KR100692366B1 - 신규한 아가로퓨란 유도체, 그 제조 방법, 이를 포함하는약제학적 조성물 및 이들의 의약으로서의 용도 - Google Patents
신규한 아가로퓨란 유도체, 그 제조 방법, 이를 포함하는약제학적 조성물 및 이들의 의약으로서의 용도 Download PDFInfo
- Publication number
- KR100692366B1 KR100692366B1 KR1020017006257A KR20017006257A KR100692366B1 KR 100692366 B1 KR100692366 B1 KR 100692366B1 KR 1020017006257 A KR1020017006257 A KR 1020017006257A KR 20017006257 A KR20017006257 A KR 20017006257A KR 100692366 B1 KR100692366 B1 KR 100692366B1
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- oxatricyclo
- formula
- trimethyl
- ene
- Prior art date
Links
- 0 CC1C=C(C[C@@](CC2)C(C)(C)O)C2(*2)C2C1 Chemical compound CC1C=C(C[C@@](CC2)C(C)(C)O)C2(*2)C2C1 0.000 description 4
- KBWZMRLWSCPGTO-UHFFFAOYSA-N CC(C)(C(CC1)CC(C2)C1(C)CCC2O)O Chemical compound CC(C)(C(CC1)CC(C2)C1(C)CCC2O)O KBWZMRLWSCPGTO-UHFFFAOYSA-N 0.000 description 2
- ZWALUOSNFDZRGP-WXHSDQCUSA-N CC(C)([C@@H](C1)CC2)O[C@@]1(C1)[I]2CC[C@]1(C)O Chemical compound CC(C)([C@@H](C1)CC2)O[C@@]1(C1)[I]2CC[C@]1(C)O ZWALUOSNFDZRGP-WXHSDQCUSA-N 0.000 description 1
- XFLVYZMNYRXLCK-TVKKRMFBSA-N CC(C)([C@H]1CC2=CCCCC2CC1)O Chemical compound CC(C)([C@H]1CC2=CCCCC2CC1)O XFLVYZMNYRXLCK-TVKKRMFBSA-N 0.000 description 1
- OPVUQUSWUUAXFJ-AWBCAMRRSA-N CCC[C@@H]1OC(CC2)=C1[C@]1(C3)OC(C)(C)[C@@H]3CC[C@@]21I Chemical compound CCC[C@@H]1OC(CC2)=C1[C@]1(C3)OC(C)(C)[C@@H]3CC[C@@]21I OPVUQUSWUUAXFJ-AWBCAMRRSA-N 0.000 description 1
- CSSOPELYSALKNJ-HLNSBACISA-N CCC[C@H]1OC2=C1[C@]1(C3)OC(C)(C)[C@@H]3CC[C@]1(C)CC2 Chemical compound CCC[C@H]1OC2=C1[C@]1(C3)OC(C)(C)[C@@H]3CC[C@]1(C)CC2 CSSOPELYSALKNJ-HLNSBACISA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB981224474A CN1199960C (zh) | 1998-11-19 | 1998-11-19 | 新的沉香呋喃衍生物,它们的制备方法,含它们的药物组合物及它们作为药物的用途 |
| CN98122447.4 | 1998-11-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010093087A KR20010093087A (ko) | 2001-10-27 |
| KR100692366B1 true KR100692366B1 (ko) | 2007-03-09 |
Family
ID=5227777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020017006257A KR100692366B1 (ko) | 1998-11-19 | 1999-11-19 | 신규한 아가로퓨란 유도체, 그 제조 방법, 이를 포함하는약제학적 조성물 및 이들의 의약으로서의 용도 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6486201B1 (zh) |
| EP (1) | EP1132383B1 (zh) |
| JP (1) | JP4321967B2 (zh) |
| KR (1) | KR100692366B1 (zh) |
| CN (1) | CN1199960C (zh) |
| AU (1) | AU1258000A (zh) |
| DE (1) | DE69942424D1 (zh) |
| WO (1) | WO2000031058A1 (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1177842C (zh) * | 2000-05-12 | 2004-12-01 | 中国医学科学院药物研究所 | 新的沉香呋喃衍生物、它们的药物组合物及它们制备药物的用途 |
| CN1322525A (zh) * | 2000-05-12 | 2001-11-21 | 中国医学科学院药物研究所 | 去氢白木香醇衍生物作为治疗或预防脑退行性病变的药物 |
| CN108947949B (zh) * | 2017-05-19 | 2022-08-19 | 泰州华元医药科技有限公司 | 抗焦虑氘代化合物及其医药用途 |
| CN108929299A (zh) * | 2017-05-23 | 2018-12-04 | 北京元气知药科技有限公司 | 布格呋喃原料药及其制备方法和应用 |
| CN107325069B (zh) * | 2017-05-26 | 2019-12-24 | 内蒙古民族大学 | 一种倍半萜类化合物的提取方法 |
| CN108813614B (zh) * | 2018-06-13 | 2022-02-01 | 中国医学科学院药用植物研究所海南分所 | 一种沉香有效部位提取物抗焦虑抗抑郁的应用及其制备方法 |
| CN114560833B (zh) * | 2021-03-23 | 2022-10-18 | 北京承颐医药科技有限公司 | 一种沉香呋喃类化合物及其制备方法和应用 |
| CN114831943B (zh) * | 2021-12-07 | 2023-06-02 | 北京协和药厂有限公司 | 一种药物组合物的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608187A5 (en) | 1976-03-03 | 1978-12-29 | Firmenich & Cie | Perfuming composition |
-
1998
- 1998-11-19 CN CNB981224474A patent/CN1199960C/zh not_active Expired - Lifetime
-
1999
- 1999-11-19 US US09/856,125 patent/US6486201B1/en not_active Expired - Fee Related
- 1999-11-19 JP JP2000583886A patent/JP4321967B2/ja not_active Expired - Fee Related
- 1999-11-19 EP EP99955648A patent/EP1132383B1/en not_active Expired - Lifetime
- 1999-11-19 AU AU12580/00A patent/AU1258000A/en not_active Abandoned
- 1999-11-19 WO PCT/CN1999/000196 patent/WO2000031058A1/zh active IP Right Grant
- 1999-11-19 KR KR1020017006257A patent/KR100692366B1/ko not_active IP Right Cessation
- 1999-11-19 DE DE69942424T patent/DE69942424D1/de not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| Chinese Chemical Letters, 8(1), 25-26, 1997 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1258000A (en) | 2000-06-13 |
| EP1132383A4 (en) | 2002-04-17 |
| DE69942424D1 (de) | 2010-07-08 |
| EP1132383B1 (en) | 2010-05-26 |
| US6486201B1 (en) | 2002-11-26 |
| KR20010093087A (ko) | 2001-10-27 |
| CN1254713A (zh) | 2000-05-31 |
| WO2000031058A1 (fr) | 2000-06-02 |
| CN1199960C (zh) | 2005-05-04 |
| JP4321967B2 (ja) | 2009-08-26 |
| JP2002530394A (ja) | 2002-09-17 |
| EP1132383A1 (en) | 2001-09-12 |
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| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20120322 Year of fee payment: 6 |
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| LAPS | Lapse due to unpaid annual fee |