 预防或减轻在抗癌治疗期间的骨髓瘫痪或中性白细胞减少症的营养支持 |
| ES2791524T3 (es) | 2009-04-03 | 2020-11-04 | Ocera Therapeutics Inc | Fenilacetato de L-ornitina y métodos de elaboración del mismo |
| EP3517110A1 (en) | 2009-06-08 | 2019-07-31 | UCL Business PLC | Treatment of inflammation using l-ornithine phenylacetate |
| US8449512B2 (en) | 2010-04-09 | 2013-05-28 | Davinci Biomedical Research Products Inc. | Stoma stabilitating device and method |
| EP2397458A1 (en) * | 2010-06-21 | 2011-12-21 | Lunamed AG | Organic salts and co-crystals of phenylbutyric acid |
| CA2989896C (en) | 2010-07-22 | 2021-02-09 | Reven Pharmaceuticals, Inc. | Methods of treating or ameliorating diseases and enhancing performance comprising the use of a magnetic dipole stabilized solution |
| KR102069790B1 (ko) * | 2010-09-24 | 2020-01-23 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | 위장 기능을 증진시키기 위한 물질 및 방법 |
| EP2625162B1 (en) | 2010-10-06 | 2019-03-13 | Ocera Therapeutics, Inc. | Methods of making l-ornithine phenyl acetate |
| TWI489981B (zh) | 2010-12-10 | 2015-07-01 | 柏萊迪健康科學有限責任公司 | 使用茉莉酸治療膀胱功能障礙 |
| EP2676664B1 (en) * | 2011-02-17 | 2017-06-21 | EA Pharma Co., Ltd. | Potentiator of antitumor activity of chemotherapeutic agent |
| PL2729008T3 (pl) * | 2011-07-07 | 2017-10-31 | Res Cancer Institute Of America | Systemy, sposoby i formulacje do leczenia raka |
| EP2968241B1 (en) | 2013-03-11 | 2018-10-31 | University of Florida Research Foundation, Inc. | Materials and methods for improving lung function and for prevention and/or treatment of radiation-induced lung complications |
| CA2928675C (en) * | 2013-11-08 | 2023-09-05 | Legacy Healthcare Ltd | Method for the management of cancer and cancer treatment-related comorbidities |
| JP6598425B2 (ja) * | 2014-02-27 | 2019-10-30 | 花王株式会社 | 疲労の評価方法 |
| BR112017010761B1 (pt) | 2014-11-24 | 2022-10-18 | Ucl Business Plc | Tratamento de doenças associadas à ativação de célula estrelada hepática com o uso de terapias de redução de amônia |
| CA2995823A1 (en) | 2015-08-18 | 2017-02-23 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
| CN105495582A (zh) * | 2015-12-11 | 2016-04-20 | 北京康比特体育科技股份有限公司 | 一款抗疲劳、促恢复的保健食品氨基酸组合物 |
| EP3621947A4 (en) | 2017-05-11 | 2021-03-10 | Ocera Therapeutics, Inc. | L-ORNITHINE PHENYLACETATE MANUFACTURING PROCESSES |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535049A (en) * | 1978-09-04 | 1980-03-11 | Otsuka Pharmaceut Factory Inc | Amino acid transfusion for cancerous patient |
| JPS58126767A (ja) * | 1982-01-22 | 1983-07-28 | Ajinomoto Co Inc | 肝臓病患者用栄養組成物 |
| DE3672950D1 (de) * | 1985-10-23 | 1990-08-30 | Mulli Kurt Nachf Gmbh | Thymusextraktfraktionen enthaltende pharmazeutische zusammensetzung. |
| US5045468A (en) * | 1986-12-12 | 1991-09-03 | Cell Enterprises, Inc. | Protein-free culture medium which promotes hybridoma growth |
| ES2063882T5 (es) * | 1989-10-02 | 2001-12-01 | Novartis Nutrition Ag | Hidrolizados de proteinas. |
| US5292773A (en) * | 1990-02-14 | 1994-03-08 | Hirsch Gerald P | Treating aids and HIV infection with methionine |
| WO1994014458A1 (en) * | 1992-12-23 | 1994-07-07 | Abbott Laboratories | Medical foods for the nutritional support of infant/toddler metabolic diseases |
| US5571783A (en) * | 1993-03-09 | 1996-11-05 | Clintec Nutrition Company | Composition and method for treating patients with hepatic disease |
| FR2705765B1 (fr) * | 1993-04-29 | 1995-08-18 | Eurofours Sa | Porte de four. |
| NZ248605A (en) * | 1993-05-28 | 1994-12-22 | Abbott Lab | Enteral nutritional product comprising protein and fat |
| US5547927A (en) * | 1993-05-28 | 1996-08-20 | Abbott Laboratories | Enteral nutritional product for patients undergoing radiation therapy and/or chemotherapy |
| US5719133A (en) * | 1994-09-21 | 1998-02-17 | Novartis Nutrition Ag | Adolescent dietary composition |
| US5656608B1 (en) * | 1995-02-23 | 2000-09-26 | Novartis Nutrition Ltd | Amino acid compositions and methods of treatment using same |
| US5728678A (en) * | 1995-06-06 | 1998-03-17 | Nestec Ltd. | Method and composition for providing nutrition to a renal failure patient |
| US5776913A (en) * | 1995-10-10 | 1998-07-07 | Colgate Palmolive Company | Therapeutic diet for metabolic abnormalities found in animals with lymphoma |
| CA2254772C (en) * | 1996-05-14 | 2004-01-27 | Stanislaw R. Burzynski | Liposomal antineoplaston therapies with markedly improved antineoplastic activity |
| US5817927A (en) * | 1997-04-11 | 1998-10-06 | Betzdearborn Inc. | Method and apparatus for monitoring water process equipment |
| US5817695A (en) * | 1997-12-24 | 1998-10-06 | Pellico; Michael A. | Nutritional product with high fat, low carbohydrate and amino acid imbalance |
| ES2205646T3 (es) | 1999-06-26 | 2004-05-01 | B. Braun Melsungen Ag | Solucion acuosa para la nutricion parenteral. |
| GB0009056D0 (en) * | 2000-04-12 | 2000-05-31 | Nestle Sa | Composition comprising free amino acids |
| US6377094B1 (en) * | 2002-03-25 | 2002-04-23 | Oak Technology, Inc. | Arbitrary waveform synthesizer using a free-running ring oscillator |
-
2001
- 2001-11-27 US US09/995,010 patent/US20030105104A1/en not_active Abandoned
-
2002
- 2002-04-26 PL PL02353656A patent/PL353656A1/xx not_active Application Discontinuation
- 2002-11-21 SI SI200220037A patent/SI21542A/sl not_active IP Right Cessation
- 2002-11-21 CA CA2468133A patent/CA2468133C/en not_active Expired - Fee Related
- 2002-11-21 EA EA200400737A patent/EA009516B1/ru not_active IP Right Cessation
- 2002-11-21 IL IL16214102A patent/IL162141A0/xx unknown
- 2002-11-21 CN CNB028236068A patent/CN100358527C/zh not_active Expired - Fee Related
- 2002-11-21 AT AT02789801T patent/ATE330595T1/de not_active IP Right Cessation
- 2002-11-21 NZ NZ532833A patent/NZ532833A/en not_active IP Right Cessation
- 2002-11-21 RO ROA200400481A patent/RO121173B1/ro unknown
- 2002-11-21 KR KR1020047007754A patent/KR100953483B1/ko not_active Expired - Fee Related
- 2002-11-21 MX MXPA04004994A patent/MXPA04004994A/es active IP Right Grant
- 2002-11-21 EP EP02789801A patent/EP1450781B1/en not_active Expired - Lifetime
- 2002-11-21 UA UA20040605059A patent/UA78977C2/uk unknown
- 2002-11-21 BR BR0214430-1A patent/BR0214430A/pt not_active Application Discontinuation
- 2002-11-21 JP JP2003546874A patent/JP4614660B2/ja not_active Expired - Fee Related
- 2002-11-21 HU HU0402240A patent/HU230986B1/hu not_active IP Right Cessation
- 2002-11-21 DE DE60212693T patent/DE60212693T2/de not_active Expired - Lifetime
- 2002-11-21 WO PCT/US2002/037354 patent/WO2003045372A1/en not_active Ceased
-
2004
- 2004-05-24 IL IL162141A patent/IL162141A/en not_active IP Right Cessation
- 2004-05-26 ZA ZA2004/04115A patent/ZA200404115B/en unknown
- 2004-06-07 NO NO20042364A patent/NO332858B1/no not_active IP Right Cessation
-
2005
- 2005-04-18 US US11/108,277 patent/US7427619B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |