KR100836971B1 - 맥관 장애 및 이종 이식술에서의 라파마이신 유도체의 용도 - Google Patents

맥관 장애 및 이종 이식술에서의 라파마이신 유도체의 용도 Download PDF

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Publication number
KR100836971B1
KR100836971B1 KR1020057005463A KR20057005463A KR100836971B1 KR 100836971 B1 KR100836971 B1 KR 100836971B1 KR 1020057005463 A KR1020057005463 A KR 1020057005463A KR 20057005463 A KR20057005463 A KR 20057005463A KR 100836971 B1 KR100836971 B1 KR 100836971B1
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KR
South Korea
Prior art keywords
rapamycin
formula
compound
rejection
vascular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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KR1020057005463A
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English (en)
Korean (ko)
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KR20050038656A (ko
Inventor
발터 슐레르
헨드릭 슈르만
기스베르트 벡크벡커
한스-귄터 제르베스
Original Assignee
노파르티스 아게
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10791127&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100836971(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Priority claimed from KR1019980707662A external-priority patent/KR100616020B1/ko
Publication of KR20050038656A publication Critical patent/KR20050038656A/ko
Application granted granted Critical
Publication of KR100836971B1 publication Critical patent/KR100836971B1/ko
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Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020057005463A 1996-03-27 1997-03-26 맥관 장애 및 이종 이식술에서의 라파마이신 유도체의 용도 Expired - Lifetime KR100836971B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9606452.2A GB9606452D0 (en) 1996-03-27 1996-03-27 Organic compounds
GB9606452.2 1996-03-27
KR1019980707662A KR100616020B1 (ko) 1996-03-27 1997-03-26 맥관장애및이종이식술에서의라파마이신유도체의용도

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1019980707662A Division KR100616020B1 (ko) 1996-03-27 1997-03-26 맥관장애및이종이식술에서의라파마이신유도체의용도

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020077008212A Division KR20070083654A (ko) 1996-03-27 1997-03-26 맥관 장애 및 이종 이식술에서의 라파마이신 유도체의 용도

Publications (2)

Publication Number Publication Date
KR20050038656A KR20050038656A (ko) 2005-04-27
KR100836971B1 true KR100836971B1 (ko) 2008-06-10

Family

ID=10791127

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020057005463A Expired - Lifetime KR100836971B1 (ko) 1996-03-27 1997-03-26 맥관 장애 및 이종 이식술에서의 라파마이신 유도체의 용도
KR1020077008212A Withdrawn KR20070083654A (ko) 1996-03-27 1997-03-26 맥관 장애 및 이종 이식술에서의 라파마이신 유도체의 용도

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020077008212A Withdrawn KR20070083654A (ko) 1996-03-27 1997-03-26 맥관 장애 및 이종 이식술에서의 라파마이신 유도체의 용도

Country Status (29)

Country Link
US (5) US6384046B1 (https=)
EP (3) EP0893996B1 (https=)
JP (2) JP2000507226A (https=)
KR (2) KR100836971B1 (https=)
CN (1) CN1124135C (https=)
AT (1) ATE224194T1 (https=)
AU (1) AU716514B2 (https=)
BR (1) BR9708358A (https=)
CA (1) CA2247275C (https=)
CY (1) CY2404B1 (https=)
CZ (1) CZ292483B6 (https=)
DE (1) DE69715611T2 (https=)
DK (2) DK0893996T3 (https=)
ES (2) ES2184078T3 (https=)
GB (1) GB9606452D0 (https=)
HU (1) HU226422B1 (https=)
ID (1) ID17195A (https=)
IL (1) IL125812A (https=)
MY (1) MY117798A (https=)
NO (1) NO316667B1 (https=)
NZ (1) NZ331463A (https=)
PL (1) PL187732B1 (https=)
PT (2) PT2008657E (https=)
RU (1) RU2214247C2 (https=)
SI (1) SI2008657T1 (https=)
SK (1) SK284343B6 (https=)
TR (1) TR199801919T2 (https=)
WO (1) WO1997035575A1 (https=)
ZA (1) ZA972719B (https=)

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Also Published As

Publication number Publication date
GB9606452D0 (en) 1996-06-05
PL328659A1 (en) 1999-02-15
MY117798A (en) 2004-08-30
JP2000507226A (ja) 2000-06-13
US20140187574A1 (en) 2014-07-03
CZ307098A3 (cs) 1999-01-13
EP0893996B1 (en) 2002-09-18
ES2184078T3 (es) 2003-04-01
EP2008657B1 (en) 2013-04-24
US20120177690A1 (en) 2012-07-12
HK1018688A1 (en) 1999-12-30
IL125812A (en) 2001-12-23
KR20050038656A (ko) 2005-04-27
DE69715611D1 (de) 2002-10-24
HUP0001267A2 (hu) 2000-11-28
ZA972719B (en) 1998-09-28
BR9708358A (pt) 1999-08-03
ES2421455T3 (es) 2013-09-02
IL125812A0 (en) 1999-04-11
JP2009102349A (ja) 2009-05-14
NO984340D0 (no) 1998-09-18
HU226422B1 (en) 2008-12-29
US6384046B1 (en) 2002-05-07
CA2247275A1 (en) 1997-10-02
CZ292483B6 (cs) 2003-09-17
US20020127248A1 (en) 2002-09-12
SK284343B6 (sk) 2005-02-04
CN1124135C (zh) 2003-10-15
SK132798A3 (en) 1999-03-12
DK2008657T3 (da) 2013-07-22
EP0893996A1 (en) 1999-02-03
AU716514B2 (en) 2000-02-24
CN1214631A (zh) 1999-04-21
EP2008657A2 (en) 2008-12-31
DK0893996T3 (da) 2002-12-09
NO316667B1 (no) 2004-03-29
NO984340L (no) 1998-09-18
EP1149581A2 (en) 2001-10-31
AU2291897A (en) 1997-10-17
PT2008657E (pt) 2013-07-12
SI2008657T1 (sl) 2013-07-31
EP1149581A3 (en) 2003-12-03
CA2247275C (en) 2011-10-11
DE69715611T2 (de) 2003-05-22
HUP0001267A3 (en) 2002-01-28
NZ331463A (en) 2001-10-26
TR199801919T2 (xx) 1999-02-22
ATE224194T1 (de) 2002-10-15
ID17195A (id) 1997-12-11
KR20070083654A (ko) 2007-08-24
PT893996E (pt) 2002-12-31
PL187732B1 (pl) 2004-09-30
WO1997035575A1 (en) 1997-10-02
RU2214247C2 (ru) 2003-10-20
CY2404B1 (en) 2004-09-10
US20100152105A1 (en) 2010-06-17
JP5124431B2 (ja) 2013-01-23
EP2008657A3 (en) 2009-02-04

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