KR100561326B1 - 3'-ｎ-옥사이드, 3'-ｎ-디메틸아민, 9-옥심 에리트로마이신 ａ 유도체 - Google Patents

3'-ｎ-옥사이드, 3'-ｎ-디메틸아민, 9-옥심 에리트로마이신 ａ 유도체 Download PDF

Info

Publication number
KR100561326B1
KR100561326B1 KR1019997007251A KR19997007251A KR100561326B1 KR 100561326 B1 KR100561326 B1 KR 100561326B1 KR 1019997007251 A KR1019997007251 A KR 1019997007251A KR 19997007251 A KR19997007251 A KR 19997007251A KR 100561326 B1 KR100561326 B1 KR 100561326B1
Authority
KR
South Korea
Prior art keywords
group
alkyl
alkyl group
groups
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019997007251A
Other languages
English (en)
Korean (ko)
Other versions
KR20000070985A (ko
Inventor
쿠이-인
릴리데이비드에이
Original Assignee
아보트 러보러터리즈
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아보트 러보러터리즈 filed Critical 아보트 러보러터리즈
Publication of KR20000070985A publication Critical patent/KR20000070985A/ko
Application granted granted Critical
Publication of KR100561326B1 publication Critical patent/KR100561326B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019997007251A 1997-02-13 1998-02-03 3'-ｎ-옥사이드, 3'-ｎ-디메틸아민, 9-옥심 에리트로마이신 ａ 유도체 Expired - Fee Related KR100561326B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8/800,009 1997-02-13
US08/800,009 1997-02-13
US08/800,009 US5864023A (en) 1997-02-13 1997-02-13 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
PCT/US1998/001929 WO1998035976A1 (en) 1997-02-13 1998-02-03 3'-n-oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives

Publications (2)

Publication Number Publication Date
KR20000070985A KR20000070985A (ko) 2000-11-25
KR100561326B1 true KR100561326B1 (ko) 2006-03-16

Family

ID=25177295

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997007251A Expired - Fee Related KR100561326B1 (ko) 1997-02-13 1998-02-03 3'-ｎ-옥사이드, 3'-ｎ-디메틸아민, 9-옥심 에리트로마이신 ａ 유도체

Country Status (25)

Country Link
US (1) US5864023A (https=)
EP (1) EP0966477B1 (https=)
JP (1) JP2001512456A (https=)
KR (1) KR100561326B1 (https=)
CN (1) CN1326865C (https=)
AR (1) AR012032A1 (https=)
AT (1) ATE252108T1 (https=)
AU (1) AU725274B2 (https=)
BG (1) BG64099B1 (https=)
BR (1) BR9807349A (https=)
CA (1) CA2279932C (https=)
CZ (1) CZ294481B6 (https=)
DE (1) DE69818977T2 (https=)
DK (1) DK0966477T3 (https=)
ES (1) ES2212266T3 (https=)
HU (1) HUP0001330A3 (https=)
IL (1) IL130697A0 (https=)
NO (1) NO993876L (https=)
NZ (1) NZ336482A (https=)
PL (1) PL187357B1 (https=)
PT (1) PT966477E (https=)
SK (1) SK284157B6 (https=)
TR (1) TR199901874T2 (https=)
WO (1) WO1998035976A1 (https=)
ZA (1) ZA98986B (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100317907B1 (ko) * 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) * 1999-07-01 2001-02-05 유충식 6-오-메틸 에리트로마이신의 제조방법
KR100336447B1 (ko) * 1999-11-24 2002-05-15 민경윤 클라리스로마이신의 개선된 제조방법
AU783055B2 (en) * 1999-12-16 2005-09-22 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs and novel polymorph IV
RU2002118308A (ru) 2000-01-11 2004-02-20 Тева Фамэситикл Индастрис Лтд. (Il) Способы получения полиморфных модификаций кларитромицина
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) * 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
HUP0302466A2 (hu) * 2000-02-29 2003-11-28 Teva Pharmaceutical Industries Ltd. Eljárások clarithromycin, clarithromycin intermedier, gyakorlatilag oximmentes clarithromycin és ezt tartalmazó gyógyszerkészítmény előállítására
ATE297941T1 (de) * 2000-03-15 2005-07-15 Hanmi Pharm Ind Co Ltd Verfahren zur herstellung von einer kristallinen form ii von clarythromycin
KR20000037126A (ko) * 2000-04-08 2000-07-05 김용규 6-메틸 에리스로마이신 ａ의 제조방법
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
CA2533358C (en) * 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005009365A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
AU2004258953B2 (en) * 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
US8758820B2 (en) * 2003-08-11 2014-06-24 Shionogi Inc. Robust pellet
JP2007502294A (ja) * 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
US8246996B2 (en) * 2003-08-29 2012-08-21 Shionogi Inc. Antibiotic product, use and formulation thereof
JP2007513869A (ja) * 2003-09-15 2007-05-31 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
JP2007517039A (ja) * 2003-12-24 2007-06-28 アドバンシス ファーマスーティカル コーポレイション 変性放出製剤の吸収増強
US8715727B2 (en) * 2004-07-02 2014-05-06 Shionogi Inc. Tablet for pulsed delivery
US7694523B2 (en) * 2004-07-19 2010-04-13 Earthrenew, Inc. Control system for gas turbine in material treatment unit
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
WO2009023191A2 (en) * 2007-08-09 2009-02-19 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of clarithromycin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
US4672109A (en) * 1984-04-06 1987-06-09 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin A derivatives
EP0254534A2 (en) * 1986-07-24 1988-01-27 William S. Robinson Erythromycin derivatives and compositions and use for inhibiting virus replication and disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
JPS61229895A (ja) * 1985-04-03 1986-10-14 Nippon Zeon Co Ltd 保護化デス−ｎ−メチルエリスロマイシン誘導体
DE3782994T2 (de) * 1986-09-18 1993-04-08 Taisho Pharma Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4672109A (en) * 1984-04-06 1987-06-09 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin A derivatives
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
EP0254534A2 (en) * 1986-07-24 1988-01-27 William S. Robinson Erythromycin derivatives and compositions and use for inhibiting virus replication and disease

Also Published As

Publication number Publication date
ATE252108T1 (de) 2003-11-15
SK97499A3 (en) 2000-01-18
BG103673A (en) 2000-02-29
PL335301A1 (en) 2000-04-10
AU6260898A (en) 1998-09-08
DE69818977T2 (de) 2004-08-12
BR9807349A (pt) 2000-04-25
CZ270499A3 (cs) 1999-11-17
DE69818977D1 (en) 2003-11-20
AR012032A1 (es) 2000-09-27
IL130697A0 (en) 2000-06-01
HUP0001330A2 (hu) 2000-08-28
AU725274B2 (en) 2000-10-12
EP0966477B1 (en) 2003-10-15
KR20000070985A (ko) 2000-11-25
TR199901874T2 (xx) 2000-04-21
NO993876D0 (no) 1999-08-11
WO1998035976A1 (en) 1998-08-20
ZA98986B (en) 1998-08-05
CN1326865C (zh) 2007-07-18
NZ336482A (en) 2001-02-23
CN1246864A (zh) 2000-03-08
BG64099B1 (bg) 2003-12-31
DK0966477T3 (da) 2004-02-23
JP2001512456A (ja) 2001-08-21
CA2279932C (en) 2008-04-22
PL187357B1 (pl) 2004-06-30
US5864023A (en) 1999-01-26
HUP0001330A3 (en) 2000-09-28
CZ294481B6 (cs) 2005-01-12
PT966477E (pt) 2004-03-31
CA2279932A1 (en) 1998-08-20
SK284157B6 (sk) 2004-10-05
EP0966477A1 (en) 1999-12-29
ES2212266T3 (es) 2004-07-16
NO993876L (no) 1999-08-11

Similar Documents

Publication Publication Date Title
KR100561326B1 (ko) 3'-ｎ-옥사이드, 3'-ｎ-디메틸아민, 9-옥심 에리트로마이신 ａ 유도체
JP4116674B2 (ja) ２′―保護，３′―ジメチルアミン，９―エーテルオキシム エリスロマイシンａ誘導体
US5872229A (en) Process for 6-O-alkylation of erythromycin derivatives
US5929219A (en) 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
EP1040107B1 (en) 6-o-alkyl derivatives of erythronolide b
KR100565025B1 (ko) 6-ｏ-알킬 에리트로마이신 ａ의 제조방법 및 이를 위한 중간체
WATANABE et al. CHEMICAL MODIFICATION OF ERYTHROMYCINS. IX. 1) SELECTIVE METHYLATION AT THE C-6 HYDROXYL GROUP OF ERYTHROMYCIN A OXIME DERIVATIVES AND PREPARATION OF CLARITHROMYCIN
JP4040877B2 (ja) クラリスロマイシンの製造方法
MXPA99007519A (en) 3'-n-oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
CA2250736C (en) 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin a derivatives
KR20010032613A (ko) 6-ｏ-알킬 에리트로마이신 ｃ의 화학적 합성 방법
KR20010010096A (ko) 클라리스로마이신의 제조방법 및 이에 사용되는 중간체
MXPA00005402A (en) 6-o-alkyl derivatives of erythronolide b

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20090121

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20100310

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20100310

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000