KR100560038B1 - 치환된 4-페닐-4-시아노시클로헥사노산의 제조 방법 - Google Patents

치환된 4-페닐-4-시아노시클로헥사노산의 제조 방법 Download PDF

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Publication number
KR100560038B1
KR100560038B1 KR1020007003742A KR20007003742A KR100560038B1 KR 100560038 B1 KR100560038 B1 KR 100560038B1 KR 1020007003742 A KR1020007003742 A KR 1020007003742A KR 20007003742 A KR20007003742 A KR 20007003742A KR 100560038 B1 KR100560038 B1 KR 100560038B1
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South Korea
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substituted
compound
formula
alkyl
water
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KR1020007003742A
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English (en)
Korean (ko)
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KR20010015709A (ko
Inventor
케빈 웹
윌포드 멘델손
지안하오 첸
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스미스클라인 비참 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020007003742A 1997-10-10 1998-10-07 치환된 4-페닐-4-시아노시클로헥사노산의 제조 방법 Expired - Fee Related KR100560038B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10
US60/061,613 1997-10-10
PCT/US1998/021061 WO1999018793A1 (en) 1997-10-10 1998-10-07 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (2)

Publication Number Publication Date
KR20010015709A KR20010015709A (ko) 2001-02-26
KR100560038B1 true KR100560038B1 (ko) 2006-03-13

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007003742A Expired - Fee Related KR100560038B1 (ko) 1997-10-10 1998-10-07 치환된 4-페닐-4-시아노시클로헥사노산의 제조 방법

Country Status (30)

Country Link
EP (1) EP1043930A4 (enExample)
JP (1) JP2001519363A (enExample)
KR (1) KR100560038B1 (enExample)
CN (1) CN1192025C (enExample)
AP (1) AP1335A (enExample)
AR (1) AR015952A1 (enExample)
AU (1) AU741832B2 (enExample)
BG (1) BG104302A (enExample)
BR (1) BR9814064A (enExample)
CA (1) CA2305614A1 (enExample)
DZ (1) DZ2619A1 (enExample)
EA (1) EA003609B1 (enExample)
HU (1) HUP0003905A3 (enExample)
ID (1) ID25536A (enExample)
IL (1) IL135434A (enExample)
MA (1) MA24670A1 (enExample)
MY (1) MY122105A (enExample)
NO (1) NO20001777L (enExample)
NZ (1) NZ503759A (enExample)
OA (1) OA11347A (enExample)
PE (1) PE121599A1 (enExample)
PL (1) PL191974B1 (enExample)
SA (1) SA99191000A (enExample)
SK (1) SK4902000A3 (enExample)
TR (1) TR200000945T2 (enExample)
TW (1) TW440557B (enExample)
UA (1) UA67753C2 (enExample)
UY (2) UY25201A1 (enExample)
WO (1) WO1999018793A1 (enExample)
ZA (1) ZA989228B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
JP2003534238A (ja) * 1999-12-15 2003-11-18 スミスクライン・ビーチャム・コーポレイション シス−４−シアノ−４−［３−（シクロペンチルオキシ）−４−メトキシフェニル］シクロヘキサン−１−カルボン酸の塩。
IL150400A0 (en) * 2000-01-26 2002-12-01 Smithkline Beecham Corp Monohydrate of cis-lithium-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl] cyclohexanecarboxylate
EP1265861A2 (en) 2000-03-16 2002-12-18 Inflazyme Pharmaceuticals, Ltd. Benzylated pde4 inhibitors
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
OA12542A (en) 2001-01-31 2006-06-05 Pfizer Prod Inc Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4isozymes.
ES2248231T3 (es) 2001-01-31 2006-03-16 Pfizer Products Inc. Derivados de eteres utiles como inhibidores de las isozimas pde4.
CA2436535A1 (en) 2001-01-31 2002-08-08 Prizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552438A (en) * 1992-04-02 1996-09-03 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
AR012550A1 (es) * 1997-02-12 2000-11-08 Smithkline Beecham Corp Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos y compuestos intermediarios
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552438A (en) * 1992-04-02 1996-09-03 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases

Also Published As

Publication number Publication date
PE121599A1 (es) 2000-02-19
AP1335A (en) 2004-11-29
EA200000406A1 (ru) 2000-10-30
UA67753C2 (uk) 2004-07-15
BR9814064A (pt) 2000-09-26
UY25201A1 (es) 2001-08-27
HUP0003905A3 (en) 2002-01-28
HUP0003905A2 (en) 2001-03-28
SA99191000A (ar) 2005-12-03
ID25536A (id) 2000-10-12
ZA989228B (en) 1999-04-12
DZ2619A1 (fr) 2003-03-08
NO20001777D0 (no) 2000-04-06
NZ503759A (en) 2002-03-01
CA2305614A1 (en) 1999-04-22
AP2000001782A0 (en) 2000-06-30
IL135434A0 (en) 2001-05-20
NO20001777L (no) 2000-05-03
MY122105A (en) 2006-03-31
CN1275052A (zh) 2000-11-29
BG104302A (en) 2001-08-31
TR200000945T2 (tr) 2000-10-23
KR20010015709A (ko) 2001-02-26
PL191974B1 (pl) 2006-07-31
JP2001519363A (ja) 2001-10-23
OA11347A (en) 2003-12-17
AR015952A1 (es) 2001-05-30
AU741832B2 (en) 2001-12-13
EP1043930A1 (en) 2000-10-18
PL339759A1 (en) 2001-01-02
IL135434A (en) 2004-12-15
MA24670A1 (fr) 1999-07-01
EA003609B1 (ru) 2003-06-26
AU9687498A (en) 1999-05-03
EP1043930A4 (en) 2004-09-15
TW440557B (en) 2001-06-16
UY25524A1 (es) 2000-02-23
CN1192025C (zh) 2005-03-09
WO1999018793A1 (en) 1999-04-22
SK4902000A3 (en) 2000-11-07

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