KR100866272B1 - 트로펜올을 제조하기 위한 공업적 합성방법 - Google Patents

트로펜올을 제조하기 위한 공업적 합성방법 Download PDF

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Publication number
KR100866272B1
KR100866272B1 KR1020037017010A KR20037017010A KR100866272B1 KR 100866272 B1 KR100866272 B1 KR 100866272B1 KR 1020037017010 A KR1020037017010 A KR 1020037017010A KR 20037017010 A KR20037017010 A KR 20037017010A KR 100866272 B1 KR100866272 B1 KR 100866272B1
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South Korea
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formula
salt
metal
added
acid addition
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Expired - Lifetime
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KR1020037017010A
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English (en)
Korean (ko)
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KR20040023631A (ko
Inventor
라프아르민발터
소봇타라이너
Original Assignee
베링거 잉겔하임 파르마 게엠베하 운트 코 카게
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Application filed by 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 filed Critical 베링거 잉겔하임 파르마 게엠베하 운트 코 카게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Lock And Its Accessories (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020037017010A 2001-06-28 2002-06-08 트로펜올을 제조하기 위한 공업적 합성방법 Expired - Lifetime KR100866272B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10131200.8 2001-06-28
DE10131200 2001-06-28
PCT/EP2002/006290 WO2003002562A1 (de) 2001-06-28 2002-06-08 Technische syntheseverfahren zur herstellung von tropenol

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020087014692A Division KR100886342B1 (ko) 2001-06-28 2002-06-08 약제 합성에 사용되는 스코핀 에스테르 유도체

Publications (2)

Publication Number Publication Date
KR20040023631A KR20040023631A (ko) 2004-03-18
KR100866272B1 true KR100866272B1 (ko) 2008-11-03

Family

ID=7689774

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020037017010A Expired - Lifetime KR100866272B1 (ko) 2001-06-28 2002-06-08 트로펜올을 제조하기 위한 공업적 합성방법
KR1020087014692A Expired - Lifetime KR100886342B1 (ko) 2001-06-28 2002-06-08 약제 합성에 사용되는 스코핀 에스테르 유도체
KR10-2003-0019708A Expired - Fee Related KR100530661B1 (ko) 2001-06-28 2003-03-28 실린더 자물쇠용 열쇠 및 실린더 자물쇠

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020087014692A Expired - Lifetime KR100886342B1 (ko) 2001-06-28 2002-06-08 약제 합성에 사용되는 스코핀 에스테르 유도체
KR10-2003-0019708A Expired - Fee Related KR100530661B1 (ko) 2001-06-28 2003-03-28 실린더 자물쇠용 열쇠 및 실린더 자물쇠

Country Status (40)

Country Link
US (1) US6610849B2 (https=)
EP (3) EP1404673B1 (https=)
JP (2) JP4485192B2 (https=)
KR (3) KR100866272B1 (https=)
CN (2) CN1982309B (https=)
AR (1) AR039056A1 (https=)
AT (3) ATE294801T1 (https=)
AU (2) AU2002257820B2 (https=)
BG (2) BG66398B1 (https=)
BR (1) BR0210664B1 (https=)
CA (1) CA2451573C (https=)
CO (1) CO5650166A2 (https=)
CY (1) CY1107681T1 (https=)
CZ (1) CZ296187B6 (https=)
DE (2) DE50209948D1 (https=)
DK (3) DK1808435T3 (https=)
EA (2) EA009808B1 (https=)
EC (1) ECSP034927A (https=)
EE (1) EE05403B1 (https=)
EG (1) EG23203A (https=)
ES (3) ES2374981T3 (https=)
HR (2) HRP20090110A2 (https=)
HU (2) HU230036B1 (https=)
IL (2) IL159239A0 (https=)
ME (1) MEP42608A (https=)
MX (1) MXPA03011516A (https=)
MY (1) MY122932A (https=)
NO (1) NO328154B1 (https=)
NZ (2) NZ541395A (https=)
PE (1) PE20030123A1 (https=)
PL (1) PL209520B1 (https=)
PT (2) PT1475379E (https=)
RS (1) RS50436B (https=)
SA (1) SA02230194B1 (https=)
SI (2) SI1404673T1 (https=)
SK (1) SK288022B6 (https=)
TW (1) TW574220B (https=)
UA (2) UA76761C2 (https=)
WO (1) WO2003002562A1 (https=)
ZA (1) ZA200308895B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6747153B2 (en) * 2002-05-31 2004-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Industrial process for preparing tropenol
US20090162562A1 (en) * 2007-12-24 2009-06-25 Bangalore Aswatha Nagaraj Methods for Applying Thermal Barrier Coating Systems
DK2240477T3 (en) * 2008-01-10 2014-12-08 Generics Uk Ltd New process for the preparation of skopinestre
NZ597920A (en) 2009-08-07 2014-05-30 Generics Uk Ltd Anhydrate of tiotropium bromide
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
CN102351856B (zh) * 2011-08-24 2013-05-01 商丘市韶华药业有限公司 一种α-托品醇的纯化方法
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
RS55996B1 (sr) * 2011-12-22 2017-09-29 Cerbios-Pharma S A Kontinuirani postupak za alkilaciju cikličnih tercijarnih amina
CN113292574B (zh) * 2020-02-21 2022-05-03 四川大学 一类手性多环的托品烷化合物及其制备方法和用途
CN111269226B (zh) * 2020-04-13 2021-09-21 石家庄四药有限公司 异丙托溴铵的合成方法
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法
CN115925534B (zh) * 2023-01-03 2025-03-07 绍兴民生医药股份有限公司 高纯度托品酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
BR9507489A (pt) * 1994-04-19 1997-08-12 Neurosearch As Derivados tropano sua preparacão e uso
DE19515625C2 (de) * 1995-04-28 1998-02-19 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Tetrahedron Letters 42, 1975-1977(2000) *
Tetrahedron Letters 42, 1975-1977(2000)*

Also Published As

Publication number Publication date
MEP42608A (en) 2011-02-10
CN1288154C (zh) 2006-12-06
AU2002257820B2 (en) 2008-05-08
CN1520413A (zh) 2004-08-11
MY122932A (en) 2006-05-31
IL159239A (en) 2010-05-17
CY1107681T1 (el) 2013-04-18
EP1808435A1 (de) 2007-07-18
BG111461A (en) 2013-08-30
HUP0400332A2 (hu) 2004-08-30
ATE359285T1 (de) 2007-05-15
HUP0400332A3 (en) 2007-06-28
KR100530661B1 (ko) 2005-11-22
HU230379B1 (hu) 2016-03-29
YU101103A (en) 2006-05-25
BG108462A (bg) 2005-01-31
DK1404673T3 (da) 2005-06-13
ES2242022T3 (es) 2005-11-01
ES2285318T3 (es) 2007-11-16
BR0210664B1 (pt) 2013-12-03
EE05403B1 (et) 2011-04-15
PT1404673E (pt) 2005-07-29
BG66398B1 (bg) 2013-12-31
SI1404673T1 (sl) 2005-10-31
IL159239A0 (en) 2004-06-01
ZA200308895B (en) 2004-06-09
KR20040023631A (ko) 2004-03-18
HRP20031085A2 (en) 2004-04-30
EA200301292A1 (ru) 2004-06-24
ATE294801T1 (de) 2005-05-15
UA86031C2 (ru) 2009-03-25
ATE527257T1 (de) 2011-10-15
EA009808B1 (ru) 2008-04-28
ES2374981T3 (es) 2012-02-23
DK1475379T3 (da) 2007-09-03
CN1982309B (zh) 2010-06-09
HK1103404A1 (zh) 2007-12-21
EA006393B1 (ru) 2005-12-29
CN1982309A (zh) 2007-06-20
DE50209948D1 (de) 2007-05-24
HRP20031085B1 (en) 2011-12-31
PT1475379E (pt) 2007-05-31
EG23203A (en) 2004-07-31
ECSP034927A (es) 2004-02-26
JP2004536830A (ja) 2004-12-09
US6610849B2 (en) 2003-08-26
HU230036B1 (hu) 2015-05-28
DK1808435T3 (da) 2012-01-16
PE20030123A1 (es) 2003-03-31
JP4485192B2 (ja) 2010-06-16
WO2003002562A1 (de) 2003-01-09
PL209520B1 (pl) 2011-09-30
MXPA03011516A (es) 2004-03-18
SK288022B6 (sk) 2012-12-03
JP2010043116A (ja) 2010-02-25
NO328154B1 (no) 2009-12-21
EP1404673B1 (de) 2005-05-04
EP1404673A1 (de) 2004-04-07
SK662004A3 (en) 2004-06-08
BR0210664A (pt) 2004-08-10
CZ296187B6 (cs) 2006-01-11
RS50436B (sr) 2009-12-31
CZ2004149A3 (cs) 2004-05-12
AU2008201565A1 (en) 2008-05-01
EP1808435B1 (de) 2011-10-05
NZ541395A (en) 2007-03-30
NZ530770A (en) 2005-11-25
EP1475379B1 (de) 2007-04-11
AU2008201565B2 (en) 2012-03-01
DE50203015D1 (de) 2005-06-09
CA2451573C (en) 2010-09-21
CA2451573A1 (en) 2003-01-09
HRP20090110A2 (en) 2009-04-30
KR20030078793A (ko) 2003-10-08
KR20080065313A (ko) 2008-07-11
KR100886342B1 (ko) 2009-03-03
HK1068613A1 (en) 2005-04-29
SI1475379T1 (sl) 2007-08-31
EA200501081A1 (ru) 2006-06-30
TW574220B (en) 2004-02-01
CO5650166A2 (es) 2006-06-30
PL366942A1 (en) 2005-02-07
SA02230194B1 (ar) 2008-03-08
US20030022917A1 (en) 2003-01-30
NO20035633D0 (no) 2003-12-17
UA76761C2 (uk) 2006-09-15
EP1475379A1 (de) 2004-11-10
AR039056A1 (es) 2005-02-09
EE200400045A (et) 2004-04-15

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