HUP0401401A2 - Eljárás 7-kinolinil-3,5-dihidroxi-hept-6-enoát előállítására - Google Patents

Eljárás 7-kinolinil-3,5-dihidroxi-hept-6-enoát előállítására

Info

Publication number
HUP0401401A2
HUP0401401A2 HU0401401A HUP0401401A HUP0401401A2 HU P0401401 A2 HUP0401401 A2 HU P0401401A2 HU 0401401 A HU0401401 A HU 0401401A HU P0401401 A HUP0401401 A HU P0401401A HU P0401401 A2 HUP0401401 A2 HU P0401401A2
Authority
HU
Hungary
Prior art keywords
general formula
dihydroxyhept
enoate
quinolinyl
compound
Prior art date
Application number
HU0401401A
Other languages
English (en)
Inventor
Kenichi Tokunaga
Masami Kozawa
Kenji Suzuki
Original Assignee
Nissan Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Industries, Ltd. filed Critical Nissan Chemical Industries, Ltd.
Publication of HUP0401401A2 publication Critical patent/HUP0401401A2/hu
Publication of HUP0401401A3 publication Critical patent/HUP0401401A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány tárgyát eljárás képezi gyógyszerek köztestermékekénthasznos 7-kinolinil-3,5-dihidroxi-hept-6-enoát nagy tisztaságbantörténő, nagy hozamú előállítására. Közelebbről, a találmány tárgyát(IV) általános képletű 7-kinolinil-3,5-dihidroxi-hept-6-enoát(amelyben <R< jelentése: alkilcsoport vagy arilcsoport) előállítására,melynek során egy (I) általános képletű vegyületet (amelyben <R<jelentése megegyezik a fentebb megadottakkal) vagy egy (II) általánosképletű vegyületet (amelyben <R< jelentése megegyezik a fentebbmegadottakkal) (III) általános képletű bórvegyület (R'OBR"2; amelybenR' és R" jelentése, egymástól függetlenül: alkilcsoport) jelenlétébennátrium-bór-hidriddel redukálnak, majd a kapott reakcióelegyethidrogén-peroxid vizes oldatával kezelik. Ó
HU0401401A 2001-04-05 2002-03-22 Method for preparing 7-quinolinyl-3,5-dihydroxyhept-6-enoate HUP0401401A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001106820 2001-04-05
PCT/JP2002/002779 WO2002081451A1 (fr) 2001-04-05 2002-03-22 Procede relatif a l'elaboration de 7-quinolinyl-3,5-dihydroxyhept-6-enoate

Publications (2)

Publication Number Publication Date
HUP0401401A2 true HUP0401401A2 (hu) 2004-12-28
HUP0401401A3 HUP0401401A3 (en) 2012-05-02

Family

ID=18959261

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401401A HUP0401401A3 (en) 2001-04-05 2002-03-22 Method for preparing 7-quinolinyl-3,5-dihydroxyhept-6-enoate

Country Status (21)

Country Link
US (1) US7038056B2 (hu)
EP (1) EP1375485B1 (hu)
JP (1) JP4380160B2 (hu)
KR (1) KR100838135B1 (hu)
CN (1) CN1241914C (hu)
AT (1) ATE506349T1 (hu)
AU (1) AU2002241271B2 (hu)
CA (1) CA2442713C (hu)
CZ (1) CZ20032633A3 (hu)
DE (1) DE60239793D1 (hu)
HU (1) HUP0401401A3 (hu)
IL (2) IL158151A0 (hu)
MX (1) MXPA03009095A (hu)
NO (1) NO326089B1 (hu)
NZ (1) NZ528149A (hu)
RU (1) RU2260001C2 (hu)
SK (1) SK287922B6 (hu)
TW (1) TWI317356B (hu)
UA (1) UA76984C2 (hu)
WO (1) WO2002081451A1 (hu)
ZA (1) ZA200307704B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100445267C (zh) * 2005-10-21 2008-12-24 上海医药工业研究院 4-(4-氟-苯基)-3-羟甲基-2-环丙基-喹啉的制备方法
KR101160152B1 (ko) * 2009-02-24 2012-06-27 한미사이언스 주식회사 스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
US4645854A (en) * 1985-04-25 1987-02-24 Merck & Co., Inc. Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit
EP0164049B1 (en) 1984-06-04 1990-12-12 Merck & Co. Inc. Process for preparing hmg-coa reductase inhibtors with a 3,5-dihydroxypentanoate subunit
JP2569746B2 (ja) * 1987-08-20 1997-01-08 日産化学工業株式会社 キノリン系メバロノラクトン類
CA1336714C (en) 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
US5753675A (en) * 1989-03-03 1998-05-19 Novartis Pharmaceuticals Corporation Quinoline analogs of mevalonolactone and derivatives thereof
JP3528186B2 (ja) * 1991-06-24 2004-05-17 日産化学工業株式会社 光学活性キノリンメバロン酸のジアステレオマー塩
JP3554036B2 (ja) * 1994-09-06 2004-08-11 宇部興産株式会社 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法
WO1999032434A1 (en) 1997-12-19 1999-07-01 Warner-Lambert Export Limited Process for the synthesis of 1,3-diols
EP1334967A4 (en) * 2000-10-13 2008-05-07 Daicel Chem PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE ETHYL (3R, 5S, 6E) -7-2-CYCLOPROPYL-4- (4-FLUOROPHENYL) QUINOLIN-3-YL-3,5-DIHYDROXY-6-HEPTENOATE
CA2437312C (en) * 2001-02-02 2010-03-23 Mitsubishi Chemical Corporation Process for producing (3r,5s)-(e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxyhept-6-enic acid esters

Also Published As

Publication number Publication date
JP4380160B2 (ja) 2009-12-09
NO20034438D0 (no) 2003-10-03
EP1375485A1 (en) 2004-01-02
CN1241914C (zh) 2006-02-15
US7038056B2 (en) 2006-05-02
KR100838135B1 (ko) 2008-06-13
RU2003132440A (ru) 2005-01-10
HUP0401401A3 (en) 2012-05-02
IL158151A (en) 2009-09-22
WO2002081451A1 (fr) 2002-10-17
IL158151A0 (en) 2004-03-28
US20050014947A1 (en) 2005-01-20
JPWO2002081451A1 (ja) 2004-07-29
SK287922B6 (sk) 2012-04-03
ATE506349T1 (de) 2011-05-15
DE60239793D1 (de) 2011-06-01
CA2442713A1 (en) 2002-10-17
KR20030086342A (ko) 2003-11-07
EP1375485B1 (en) 2011-04-20
NO326089B1 (no) 2008-09-15
CZ20032633A3 (cs) 2003-12-17
UA76984C2 (en) 2006-10-16
MXPA03009095A (es) 2004-02-12
RU2260001C2 (ru) 2005-09-10
SK12372003A3 (sk) 2004-04-06
EP1375485A4 (en) 2005-03-23
CA2442713C (en) 2010-05-18
AU2002241271B2 (en) 2007-01-25
CN1500079A (zh) 2004-05-26
NO20034438L (no) 2003-10-03
NZ528149A (en) 2005-05-27
ZA200307704B (en) 2004-10-04
TWI317356B (hu) 2009-11-21

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees