DZ2619A1 - Procédé pour la préparation d'acides 4-phényl-4-cyanocyclohexanoïques substitués. - Google Patents

Procédé pour la préparation d'acides 4-phényl-4-cyanocyclohexanoïques substitués.

Info

Publication number
DZ2619A1
DZ2619A1 DZ980229A DZ980229A DZ2619A1 DZ 2619 A1 DZ2619 A1 DZ 2619A1 DZ 980229 A DZ980229 A DZ 980229A DZ 980229 A DZ980229 A DZ 980229A DZ 2619 A1 DZ2619 A1 DZ 2619A1
Authority
DZ
Algeria
Prior art keywords
phenyl
substituted
preparation
cyanocyclohexanoic
acids
Prior art date
Application number
DZ980229A
Other languages
English (en)
French (fr)
Inventor
Kevin Webb
Wilford Mendelson
Jian-Hoa Chen
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of DZ2619A1 publication Critical patent/DZ2619A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DZ980229A 1997-10-10 1998-10-07 Procédé pour la préparation d'acides 4-phényl-4-cyanocyclohexanoïques substitués. DZ2619A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10

Publications (1)

Publication Number Publication Date
DZ2619A1 true DZ2619A1 (fr) 2003-03-08

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ980229A DZ2619A1 (fr) 1997-10-10 1998-10-07 Procédé pour la préparation d'acides 4-phényl-4-cyanocyclohexanoïques substitués.

Country Status (30)

Country Link
EP (1) EP1043930A4 (enExample)
JP (1) JP2001519363A (enExample)
KR (1) KR100560038B1 (enExample)
CN (1) CN1192025C (enExample)
AP (1) AP1335A (enExample)
AR (1) AR015952A1 (enExample)
AU (1) AU741832B2 (enExample)
BG (1) BG104302A (enExample)
BR (1) BR9814064A (enExample)
CA (1) CA2305614A1 (enExample)
DZ (1) DZ2619A1 (enExample)
EA (1) EA003609B1 (enExample)
HU (1) HUP0003905A3 (enExample)
ID (1) ID25536A (enExample)
IL (1) IL135434A (enExample)
MA (1) MA24670A1 (enExample)
MY (1) MY122105A (enExample)
NO (1) NO20001777L (enExample)
NZ (1) NZ503759A (enExample)
OA (1) OA11347A (enExample)
PE (1) PE121599A1 (enExample)
PL (1) PL191974B1 (enExample)
SA (1) SA99191000A (enExample)
SK (1) SK4902000A3 (enExample)
TR (1) TR200000945T2 (enExample)
TW (1) TW440557B (enExample)
UA (1) UA67753C2 (enExample)
UY (2) UY25201A1 (enExample)
WO (1) WO1999018793A1 (enExample)
ZA (1) ZA989228B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
JP2003534238A (ja) * 1999-12-15 2003-11-18 スミスクライン・ビーチャム・コーポレイション シス−4−シアノ−4−[3−(シクロペンチルオキシ)−4−メトキシフェニル]シクロヘキサン−1−カルボン酸の塩。
IL150400A0 (en) * 2000-01-26 2002-12-01 Smithkline Beecham Corp Monohydrate of cis-lithium-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl] cyclohexanecarboxylate
EP1265861A2 (en) 2000-03-16 2002-12-18 Inflazyme Pharmaceuticals, Ltd. Benzylated pde4 inhibitors
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
OA12542A (en) 2001-01-31 2006-06-05 Pfizer Prod Inc Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4isozymes.
ES2248231T3 (es) 2001-01-31 2006-03-16 Pfizer Products Inc. Derivados de eteres utiles como inhibidores de las isozimas pde4.
CA2436535A1 (en) 2001-01-31 2002-08-08 Prizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
SK279958B6 (sk) * 1992-04-02 1999-06-11 Smithkline Beecham Corporation Zlúčeniny s protialergickým a protizápalovým účink
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
AR012550A1 (es) * 1997-02-12 2000-11-08 Smithkline Beecham Corp Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos y compuestos intermediarios
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
PE121599A1 (es) 2000-02-19
AP1335A (en) 2004-11-29
EA200000406A1 (ru) 2000-10-30
UA67753C2 (uk) 2004-07-15
BR9814064A (pt) 2000-09-26
UY25201A1 (es) 2001-08-27
HUP0003905A3 (en) 2002-01-28
HUP0003905A2 (en) 2001-03-28
SA99191000A (ar) 2005-12-03
ID25536A (id) 2000-10-12
ZA989228B (en) 1999-04-12
NO20001777D0 (no) 2000-04-06
NZ503759A (en) 2002-03-01
CA2305614A1 (en) 1999-04-22
AP2000001782A0 (en) 2000-06-30
IL135434A0 (en) 2001-05-20
NO20001777L (no) 2000-05-03
MY122105A (en) 2006-03-31
CN1275052A (zh) 2000-11-29
BG104302A (en) 2001-08-31
KR100560038B1 (ko) 2006-03-13
TR200000945T2 (tr) 2000-10-23
KR20010015709A (ko) 2001-02-26
PL191974B1 (pl) 2006-07-31
JP2001519363A (ja) 2001-10-23
OA11347A (en) 2003-12-17
AR015952A1 (es) 2001-05-30
AU741832B2 (en) 2001-12-13
EP1043930A1 (en) 2000-10-18
PL339759A1 (en) 2001-01-02
IL135434A (en) 2004-12-15
MA24670A1 (fr) 1999-07-01
EA003609B1 (ru) 2003-06-26
AU9687498A (en) 1999-05-03
EP1043930A4 (en) 2004-09-15
TW440557B (en) 2001-06-16
UY25524A1 (es) 2000-02-23
CN1192025C (zh) 2005-03-09
WO1999018793A1 (en) 1999-04-22
SK4902000A3 (en) 2000-11-07

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