KR100714545B1 - 치료제로 유용한 티에노피리딘의 벤조융합된 헤테로아릴아마이드 유도체를 포함하는 약학 조성물 및 그의 사용방법 - Google Patents
치료제로 유용한 티에노피리딘의 벤조융합된 헤테로아릴아마이드 유도체를 포함하는 약학 조성물 및 그의 사용방법 Download PDFInfo
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- KR100714545B1 KR100714545B1 KR1020067019988A KR20067019988A KR100714545B1 KR 100714545 B1 KR100714545 B1 KR 100714545B1 KR 1020067019988 A KR1020067019988 A KR 1020067019988A KR 20067019988 A KR20067019988 A KR 20067019988A KR 100714545 B1 KR100714545 B1 KR 100714545B1
- Authority
- KR
- South Korea
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- prepared
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- carboxylic acid
- thieno
- indole
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- Expired - Fee Related
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- 0 CC1Oc2cc(Oc3cc**4c3[o]cc4)ccc2C1C(*)=O Chemical compound CC1Oc2cc(Oc3cc**4c3[o]cc4)ccc2C1C(*)=O 0.000 description 3
- DKMIBBCPXXRUNX-UHFFFAOYSA-N CCC(Cc(c(NC(OC(C)(C)C)=O)c1)ccc1OC)=O Chemical compound CCC(Cc(c(NC(OC(C)(C)C)=O)c1)ccc1OC)=O DKMIBBCPXXRUNX-UHFFFAOYSA-N 0.000 description 1
- WPYZXRYDNCHLNB-UHFFFAOYSA-N CCC(c1cc(nccc2Oc3ccc4c(C(NCCCN5CCOCC5)=O)c(C)[n](C)c4c3)c2[s]1)=O Chemical compound CCC(c1cc(nccc2Oc3ccc4c(C(NCCCN5CCOCC5)=O)c(C)[n](C)c4c3)c2[s]1)=O WPYZXRYDNCHLNB-UHFFFAOYSA-N 0.000 description 1
- KNLMHNGNYAEMCK-UHFFFAOYSA-N CCCCNC(c1c(C)[o]c2cc(Oc3ccnc4c3[s]cc4)ccc12)=O Chemical compound CCCCNC(c1c(C)[o]c2cc(Oc3ccnc4c3[s]cc4)ccc12)=O KNLMHNGNYAEMCK-UHFFFAOYSA-N 0.000 description 1
- DRKDDVKBYUXUAC-UHFFFAOYSA-N CCCNC(c1c(C)[s]c2cc(Oc3ccnc4c3[s]c(-c3ncc[n]3C)c4)ccc12)=O Chemical compound CCCNC(c1c(C)[s]c2cc(Oc3ccnc4c3[s]c(-c3ncc[n]3C)c4)ccc12)=O DRKDDVKBYUXUAC-UHFFFAOYSA-N 0.000 description 1
- ARGYNMKYEZDWNC-UHFFFAOYSA-N CCc([s]c1c2)c(C(NC)=O)c1ccc2O Chemical compound CCc([s]c1c2)c(C(NC)=O)c1ccc2O ARGYNMKYEZDWNC-UHFFFAOYSA-N 0.000 description 1
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- YNHOCCULFYKDQK-UHFFFAOYSA-N Cc([n](C)c1c2)c(C(NCCCO)=O)c1ccc2O Chemical compound Cc([n](C)c1c2)c(C(NCCCO)=O)c1ccc2O YNHOCCULFYKDQK-UHFFFAOYSA-N 0.000 description 1
- RWHRNPSCCGNCGJ-UHFFFAOYSA-N Cc([n](C)c1c2)c(C(NCCCO)=O)c1ccc2Oc1ccnc2c1[s]c(C(N1CCC1)=O)c2 Chemical compound Cc([n](C)c1c2)c(C(NCCCO)=O)c1ccc2Oc1ccnc2c1[s]c(C(N1CCC1)=O)c2 RWHRNPSCCGNCGJ-UHFFFAOYSA-N 0.000 description 1
- ASPNXNNUFHGNHT-AWEZNQCLSA-N Cc([o]c1c2)c(C(NC)=O)c1ccc2Oc1ccnc2c1[s]c(C(N1[C@H](CO)CCC1)=O)c2 Chemical compound Cc([o]c1c2)c(C(NC)=O)c1ccc2Oc1ccnc2c1[s]c(C(N1[C@H](CO)CCC1)=O)c2 ASPNXNNUFHGNHT-AWEZNQCLSA-N 0.000 description 1
- KKGOMHQLUWLEQT-CYBMUJFWSA-N Cc([s]c1c2)c(C(NC)=O)c1ccc2Oc1ccnc2c1[s]c(C(N(CC1)C[C@@H]1O)=O)c2 Chemical compound Cc([s]c1c2)c(C(NC)=O)c1ccc2Oc1ccnc2c1[s]c(C(N(CC1)C[C@@H]1O)=O)c2 KKGOMHQLUWLEQT-CYBMUJFWSA-N 0.000 description 1
- JSNGZHZZZAWMTI-KRWDZBQOSA-N Cc([s]c1c2)c(C(NC3CC3)=O)c1ccc2Oc1ccnc2c1[s]c(C(N1[C@H](COC)CCC1)=O)c2 Chemical compound Cc([s]c1c2)c(C(NC3CC3)=O)c1ccc2Oc1ccnc2c1[s]c(C(N1[C@H](COC)CCC1)=O)c2 JSNGZHZZZAWMTI-KRWDZBQOSA-N 0.000 description 1
- CZKQOWUNEQPWOG-UHFFFAOYSA-N Cc([s]c1c2)c(C(NCCN3CCOCC3)=O)c1ccc2Oc1ccnc2c1[s]cc2 Chemical compound Cc([s]c1c2)c(C(NCCN3CCOCC3)=O)c1ccc2Oc1ccnc2c1[s]cc2 CZKQOWUNEQPWOG-UHFFFAOYSA-N 0.000 description 1
- NUAOQCHBPXUPID-UHFFFAOYSA-N Cc1c(C(NC)=O)c(ccc(O)c2)c2[o]1 Chemical compound Cc1c(C(NC)=O)c(ccc(O)c2)c2[o]1 NUAOQCHBPXUPID-UHFFFAOYSA-N 0.000 description 1
- HUWCCPSRSXXDPO-UHFFFAOYSA-N Cc1c(C(NCCc2c[nH]c3cc(F)ccc23)=O)c(ccc(Oc2ccnc3c2[s]cc3)c2)c2[o]1 Chemical compound Cc1c(C(NCCc2c[nH]c3cc(F)ccc23)=O)c(ccc(Oc2ccnc3c2[s]cc3)c2)c2[o]1 HUWCCPSRSXXDPO-UHFFFAOYSA-N 0.000 description 1
- MXJKMGFSNGJNAL-UHFFFAOYSA-N O=C(C1)CN1C(c1ccccc1)C1=CCCC=C1 Chemical compound O=C(C1)CN1C(c1ccccc1)C1=CCCC=C1 MXJKMGFSNGJNAL-UHFFFAOYSA-N 0.000 description 1
- UUCKNXORXAJSNF-UHFFFAOYSA-N OC(C1)CN1C(c1cc(nccc2Cl)c2[s]1)=O Chemical compound OC(C1)CN1C(c1cc(nccc2Cl)c2[s]1)=O UUCKNXORXAJSNF-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38911002P | 2002-06-14 | 2002-06-14 | |
| US60/389,110 | 2002-06-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047020286A Division KR100671632B1 (ko) | 2002-06-14 | 2003-06-04 | 치료제로 유용한 티에노피리딘의 벤조융합된 헤테로아릴 아마이드 유도체 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20060110011A KR20060110011A (ko) | 2006-10-23 |
| KR100714545B1 true KR100714545B1 (ko) | 2007-05-07 |
Family
ID=29736588
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067019988A Expired - Fee Related KR100714545B1 (ko) | 2002-06-14 | 2003-06-04 | 치료제로 유용한 티에노피리딘의 벤조융합된 헤테로아릴아마이드 유도체를 포함하는 약학 조성물 및 그의 사용방법 |
| KR1020047020286A Expired - Fee Related KR100671632B1 (ko) | 2002-06-14 | 2003-06-04 | 치료제로 유용한 티에노피리딘의 벤조융합된 헤테로아릴 아마이드 유도체 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047020286A Expired - Fee Related KR100671632B1 (ko) | 2002-06-14 | 2003-06-04 | 치료제로 유용한 티에노피리딘의 벤조융합된 헤테로아릴 아마이드 유도체 |
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Families Citing this family (53)
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|---|---|---|---|---|
| KR100600550B1 (ko) * | 2000-10-20 | 2006-07-13 | 에자이 가부시키가이샤 | 질소 함유 방향환 유도체 |
| ES2293005T3 (es) | 2002-10-03 | 2008-03-16 | F. Hoffmann-La Roche Ag | Indol-3-carboxamidas como activadores de la glucocinasa. |
| EP1604665B1 (en) * | 2003-03-10 | 2011-05-11 | Eisai R&D Management Co., Ltd. | C-kit kinase inhibitor |
| US7321065B2 (en) * | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
| JP4303726B2 (ja) * | 2003-11-11 | 2009-07-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ウレア誘導体およびその製造方法 |
| US7626030B2 (en) * | 2004-01-23 | 2009-12-01 | Amgen Inc. | Compounds and methods of use |
| WO2006030941A1 (ja) | 2004-09-13 | 2006-03-23 | Eisai R & D Management Co., Ltd. | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| US8772269B2 (en) * | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| US8969379B2 (en) * | 2004-09-17 | 2015-03-03 | Eisai R&D Management Co., Ltd. | Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide |
| WO2006043172A1 (en) * | 2004-10-19 | 2006-04-27 | Pfizer Inc. | Pharmaceutical compositions and methods for sub-tenon delivery |
| WO2006117666A2 (en) * | 2005-04-29 | 2006-11-09 | Pfizer Inc. | Dosage forms, pharmaceutical compositions and methods for sub-tenon delivery |
| JP5066446B2 (ja) * | 2005-08-01 | 2012-11-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を予測する方法 |
| JP4989476B2 (ja) | 2005-08-02 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を検定する方法 |
| CN102716490A (zh) * | 2005-09-01 | 2012-10-10 | 卫材R&D管理有限公司 | 药物组合物的崩解性的改善方法 |
| AR055625A1 (es) * | 2005-09-02 | 2007-08-29 | Pfizer | Procedimientos mejorados para preparar derivados de tienopiridinas heteroaril amida benzocondensados |
| KR101353763B1 (ko) | 2005-11-07 | 2014-01-21 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 혈관 신생 저해 물질과 ｃ―ｋｉｔ 키나아제 저해 물질의병용 |
| US20090247576A1 (en) * | 2005-11-22 | 2009-10-01 | Eisai R & D Management Co., Ltd. | Anti-tumor agent for multiple myeloma |
| US8003662B2 (en) | 2006-01-30 | 2011-08-23 | Array Biopharma, Inc. | Heterobicyclic thiophene compounds and methods of use |
| AU2007214434B2 (en) * | 2006-02-15 | 2012-06-14 | Allergan, Inc. | Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
| GB0604937D0 (en) * | 2006-03-10 | 2006-04-19 | Novartis Ag | Organic compounds |
| CN104706637A (zh) * | 2006-05-18 | 2015-06-17 | 卫材R&D管理有限公司 | 针对甲状腺癌的抗肿瘤剂 |
| US20090203693A1 (en) * | 2006-06-29 | 2009-08-13 | Eisai R & D Management Co., Ltd. | Therapeutic agent for liver fibrosis |
| JP5368096B2 (ja) * | 2006-08-28 | 2013-12-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 未分化型胃癌に対する抗腫瘍剤 |
| WO2008093855A1 (ja) * | 2007-01-29 | 2008-08-07 | Eisai R & D Management Co., Ltd. | 未分化型胃癌治療用組成物 |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| WO2009026720A1 (en) * | 2007-08-29 | 2009-03-05 | Methylgene Inc. | Processes and intermediates for preparing fused heterocyclic kinase inhibitors |
| EP2183254B1 (en) * | 2007-08-29 | 2017-06-21 | MethylGene Inc. | Inhibitors of protein tyrosine kinase activity |
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