KR100904356B1 - 메틸히드록시알킬셀룰로오스의 공업적 제조 방법 및 장치 - Google Patents
메틸히드록시알킬셀룰로오스의 공업적 제조 방법 및 장치 Download PDFInfo
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- KR100904356B1 KR100904356B1 KR1020020055598A KR20020055598A KR100904356B1 KR 100904356 B1 KR100904356 B1 KR 100904356B1 KR 1020020055598 A KR1020020055598 A KR 1020020055598A KR 20020055598 A KR20020055598 A KR 20020055598A KR 100904356 B1 KR100904356 B1 KR 100904356B1
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- South Korea
- Prior art keywords
- reactor
- reaction
- cellulose
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- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title description 4
- 238000006243 chemical reaction Methods 0.000 claims abstract description 28
- 229920002678 cellulose Polymers 0.000 claims abstract description 21
- 239000001913 cellulose Substances 0.000 claims abstract description 21
- 238000000227 grinding Methods 0.000 claims abstract description 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 9
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 7
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims abstract description 6
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
- 230000005484 gravity Effects 0.000 claims abstract description 4
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 claims abstract 3
- 238000002156 mixing Methods 0.000 claims description 20
- 238000007790 scraping Methods 0.000 claims 2
- GOWMBYUZXIZENX-CAUSLRQDSA-N 1-[(2r,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hexadecylamino)pyrimidin-2-one Chemical compound O=C1N=C(NCCCCCCCCCCCCCCCC)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 GOWMBYUZXIZENX-CAUSLRQDSA-N 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 10
- 238000006266 etherification reaction Methods 0.000 description 10
- 208000019651 NDE1-related microhydranencephaly Diseases 0.000 description 9
- -1 methyl hydroxypropyl Chemical group 0.000 description 8
- 238000006467 substitution reaction Methods 0.000 description 8
- 230000003113 alkalizing effect Effects 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 239000008186 active pharmaceutical agent Substances 0.000 description 5
- 229920003086 cellulose ether Polymers 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 4
- 239000007795 chemical reaction product Substances 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000001856 Ethyl cellulose Substances 0.000 description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229920001249 ethyl cellulose Polymers 0.000 description 2
- 235000019325 ethyl cellulose Nutrition 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000009776 industrial production Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000021962 pH elevation Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 229940050176 methyl chloride Drugs 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000007613 slurry method Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B17/00—Apparatus for esterification or etherification of cellulose
- C08B17/06—Apparatus for esterification or etherification of cellulose for making cellulose ethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B11/00—Preparation of cellulose ethers
- C08B11/02—Alkyl or cycloalkyl ethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B11/00—Preparation of cellulose ethers
- C08B11/193—Mixed ethers, i.e. ethers with two or more different etherifying groups
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
Description
Claims (14)
- 2.5 미만의 길이/직경 비 (L/D 비)를 가지며, 무용 부피 분율 VU/VT가 0.007 미만이며, VU는 혼합되지 않은 영역의 부피이고, VT는 전체 부피인 반응기에서 배치식으로 반응을 수행하고, 배치 반응기는 입구 앞쪽에 연속적으로 작동되는 셀룰로오스 분쇄 장치가 위치하고, 출구 뒤쪽에 중력의 작용에 의해 운반되는 생성물을 분쇄 및 건조하기 위한 연속적으로 운행하는 설비가 위치하는 것을 특징으로 하는, 수산화 알칼리 금속과 셀룰로오스의 반응 및 후속하는 할로겐화 알킬 및 히드록시알킬화제와의 반응에 의해 메틸히드록시알킬셀룰로오스 (MHAC)를 공업적 제조하는 방법.
- 제1항에 있어서, 반응기가 양 말단에 탑재된 하나 이상의 수평 샤프트를 갖는 혼합 장치를 갖는 기계적인 혼합기를 갖는 것을 특징으로 하는 방법.
- 제1항 또는 제2항에 있어서, 샤프트가 양 말단에서 작동하는 것을 특징으로 하는 방법.
- 제1항 또는 제2항에 있어서, 반응기가, 서로 바로 반대쪽에 위치하고 다른 회전 속도, 회전 방향 및 구조로 독립적으로 작동할 수 있는 2개의 별도의 샤프트를 갖는 것을 특징으로 하는 방법.
- 제1항 또는 제2항에 있어서, 반응기가·원통형 구조,·완전히 충전되고 비워질 수 있도록 배열된 입구 및 출구 밸브,·케이크 생성물을 반응기의 끝 면에서 긁어낼 수 있는 샤프트 구조, 및·샤프트가 장착된 혼합기의 구조에 맞추어진 초퍼(chopper) 수와 초퍼 배열을 갖는 것을 특징으로 하는 방법.
- 삭제
- 길이/직경 비 (L/D 비)가 2.5 미만인 반응기를 포함하는 장치를 특징으로 하는, 수산화 알칼리 금속과 셀룰로오스의 반응 및 후속하는 할로겐화 알킬 및 히드록시알킬화제와의 반응에 의해 메틸히드록시알킬셀룰로오스 (MHAC)를 공업적으로 제조하기 위한 장치.
- 제7항에 있어서, 반응기가 양 말단에 탑재된 하나 이상의 수평 샤프트를 갖는 혼합 장치를 갖는 기계적인 혼합기를 갖는 것을 특징으로 하는 장치.
- 제8항에 있어서, 샤프트가 양 말단에서 작동하는 것을 특징으로 하는 장치.
- 제7항 내지 제9항 중 어느 한 항에 있어서, 반응기가, 서로 바로 반대쪽에 위치하고 다른 회전 속도, 회전 방향 및 구조로 독립적으로 작동할 수 있는 2개의 별도의 샤프트를 갖는 것을 특징으로 하는 장치.
- 제7항 내지 제9항 중 어느 한 항에 있어서, 반응기가·원통형 구조,·완전히 충전되고 비워질 수 있도록 배열된 입구 및 출구 밸브,·케이크 생성물을 반응기의 끝 면에서 긁어낼 수 있는 샤프트 구조, 및·샤프트가 장착된 혼합기의 구조에 맞추어진 초퍼 수와 초퍼 배열을 갖는 것을 특징으로 하는 장치.
- 제7항 내지 제9항 중 어느 한 항에 있어서, 최소 무용 부피 분율 VU/VT가 0.007 미만인 것을 특징으로 하는 장치.
- 삭제
- 삭제
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10145408.2 | 2001-09-14 | ||
DE10145408 | 2001-09-14 | ||
DE10234426A DE10234426A1 (de) | 2001-09-14 | 2002-07-29 | Verfahren und Vorrichtung zur industriellen Herstellung von Methylhydroxyalkylcellulose |
DE10234426.4 | 2002-07-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20030023561A KR20030023561A (ko) | 2003-03-19 |
KR100904356B1 true KR100904356B1 (ko) | 2009-06-23 |
Family
ID=26010143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020020055598A KR100904356B1 (ko) | 2001-09-14 | 2002-09-13 | 메틸히드록시알킬셀룰로오스의 공업적 제조 방법 및 장치 |
Country Status (12)
Country | Link |
---|---|
US (1) | US6667395B2 (ko) |
EP (1) | EP1293515B1 (ko) |
JP (1) | JP2003176302A (ko) |
KR (1) | KR100904356B1 (ko) |
CN (1) | CN100537605C (ko) |
AT (1) | ATE359303T1 (ko) |
BR (1) | BR0203732A (ko) |
CA (1) | CA2402754A1 (ko) |
DE (1) | DE50209901D1 (ko) |
DK (1) | DK1293515T3 (ko) |
ES (1) | ES2284755T3 (ko) |
MX (1) | MXPA02009023A (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004019296B4 (de) * | 2004-04-21 | 2006-01-05 | Wolff Cellulosics Gmbh & Co. Kg | Verfahren zur Herstellung von Methylhydroxyalkylcellulose |
EP2098539B1 (en) | 2008-03-03 | 2017-05-10 | SE Tylose GmbH & Co.KG | Homogeneous synthesis of cellulose ethers in ionic liquids |
CN115215944B (zh) * | 2022-05-13 | 2023-03-10 | 浙江致为新材料有限公司 | 一种羟丙基甲基纤维素醚生产工艺 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4015067A (en) * | 1975-08-18 | 1977-03-29 | The Dow Chemical Company | Method of preparing polysaccharide ethers and apparatus |
US4363784A (en) * | 1979-06-15 | 1982-12-14 | Hoechst Aktiengesellschaft | Apparatus for continuously producing water-soluble hydroxyalkyl cellulose and related ethers |
KR0152177B1 (ko) * | 1995-07-10 | 1998-10-01 | 이승웅 | 히드록시알킬셀룰로오스의 연속 제조공정 |
JP2001302701A (ja) * | 2000-02-15 | 2001-10-31 | Shin Etsu Chem Co Ltd | アルカリセルロース及びセルロースエーテルの製造方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA831753A (en) * | 1970-01-13 | A. Laakso Oliver | Cellulose digester with washing apparatus | |
DE1543136C3 (de) * | 1965-12-30 | 1980-04-17 | Hoechst Ag, 6000 Frankfurt | Verfahren zur kontinuierlichen Herstellung von Methylcellulose oder Methylhydroxyalkylcellulose |
DE2635403B2 (de) | 1976-08-06 | 1979-07-12 | Loedige Fritz | Verfahren zum Herstellen von CeUuIoseäthern |
US4199266A (en) | 1977-08-31 | 1980-04-22 | Giusti Raolo B | Processing vessels |
US4728731A (en) * | 1986-03-10 | 1988-03-01 | Henkel Kommanditgesellschaft Auf Aktien | Reactor and its use in polysaccharide ether production |
DE3821033A1 (de) | 1988-06-22 | 1989-12-28 | Huels Chemische Werke Ag | Ruehrkessel mit radial foerderndem ruehrer und mindestens einem stromstoerer sowie verfahren zum durchmischen von fluessigkeiten mit hilfe dieses ruehrkessels |
EP0470493B1 (en) | 1990-08-07 | 1996-09-25 | Shinko Pantec Co., Ltd. | Mixing apparatus |
-
2002
- 2002-09-02 AT AT02019171T patent/ATE359303T1/de not_active IP Right Cessation
- 2002-09-02 EP EP02019171A patent/EP1293515B1/de not_active Revoked
- 2002-09-02 DE DE50209901T patent/DE50209901D1/de not_active Expired - Lifetime
- 2002-09-02 DK DK02019171T patent/DK1293515T3/da active
- 2002-09-02 ES ES02019171T patent/ES2284755T3/es not_active Expired - Lifetime
- 2002-09-06 JP JP2002261107A patent/JP2003176302A/ja active Pending
- 2002-09-11 US US10/241,711 patent/US6667395B2/en not_active Expired - Lifetime
- 2002-09-11 CA CA002402754A patent/CA2402754A1/en not_active Abandoned
- 2002-09-13 MX MXPA02009023A patent/MXPA02009023A/es active IP Right Grant
- 2002-09-13 KR KR1020020055598A patent/KR100904356B1/ko active IP Right Grant
- 2002-09-13 BR BR0203732-7A patent/BR0203732A/pt not_active Application Discontinuation
- 2002-09-16 CN CNB021431671A patent/CN100537605C/zh not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4015067A (en) * | 1975-08-18 | 1977-03-29 | The Dow Chemical Company | Method of preparing polysaccharide ethers and apparatus |
US4363784A (en) * | 1979-06-15 | 1982-12-14 | Hoechst Aktiengesellschaft | Apparatus for continuously producing water-soluble hydroxyalkyl cellulose and related ethers |
KR0152177B1 (ko) * | 1995-07-10 | 1998-10-01 | 이승웅 | 히드록시알킬셀룰로오스의 연속 제조공정 |
JP2001302701A (ja) * | 2000-02-15 | 2001-10-31 | Shin Etsu Chem Co Ltd | アルカリセルロース及びセルロースエーテルの製造方法 |
Also Published As
Publication number | Publication date |
---|---|
ES2284755T3 (es) | 2007-11-16 |
MXPA02009023A (es) | 2004-09-13 |
KR20030023561A (ko) | 2003-03-19 |
US20030065166A1 (en) | 2003-04-03 |
DK1293515T3 (da) | 2007-07-30 |
JP2003176302A (ja) | 2003-06-24 |
US6667395B2 (en) | 2003-12-23 |
CN1408728A (zh) | 2003-04-09 |
DE50209901D1 (de) | 2007-05-24 |
BR0203732A (pt) | 2003-05-27 |
EP1293515A1 (de) | 2003-03-19 |
EP1293515B1 (de) | 2007-04-11 |
CA2402754A1 (en) | 2003-03-14 |
ATE359303T1 (de) | 2007-05-15 |
CN100537605C (zh) | 2009-09-09 |
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