ATE364036T1 - Eintopfsynthese von 3-cyclopropylamino-2- 2,4- dibromo-3-(difluoromethoxy)benzoylö-2-propensäu e alkylester als nützliches zwischenprodukt für antibakterielle quinolon-arzneistoffe - Google Patents
Eintopfsynthese von 3-cyclopropylamino-2- 2,4- dibromo-3-(difluoromethoxy)benzoylö-2-propensäu e alkylester als nützliches zwischenprodukt für antibakterielle quinolon-arzneistoffeInfo
- Publication number
- ATE364036T1 ATE364036T1 AT01908049T AT01908049T ATE364036T1 AT E364036 T1 ATE364036 T1 AT E364036T1 AT 01908049 T AT01908049 T AT 01908049T AT 01908049 T AT01908049 T AT 01908049T AT E364036 T1 ATE364036 T1 AT E364036T1
- Authority
- AT
- Austria
- Prior art keywords
- difluoromethoxy
- dibromo
- benzoylö
- cyclopropylamino
- alkyl ester
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 238000005580 one pot reaction Methods 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 229940072132 quinolone antibacterials Drugs 0.000 title 1
- -1 alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN196DE2000 | 2000-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE364036T1 true ATE364036T1 (de) | 2007-06-15 |
Family
ID=11097039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01908049T ATE364036T1 (de) | 2000-03-07 | 2001-03-07 | Eintopfsynthese von 3-cyclopropylamino-2- 2,4- dibromo-3-(difluoromethoxy)benzoylö-2-propensäu e alkylester als nützliches zwischenprodukt für antibakterielle quinolon-arzneistoffe |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6835848B1 (enExample) |
| EP (1) | EP1278717B1 (enExample) |
| JP (1) | JP4751557B2 (enExample) |
| KR (1) | KR100763077B1 (enExample) |
| CN (1) | CN1202075C (enExample) |
| AT (1) | ATE364036T1 (enExample) |
| AU (1) | AU3590801A (enExample) |
| DE (1) | DE60128797D1 (enExample) |
| WO (1) | WO2001066512A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7759362B2 (en) * | 2004-04-21 | 2010-07-20 | Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences | Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof |
| CN1244582C (zh) * | 2004-04-21 | 2006-03-08 | 中国医学科学院医药生物技术研究所 | 喹诺酮羧酸类化合物及其制备方法和医药用途 |
| KR200457934Y1 (ko) * | 2010-10-26 | 2012-01-12 | 주식회사 삼진엘앤디 | 등기구 마운팅 구조 |
| WO2013157018A1 (en) | 2012-04-18 | 2013-10-24 | Indian Institute Of Technology Madras | A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics |
| CN105777631B (zh) * | 2016-04-18 | 2018-06-29 | 浙江中欣氟材股份有限公司 | 一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的合成方法 |
| CN105801482B (zh) * | 2016-04-18 | 2018-06-22 | 浙江中欣氟材股份有限公司 | 一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的制备方法 |
| CN114716373B (zh) * | 2022-04-14 | 2023-01-10 | 内蒙古源宏精细化工有限公司 | 一种加替沙星环合酯的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0784423B2 (ja) * | 1987-06-18 | 1995-09-13 | 宇部興産株式会社 | ３−アミノ−２−置換ベンゾイルアクリル酸誘導体 |
| JPH05194336A (ja) * | 1992-01-14 | 1993-08-03 | Kyorin Pharmaceut Co Ltd | アミノアクリル酸誘導体 |
| JP2918134B2 (ja) * | 1992-05-15 | 1999-07-12 | 宇部興産株式会社 | ３−ジアルキルアミノ−２−置換ベンゾイルアクリル酸誘導体 |
| JPH0616642A (ja) * | 1992-07-02 | 1994-01-25 | Katayama Seiyakushiyo:Kk | キノリンカルボン酸誘導体の製造方法 |
| WO1996005192A1 (en) | 1994-08-12 | 1996-02-22 | Toyama Chemical Co., Ltd. | Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof |
| WO1999021849A1 (en) * | 1997-10-27 | 1999-05-06 | Toyama Chemical Co., Ltd. | Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient |
| US6531624B1 (en) * | 1998-11-18 | 2003-03-11 | Asahi Glass Company Ltd. | Aminoacrylic acid derivatives and process for producing the same |
| EP1167344A4 (en) * | 1999-03-17 | 2004-06-16 | Daiichi Seiyaku Co | PROCESS FOR THE PRODUCTION OF 5-AMINO-8-ALKYLQUINOLO NECARBOXYLIC ACID DERIVATIVES AND INTERMEDIATE PRODUCTS IN THE PRODUCTION |
-
2001
- 2001-03-07 JP JP2001565332A patent/JP4751557B2/ja not_active Expired - Lifetime
- 2001-03-07 DE DE60128797T patent/DE60128797D1/de not_active Expired - Lifetime
- 2001-03-07 US US10/221,113 patent/US6835848B1/en not_active Expired - Lifetime
- 2001-03-07 CN CNB018090362A patent/CN1202075C/zh not_active Expired - Lifetime
- 2001-03-07 AT AT01908049T patent/ATE364036T1/de not_active IP Right Cessation
- 2001-03-07 EP EP01908049A patent/EP1278717B1/en not_active Expired - Lifetime
- 2001-03-07 KR KR1020027011757A patent/KR100763077B1/ko not_active Expired - Lifetime
- 2001-03-07 AU AU35908/01A patent/AU3590801A/en not_active Abandoned
- 2001-03-07 WO PCT/IB2001/000316 patent/WO2001066512A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20040267019A1 (en) | 2004-12-30 |
| JP2003534243A (ja) | 2003-11-18 |
| JP4751557B2 (ja) | 2011-08-17 |
| EP1278717A4 (en) | 2005-06-08 |
| EP1278717A1 (en) | 2003-01-29 |
| KR20030017473A (ko) | 2003-03-03 |
| CN1202075C (zh) | 2005-05-18 |
| EP1278717B1 (en) | 2007-06-06 |
| DE60128797D1 (de) | 2007-07-19 |
| WO2001066512A1 (en) | 2001-09-13 |
| CN1427815A (zh) | 2003-07-02 |
| AU3590801A (en) | 2001-09-17 |
| US6835848B1 (en) | 2004-12-28 |
| KR100763077B1 (ko) | 2007-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |