KR100838135B1 - 7-퀴놀리닐-3,5-디히드록시헵트-6-엔산에스테르의 제조법 - Google Patents

7-퀴놀리닐-3,5-디히드록시헵트-6-엔산에스테르의 제조법 Download PDF

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Publication number
KR100838135B1
KR100838135B1 KR1020037012898A KR20037012898A KR100838135B1 KR 100838135 B1 KR100838135 B1 KR 100838135B1 KR 1020037012898 A KR1020037012898 A KR 1020037012898A KR 20037012898 A KR20037012898 A KR 20037012898A KR 100838135 B1 KR100838135 B1 KR 100838135B1
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KR
South Korea
Prior art keywords
formula
dihydroxyhept
acid ester
enoic acid
hydrogen peroxide
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020037012898A
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English (en)
Korean (ko)
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KR20030086342A (ko
Inventor
도꾸나가겐이찌
고자와마사미
스즈끼겐지
Original Assignee
닛산 가가쿠 고교 가부시키 가이샤
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Publication of KR20030086342A publication Critical patent/KR20030086342A/ko
Application granted granted Critical
Publication of KR100838135B1 publication Critical patent/KR100838135B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020037012898A 2001-04-05 2002-03-22 7-퀴놀리닐-3,5-디히드록시헵트-6-엔산에스테르의 제조법 Expired - Fee Related KR100838135B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2001-00106820 2001-04-05
JP2001106820 2001-04-05
PCT/JP2002/002779 WO2002081451A1 (en) 2001-04-05 2002-03-22 Method for preparing 7-quinolinyl-3,5-dihydroxyhept-6-enoate

Publications (2)

Publication Number Publication Date
KR20030086342A KR20030086342A (ko) 2003-11-07
KR100838135B1 true KR100838135B1 (ko) 2008-06-13

Family

ID=18959261

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037012898A Expired - Fee Related KR100838135B1 (ko) 2001-04-05 2002-03-22 7-퀴놀리닐-3,5-디히드록시헵트-6-엔산에스테르의 제조법

Country Status (21)

Country Link
US (1) US7038056B2 (enExample)
EP (1) EP1375485B1 (enExample)
JP (1) JP4380160B2 (enExample)
KR (1) KR100838135B1 (enExample)
CN (1) CN1241914C (enExample)
AT (1) ATE506349T1 (enExample)
AU (1) AU2002241271B2 (enExample)
CA (1) CA2442713C (enExample)
CZ (1) CZ20032633A3 (enExample)
DE (1) DE60239793D1 (enExample)
HU (1) HUP0401401A3 (enExample)
IL (2) IL158151A0 (enExample)
MX (1) MXPA03009095A (enExample)
NO (1) NO326089B1 (enExample)
NZ (1) NZ528149A (enExample)
RU (1) RU2260001C2 (enExample)
SK (1) SK287922B6 (enExample)
TW (1) TWI317356B (enExample)
UA (1) UA76984C2 (enExample)
WO (1) WO2002081451A1 (enExample)
ZA (1) ZA200307704B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101160152B1 (ko) * 2009-02-24 2012-06-27 한미사이언스 주식회사 스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100445267C (zh) * 2005-10-21 2008-12-24 上海医药工业研究院 4-(4-氟-苯基)-3-羟甲基-2-环丙基-喹啉的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0164049A2 (en) * 1984-06-04 1985-12-11 Merck & Co. Inc. Process for preparing HMG-CoA reductase inhibtors with a 3,5-dihydroxypentanoate subunit
JPH0892217A (ja) * 1994-09-06 1996-04-09 Ube Ind Ltd 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法
WO1999032434A1 (en) * 1997-12-19 1999-07-01 Warner-Lambert Export Limited Process for the synthesis of 1,3-diols

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
US4645854A (en) * 1985-04-25 1987-02-24 Merck & Co., Inc. Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit
CA1336714C (en) 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
JP2569746B2 (ja) * 1987-08-20 1997-01-08 日産化学工業株式会社 キノリン系メバロノラクトン類
US5753675A (en) * 1989-03-03 1998-05-19 Novartis Pharmaceuticals Corporation Quinoline analogs of mevalonolactone and derivatives thereof
JP3528186B2 (ja) * 1991-06-24 2004-05-17 日産化学工業株式会社 光学活性キノリンメバロン酸のジアステレオマー塩
JP3130342B2 (ja) * 1991-10-04 2001-01-31 日産化学工業株式会社 動脈硬化性血管内膜肥厚抑制薬
JP4236463B2 (ja) * 2000-10-13 2009-03-11 ダイセル化学工業株式会社 光学活性な（３ｒ，５ｓ，６ｅ）−７−［２−シクロプロピル−４−（４−フルオロフェニル）キノリン−３−イル］−３，５−ジヒドロキシ−６−ヘプテン酸エチルの製造方法
EP1365029A4 (en) * 2001-02-02 2009-07-29 Mitsubishi Chem Corp "PROCESS FOR PREPARING (3R, 5S) - (E) -7-2-CYCLOPROPYL-4- (4-FLUORPHENYL) CHINOLINE-3-YL-3,5-DIHYDROXY-HEPT-6-ACID ESTERS"

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0164049A2 (en) * 1984-06-04 1985-12-11 Merck & Co. Inc. Process for preparing HMG-CoA reductase inhibtors with a 3,5-dihydroxypentanoate subunit
JPH0892217A (ja) * 1994-09-06 1996-04-09 Ube Ind Ltd 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法
WO1999032434A1 (en) * 1997-12-19 1999-07-01 Warner-Lambert Export Limited Process for the synthesis of 1,3-diols

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101160152B1 (ko) * 2009-02-24 2012-06-27 한미사이언스 주식회사 스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물

Also Published As

Publication number Publication date
CA2442713C (en) 2010-05-18
IL158151A (en) 2009-09-22
RU2003132440A (ru) 2005-01-10
SK287922B6 (sk) 2012-04-03
NZ528149A (en) 2005-05-27
NO20034438L (no) 2003-10-03
NO326089B1 (no) 2008-09-15
SK12372003A3 (sk) 2004-04-06
AU2002241271B2 (en) 2007-01-25
JP4380160B2 (ja) 2009-12-09
EP1375485A1 (en) 2004-01-02
EP1375485B1 (en) 2011-04-20
KR20030086342A (ko) 2003-11-07
CZ20032633A3 (cs) 2003-12-17
UA76984C2 (en) 2006-10-16
MXPA03009095A (es) 2004-02-12
ATE506349T1 (de) 2011-05-15
TWI317356B (enExample) 2009-11-21
ZA200307704B (en) 2004-10-04
CA2442713A1 (en) 2002-10-17
WO2002081451A1 (en) 2002-10-17
JPWO2002081451A1 (ja) 2004-07-29
US20050014947A1 (en) 2005-01-20
CN1241914C (zh) 2006-02-15
DE60239793D1 (de) 2011-06-01
EP1375485A4 (en) 2005-03-23
HUP0401401A3 (en) 2012-05-02
CN1500079A (zh) 2004-05-26
HUP0401401A2 (hu) 2004-12-28
IL158151A0 (en) 2004-03-28
NO20034438D0 (no) 2003-10-03
RU2260001C2 (ru) 2005-09-10
US7038056B2 (en) 2006-05-02

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