KR100873541B1 - Jnk 억제제로서 인다졸 유도체 및 이와 관련된 조성물및 방법 - Google Patents
Jnk 억제제로서 인다졸 유도체 및 이와 관련된 조성물및 방법 Download PDFInfo
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- KR100873541B1 KR100873541B1 KR1020037001429A KR20037001429A KR100873541B1 KR 100873541 B1 KR100873541 B1 KR 100873541B1 KR 1020037001429 A KR1020037001429 A KR 1020037001429A KR 20037001429 A KR20037001429 A KR 20037001429A KR 100873541 B1 KR100873541 B1 KR 100873541B1
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- KR
- South Korea
- Prior art keywords
- indazol
- alkyl
- phenyl
- fluorophenyl
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 C*Cc1c(C)ccc(*c2n[n]c3c2cc(*)cc3)c1 Chemical compound C*Cc1c(C)ccc(*c2n[n]c3c2cc(*)cc3)c1 0.000 description 12
- FQYCDSITHOCSFK-UHFFFAOYSA-N C=C(CCC(O)=O)C(c(cc1)cc2c1ncc2-c(cc1)ccc1F)=[U] Chemical compound C=C(CCC(O)=O)C(c(cc1)cc2c1ncc2-c(cc1)ccc1F)=[U] FQYCDSITHOCSFK-UHFFFAOYSA-N 0.000 description 1
- MTAAENOKWBYKAD-UHFFFAOYSA-N CC(C(C)(C)C)C(CC(CC(c(cc12)ccc1[nH]cc2-c(cc1)ccc1F)=O)=N)=O Chemical compound CC(C(C)(C)C)C(CC(CC(c(cc12)ccc1[nH]cc2-c(cc1)ccc1F)=O)=N)=O MTAAENOKWBYKAD-UHFFFAOYSA-N 0.000 description 1
- AUGCJYLSODUVJX-ZDLGFXPLSA-N CC(C)CC(Nc1cc(C(C2=C3)NNC2=CCC3C(NC(C/C=C(/C)\CC=C)N)=N)ccc1)O Chemical compound CC(C)CC(Nc1cc(C(C2=C3)NNC2=CCC3C(NC(C/C=C(/C)\CC=C)N)=N)ccc1)O AUGCJYLSODUVJX-ZDLGFXPLSA-N 0.000 description 1
- VKUVXPAKNJCGTR-UHFFFAOYSA-N CC(CC(CC1)/C(/N)=N/[U])C1NC(C(CC1)CCC1(C)[ClH]CN1CCC1)I Chemical compound CC(CC(CC1)/C(/N)=N/[U])C1NC(C(CC1)CCC1(C)[ClH]CN1CCC1)I VKUVXPAKNJCGTR-UHFFFAOYSA-N 0.000 description 1
- DBXNAUTWWWNIGN-VVHSMMNKSA-N CCC(C1)c(cc(cc2)NC3[C@@]4(C)[C@@H](C)CC34)c2C1=N Chemical compound CCC(C1)c(cc(cc2)NC3[C@@]4(C)[C@@H](C)CC34)c2C1=N DBXNAUTWWWNIGN-VVHSMMNKSA-N 0.000 description 1
- LRULPYWDMSGQCV-KXDUQGBNSA-N CCC/C=C(/C(N)Nc1cc(C(C(C(CC)=CC2)=CC2C(N)/N=C(\C)/CNC)N)ccc1)\C=C Chemical compound CCC/C=C(/C(N)Nc1cc(C(C(C(CC)=CC2)=CC2C(N)/N=C(\C)/CNC)N)ccc1)\C=C LRULPYWDMSGQCV-KXDUQGBNSA-N 0.000 description 1
- FSGNXKHIOCXGGM-UHFFFAOYSA-N COc(ccc(-c1[n-][nH]c(cc2)c1cc2N)c1)c1OC Chemical compound COc(ccc(-c1[n-][nH]c(cc2)c1cc2N)c1)c1OC FSGNXKHIOCXGGM-UHFFFAOYSA-N 0.000 description 1
- FVCQJNBZIQPHBC-UHFFFAOYSA-N COc(cccc1)c1-c1n[nH]c2c1cccc2 Chemical compound COc(cccc1)c1-c1n[nH]c2c1cccc2 FVCQJNBZIQPHBC-UHFFFAOYSA-N 0.000 description 1
- MDYCKKXFSHOVCJ-UHFFFAOYSA-N COc1ccccc1C(Nc(cc12)ccc1[nH]nc2-c(cc1)ccc1F)=O Chemical compound COc1ccccc1C(Nc(cc12)ccc1[nH]nc2-c(cc1)ccc1F)=O MDYCKKXFSHOVCJ-UHFFFAOYSA-N 0.000 description 1
- JAXHOAMUEIQIHI-UHFFFAOYSA-N Fc(cc1)ccc1-c1n[nH]c(cc2)c1cc2-c1nc(-c2ccccc2)n[nH]1 Chemical compound Fc(cc1)ccc1-c1n[nH]c(cc2)c1cc2-c1nc(-c2ccccc2)n[nH]1 JAXHOAMUEIQIHI-UHFFFAOYSA-N 0.000 description 1
- LLPAFTHNIULCDH-UHFFFAOYSA-N Fc(cc1)ccc1-c1n[nH]c2c1cccc2 Chemical compound Fc(cc1)ccc1-c1n[nH]c2c1cccc2 LLPAFTHNIULCDH-UHFFFAOYSA-N 0.000 description 1
- BBIYWBMKGNBJRZ-OWOJBTEDSA-N Fc(cc1)ccc1-c1n[nH]c2ccc(/C=C/c3ccncc3)cc12 Chemical compound Fc(cc1)ccc1-c1n[nH]c2ccc(/C=C/c3ccncc3)cc12 BBIYWBMKGNBJRZ-OWOJBTEDSA-N 0.000 description 1
- MOBJHQPTGMYKCJ-UHFFFAOYSA-N Nc(cc1)cc2c1[nH]nc2-c1ccccc1 Chemical compound Nc(cc1)cc2c1[nH]nc2-c1ccccc1 MOBJHQPTGMYKCJ-UHFFFAOYSA-N 0.000 description 1
- ZOSAOCBPZBJXLH-UHFFFAOYSA-N Nc(ccc(NC(c1ccccc1O)=O)c1)c1C(c1ccccc1)=N Chemical compound Nc(ccc(NC(c1ccccc1O)=O)c1)c1C(c1ccccc1)=N ZOSAOCBPZBJXLH-UHFFFAOYSA-N 0.000 description 1
- ZRFIKGBVWHXSOY-OWOJBTEDSA-N Nc1ccc(/C=C/c(cc23)ccc2[nH]nc3-c(cc2)ccc2F)cc1 Chemical compound Nc1ccc(/C=C/c(cc23)ccc2[nH]nc3-c(cc2)ccc2F)cc1 ZRFIKGBVWHXSOY-OWOJBTEDSA-N 0.000 description 1
- ACPSOWJNEYLMEJ-UHFFFAOYSA-N O=Nc(cc12)ccc1[nH]nc2-c1ccccc1 Chemical compound O=Nc(cc12)ccc1[nH]nc2-c1ccccc1 ACPSOWJNEYLMEJ-UHFFFAOYSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N OC(C(F)(F)F)=O Chemical compound OC(C(F)(F)F)=O DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- NZJALEIHUDTUQG-UHFFFAOYSA-N [O-][N+](c(cc12)ccc1[nH]nc2-c1cccc2c1cccc2)=O Chemical compound [O-][N+](c(cc12)ccc1[nH]nc2-c1cccc2c1cccc2)=O NZJALEIHUDTUQG-UHFFFAOYSA-N 0.000 description 1
- ISWUVPOUIMHFBC-SNAWJCMRSA-N [O-][N+](c1cccc(/C=C/c(cc23)ccc2[nH]nc3-c(cc2)ccc2F)c1)=O Chemical compound [O-][N+](c1cccc(/C=C/c(cc23)ccc2[nH]nc3-c(cc2)ccc2F)c1)=O ISWUVPOUIMHFBC-SNAWJCMRSA-N 0.000 description 1
- SXAJOTBDSDVHFJ-UHFFFAOYSA-N c1ccc(cc(cc2)-c(c3c4)n[nH]c3ccc4-c3nnn[nH]3)c2c1 Chemical compound c1ccc(cc(cc2)-c(c3c4)n[nH]c3ccc4-c3nnn[nH]3)c2c1 SXAJOTBDSDVHFJ-UHFFFAOYSA-N 0.000 description 1
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22179900P | 2000-07-31 | 2000-07-31 | |
| US60/221,799 | 2000-07-31 | ||
| PCT/US2001/023890 WO2002010137A2 (en) | 2000-07-31 | 2001-07-30 | Indazole derivatives as jnk inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20030065459A KR20030065459A (ko) | 2003-08-06 |
| KR100873541B1 true KR100873541B1 (ko) | 2008-12-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020037001429A Expired - Fee Related KR100873541B1 (ko) | 2000-07-31 | 2001-07-30 | Jnk 억제제로서 인다졸 유도체 및 이와 관련된 조성물및 방법 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6897231B2 (https=) |
| EP (1) | EP1313711A2 (https=) |
| JP (1) | JP2004513882A (https=) |
| KR (1) | KR100873541B1 (https=) |
| AU (2) | AU2001279089B2 (https=) |
| CA (1) | CA2417650A1 (https=) |
| IL (1) | IL154217A0 (https=) |
| NZ (1) | NZ524045A (https=) |
| WO (1) | WO2002010137A2 (https=) |
| ZA (1) | ZA200300886B (https=) |
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| US6897231B2 (en) | 2005-05-24 |
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| NZ524045A (en) | 2004-07-30 |
| EP1313711A2 (en) | 2003-05-28 |
| US20040077877A1 (en) | 2004-04-22 |
| CA2417650A1 (en) | 2002-02-07 |
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