HUP9904608A2 - Eljárás N-(amino-4,6-dihalogén-pirimidin)-formamidok előállítására - Google Patents

Eljárás N-(amino-4,6-dihalogén-pirimidin)-formamidok előállítására

Info

Publication number
HUP9904608A2
HUP9904608A2 HU9904608A HUP9904608A HUP9904608A2 HU P9904608 A2 HUP9904608 A2 HU P9904608A2 HU 9904608 A HU9904608 A HU 9904608A HU P9904608 A HUP9904608 A HU P9904608A HU P9904608 A2 HUP9904608 A2 HU P9904608A2
Authority
HU
Hungary
Prior art keywords
general formula
amino
dihalogeno
pyrimidin
producing
Prior art date
Application number
HU9904608A
Other languages
English (en)
Inventor
Walter Brieden
Elie Saikali
Original Assignee
Lonza Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag. filed Critical Lonza Ag.
Publication of HU9904608D0 publication Critical patent/HU9904608D0/hu
Publication of HUP9904608A2 publication Critical patent/HUP9904608A2/hu
Publication of HUP9904608A3 publication Critical patent/HUP9904608A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pyridine Compounds (AREA)

Abstract

A találmány tárgya új eljárás (I) vagy (II) általánős képletű N-(aminő-4,6-dihalőgén-pirimidin)-főrmamidők előállítására (III)általánős képletű 2,5-diaminő-4,6-dihalőgén-pirimidinekből. Aképletekben X jelentése halőgénatőm. Az eljárás szerint a (III)általánős képletű 2,5-diaminő-4,6-dihalőgén-pirimidin-származékőkathangyasavval reagáltatják a kívánt céltermékké. Az (I) és (II)általánős képletű vegyületek vírűsgátló hatású nűkleőtidszármazékőkintermedierjei. ŕ
HU9904608A 1998-12-21 1999-12-16 Process for producing n-(amino-4,6-dihalogeno-pyrimidin)-formamide derivatives HUP9904608A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98124188 1998-12-21
EP99100788 1999-01-18
EP99107161 1999-04-12
US14610699P 1999-07-29 1999-07-29

Publications (3)

Publication Number Publication Date
HU9904608D0 HU9904608D0 (en) 2000-03-28
HUP9904608A2 true HUP9904608A2 (hu) 2000-08-28
HUP9904608A3 HUP9904608A3 (en) 2001-03-28

Family

ID=27443679

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904608A HUP9904608A3 (en) 1998-12-21 1999-12-16 Process for producing n-(amino-4,6-dihalogeno-pyrimidin)-formamide derivatives

Country Status (16)

Country Link
US (2) US6271376B1 (hu)
EP (2) EP1013647B1 (hu)
JP (1) JP3543709B2 (hu)
KR (1) KR100645270B1 (hu)
CN (1) CN1156449C (hu)
AT (2) ATE228508T1 (hu)
CA (1) CA2293011C (hu)
CZ (2) CZ296832B6 (hu)
DE (2) DE59907401D1 (hu)
DK (1) DK1013647T3 (hu)
ES (2) ES2204798T3 (hu)
HU (1) HUP9904608A3 (hu)
NO (1) NO313878B1 (hu)
PL (1) PL337354A1 (hu)
PT (1) PT1013647E (hu)
SK (2) SK285222B6 (hu)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US7208010B2 (en) * 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
GB2344550A (en) * 1998-12-09 2000-06-14 Ibm Pad design for electronic package
KR100819895B1 (ko) 2000-10-16 2008-04-07 코너 메드시스템즈 인코포레이티드 약제 전달용 팽창 가능한 의료 장치
US20040204756A1 (en) * 2004-02-11 2004-10-14 Diaz Stephen Hunter Absorbent article with improved liquid acquisition capacity
US7056338B2 (en) * 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US20040249443A1 (en) * 2001-08-20 2004-12-09 Shanley John F. Expandable medical device for treating cardiac arrhythmias
CA2484761C (en) * 2002-05-24 2010-11-09 Angiotech International Ag Compositions and methods for coating medical implants
JP2006505364A (ja) * 2002-11-08 2006-02-16 コナー　メドシステムズ，　インコーポレイテッド 血管新生因子の局所供給を用いる、慢性全梗塞を処置するための拡張可能な医療装置および方法
CN1329088C (zh) * 2002-11-08 2007-08-01 柯诺医疗系统有限公司 用于降低局部缺血性损伤后的组织损害的方法和设备
US20040142014A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
FR2849030A1 (fr) * 2002-12-20 2004-06-25 Isochem Sa Procede de preparation des n-(2-amino-4, 6-dihalogenopyrimidin-5-yl) formamides
US20040202692A1 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device and method for in situ selective modulation of agent delivery
US20050010170A1 (en) * 2004-02-11 2005-01-13 Shanley John F Implantable medical device with beneficial agent concentration gradient
EP1610823B1 (en) 2003-03-28 2011-09-28 Innovational Holdings, LLC Implantable medical device with continuous agent concentration gradient
WO2004103979A1 (ja) * 2003-05-26 2004-12-02 Sumitomo Chemical Company, Limited Ｎ－（２－アミノ－４，６－ジクロロピリミジン－５－イル）ホルムアミドの製造方法
US7208596B2 (en) * 2003-11-25 2007-04-24 Bristol-Myers Squibb Pharma Company Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
US20050287287A1 (en) * 2004-06-24 2005-12-29 Parker Theodore L Methods and systems for loading an implantable medical device with beneficial agent
CN101003511B (zh) * 2007-01-19 2010-06-09 中国科学院上海有机化学研究所 制备2-氨基-4,6-二氯-5-甲酰氨基嘧啶的方法
CZ305457B6 (cs) 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
EP2882720A1 (en) * 2012-08-06 2015-06-17 Enantia, S.L. A process for the preparation of an intermediate for a triazolopyrimidine carbonucleoside
CN103936681B (zh) * 2014-04-04 2015-07-29 苏州开元民生科技股份有限公司 2-氨基-4,6-二氯-5-甲酰胺基嘧啶的制备方法
CN115536595B (zh) * 2022-11-29 2023-03-10 苏州开元民生科技股份有限公司 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445293A1 (de) * 1984-12-12 1986-06-12 Bayer Ag, 5090 Leverkusen Neue 2,4-diaminopyrimidine
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
CN1019575B (zh) * 1988-02-19 1992-12-23 石原产业株式会社 2-氨基-4，6-二氯嘧啶的生产方法
DE3900471A1 (de) * 1989-01-10 1990-07-12 Basf Ag Verfahren zur herstellung von 2-amino-4-fluorpyrimidinderivaten
GB8916698D0 (en) * 1989-07-21 1989-09-06 Beecham Group Plc Novel process
SK279618B6 (sk) * 1992-01-22 1999-01-11 Lonza A.G. (Dir.:Basel) N-5-chránené 2,5-diamino-4,6-dichlórpyrimidíny a s
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
CA2145928C (en) * 1994-04-27 2007-10-09 Gerhard Stucky N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation
AT402924B (de) * 1994-05-13 1997-09-25 Chemie Linz Gmbh Verfahren zur herstellung von 2-amino-4,6-dichloro-pyrimidin

Also Published As

Publication number Publication date
NO313878B1 (no) 2002-12-16
HUP9904608A3 (en) 2001-03-28
CN1156449C (zh) 2004-07-07
DK1013647T3 (da) 2003-03-10
KR20000052540A (ko) 2000-08-25
CA2293011A1 (en) 2000-06-21
DE59903535D1 (de) 2003-01-09
SK285222B6 (sk) 2006-09-07
SK283681B6 (sk) 2003-11-04
EP1013647A3 (de) 2000-10-04
JP2000191647A (ja) 2000-07-11
PT1013647E (pt) 2003-04-30
PL337354A1 (en) 2000-07-03
KR100645270B1 (ko) 2006-11-13
CA2293011C (en) 2004-08-10
CZ9904598A3 (cs) 2001-03-14
JP3543709B2 (ja) 2004-07-21
CZ296753B6 (cs) 2006-06-14
CZ296832B6 (cs) 2006-06-14
DE59907401D1 (de) 2003-11-20
CN1265393A (zh) 2000-09-06
ATE228508T1 (de) 2002-12-15
ES2204798T3 (es) 2004-05-01
NO996325D0 (no) 1999-12-20
ATE252087T1 (de) 2003-11-15
EP1188750A1 (de) 2002-03-20
US6716981B2 (en) 2004-04-06
EP1188750B1 (de) 2003-10-15
US6271376B1 (en) 2001-08-07
ES2187112T3 (es) 2003-05-16
US20010031868A1 (en) 2001-10-18
HU9904608D0 (en) 2000-03-28
EP1013647A2 (de) 2000-06-28
NO996325L (no) 2000-06-22
SK178499A3 (en) 2000-09-12
EP1013647B1 (de) 2002-11-27

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees