KR100763077B1 - 항균 퀴놀론 약제용으로 유용한 중간 물질로서의 알킬 3-시클로프로필아미노-2-[2,4-디브로모-3-(디플루오로메톡시)벤조일]-2-프로페노에이트의 원-포트 합성 방법 - Google Patents

항균 퀴놀론 약제용으로 유용한 중간 물질로서의 알킬 3-시클로프로필아미노-2-[2,4-디브로모-3-(디플루오로메톡시)벤조일]-2-프로페노에이트의 원-포트 합성 방법 Download PDF

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KR100763077B1
KR100763077B1 KR1020027011757A KR20027011757A KR100763077B1 KR 100763077 B1 KR100763077 B1 KR 100763077B1 KR 1020027011757 A KR1020027011757 A KR 1020027011757A KR 20027011757 A KR20027011757 A KR 20027011757A KR 100763077 B1 KR100763077 B1 KR 100763077B1
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formula
alkyl
difluoromethoxy
dibromo
ethyl
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KR20030017473A (ko
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보세프로센지트
쿠마르나레쉬
기요토타로
Original Assignee
랜박시 래보러터리스 리미티드
도야마 가가쿠 고교 가부시키가이샤
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Publication of KR20030017473A publication Critical patent/KR20030017473A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020027011757A 2000-03-07 2001-03-07 항균 퀴놀론 약제용으로 유용한 중간 물질로서의 알킬 3-시클로프로필아미노-2-[2,4-디브로모-3-(디플루오로메톡시)벤조일]-2-프로페노에이트의 원-포트 합성 방법 Expired - Lifetime KR100763077B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN196/DEL/2000 2000-03-07
IN196DE2000 2000-03-07
PCT/IB2001/000316 WO2001066512A1 (en) 2000-03-07 2001-03-07 One-pot synthesis of alkyl 3-cyclopropylamino-2-[2,4-dibromo-3-(difluoromethoxy)benzoyl]-2-propenoate as a useful intermediate for antibacterial quinolone medicaments

Publications (2)

Publication Number Publication Date
KR20030017473A KR20030017473A (ko) 2003-03-03
KR100763077B1 true KR100763077B1 (ko) 2007-10-04

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ID=11097039

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KR1020027011757A Expired - Lifetime KR100763077B1 (ko) 2000-03-07 2001-03-07 항균 퀴놀론 약제용으로 유용한 중간 물질로서의 알킬 3-시클로프로필아미노-2-[2,4-디브로모-3-(디플루오로메톡시)벤조일]-2-프로페노에이트의 원-포트 합성 방법

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US (1) US6835848B1 (enExample)
EP (1) EP1278717B1 (enExample)
JP (1) JP4751557B2 (enExample)
KR (1) KR100763077B1 (enExample)
CN (1) CN1202075C (enExample)
AT (1) ATE364036T1 (enExample)
AU (1) AU3590801A (enExample)
DE (1) DE60128797D1 (enExample)
WO (1) WO2001066512A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759362B2 (en) * 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
CN1244582C (zh) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 喹诺酮羧酸类化合物及其制备方法和医药用途
KR200457934Y1 (ko) * 2010-10-26 2012-01-12 주식회사 삼진엘앤디 등기구 마운팅 구조
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
CN105777631B (zh) * 2016-04-18 2018-06-29 浙江中欣氟材股份有限公司 一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的合成方法
CN105801482B (zh) * 2016-04-18 2018-06-22 浙江中欣氟材股份有限公司 一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的制备方法
CN114716373B (zh) * 2022-04-14 2023-01-10 内蒙古源宏精细化工有限公司 一种加替沙星环合酯的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2307824A1 (en) * 1997-10-27 1999-05-06 Toyama Chemical Co., Ltd. Processes for producing 7-isoindolinequinolonecarboxylic acid derivatives and intermediates therefor,salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and compositions containing the same as active ingredient.
US5935952A (en) 1994-08-12 1999-08-10 Toyama Chemical Co., Ltd. Quinolone- or naphthylidone-carboxylic acid derivates or their salts

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0784423B2 (ja) * 1987-06-18 1995-09-13 宇部興産株式会社 ３−アミノ−２−置換ベンゾイルアクリル酸誘導体
JPH05194336A (ja) * 1992-01-14 1993-08-03 Kyorin Pharmaceut Co Ltd アミノアクリル酸誘導体
JP2918134B2 (ja) * 1992-05-15 1999-07-12 宇部興産株式会社 ３−ジアルキルアミノ−２−置換ベンゾイルアクリル酸誘導体
JPH0616642A (ja) * 1992-07-02 1994-01-25 Katayama Seiyakushiyo:Kk キノリンカルボン酸誘導体の製造方法
US6531624B1 (en) * 1998-11-18 2003-03-11 Asahi Glass Company Ltd. Aminoacrylic acid derivatives and process for producing the same
EP1167344A4 (en) * 1999-03-17 2004-06-16 Daiichi Seiyaku Co PROCESS FOR THE PRODUCTION OF 5-AMINO-8-ALKYLQUINOLO NECARBOXYLIC ACID DERIVATIVES AND INTERMEDIATE PRODUCTS IN THE PRODUCTION

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935952A (en) 1994-08-12 1999-08-10 Toyama Chemical Co., Ltd. Quinolone- or naphthylidone-carboxylic acid derivates or their salts
CA2307824A1 (en) * 1997-10-27 1999-05-06 Toyama Chemical Co., Ltd. Processes for producing 7-isoindolinequinolonecarboxylic acid derivatives and intermediates therefor,salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and compositions containing the same as active ingredient.

Also Published As

Publication number Publication date
US20040267019A1 (en) 2004-12-30
JP2003534243A (ja) 2003-11-18
JP4751557B2 (ja) 2011-08-17
EP1278717A4 (en) 2005-06-08
EP1278717A1 (en) 2003-01-29
KR20030017473A (ko) 2003-03-03
CN1202075C (zh) 2005-05-18
EP1278717B1 (en) 2007-06-06
DE60128797D1 (de) 2007-07-19
WO2001066512A1 (en) 2001-09-13
CN1427815A (zh) 2003-07-02
ATE364036T1 (de) 2007-06-15
AU3590801A (en) 2001-09-17
US6835848B1 (en) 2004-12-28

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