KR100865706B1 - 화학적인 위치 변화에 의해 면역자극 올리고누클레오티드유사체의 면역자극 활성을 조절하는 방법 - Google Patents

화학적인 위치 변화에 의해 면역자극 올리고누클레오티드유사체의 면역자극 활성을 조절하는 방법

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Publication number
KR100865706B1
KR100865706B1 KR1020037004314A KR20037004314A KR100865706B1 KR 100865706 B1 KR100865706 B1 KR 100865706B1 KR 1020037004314 A KR1020037004314 A KR 1020037004314A KR 20037004314 A KR20037004314 A KR 20037004314A KR 100865706 B1 KR100865706 B1 KR 100865706B1
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South Korea
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immunostimulatory
delete delete
oligo
oligonucleotides
oligonucleotide
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Expired - Fee Related
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English (en)
Korean (ko)
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KR20030061812A (ko
Inventor
에캄바 알. 칸디말라
퀴얀 자오
동 유
수드히르 아그라월
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이데라 파마슈티칼즈, 인코포레이티드
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020037004314A 2000-09-26 2001-09-26 화학적인 위치 변화에 의해 면역자극 올리고누클레오티드유사체의 면역자극 활성을 조절하는 방법 Expired - Fee Related KR100865706B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23545200P 2000-09-26 2000-09-26
US23545300P 2000-09-26 2000-09-26
US60/235,453 2000-09-26
US60/235,452 2000-09-26
US71289800A 2000-11-15 2000-11-15
US09/712,898 2000-11-15
PCT/US2001/030137 WO2002026757A2 (en) 2000-09-26 2001-09-26 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes

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KR1020087002314A Division KR100894767B1 (ko) 2000-09-26 2001-09-26 화학적인 위치 변화에 의해 면역자극 올리고누클레오티드유사체의 면역자극 활성을 조절하는 방법

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KR20030061812A KR20030061812A (ko) 2003-07-22
KR100865706B1 true KR100865706B1 (ko) 2008-10-28

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KR1020087002314A Expired - Fee Related KR100894767B1 (ko) 2000-09-26 2001-09-26 화학적인 위치 변화에 의해 면역자극 올리고누클레오티드유사체의 면역자극 활성을 조절하는 방법
KR1020037004314A Expired - Fee Related KR100865706B1 (ko) 2000-09-26 2001-09-26 화학적인 위치 변화에 의해 면역자극 올리고누클레오티드유사체의 면역자극 활성을 조절하는 방법

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KR1020087002314A Expired - Fee Related KR100894767B1 (ko) 2000-09-26 2001-09-26 화학적인 위치 변화에 의해 면역자극 올리고누클레오티드유사체의 면역자극 활성을 조절하는 방법

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US (8) US7262286B2 (enExample)
EP (2) EP1322656B1 (enExample)
JP (1) JP2004509970A (enExample)
KR (2) KR100894767B1 (enExample)
AT (1) ATE384072T1 (enExample)
AU (2) AU9475001A (enExample)
CA (1) CA2423487C (enExample)
DE (1) DE60132471T2 (enExample)
ES (1) ES2298269T3 (enExample)
WO (1) WO2002026757A2 (enExample)

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