KR100898845B1 - 다가 백신 조성물 - Google Patents
다가 백신 조성물 Download PDFInfo
- Publication number
- KR100898845B1 KR100898845B1 KR1020087013186A KR20087013186A KR100898845B1 KR 100898845 B1 KR100898845 B1 KR 100898845B1 KR 1020087013186 A KR1020087013186 A KR 1020087013186A KR 20087013186 A KR20087013186 A KR 20087013186A KR 100898845 B1 KR100898845 B1 KR 100898845B1
- Authority
- KR
- South Korea
- Prior art keywords
- immunogenic composition
- vaccine
- hib
- neisseria meningitidis
- capsular polysaccharide
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 90
- 229940031348 multivalent vaccine Drugs 0.000 title abstract description 5
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 107
- 239000005017 polysaccharide Substances 0.000 claims abstract description 107
- 150000004676 glycans Chemical class 0.000 claims abstract description 103
- 108091007433 antigens Proteins 0.000 claims abstract description 34
- 102000036639 antigens Human genes 0.000 claims abstract description 34
- 239000000427 antigen Substances 0.000 claims abstract description 33
- 241000588650 Neisseria meningitidis Species 0.000 claims abstract description 28
- 229960000814 tetanus toxoid Drugs 0.000 claims abstract description 28
- 241000606768 Haemophilus influenzae Species 0.000 claims abstract description 27
- 239000002671 adjuvant Substances 0.000 claims abstract description 24
- 230000001580 bacterial effect Effects 0.000 claims abstract description 18
- 229960003983 diphtheria toxoid Drugs 0.000 claims abstract description 17
- 201000005702 Pertussis Diseases 0.000 claims abstract description 9
- 208000002672 hepatitis B Diseases 0.000 claims abstract description 6
- 229960005486 vaccine Drugs 0.000 claims description 68
- 230000002163 immunogen Effects 0.000 claims description 31
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims description 18
- 101710188053 Protein D Proteins 0.000 claims description 18
- 101710132893 Resolvase Proteins 0.000 claims description 18
- 241000588832 Bordetella pertussis Species 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- 108010078791 Carrier Proteins Proteins 0.000 claims description 12
- 102000014914 Carrier Proteins Human genes 0.000 claims description 12
- 206010013023 diphtheria Diseases 0.000 claims description 10
- 241000186216 Corynebacterium Species 0.000 claims description 8
- 210000002966 serum Anatomy 0.000 claims description 8
- 241000700721 Hepatitis B virus Species 0.000 claims description 7
- 230000007123 defense Effects 0.000 claims description 7
- 241000193403 Clostridium Species 0.000 claims description 6
- 208000003217 Tetany Diseases 0.000 claims description 6
- 230000002238 attenuated effect Effects 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 229940047650 haemophilus influenzae Drugs 0.000 claims description 6
- 238000001727 in vivo Methods 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims description 5
- 230000004224 protection Effects 0.000 claims description 5
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical group [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000005847 immunogenicity Effects 0.000 claims description 4
- 241000991587 Enterovirus C Species 0.000 claims description 3
- 241000709721 Hepatovirus A Species 0.000 claims description 3
- 241000193449 Clostridium tetani Species 0.000 claims description 2
- 102000016607 Diphtheria Toxin Human genes 0.000 claims description 2
- 108010053187 Diphtheria Toxin Proteins 0.000 claims description 2
- 230000000890 antigenic effect Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 201000009906 Meningitis Diseases 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 101710116435 Outer membrane protein Proteins 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 abstract description 15
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract description 13
- 150000003839 salts Chemical class 0.000 abstract description 13
- 208000037798 influenza B Diseases 0.000 abstract 3
- 238000009472 formulation Methods 0.000 description 21
- 230000028993 immune response Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 229960004443 hemophilus influenzae b vaccines Drugs 0.000 description 6
- 230000003053 immunization Effects 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 241000193990 Streptococcus sp. 'group B' Species 0.000 description 5
- 229940035032 monophosphoryl lipid a Drugs 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 239000003053 toxin Substances 0.000 description 5
- 231100000765 toxin Toxicity 0.000 description 5
- 108700012359 toxins Proteins 0.000 description 5
- 238000002965 ELISA Methods 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 206010043376 Tetanus Diseases 0.000 description 4
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical class O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- -1 1-cyano-dimethylaminopyridinium tetrafluoroborate Chemical compound 0.000 description 3
- 108700020122 Hiberix Proteins 0.000 description 3
- 229940124885 Hiberix Drugs 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229960000074 biopharmaceutical Drugs 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 108010021711 pertactin Proteins 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 108010060123 Conjugate Vaccines Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical class [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229940031670 conjugate vaccine Drugs 0.000 description 2
- 238000007333 cyanation reaction Methods 0.000 description 2
- 230000002939 deleterious effect Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000000411 inducer Substances 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229910017119 AlPO Inorganic materials 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical class [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 101000597577 Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5) Outer membrane protein Proteins 0.000 description 1
- 229940124914 Havrix Drugs 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000588621 Moraxella Species 0.000 description 1
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 description 1
- 241000947238 Neisseria meningitidis serogroup C Species 0.000 description 1
- 241001573069 Neisseria meningitidis serogroup Y Species 0.000 description 1
- 101100521383 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) prp-5 gene Proteins 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 206010033078 Otitis media Diseases 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 101710183389 Pneumolysin Proteins 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical class [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 125000000129 anionic group Chemical class 0.000 description 1
- 230000003497 anti-pneumococcal effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 125000002091 cationic group Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229940001442 combination vaccine Drugs 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000007124 immune defense Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000002480 immunoprotective effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000021633 leukocyte mediated immunity Effects 0.000 description 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical group O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940031999 pneumococcal conjugate vaccine Drugs 0.000 description 1
- 229940124733 pneumococcal vaccine Drugs 0.000 description 1
- 229960001539 poliomyelitis vaccine Drugs 0.000 description 1
- 229920002627 poly(phosphazenes) Chemical class 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 229940031418 trivalent vaccine Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229910052725 zinc Chemical class 0.000 description 1
- 239000011701 zinc Chemical class 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
- A61K39/0018—Combination vaccines based on acellular diphtheria-tetanus-pertussis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/13—Poliovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (18)
- 보르데텔라 백일해, 클로스트리듐 테타니, 코리네박테리움 디프테리애, B형 간염 바이러스, 헤모필루스 인플루엔자 및 나이세리아 메닌지티디스에 의해 유도되는 질병에 대해 숙주에게 방어능력을 부여하는 다가의 면역원성 조성물로서,a) 사멸된 전세포 보르데텔라 백일해, 또는 2개 이상의 무세포성 백일해 성분,b) 파상풍 톡소이드,c) 디프테리아 톡소이드,d) B형 간염 표면 항원,e) 헤모필루스 인플루엔자 타입 B 협막 다당류와 캐리어 단백질의 컨쥬게이트, 및f) 나이세리아 메닌지티디스 타입 A 및 나이세리아 메닌지티디스 타입 C의 군으로부터 선택된 세균 협막 다당류와 캐리어 단백질의 하나 이상의 컨쥬게이트를 포함하는 면역원성 조성물.
- 제 1항에 있어서, 나이세리아 메닌지티디스 타입 Y 및 나이세리아 메닌지티디스 타입 W의 군으로부터 선택된 세균 협막 다당류와 캐리어 단백질의 하나 이상의 컨쥬게이트를 추가로 포함함을 특징으로 하는 면역원성 조성물.
- 제 1항에 있어서, 사멸되고 약독된 A형 간염 바이러스를 추가로 포함함을 특징으로 하는 면역원성 조성물.
- 제 1항에 있어서, 비활성화된 소아마비 바이러스를 추가로 포함함을 특징으로 하는 면역원성 조성물.
- 제 1항에 있어서, 사용된 캐리어 단백질(들)이 파상풍 톡소이드, 디프테리아 톡소이드, 교차반응성 물질 197 (CRM197), 재조합 디프테리아 독소, 나이세리아 메닌지티디스로부터의 외막 단백질 복합체 (OMPC) 및 헤모필루스 인플루엔자로부터의 단백질 D를 포함하는 군으로부터 선택됨을 특징으로 하는 면역원성 조성물.
- 제 1항에 있어서, 숙주에게 생체내 투여하기 위한 백신으로서 제형화되며, 조성물의 개개의 성분은 개개의 성분의 면역원성이 조성물의 나머지 개개의 성분에 의해 약화되지 않도록 제형화됨을 특징으로 하는 면역원성 조성물.
- 제 1항에 있어서, 숙주에게 생체내 투여하기 위한 백신으로서 제형화되며, 허용되는 비율의 인간 피검자에 대해 각각의 항원 성분에 대한 혈청방어 기준보다 우수한 항체 역가를 부여함을 특징으로 하는 면역원성 조성물.
- 제 1항에 있어서, 애쥬번트를 추가로 포함함을 특징으로 하는 면역원성 조성물.
- 제 8항에 있어서, 애쥬번트가 알루미늄염임을 특징으로 하는 면역원성 조성물.
- 제 1항 내지 제 9항 중 어느 한 항에 있어서, 약제로서 사용됨을 특징으로 하는 다가의 면역원성 조성물.
- 제 1항 내지 제 9항 중 어느 한 항에 따른 면역원성 조성물을 포함하는, 보르데텔라 백일해, 클로스트리듐 테타니, 코리네박테리움 디프테리애, B형 간염 바이러스, 헤모필루스 인플루엔자 및 나이세리아 메닌지티디스에 의한 감염에 의해 유도된 질병을 치료하거나 예방하기 위한 백신.
- 삭제
- 개개의 성분을 함께 혼합하는 단계를 포함하여, 제 1항 내지 제 9항 중 어느 한 항에 따른 다가의 면역원성 조성물을 제조하는 방법.
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0015999.6 | 2000-06-29 | ||
GBGB0015999.6A GB0015999D0 (en) | 2000-06-29 | 2000-06-29 | Novel compounds |
GBGB0108364.1A GB0108364D0 (en) | 2001-04-03 | 2001-04-03 | Vaccine composition |
GB0108363.3 | 2001-04-03 | ||
GB0108363A GB0108363D0 (en) | 2001-04-03 | 2001-04-03 | Vaccine composition |
GB0108364.1 | 2001-04-03 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020077019832A Division KR20070091698A (ko) | 2000-06-29 | 2001-06-27 | 다가 백신 조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20080052700A KR20080052700A (ko) | 2008-06-11 |
KR100898845B1 true KR100898845B1 (ko) | 2009-05-21 |
Family
ID=27255788
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020027017928A KR100837917B1 (ko) | 2000-06-29 | 2001-06-27 | 다가 백신 조성물 |
KR1020077019832A KR20070091698A (ko) | 2000-06-29 | 2001-06-27 | 다가 백신 조성물 |
KR1020087013186A KR100898845B1 (ko) | 2000-06-29 | 2001-06-27 | 다가 백신 조성물 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020027017928A KR100837917B1 (ko) | 2000-06-29 | 2001-06-27 | 다가 백신 조성물 |
KR1020077019832A KR20070091698A (ko) | 2000-06-29 | 2001-06-27 | 다가 백신 조성물 |
Country Status (35)
Country | Link |
---|---|
US (2) | US20030180316A1 (ko) |
EP (4) | EP1946769B1 (ko) |
JP (2) | JP4870895B2 (ko) |
KR (3) | KR100837917B1 (ko) |
CN (2) | CN101708333B (ko) |
AP (1) | AP1695A (ko) |
AT (1) | ATE534402T1 (ko) |
AU (2) | AU2001281895C1 (ko) |
BG (2) | BG66238B1 (ko) |
BR (2) | BR122012003821B8 (ko) |
CA (2) | CA2783274C (ko) |
CY (2) | CY1112280T1 (ko) |
CZ (1) | CZ20024224A3 (ko) |
DK (2) | DK1296715T4 (ko) |
DZ (1) | DZ3399A1 (ko) |
EA (2) | EA011480B1 (ko) |
EG (1) | EG24742A (ko) |
ES (2) | ES2385100T3 (ko) |
HK (1) | HK1055244A1 (ko) |
HU (3) | HU228384B1 (ko) |
IL (2) | IL153506A0 (ko) |
MA (1) | MA25824A1 (ko) |
MX (1) | MXPA03000198A (ko) |
MY (1) | MY133981A (ko) |
NO (1) | NO332495B1 (ko) |
NZ (1) | NZ523319A (ko) |
OA (1) | OA12302A (ko) |
PE (1) | PE20020126A1 (ko) |
PL (2) | PL393584A1 (ko) |
PT (2) | PT1296715E (ko) |
SI (2) | SI1946769T1 (ko) |
SK (1) | SK288007B6 (ko) |
UA (2) | UA76952C2 (ko) |
UY (1) | UY26801A1 (ko) |
WO (1) | WO2002000249A2 (ko) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4540795B2 (ja) * | 2000-03-10 | 2010-09-08 | 一般財団法人阪大微生物病研究会 | 生ワクチンの細胞性免疫活性を不活化ワクチンにも起こさせる方法、及びこれより得られる混合ワクチン |
GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
CA2783274C (en) | 2000-06-29 | 2018-08-07 | Glaxosmithkline Biologicals S.A. | Multivalent vaccine composition with reduced dose of haemophilus influenza type b |
JP2005504718A (ja) | 2001-01-23 | 2005-02-17 | アヴェンティス パストゥール | 多価髄膜炎菌多糖−タンパク質複合ワクチン |
AU2007200116A1 (en) * | 2001-04-03 | 2007-02-01 | Glaxosmithkline Biologicals S.A. | Vaccine composition |
EP1399183B1 (en) | 2001-05-31 | 2010-06-30 | Novartis Vaccines and Diagnostics, Inc. | Chimeric alphavirus replicon particles |
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
RU2378008C2 (ru) * | 2002-05-14 | 2010-01-10 | Новартис Вэксинес Энд Дайэгностикс С.Р.Л. | Комбинированные вакцины против бактериального менингита для введения через слизистую оболочку |
GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
MXPA04011249A (es) | 2002-05-14 | 2005-06-06 | Chiron Srl | Vacunas mucosales con adyuvante de quitosano y antigenos meningococicos. |
AU2003274511B2 (en) | 2002-10-11 | 2009-06-04 | Glaxosmithkline Biologicals S.A. | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
WO2004039417A2 (en) * | 2002-11-01 | 2004-05-13 | Glaxosmithkline Biologicals S.A. | Drying process |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
WO2004067030A2 (en) | 2003-01-30 | 2004-08-12 | Chiron Srl | Injectable vaccines against multiple meningococcal serogroups |
JP2006516609A (ja) * | 2003-01-30 | 2006-07-06 | カイロン ソチエタ ア レスポンサビリタ リミタータ | 粘膜髄膜炎菌性ワクチン |
CN1819843A (zh) | 2003-05-07 | 2006-08-16 | 安万特巴斯德公司 | 增强脑膜炎球菌疫苗接种免疫原性的方法 |
GB0313916D0 (en) | 2003-06-16 | 2003-07-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
AU2004251742A1 (en) * | 2003-06-23 | 2005-01-06 | Sanofi Pasteur, Inc. | Immunization method against Neisseria meningitidis serogroups A and C |
GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
ES2397923T3 (es) * | 2003-10-02 | 2013-03-12 | Novartis Ag | Vacunas líquidas para múltiples serogrupos meningocócicos |
CU23404A1 (es) * | 2003-11-19 | 2009-08-04 | Ct Ingenieria Genetica Biotech | Polisacáridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes |
GB0405787D0 (en) * | 2004-03-15 | 2004-04-21 | Chiron Srl | Low dose vaccines |
GB0409745D0 (en) * | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
DK1740217T3 (da) | 2004-04-30 | 2011-09-26 | Novartis Ag | Meningokok-konjugat-vaccination |
GB0502096D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
US20070184072A1 (en) * | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
ME01334B (me) | 2005-04-08 | 2013-12-20 | Wyeth Llc | Polivalentni pripravak konjugata pneumokoknog polisaharida s proteinom |
EP1871411A4 (en) | 2005-04-18 | 2010-07-21 | Novartis Vaccines & Diagnostic | EXPRESSION OF HEPATITIS B VIRUS SURFACE ANTIGEN FOR VACCINE MANUFACTURE |
MX2007016403A (es) * | 2005-06-27 | 2008-03-07 | Glaxosmithkline Biolog Sa | Composicion inmunogenica. |
GB0513069D0 (en) * | 2005-06-27 | 2005-08-03 | Glaxosmithkline Biolog Sa | Immunogenic composition |
CN1709505B (zh) * | 2005-07-13 | 2010-06-16 | 北京绿竹生物制药有限公司 | 多价细菌荚膜多糖-蛋白质结合物联合疫苗 |
JP5135220B2 (ja) * | 2005-09-01 | 2013-02-06 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 血清群c髄膜炎菌を含む複数ワクチン接種 |
WO2007047749A1 (en) | 2005-10-18 | 2007-04-26 | Novartis Vaccines And Diagnostics Inc. | Mucosal and systemic immunizations with alphavirus replicon particles |
GB0522765D0 (en) | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
GB0607088D0 (en) * | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
AR058592A1 (es) * | 2005-12-22 | 2008-02-13 | Glaxosmithkline Biolog Sa | Vacuna |
EA200801368A1 (ru) * | 2005-12-23 | 2008-12-30 | Глаксосмитклайн Байолоджикалс С.А. | Конъюгатные вакцины |
CA2636566C (en) * | 2006-01-17 | 2018-03-13 | Arne Forsgren | A novel surface exposed haemophilus influenzae protein (protein e; pe) |
NZ572054A (en) | 2006-03-22 | 2011-12-22 | Novartis Ag | Regimens for immunisation with meningococcal conjugates |
TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
EP1872791A1 (en) | 2006-06-30 | 2008-01-02 | Institut Pasteur | Use of bacterial polysaccharides for biofilm inhibition |
PL2097102T3 (pl) * | 2006-09-07 | 2012-10-31 | Glaxosmithkline Biologicals Sa | Szczepionka skojarzona o zmniejszonej ilości antygenu wirusa polio |
TW200914042A (en) | 2007-05-02 | 2009-04-01 | Glaxosmithkline Biolog Sa | Vaccine |
CA2688268A1 (en) | 2007-06-04 | 2008-12-11 | Novartis Ag | Formulation of meningitis vaccines |
CN101883583B (zh) * | 2007-06-26 | 2017-05-17 | 葛兰素史密丝克莱恩生物有限公司 | 含有肺炎链球菌荚膜多糖缀合物的疫苗 |
GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
NZ589812A (en) * | 2008-05-30 | 2012-08-31 | U S A As Represented By The Secretary Of The Army On Behalf Of Walter Reed Army Inst Of Res | Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof |
PE20100365A1 (es) * | 2008-10-24 | 2010-05-21 | Panacea Biotec Ltd | Novedosas vacunas de combinacion con tos ferina de celulas enteras y metodo para su elaboracion |
GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
KR101609032B1 (ko) * | 2010-06-04 | 2016-04-04 | 와이어쓰 엘엘씨 | 스트렙토코커스 뉴모니아 백신 제제 |
PT3023106T (pt) | 2010-12-14 | 2019-11-04 | Glaxosmithkline Biologicals Sa | Composição antigénica de micobactéria |
RU2705163C2 (ru) | 2011-01-05 | 2019-11-05 | Бхарат Байотек Интернэшнл Лимитед | Комбинированная семивалентная вакцина |
GB201105981D0 (en) | 2011-04-08 | 2011-05-18 | Glaxosmithkline Biolog Sa | Novel process |
EP2592137A1 (en) | 2011-11-11 | 2013-05-15 | Novartis AG | Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use |
GB2495341B (en) | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
DE102011118371B4 (de) | 2011-11-11 | 2014-02-13 | Novartis Ag | Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung |
DE102011122891B4 (de) | 2011-11-11 | 2014-12-24 | Novartis Ag | Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen |
RU2634405C2 (ru) * | 2012-01-30 | 2017-10-26 | Серум Инститьют Оф Индия Лтд. | Иммуногенная композиция |
CN104159603A (zh) * | 2012-03-08 | 2014-11-19 | 诺华股份有限公司 | 带有tlr4激动剂的联合疫苗 |
US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
AU2013301312A1 (en) | 2012-08-06 | 2015-03-19 | Glaxosmithkline Biologicals S.A. | Method for eliciting in infants an immune response against RSV and B. pertussis |
KR20150065878A (ko) | 2012-10-12 | 2015-06-15 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 조합 백신에서 사용하기 위한 가교되지 않은 무세포 백일해 항원 |
WO2014060385A1 (en) * | 2012-10-17 | 2014-04-24 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
KR20140075201A (ko) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
ES2597832T3 (es) | 2013-03-08 | 2017-01-23 | Janssen Vaccines & Prevention B.V. | Vacuna acelular contra la tosferina |
MX2016000099A (es) * | 2013-07-07 | 2016-07-07 | Max Planck Ges Zur Förderung Der Wissenschaften E V | Vacunas sinteticas contra streptococcus pneumoniae tipo 1. |
AU2014304545A1 (en) | 2013-08-05 | 2016-02-25 | Glaxosmithkline Biologicals S.A. | Combination immunogenic compositions |
US11160855B2 (en) * | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
RU2626532C2 (ru) * | 2015-01-16 | 2017-07-28 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации | Комбинированная вакцина для профилактики коклюша, дифтерии, столбняка, гепатита в и инфекции, вызываемой haemophilus influenzae тип в |
CN107249626A (zh) * | 2015-02-19 | 2017-10-13 | 辉瑞大药厂 | 脑膜炎奈瑟球菌组合物及其方法 |
SG11201900794PA (en) | 2016-08-05 | 2019-02-27 | Sanofi Pasteur Inc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
CA3031797A1 (en) | 2016-08-05 | 2018-02-08 | Sanofi Pasteur, Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
MX2019002489A (es) | 2016-09-02 | 2019-10-21 | Sanofi Pasteur Inc | Vacuna contra neisseria meningitidis. |
US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
SG11202005255PA (en) | 2017-12-06 | 2020-07-29 | Merck Sharp & Dohme | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
AU2019215216A1 (en) | 2018-02-05 | 2020-07-23 | Sk Bioscience Co., Ltd. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
AU2019215212A1 (en) | 2018-02-05 | 2020-07-23 | Sk Bioscience Co., Ltd. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US11951162B2 (en) | 2018-04-18 | 2024-04-09 | Sk Bioscience Co., Ltd. | Streptococcus pneumoniae capsular polysaccharides and immunogenic conjugate thereof |
EP3788143B1 (en) * | 2018-04-30 | 2023-06-28 | Merck Sharp & Dohme LLC | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
KR20200005458A (ko) | 2018-07-06 | 2020-01-15 | 주식회사 유바이오로직스 | 다가 폐렴구균 다당체-단백질 접합체를 포함하는 면역원성 조성물, 및 이를 포함하는 약학 조성물 |
US20210401960A1 (en) * | 2018-11-10 | 2021-12-30 | Bharat Biotech International Limited | Multivalent glycoconjugates immunogenic compositions |
TWI788610B (zh) | 2018-12-19 | 2023-01-01 | 美商默沙東有限責任公司 | 包含肺炎鏈球菌多醣-蛋白質結合物之組合物及其使用方法 |
AU2020277403A1 (en) | 2019-05-20 | 2022-01-06 | Soligenix, Inc. | Compositions and methods of manufacturing trivalent filovirus vaccines |
CN111821432B (zh) * | 2020-08-05 | 2022-10-18 | 北京智飞绿竹生物制药有限公司 | 一种多价肺炎球菌结合疫苗 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4057685A (en) * | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
US4235877A (en) * | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
EP0027888B1 (en) * | 1979-09-21 | 1986-04-16 | Hitachi, Ltd. | Semiconductor switch |
US4372945A (en) | 1979-11-13 | 1983-02-08 | Likhite Vilas V | Antigen compounds |
IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
US4673574A (en) * | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
US4459286A (en) * | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
JPS6061288A (ja) * | 1983-09-13 | 1985-04-09 | Fuji Photo Film Co Ltd | 感熱記録材料 |
US4808700A (en) * | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
US4709017A (en) | 1985-06-07 | 1987-11-24 | President And Fellows Of Harvard College | Modified toxic vaccines |
GB8516442D0 (en) | 1985-06-28 | 1985-07-31 | Wellcome Found | Cloned antigen |
GB8727489D0 (en) | 1987-11-24 | 1987-12-23 | Connaught Lab | Detoxification of pertussis toxin |
GB8914122D0 (en) | 1989-06-20 | 1989-08-09 | Wellcome Found | Polypeptide expression |
SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
WO1993021769A1 (en) | 1992-05-06 | 1993-11-11 | President And Fellows Of Harvard College | Diphtheria toxin receptor-binding region |
ES2118963T3 (es) * | 1992-05-23 | 1998-10-01 | Smithkline Beecham Biolog | Vacunas combinadas, que contienen antigeno de superficie de la hepatitis b y otros antigenos. |
DE69327534T2 (de) | 1992-06-18 | 2000-06-08 | Harvard College | Impfstoffe gegen diphtherietoxin |
DK0671948T3 (da) | 1992-06-25 | 1997-09-01 | Smithkline Beecham Biolog | Vaccinepræparat indeholdende adjuvanser |
SG47725A1 (en) * | 1992-10-27 | 1998-04-17 | American Cyanamid Co | Combination pediatric vaccine with enhanced immunogenicity of each vaccine component |
KR100376361B1 (ko) | 1993-09-22 | 2003-07-18 | 헨리 엠. 잭슨 파운데이션 포 더 어드벤스먼트 오브 밀리터리 메디신 | 면역원성구조체의제조를위하여신규한시아닐레이팅시약을사용하여용해성탄수화물을활성화하는방법 |
US5849301A (en) * | 1993-09-22 | 1998-12-15 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
US5869058A (en) * | 1994-05-25 | 1999-02-09 | Yeda Research And Development Co. Ltd. | Peptides used as carriers in immunogenic constructs suitable for development of synthetic vaccines |
US6455673B1 (en) | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
US5917017A (en) | 1994-06-08 | 1999-06-29 | President And Fellows Of Harvard College | Diphtheria toxin vaccines bearing a mutated R domain |
WO1996002555A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
GB9422096D0 (en) * | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
CN1146444C (zh) * | 1995-06-23 | 2004-04-21 | 史密斯克莱·比奇曼生物公司 | 含有吸附于磷酸铝上的多糖偶联抗原的疫苗组合物 |
US5997881A (en) | 1995-11-22 | 1999-12-07 | University Of Maryland, Baltimore | Method of making non-pyrogenic lipopolysaccharide or A |
AU5873498A (en) | 1997-01-30 | 1998-08-25 | Imperial College Of Science, Technology And Medicine | Mutant (msbb) or (htrb) genes |
DE69735191T2 (de) * | 1997-09-15 | 2006-10-05 | Sanofi Pasteur Msd | Verfahren zur Herstellung multivalenter Impfstoffe |
US5965714A (en) * | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
GB9806456D0 (en) * | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
US6146902A (en) * | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
GB9925559D0 (en) | 1999-10-28 | 1999-12-29 | Smithkline Beecham Biolog | Novel method |
FR2806304B1 (fr) * | 2000-03-17 | 2002-05-10 | Aventis Pasteur | Conjugues polysaccharidiques du pneumocoque a usage vaccinal contre le tetanos et la diphterie |
GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
CA2783274C (en) | 2000-06-29 | 2018-08-07 | Glaxosmithkline Biologicals S.A. | Multivalent vaccine composition with reduced dose of haemophilus influenza type b |
AU2003257003A1 (en) * | 2002-07-30 | 2004-02-16 | Baxter Healthcare S.A. | Chimeric multivalent polysaccharide conjugate vaccines |
GB0405787D0 (en) * | 2004-03-15 | 2004-04-21 | Chiron Srl | Low dose vaccines |
GB0500787D0 (en) * | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
GB0428394D0 (en) * | 2004-12-24 | 2005-02-02 | Chiron Srl | Saccharide conjugate vaccines |
GB0502095D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
MX2007016403A (es) * | 2005-06-27 | 2008-03-07 | Glaxosmithkline Biolog Sa | Composicion inmunogenica. |
GB0607088D0 (en) * | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
AR058592A1 (es) * | 2005-12-22 | 2008-02-13 | Glaxosmithkline Biolog Sa | Vacuna |
EA200801368A1 (ru) * | 2005-12-23 | 2008-12-30 | Глаксосмитклайн Байолоджикалс С.А. | Конъюгатные вакцины |
GB0700135D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Vaccine |
GB0700136D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
US8885224B2 (en) * | 2007-03-14 | 2014-11-11 | Konica Minolta Business Technologies, Inc. | Information embedding method, its program and information embedding device |
TW200914042A (en) * | 2007-05-02 | 2009-04-01 | Glaxosmithkline Biolog Sa | Vaccine |
CA2688268A1 (en) * | 2007-06-04 | 2008-12-11 | Novartis Ag | Formulation of meningitis vaccines |
CN101883583B (zh) * | 2007-06-26 | 2017-05-17 | 葛兰素史密丝克莱恩生物有限公司 | 含有肺炎链球菌荚膜多糖缀合物的疫苗 |
-
2001
- 2001-06-27 CA CA2783274A patent/CA2783274C/en not_active Expired - Lifetime
- 2001-06-27 WO PCT/EP2001/007288 patent/WO2002000249A2/en active IP Right Grant
- 2001-06-27 HU HU0301413A patent/HU228384B1/hu unknown
- 2001-06-27 KR KR1020027017928A patent/KR100837917B1/ko active IP Right Grant
- 2001-06-27 EA EA200501070A patent/EA011480B1/ru not_active IP Right Cessation
- 2001-06-27 CN CN200910174266.7A patent/CN101708333B/zh not_active Expired - Lifetime
- 2001-06-27 UA UA20021210397A patent/UA76952C2/uk unknown
- 2001-06-27 MX MXPA03000198A patent/MXPA03000198A/es active IP Right Grant
- 2001-06-27 HU HU1000593A patent/HU227893B1/hu unknown
- 2001-06-27 IL IL15350601A patent/IL153506A0/xx unknown
- 2001-06-27 PE PE2001000629A patent/PE20020126A1/es not_active Application Discontinuation
- 2001-06-27 KR KR1020077019832A patent/KR20070091698A/ko not_active Application Discontinuation
- 2001-06-27 BR BR122012003821A patent/BR122012003821B8/pt not_active IP Right Cessation
- 2001-06-27 UY UY26801A patent/UY26801A1/es not_active IP Right Cessation
- 2001-06-27 SI SI200131012T patent/SI1946769T1/sl unknown
- 2001-06-27 BR BRPI0112057A patent/BRPI0112057B8/pt not_active IP Right Cessation
- 2001-06-27 ES ES07116669T patent/ES2385100T3/es not_active Expired - Lifetime
- 2001-06-27 EP EP07116669A patent/EP1946769B1/en not_active Expired - Lifetime
- 2001-06-27 EA EA200201240A patent/EA006313B1/ru not_active IP Right Cessation
- 2001-06-27 EP EP01960390.1A patent/EP1296715B2/en not_active Expired - Lifetime
- 2001-06-27 EP EP10178449A patent/EP2279748A1/en not_active Withdrawn
- 2001-06-27 NZ NZ523319A patent/NZ523319A/en not_active IP Right Cessation
- 2001-06-27 SK SK1843-2002A patent/SK288007B6/sk not_active IP Right Cessation
- 2001-06-27 AT AT01960390T patent/ATE534402T1/de active
- 2001-06-27 CA CA2412497A patent/CA2412497C/en not_active Expired - Lifetime
- 2001-06-27 EG EG20010701A patent/EG24742A/xx active
- 2001-06-27 CN CN018146198A patent/CN1449293B/zh not_active Expired - Lifetime
- 2001-06-27 HU HU1000594A patent/HU227613B1/hu unknown
- 2001-06-27 AP APAP/P/2002/002700A patent/AP1695A/en active
- 2001-06-27 PL PL393584A patent/PL393584A1/pl unknown
- 2001-06-27 AU AU2001281895A patent/AU2001281895C1/en active Active
- 2001-06-27 US US10/312,090 patent/US20030180316A1/en not_active Abandoned
- 2001-06-27 EP EP10178451A patent/EP2277541A1/en not_active Withdrawn
- 2001-06-27 ES ES01960390.1T patent/ES2375704T5/es not_active Expired - Lifetime
- 2001-06-27 MY MYPI20013027 patent/MY133981A/en unknown
- 2001-06-27 DK DK01960390.1T patent/DK1296715T4/en active
- 2001-06-27 CZ CZ20024224A patent/CZ20024224A3/cs not_active IP Right Cessation
- 2001-06-27 PT PT01960390T patent/PT1296715E/pt unknown
- 2001-06-27 SI SI200131007T patent/SI1296715T2/sl unknown
- 2001-06-27 DK DK07116669.8T patent/DK1946769T3/da active
- 2001-06-27 DZ DZ013399A patent/DZ3399A1/xx active
- 2001-06-27 PL PL360265A patent/PL210015B1/pl unknown
- 2001-06-27 AU AU8189501A patent/AU8189501A/xx active Pending
- 2001-06-27 UA UAA200604994A patent/UA85853C2/uk unknown
- 2001-06-27 KR KR1020087013186A patent/KR100898845B1/ko active IP Right Grant
- 2001-06-27 OA OA1200200395A patent/OA12302A/en unknown
- 2001-06-27 PT PT07116669T patent/PT1946769E/pt unknown
- 2001-06-27 JP JP2002505030A patent/JP4870895B2/ja not_active Expired - Lifetime
-
2002
- 2002-12-17 IL IL153506A patent/IL153506A/en active IP Right Grant
- 2002-12-20 NO NO20026175A patent/NO332495B1/no not_active IP Right Cessation
- 2002-12-26 MA MA26980A patent/MA25824A1/fr unknown
- 2002-12-28 BG BG107422A patent/BG66238B1/bg active Active
-
2003
- 2003-08-27 HK HK03106153.7A patent/HK1055244A1/xx not_active IP Right Cessation
-
2009
- 2009-11-06 BG BG10110518A patent/BG66249B1/bg active Active
-
2010
- 2010-03-15 JP JP2010057779A patent/JP5346308B2/ja not_active Expired - Lifetime
-
2012
- 2012-01-30 CY CY20121100103T patent/CY1112280T1/el unknown
- 2012-04-04 US US13/439,829 patent/US9233151B2/en not_active Expired - Fee Related
- 2012-06-15 CY CY20121100549T patent/CY1112915T1/el unknown
Non-Patent Citations (1)
Title |
---|
Eur. J. Pediatr., 156(1), 18-24 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR100898845B1 (ko) | 다가 백신 조성물 | |
KR101045412B1 (ko) | 백신 조성물 | |
AU2001281895A1 (en) | Vaccine Composition | |
ZA200300755B (en) | Multivalent vaccine composition. | |
AU2005203302A1 (en) | Vaccine composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A107 | Divisional application of patent | ||
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20130429 Year of fee payment: 5 |
|
FPAY | Annual fee payment |
Payment date: 20140430 Year of fee payment: 6 |
|
FPAY | Annual fee payment |
Payment date: 20160330 Year of fee payment: 8 |
|
FPAY | Annual fee payment |
Payment date: 20170330 Year of fee payment: 9 |
|
FPAY | Annual fee payment |
Payment date: 20180329 Year of fee payment: 10 |
|
FPAY | Annual fee payment |
Payment date: 20190327 Year of fee payment: 11 |