KR100802625B1 - 생물학적으로 활성인 친수성 화합물의 비경구적 투여를위한 서방성 약제학적 조성물 - Google Patents

생물학적으로 활성인 친수성 화합물의 비경구적 투여를위한 서방성 약제학적 조성물 Download PDF

Info

Publication number
KR100802625B1
KR100802625B1 KR1020027015828A KR20027015828A KR100802625B1 KR 100802625 B1 KR100802625 B1 KR 100802625B1 KR 1020027015828 A KR1020027015828 A KR 1020027015828A KR 20027015828 A KR20027015828 A KR 20027015828A KR 100802625 B1 KR100802625 B1 KR 100802625B1
Authority
KR
South Korea
Prior art keywords
microemulsion
biologically active
active compound
microemulsions
acetate
Prior art date
Application number
KR1020027015828A
Other languages
English (en)
Korean (ko)
Other versions
KR20030011856A (ko
Inventor
프란체스코 아우투오리
카를로 비안치니
기우세페 보토니
플라비오 레오니
파올로 마스카그니
발멘 몬자니
오레스테 피콜로
Original Assignee
이탈파르마코 에스.피.아.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이탈파르마코 에스.피.아. filed Critical 이탈파르마코 에스.피.아.
Publication of KR20030011856A publication Critical patent/KR20030011856A/ko
Application granted granted Critical
Publication of KR100802625B1 publication Critical patent/KR100802625B1/ko

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26Androgens
KR1020027015828A 2000-05-26 2001-05-23 생물학적으로 활성인 친수성 화합물의 비경구적 투여를위한 서방성 약제학적 조성물 KR100802625B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000MI001173A IT1318539B1 (it) 2000-05-26 2000-05-26 Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente
ITMI2000A001173 2000-05-26
PCT/EP2001/005949 WO2001089479A2 (en) 2000-05-26 2001-05-23 Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds

Publications (2)

Publication Number Publication Date
KR20030011856A KR20030011856A (ko) 2003-02-11
KR100802625B1 true KR100802625B1 (ko) 2008-02-13

Family

ID=11445131

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027015828A KR100802625B1 (ko) 2000-05-26 2001-05-23 생물학적으로 활성인 친수성 화합물의 비경구적 투여를위한 서방성 약제학적 조성물

Country Status (28)

Country Link
US (1) US7157099B2 (pt)
EP (1) EP1283700B1 (pt)
JP (1) JP4954423B2 (pt)
KR (1) KR100802625B1 (pt)
CN (1) CN100479856C (pt)
AT (1) ATE321533T1 (pt)
AU (2) AU8178601A (pt)
BR (1) BRPI0111016B8 (pt)
CA (1) CA2409854C (pt)
CY (1) CY1105262T1 (pt)
CZ (1) CZ302059B6 (pt)
DE (1) DE60118395T2 (pt)
DK (1) DK1283700T3 (pt)
ES (1) ES2257428T3 (pt)
HR (1) HRP20020929A2 (pt)
HU (1) HU228926B1 (pt)
IL (1) IL153011A0 (pt)
IT (1) IT1318539B1 (pt)
MX (1) MXPA02011539A (pt)
NO (1) NO334880B1 (pt)
PL (1) PL203354B1 (pt)
PT (1) PT1283700E (pt)
RU (1) RU2272615C2 (pt)
SI (1) SI1283700T1 (pt)
SK (1) SK16552002A3 (pt)
WO (1) WO2001089479A2 (pt)
YU (1) YU88202A (pt)
ZA (1) ZA200209520B (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10478470B2 (en) 2014-07-28 2019-11-19 Sk Chemicals Co., Ltd. Pharmaceutical composition containing leuprolide and having both immediate and sustained release properties

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119159B2 (en) 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
PL1787658T3 (pl) 2005-11-10 2012-08-31 Italfarmaco Spa Formulacje o przedłużonym uwalnianiu analogów somatostatyny będących inhibitorami hormonu wzrostu
BRPI0710503A2 (pt) 2006-04-07 2011-08-16 Merrion Res Iii Ltd uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral
KR100816065B1 (ko) * 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐
RU2362544C2 (ru) * 2007-04-09 2009-07-27 Закрытое акционерное общество "Санкт-Петербургский институт фармации" Наноэмульсия с биологически активными веществами
CA2702135C (en) * 2007-10-04 2013-08-20 Daniel Py Apparatus and method for formulating and aseptically filling liquid products
KR20110007242A (ko) * 2008-05-07 2011-01-21 메리온 리서치 Ⅲ 리미티드 펩티드 조성물 및 그의 제조 방법
US9352012B2 (en) 2010-01-13 2016-05-31 Ipsen Pharma S.A.S. Process for the preparation of pharmaceutical compositions for the sustained release of somatostatin analogs
WO2011120033A1 (en) 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
US9944671B2 (en) 2010-06-02 2018-04-17 Alnylam Pharmaceuticals, Inc. Compositions and methods directed to treating liver fibrosis
US9107822B2 (en) 2010-09-03 2015-08-18 Santen Sas Water-in oil type emulsion for treating a disease of the eye
PT2425814E (pt) 2010-09-03 2013-09-02 Novagali Pharma Sa Emulsão de tipo água em óleo para tratamento de uma doença ocular
MX2013002115A (es) 2010-09-03 2013-06-28 Novagali Pharma Sa Una emulsion del tipo de agua en aceite para tratar una enfermedad de los ojos.
EP2649182A4 (en) 2010-12-10 2015-05-06 Alnylam Pharmaceuticals Inc COMPOSITIONS AND METHOD FOR INCREASING AN ERYTHROPOIETIN (EPO) PREPARATION
EP2648763A4 (en) 2010-12-10 2014-05-14 Alnylam Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR EXPRESSION INHIBITION OF GENES KLF-1 AND BCL11A
WO2012094598A2 (en) 2011-01-07 2012-07-12 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
RU2702501C2 (ru) 2011-03-29 2019-10-08 Элнилэм Фармасьютикалз, Инк. Композиции и способы ингибирования экспрессии гена tmprss6
RU2631807C2 (ru) 2011-06-02 2017-09-26 Президент Энд Феллоуз Ов Харвард Колледж Способы и применение систем культуры ткани ex vivo
CA2839896A1 (en) 2011-06-21 2012-12-27 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
AU2012272970A1 (en) 2011-06-21 2014-02-06 Alnylam Pharmaceuticals, Inc. Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
WO2012178033A2 (en) 2011-06-23 2012-12-27 Alnylam Pharmaceuticals, Inc. Serpina1 sirnas: compositions of matter and methods of treatment
JP2014527036A (ja) 2011-06-27 2014-10-09 ザ ジャクソン ラボラトリー 癌および自己免疫疾患の処置のための方法および組成物
US20140328811A1 (en) 2011-08-01 2014-11-06 Alnylam Pharmaceuticals, Inc. Method for improving the success rate of hematopoietic stem cell transplants
CN102552138A (zh) * 2012-02-28 2012-07-11 大连医科大学 口服羟丝肽w/o微乳制剂及其制备方法
CN102552187B (zh) * 2012-02-28 2015-10-28 大连医科大学 口服羟丝肽纳米粒及其制备方法
ES2802811T3 (es) * 2012-03-05 2021-01-21 Archer Daniels Midland Co Uso de microemulsiones como sistemas de administración
US9133461B2 (en) 2012-04-10 2015-09-15 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the ALAS1 gene
US9127274B2 (en) 2012-04-26 2015-09-08 Alnylam Pharmaceuticals, Inc. Serpinc1 iRNA compositions and methods of use thereof
LT2929031T (lt) 2012-12-05 2018-02-12 Alnylam Pharmaceuticals, Inc. Pcsk9 irna kompozicijos ir jų naudojimo būdai
KR102605775B1 (ko) 2013-03-14 2023-11-29 알닐람 파마슈티칼스 인코포레이티드 보체 성분 C5 iRNA 조성물 및 그 이용 방법
CA2918194C (en) 2013-03-27 2022-12-06 The General Hospital Corporation Methods and agents for treating alzheimer's disease
AR096203A1 (es) 2013-05-06 2015-12-16 Alnylam Pharmaceuticals Inc Dosificaciones y métodos para administrar moléculas de ácido nucleico formuladas en lípidos
SG11201510565TA (en) 2013-05-22 2016-01-28 Alnylam Pharmaceuticals Inc Tmprss6 irna compositions and methods of use thereof
KR102463973B1 (ko) 2013-05-22 2022-11-07 알닐람 파마슈티칼스 인코포레이티드 SERPINA1 iRNA 조성물 및 이의 사용 방법
RU2679896C2 (ru) 2013-06-14 2019-02-14 Акамара Терапьютикс, Инк. Соединения на основе платины и липидов и наночастицы
EP2823808A1 (en) * 2013-07-09 2015-01-14 Ipsen Pharma S.A.S. Pharmaceutical composition for a sustained release of lanreotide
EP2832361A1 (en) * 2013-07-29 2015-02-04 Ipsen Pharma S.A.S. Aqueous sustained release compositions of LHRH analogs
US10077444B2 (en) 2013-10-02 2018-09-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the LECT2 gene
PE20161130A1 (es) 2013-10-04 2016-11-25 Icahn School Med Mount Sinai Composiciones y metodos para inhibir la expresion del gen alas1
IL282401B (en) 2013-12-12 2022-08-01 Alnylam Pharmaceuticals Inc Complementary component irna compositions and methods for using them
CN113057959A (zh) 2014-02-11 2021-07-02 阿尔尼拉姆医药品有限公司 己酮糖激酶(KHK)iRNA组合物及其使用方法
WO2015175510A1 (en) 2014-05-12 2015-11-19 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating a serpinc1-associated disorder
JP6811094B2 (ja) 2014-05-22 2021-01-13 アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. アンジオテンシノーゲン(AGT)iRNA組成物およびその使用
EP3191591A1 (en) 2014-09-12 2017-07-19 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting complement component c5 and methods of use thereof
JOP20200115A1 (ar) 2014-10-10 2017-06-16 Alnylam Pharmaceuticals Inc تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
WO2016061487A1 (en) 2014-10-17 2016-04-21 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
EP3904519A1 (en) 2014-10-30 2021-11-03 Genzyme Corporation Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
JOP20200092A1 (ar) 2014-11-10 2017-06-16 Alnylam Pharmaceuticals Inc تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
EP3221451A1 (en) 2014-11-17 2017-09-27 Alnylam Pharmaceuticals, Inc. Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
JP2018503685A (ja) 2015-01-20 2018-02-08 ザ・チルドレンズ・メディカル・センター・コーポレーション 線維化を処置および予防するためのならびに創傷治癒を促進するための抗net化合物
CN107205948B (zh) 2015-01-29 2021-12-14 诺和诺德股份有限公司 包含glp-1激动剂和肠溶衣的片剂
EP3256587A2 (en) 2015-02-13 2017-12-20 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
WO2016164746A1 (en) 2015-04-08 2016-10-13 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the lect2 gene
CA2982450A1 (en) 2015-04-13 2016-10-20 Alnylam Pharmaceuticals, Inc. Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
KR20180002688A (ko) 2015-05-06 2018-01-08 알닐람 파마슈티칼스 인코포레이티드 인자 XII(하게만 인자)(F12), 칼리크레인 B, 혈장(플레처 인자) 1(KLKB1) 및 키니노겐 1(KNG1) iRNA 조성물 및 그의 이용 방법
EP4365291A2 (en) 2015-06-12 2024-05-08 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
EP3310918B1 (en) 2015-06-18 2020-08-05 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
WO2016209862A1 (en) 2015-06-23 2016-12-29 Alnylam Pharmaceuticals, Inc. Glucokinase (gck) irna compositions and methods of use thereof
US10494632B2 (en) 2015-07-10 2019-12-03 Alnylam Pharmaceuticals, Inc. Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof
CN108368507B (zh) 2015-09-02 2022-03-22 阿尔尼拉姆医药品有限公司 程序性细胞死亡1配体1(PD-L1)的iRNA组合物及其使用方法
EP3350328A1 (en) 2015-09-14 2018-07-25 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
TW201718857A (zh) 2015-09-14 2017-06-01 艾爾妮蘭製藥公司 用於抑制alas1基因表現之組合物及方法
WO2017064657A1 (en) 2015-10-16 2017-04-20 Invictus Oncology Pvt. Ltd. Fluorescent anticancer platinum drugs
EP3386518A1 (en) 2015-12-07 2018-10-17 Genzyme Corporation Methods and compositions for treating a serpinc1-associated disorder
WO2017100542A1 (en) 2015-12-10 2017-06-15 Alnylam Pharmaceuticals, Inc. Sterol regulatory element binding protein (srebp) chaperone (scap) irna compositions and methods of use thereof
MA45295A (fr) 2016-04-19 2019-02-27 Alnylam Pharmaceuticals Inc Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
US20190256845A1 (en) 2016-06-10 2019-08-22 Alnylam Pharmaceuticals, Inc. COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
TWI788312B (zh) 2016-11-23 2023-01-01 美商阿尼拉製藥公司 絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
WO2018112320A1 (en) 2016-12-16 2018-06-21 Alnylam Pharmaceuticals, Inc. Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
JP7277432B2 (ja) 2017-07-13 2023-05-19 アルナイラム ファーマシューティカルズ, インコーポレイテッド 乳酸脱水素酵素A(LDHA)iRNA組成物及びその使用方法
US11866701B2 (en) 2017-11-01 2024-01-09 Alnylam Pharmaceuticals, Inc. Complement component C3 iRNA compositions and methods of use thereof
US20200385719A1 (en) 2017-11-16 2020-12-10 Alnylam Pharmaceuticals, Inc. Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
WO2019100039A1 (en) 2017-11-20 2019-05-23 Alnylam Pharmaceuticals, Inc. Serum amyloid p component (apcs) irna compositions and methods of use thereof
EP3728593A1 (en) 2017-12-18 2020-10-28 Alnylam Pharmaceuticals, Inc. High mobility group box-1 (hmgb1) irna compositions and methods of use thereof
EP3837367A1 (en) 2018-08-16 2021-06-23 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the lect2 gene
US20210332367A1 (en) 2018-09-18 2021-10-28 Alnylam Pharmaceuticals, Inc. KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
US10913951B2 (en) 2018-10-31 2021-02-09 University of Pittsburgh—of the Commonwealth System of Higher Education Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
EP4013870A1 (en) 2019-08-13 2022-06-22 Alnylam Pharmaceuticals, Inc. Small ribosomal protein subunit 25 (rps25) irna agent compositions and methods of use thereof
CN114616331A (zh) 2019-09-03 2022-06-10 阿尔尼拉姆医药品有限公司 抑制lect2基因表达的组合物和方法
EP4038189A1 (en) 2019-10-04 2022-08-10 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing ugt1a1 gene expression
WO2021087325A1 (en) 2019-11-01 2021-05-06 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing dnajb1-prkaca fusion gene expression
EP4051795A1 (en) 2019-11-01 2022-09-07 Alnylam Pharmaceuticals, Inc. Huntingtin (htt) irna agent compositions and methods of use thereof
BR112022011417A2 (pt) 2019-12-13 2022-08-30 Alnylam Pharmaceuticals Inc Composições do agente de irna da fase de leitura aberta 72 do cromossomo humano 9 (c9orf72) e métodos de uso das mesmas
WO2021154941A1 (en) 2020-01-31 2021-08-05 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
JP2023514190A (ja) 2020-02-10 2023-04-05 アルナイラム ファーマシューティカルズ, インコーポレイテッド Vegf-a発現をサイレンシングするための組成物および方法
WO2021178607A1 (en) 2020-03-05 2021-09-10 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
EP4121534A1 (en) 2020-03-18 2023-01-25 Alnylam Pharmaceuticals, Inc. Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
EP4127168A1 (en) 2020-03-26 2023-02-08 Alnylam Pharmaceuticals, Inc. Coronavirus irna compositions and methods of use thereof
US20230190785A1 (en) 2020-03-30 2023-06-22 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing dnajc15 gene expression
KR20230008729A (ko) 2020-04-06 2023-01-16 알닐람 파마슈티칼스 인코포레이티드 Myoc 발현을 사일런싱하기 위한 조성물 및 방법
WO2021207189A1 (en) 2020-04-07 2021-10-14 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing scn9a expression
WO2021206922A1 (en) 2020-04-07 2021-10-14 Alnylam Pharmaceuticals, Inc. Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
WO2021206917A1 (en) 2020-04-07 2021-10-14 Alnylam Pharmaceuticals, Inc. ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
BR112022021813A2 (pt) 2020-04-27 2023-01-17 Alnylam Pharmaceuticals Inc Composições de agente de apolipoproteína e (apoe) irna e métodos de uso das mesmas
US20230183707A1 (en) 2020-05-21 2023-06-15 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting marc1 gene expression
WO2021252557A1 (en) 2020-06-09 2021-12-16 Alnylam Pharmaceuticals, Inc. Rnai compositions and methods of use thereof for delivery by inhalation
EP4217489A1 (en) 2020-09-24 2023-08-02 Alnylam Pharmaceuticals, Inc. Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
JP2023544413A (ja) 2020-10-05 2023-10-23 アルナイラム ファーマシューティカルズ, インコーポレイテッド Gタンパク質共役受容体75(GPR75)iRNA組成物およびその使用方法
EP4232581A1 (en) 2020-10-21 2023-08-30 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating primary hyperoxaluria
EP4232582A1 (en) 2020-10-23 2023-08-30 Alnylam Pharmaceuticals, Inc. Mucin 5b (muc5b) irna compositions and methods of use thereof
WO2022119873A1 (en) 2020-12-01 2022-06-09 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
WO2022174000A2 (en) 2021-02-12 2022-08-18 Alnylam Pharmaceuticals, Inc. Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases
CN117222739A (zh) 2021-02-25 2023-12-12 阿尔尼拉姆医药品有限公司 朊病毒蛋白(prnp)irna组合物和其使用方法
WO2022192519A1 (en) 2021-03-12 2022-09-15 Alnylam Pharmaceuticals, Inc. Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
BR112023019981A2 (pt) 2021-03-29 2023-12-12 Alnylam Pharmaceuticals Inc Composições do agente irna de huntingtina (htt) e métodos de uso das mesmas
KR20220139791A (ko) * 2021-04-08 2022-10-17 주식회사 티온랩테라퓨틱스 서방성 지질 전구 제제
WO2022245583A1 (en) 2021-05-18 2022-11-24 Alnylam Pharmaceuticals, Inc. Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
EP4347822A2 (en) 2021-06-04 2024-04-10 Alnylam Pharmaceuticals, Inc. Human chromosome 9 open reading frame 72 (c9orf72) irna agent compositions and methods of use thereof
WO2023003805A1 (en) 2021-07-19 2023-01-26 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating subjects having or at risk of developing a non-primary hyperoxaluria disease or disorder
TW202334418A (zh) 2021-10-29 2023-09-01 美商艾拉倫製藥股份有限公司 杭丁頓(HTT)iRNA劑組成物及其使用方法
WO2023141314A2 (en) 2022-01-24 2023-07-27 Alnylam Pharmaceuticals, Inc. Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
WO2024059165A1 (en) 2022-09-15 2024-03-21 Alnylam Pharmaceuticals, Inc. 17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008610A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Corporation Pharmaceutical emulsion compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE512663C2 (sv) * 1997-10-23 2000-04-17 Biogram Ab Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
WO1999021533A2 (en) * 1997-10-24 1999-05-06 Neorx Corporation Delivery vehicles for bioactive agents and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008610A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Corporation Pharmaceutical emulsion compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10478470B2 (en) 2014-07-28 2019-11-19 Sk Chemicals Co., Ltd. Pharmaceutical composition containing leuprolide and having both immediate and sustained release properties

Also Published As

Publication number Publication date
IL153011A0 (en) 2003-06-24
AU2001281786B2 (en) 2005-07-21
ITMI20001173A0 (it) 2000-05-26
DE60118395T2 (de) 2006-12-07
BRPI0111016B8 (pt) 2021-05-25
US20030171299A1 (en) 2003-09-11
JP2003534265A (ja) 2003-11-18
CY1105262T1 (el) 2010-03-03
SI1283700T1 (sl) 2006-08-31
CZ302059B6 (cs) 2010-09-22
RU2272615C2 (ru) 2006-03-27
DE60118395D1 (de) 2006-05-18
EP1283700A2 (en) 2003-02-19
DK1283700T3 (da) 2006-07-24
CN1430502A (zh) 2003-07-16
HUP0301921A3 (en) 2005-11-28
YU88202A (sh) 2006-01-16
AU2001281786B8 (en) 2005-11-17
HU228926B1 (en) 2013-06-28
NO334880B1 (no) 2014-06-30
JP4954423B2 (ja) 2012-06-13
KR20030011856A (ko) 2003-02-11
WO2001089479A3 (en) 2002-03-28
PT1283700E (pt) 2006-07-31
PL203354B1 (pl) 2009-09-30
MXPA02011539A (es) 2004-08-12
US7157099B2 (en) 2007-01-02
CZ20023772A3 (cs) 2003-02-12
IT1318539B1 (it) 2003-08-27
ITMI20001173A1 (it) 2001-11-26
EP1283700B1 (en) 2006-03-29
AU8178601A (en) 2001-12-03
WO2001089479A2 (en) 2001-11-29
BRPI0111016B1 (pt) 2017-11-21
HUP0301921A2 (hu) 2003-09-29
BR0111016A (pt) 2003-04-15
NO20025621D0 (no) 2002-11-22
ES2257428T3 (es) 2006-08-01
CN100479856C (zh) 2009-04-22
CA2409854A1 (en) 2001-11-29
PL359601A1 (en) 2004-08-23
ATE321533T1 (de) 2006-04-15
HRP20020929A2 (en) 2004-02-29
CA2409854C (en) 2011-02-08
ZA200209520B (en) 2003-11-24
SK16552002A3 (sk) 2003-05-02
NO20025621L (no) 2003-01-27

Similar Documents

Publication Publication Date Title
KR100802625B1 (ko) 생물학적으로 활성인 친수성 화합물의 비경구적 투여를위한 서방성 약제학적 조성물
AU2001281786A1 (en) Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds
AU691248B2 (en) Oil-in-water emulsions
KR100220546B1 (ko) 호지성 담체 제제
EP0666752A1 (en) Therapeutic microemulsions
WO1994008605A9 (en) Therapeutic microemulsions
AU667483B2 (en) W/O microemulsions
EP0671937A1 (en) Pharmaceutical emulsion compositions
EP0671929A1 (en) Compositions
Matsuzawa et al. Absorption of insulin using water-in-oil-in-water emulsion from an enteral loop in rats
Bjerregaard et al. Sustained elevated plasma aprotinin concentration in mice following intraperitoneal injections of w/o emulsions incorporating aprotinin
KR100520738B1 (ko) 간염 치료제
JP2004043355A (ja) O/w型エマルション製剤
EP0350864B1 (en) Aqueous solution containing fat-soluble vitamin k
BRPI0808733A2 (pt) Uso de uma microemulsão aquosa para a preparação de uma formulação para o tratamento de doença adiposas
KR100524700B1 (ko) 자가미세유화형 약물전달시스템을 이용한 고지혈증치료용약제 조성물
EP0648497A1 (en) Emulsified preparation of aureobasidin
KR20060086489A (ko) 사이클로스포린-함유 연질캅셀제

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E902 Notification of reason for refusal
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
G170 Re-publication after modification of scope of protection [patent]
FPAY Annual fee payment

Payment date: 20130124

Year of fee payment: 6

FPAY Annual fee payment

Payment date: 20140124

Year of fee payment: 7

FPAY Annual fee payment

Payment date: 20150126

Year of fee payment: 8

FPAY Annual fee payment

Payment date: 20160122

Year of fee payment: 9

FPAY Annual fee payment

Payment date: 20170125

Year of fee payment: 10

FPAY Annual fee payment

Payment date: 20180125

Year of fee payment: 11

FPAY Annual fee payment

Payment date: 20190123

Year of fee payment: 12

FPAY Annual fee payment

Payment date: 20200123

Year of fee payment: 13