CN1202075C - 作为抗菌剂喹诺酮药物的有用中间体的3－环丙基氨基－2－[2,4－二溴－3－(二氟甲氧基 )苯甲酰基]－2－丙烯酸烷酯的－锅合成 - Google Patents

作为抗菌剂喹诺酮药物的有用中间体的3－环丙基氨基－2－[2,4－二溴－3－(二氟甲氧基 )苯甲酰基]－2－丙烯酸烷酯的－锅合成 Download PDF

Info

Publication number
CN1202075C
CN1202075C CNB018090362A CN01809036A CN1202075C CN 1202075 C CN1202075 C CN 1202075C CN B018090362 A CNB018090362 A CN B018090362A CN 01809036 A CN01809036 A CN 01809036A CN 1202075 C CN1202075 C CN 1202075C
Authority
CN
China
Prior art keywords
formula
ethyl
dibromo
alkyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB018090362A
Other languages
English (en)
Chinese (zh)
Other versions
CN1427815A (zh
Inventor
P·鲍斯
N·库马
清都太郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd, Toyama Chemical Co Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of CN1427815A publication Critical patent/CN1427815A/zh
Application granted granted Critical
Publication of CN1202075C publication Critical patent/CN1202075C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB018090362A 2000-03-07 2001-03-07 作为抗菌剂喹诺酮药物的有用中间体的3－环丙基氨基－2－[2,4－二溴－3－(二氟甲氧基 )苯甲酰基]－2－丙烯酸烷酯的－锅合成 Expired - Lifetime CN1202075C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN196/DEL/2000 2000-03-07
IN196DE2000 2000-03-07

Publications (2)

Publication Number Publication Date
CN1427815A CN1427815A (zh) 2003-07-02
CN1202075C true CN1202075C (zh) 2005-05-18

Family

ID=11097039

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018090362A Expired - Lifetime CN1202075C (zh) 2000-03-07 2001-03-07 作为抗菌剂喹诺酮药物的有用中间体的3－环丙基氨基－2－[2,4－二溴－3－(二氟甲氧基 )苯甲酰基]－2－丙烯酸烷酯的－锅合成

Country Status (9)

Country Link
US (1) US6835848B1 (enExample)
EP (1) EP1278717B1 (enExample)
JP (1) JP4751557B2 (enExample)
KR (1) KR100763077B1 (enExample)
CN (1) CN1202075C (enExample)
AT (1) ATE364036T1 (enExample)
AU (1) AU3590801A (enExample)
DE (1) DE60128797D1 (enExample)
WO (1) WO2001066512A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759362B2 (en) * 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
CN1244582C (zh) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 喹诺酮羧酸类化合物及其制备方法和医药用途
KR200457934Y1 (ko) * 2010-10-26 2012-01-12 주식회사 삼진엘앤디 등기구 마운팅 구조
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
CN105777631B (zh) * 2016-04-18 2018-06-29 浙江中欣氟材股份有限公司 一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的合成方法
CN105801482B (zh) * 2016-04-18 2018-06-22 浙江中欣氟材股份有限公司 一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的制备方法
CN114716373B (zh) * 2022-04-14 2023-01-10 内蒙古源宏精细化工有限公司 一种加替沙星环合酯的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0784423B2 (ja) * 1987-06-18 1995-09-13 宇部興産株式会社 ３−アミノ−２−置換ベンゾイルアクリル酸誘導体
JPH05194336A (ja) * 1992-01-14 1993-08-03 Kyorin Pharmaceut Co Ltd アミノアクリル酸誘導体
JP2918134B2 (ja) * 1992-05-15 1999-07-12 宇部興産株式会社 ３−ジアルキルアミノ−２−置換ベンゾイルアクリル酸誘導体
JPH0616642A (ja) * 1992-07-02 1994-01-25 Katayama Seiyakushiyo:Kk キノリンカルボン酸誘導体の製造方法
WO1996005192A1 (en) 1994-08-12 1996-02-22 Toyama Chemical Co., Ltd. Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof
WO1999021849A1 (en) * 1997-10-27 1999-05-06 Toyama Chemical Co., Ltd. Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient
US6531624B1 (en) * 1998-11-18 2003-03-11 Asahi Glass Company Ltd. Aminoacrylic acid derivatives and process for producing the same
EP1167344A4 (en) * 1999-03-17 2004-06-16 Daiichi Seiyaku Co PROCESS FOR THE PRODUCTION OF 5-AMINO-8-ALKYLQUINOLO NECARBOXYLIC ACID DERIVATIVES AND INTERMEDIATE PRODUCTS IN THE PRODUCTION

Also Published As

Publication number Publication date
US20040267019A1 (en) 2004-12-30
JP2003534243A (ja) 2003-11-18
JP4751557B2 (ja) 2011-08-17
EP1278717A4 (en) 2005-06-08
EP1278717A1 (en) 2003-01-29
KR20030017473A (ko) 2003-03-03
EP1278717B1 (en) 2007-06-06
DE60128797D1 (de) 2007-07-19
WO2001066512A1 (en) 2001-09-13
CN1427815A (zh) 2003-07-02
ATE364036T1 (de) 2007-06-15
AU3590801A (en) 2001-09-17
US6835848B1 (en) 2004-12-28
KR100763077B1 (ko) 2007-10-04

Similar Documents

Publication Publication Date Title
CN1097583C (zh) 制备氟苯尼考的中间体的方法
US7732597B2 (en) Crystalline form of linezolid
CN1202075C (zh) 作为抗菌剂喹诺酮药物的有用中间体的3－环丙基氨基－2－[2,4－二溴－3－(二氟甲氧基 )苯甲酰基]－2－丙烯酸烷酯的－锅合成
CN107963996A (zh) 一锅法制备3-三氟甲基异噁唑化合物的方法
WO2000076960A1 (en) Process for the preparation of optically active n-acyl derivatives of methyl n-(2,6-dimethylphenyl)-d-alaninate
CN111875514A (zh) 一种制备正壬酸香草酰胺的方法
DE4237882A1 (de) Verfahren zur Herstellung von alpha-Fluor-beta-dicarbonylverbindungen
JP5751104B2 (ja) シクロヘキサントリカルボン酸無水物のトランス体製造法
US7030272B2 (en) β-hydroxyalkylamides process for their production and their use
CN109232316B (zh) 一类α-三级腈结构β-二羰基化合物的合成方法
EP0345464B1 (de) Verfahren zur Herstellung von substituierten 3-Amino-2(benzoyl)-acrylsäureestern sowie ein Verfahren zur Herstellung von Zwischenprodukten für antibakterielle Wirkstoffe aus diesen Verbindungen
CN1298384A (zh) 制备n－(1－氰基烷基)－2－苯氧基丙酰胺衍生物的改进方法
CS268827B2 (en) Method of 2,3,4,5-tetrafluorobenzoyl acetates preparation
CN106905099B (zh) 一种可见光诱导高效合成β-酮类磺酰化合物的方法
EP2155653B1 (en) Process for preparing alkyl alkoxybenzoates in one step
CN1166657C (zh) 一种二氢呋喃杂环化合物及其合成方法
JP2010222262A (ja) アルコキシｎ，ｎ−ジアルキル酢酸アミドの製造方法、及びポリマー溶液
RU2217412C2 (ru) Способ получения сложного эфира 2-алкилиден-4-бромацетоуксусной кислоты
CN108463452B (zh) 酰卤溶液的制造方法以及单酯化合物的制造方法
CN117466730A (zh) 一种苯氧羧酸盐类除草剂的制备方法
PL89681B1 (enExample)
JP3655311B2 (ja) フタリド化合物の製造方法
CN1847225A (zh) 一种喹啉类化合物及其制备方法
JPH10251190A (ja) 芳香族ケトン化合物、その製造方法およびその中間体
US5138088A (en) Nitrobenzoyl-3-cyclopropylaminoacrylates and a process for the preparation thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: TOYAMA CHEMICAL CO., LTD.

Free format text: FORMER OWNER: RANBAXY LABORATORIES LTD.

Effective date: 20101117

Free format text: FORMER OWNER: TOYAMA CHEMICAL CO., LTD.

C41 Transfer of patent application or patent right or utility model
COR Change of bibliographic data

Free format text: CORRECT: ADDRESS; FROM: NEW DELHI, INDIA TO: TOYAMA CITY, JAPAN

TR01 Transfer of patent right

Effective date of registration: 20101117

Address after: Toyama, Japan

Patentee after: Toyama Chemical Co., Ltd.

Address before: India New Delhi

Co-patentee before: Toyama Chemical Co., Ltd.

Patentee before: Ranbaxy Laboratories Ltd.

C56 Change in the name or address of the patentee
CP02 Change in the address of a patent holder

Address after: Tokyo, Japan

Patentee after: Toyama Chemical Co., Ltd.

Address before: Toyama, Japan

Patentee before: Toyama Chemical Co., Ltd.

CX01 Expiry of patent term

Granted publication date: 20050518

CX01 Expiry of patent term