KR100557899B1 - 비색 분석 방법 및 이것에 이용하는 시약 - Google Patents
비색 분석 방법 및 이것에 이용하는 시약 Download PDFInfo
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- KR100557899B1 KR100557899B1 KR1020037015691A KR20037015691A KR100557899B1 KR 100557899 B1 KR100557899 B1 KR 100557899B1 KR 1020037015691 A KR1020037015691 A KR 1020037015691A KR 20037015691 A KR20037015691 A KR 20037015691A KR 100557899 B1 KR100557899 B1 KR 100557899B1
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- bipyridyl
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
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- Urology & Nephrology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Spectrometry And Color Measurement (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (24)
- 산화 환원 효소에 의해, 분석 대상물로부터, 미디에이터를 통하여, 환원에 의해 발색하는 발색제에 전자를 전달하고, 그 결과 발생하는 상기 발색제의 발색을 측정함으로써, 상기 분석 대상물의 정성 혹은 정량을 행하는 비색 분석 방법으로서, 상기 미디에이터가 구리 착체, 철 착체, 오스뮴 착체 및 루테늄 착체로 이루어지는 그룹 중에서 선택된 적어도 1개인 것을 특징으로 하는 비색 분석 방법.
- 제1항에 있어서, 상기 착체의 배위자의 배위 원자가 질소, 산소 및 황으로 이루어지는 그룹 중에서 선택된 적어도 1개인 것을 특징으로 하는 비색 분석 방법.
- 제1항에 있어서, 상기 착체의 배위자가 암모니아, 비피리딜 화합물, 이미다졸 화합물, 페난트롤린 화합물, 에틸렌디아민 화합물, 아미노산, 트리아진 화합물, 비퀴놀린 화합물, 피리딜아조 화합물, 니트로소 화합물, 옥신 화합물, 벤조티아졸 화합물, 아세틸아세톤 화합물, 안트라퀴논 화합물, 크산텐 화합물, 옥살산 및 상기 각 화합물의 유도체로 이루어지는 그룹에서 선택되는 적어도 1개이고,상기 각 화합물의 유도체는, 배위자인 상기 각 화합물의 배위 위치 이외에 있어서의 수소 원자의 적어도 1개가 치환기에 의해 치환된 것이고, 상기 치환기가 알킬기, 아릴기, 알릴기, 페닐기, 히드록시기, 알콕시기, 카르복시기, 카르보닐기, 술폰기, 술포닐기, 니트로기, 니트로소기, 1급 아민, 2급 아민, 3급 아민, 아미노기, 아실기, 아미드기 및 할로겐기로 이루어지는 그룹 중에서 선택된 적어도 1개인 것을 특징으로 하는 비색 분석 방법.
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- 제1항에 있어서, 착체가 배위자를 2종류 이상 갖는 것을 특징으로 하는 비색 분석 방법.
- 제1항에 있어서, 산화 환원 효소가 탈수소 효소 혹은 산화 효소인 것을 특징으로 하는 비색 분석 방법.
- 제1항 내지 제3항, 제6항 및 제7항 중 어느 한 항에 있어서, 발색제가 테트라졸륨염인 것을 특징으로 하는 비색 분석 방법.
- 제8항에 있어서, 테트라졸륨염이 니트로페닐기, 티아졸릴기 및 벤조티아졸릴기의 적어도 1개의 기를 갖는 것을 특징으로 하는 비색 분석 방법.
- 제8항에 있어서, 테트라졸륨염이 MTT, INT, 네오-TB, 니트로-TB, TB, WST-1, WST-3, WST-4, WST-5, WST-8, 2-(2-벤조티아졸릴)-3,5-디페닐테트라졸륨브로마이 드, 2-(2-벤조티아졸릴)-3-(4-니트로페닐)-5-페닐테트라졸륨브로마이드, 2,3-비스(4-니트로페닐)-5-페닐테트라졸륨클로라이드, 2,3-디(4-니트로페닐)테트라졸륨퍼클로레이트, 3-(3-니트로페닐)-5-메틸-2-페닐테트라졸륨클로라이드, 및, 3-(4-니트로페닐)-5-메틸-2-페닐테트라졸륨클로라이드로 이루어지는 그룹 중에서 선택된 적어도 1개의 발색제인 것을 특징으로 하는 비색 분석 방법.
- 제1항에 있어서, 분석 대상물이 글루코오스, 콜레스테롤, 요산, 피루브산, 크레아틴, 크레아티닌 혹은 유산이며, 산화 환원 효소가 상기 각 물질에 대응하는 탈수소 효소 혹은 산화 효소인 것을 특징으로 하는 비색 분석 방법.
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001400380 | 2001-12-28 | ||
JPJP-P-2001-00400380 | 2001-12-28 | ||
PCT/JP2003/000027 WO2003057905A1 (fr) | 2001-12-28 | 2003-01-06 | Procede de colorimetrie et reactif utilise dans ce procede |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020067001158A Division KR100693899B1 (ko) | 2001-12-28 | 2003-01-06 | 비색 분석 방법에 이용하는 시약 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20040010671A KR20040010671A (ko) | 2004-01-31 |
KR100557899B1 true KR100557899B1 (ko) | 2006-03-10 |
Family
ID=19189611
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020037015691A KR100557899B1 (ko) | 2001-12-28 | 2003-01-06 | 비색 분석 방법 및 이것에 이용하는 시약 |
KR1020067001158A KR100693899B1 (ko) | 2001-12-28 | 2003-01-06 | 비색 분석 방법에 이용하는 시약 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020067001158A KR100693899B1 (ko) | 2001-12-28 | 2003-01-06 | 비색 분석 방법에 이용하는 시약 |
Country Status (14)
Country | Link |
---|---|
US (2) | US7550273B2 (ko) |
EP (2) | EP1457572B1 (ko) |
JP (1) | JP4045323B2 (ko) |
KR (2) | KR100557899B1 (ko) |
CN (1) | CN1261588C (ko) |
AT (2) | ATE426676T1 (ko) |
AU (1) | AU2003201901B2 (ko) |
CA (1) | CA2448128C (ko) |
DE (2) | DE60326814D1 (ko) |
ES (2) | ES2350507T3 (ko) |
NZ (1) | NZ529279A (ko) |
PL (1) | PL213316B1 (ko) |
WO (1) | WO2003057905A1 (ko) |
ZA (1) | ZA200308519B (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL213316B1 (pl) | 2001-12-28 | 2013-02-28 | Arkray | Sposób analizy kolorymetrycznej, odczynnik i próbka do badan |
CN1306039C (zh) * | 2001-12-28 | 2007-03-21 | 爱科来株式会社 | 比色分析方法及其使用的试剂 |
JP4717637B2 (ja) * | 2004-01-07 | 2011-07-06 | アークレイ株式会社 | 試薬部の配置を改良した分析用具および分析方法 |
WO2009144881A1 (ja) * | 2008-05-16 | 2009-12-03 | パナソニック株式会社 | クレアチニン濃度の測定方法、測定デバイス、及び測定装置、並びにそれらを用いた塩分量の測定方法、測定デバイス、及び測定装置 |
EP2636750A1 (en) | 2012-03-06 | 2013-09-11 | Roche Diagniostics GmbH | Compatible solute ectoine as well as derivatives thereof for enzyme stabilization |
EP2994536B1 (en) | 2013-05-08 | 2017-06-14 | Roche Diabetes Care GmbH | Stabilization of enzymes by nicotinic acid |
EP2927319A1 (en) | 2014-03-31 | 2015-10-07 | Roche Diagnostics GmbH | High load enzyme immobilization by crosslinking |
ES2756714T3 (es) | 2014-08-25 | 2020-04-27 | Hoffmann La Roche | Tira reactiva de dos electrodos que compensan la interferencia |
EP3523639A4 (en) | 2016-10-05 | 2020-06-03 | H. Hoffnabb-La Roche Ag | DETECTION REAGENTS AND ELECTRODE ARRANGEMENTS FOR DIAGNOSTIC MULTIANALYTE TEST ELEMENTS AND METHOD FOR USE THEREOF |
US11986288B2 (en) | 2017-03-06 | 2024-05-21 | Medtronic Minimed, Inc. | Colorometric sensor for the non-invasive screening of glucose in sweat in pre and type 2 diabetes |
WO2018165180A1 (en) | 2017-03-06 | 2018-09-13 | Medtronic Minimed, Inc. | Colorometric sensor for the non-invasive screening of glucose in sweat in pre and type 2 diabetes |
JP7072797B2 (ja) * | 2018-02-20 | 2022-05-23 | 公立大学法人山陽小野田市立山口東京理科大学 | 化合物及び光触媒用助触媒 |
CN116018084A (zh) | 2020-09-18 | 2023-04-25 | 美敦力迷你迈德公司 | 酮体感测装置和方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4233402A (en) * | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
JPS57192483A (en) | 1981-05-21 | 1982-11-26 | Mitsubishi Electric Corp | Electrochromic display element consisting of organic metal complex |
DE3374019D1 (en) * | 1982-07-23 | 1987-11-12 | Wako Pure Chem Ind Ltd | Process for quantitative determination of substrate treated with oxidase |
US4701420A (en) * | 1985-04-01 | 1987-10-20 | Eastman Kodak Company | Analytical compositions, elements and methods utilizing reduction of ferric ion chelates to form detectable dyes |
US5036000A (en) * | 1986-12-16 | 1991-07-30 | Enzymatics, Inc. | Threshold color control system |
JPH0659236B2 (ja) | 1987-12-14 | 1994-08-10 | 理化学研究所 | 生体基質濃度の測定方法及びそれに使用する酸素センサー |
AU640162B2 (en) | 1989-08-28 | 1993-08-19 | Lifescan, Inc. | Blood separation and analyte detection techniques |
JPH0343096A (ja) | 1990-06-18 | 1991-02-25 | Iatron Lab Inc | 基質又は酵素の定量方法 |
WO1992015701A1 (en) | 1991-02-27 | 1992-09-17 | Boehringer Mannheim Corporation | Improved method and reagent for determination of an analyte |
US5264348A (en) | 1991-05-13 | 1993-11-23 | Miles Inc. | Ascorbate interference-resistant composition, device and method of assaying for predetermined analyte |
FR2699170B1 (fr) | 1992-12-15 | 1995-07-28 | Asulab Sa | Complexes d'un métal de transition à ligands 2,2'-bipyridine substitués par au moins un radical ammonium alkyle, leur procédé de fabrication et leur application comme médiateur redox. |
JP3217066B2 (ja) | 1993-01-28 | 2001-10-09 | ロシュ ダイアグノスティックス コーポレーション | アナライトの嫌気的定量に有用な組成物 |
ES2182892T3 (es) * | 1995-02-14 | 2003-03-16 | Roche Diagnostics Corp | Mediador redox conteniendo osmio. |
US5938917A (en) * | 1995-04-05 | 1999-08-17 | The Regents Of The University Of California | Electrodes for measurement of peroxides |
JP3881415B2 (ja) | 1997-03-11 | 2007-02-14 | ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 免疫分析装置 |
WO1999017115A1 (en) * | 1997-09-30 | 1999-04-08 | Amira Medical | Membrane based electrochemical test device and related methods |
ES2206853T3 (es) * | 1998-11-10 | 2004-05-16 | Unilever N.V. | Catalizadores de blanqueo y oxidacion. |
AU7590300A (en) | 1999-09-20 | 2001-04-24 | Roche Diagnostics Corporation | Small volume biosensor for continuous analyte monitoring |
CN1306039C (zh) | 2001-12-28 | 2007-03-21 | 爱科来株式会社 | 比色分析方法及其使用的试剂 |
PL213316B1 (pl) | 2001-12-28 | 2013-02-28 | Arkray | Sposób analizy kolorymetrycznej, odczynnik i próbka do badan |
-
2003
- 2003-01-06 PL PL369143A patent/PL213316B1/pl unknown
- 2003-01-06 AT AT03700461T patent/ATE426676T1/de active
- 2003-01-06 US US10/476,298 patent/US7550273B2/en not_active Expired - Lifetime
- 2003-01-06 ES ES08006461T patent/ES2350507T3/es not_active Expired - Lifetime
- 2003-01-06 DE DE60326814T patent/DE60326814D1/de not_active Expired - Lifetime
- 2003-01-06 KR KR1020037015691A patent/KR100557899B1/ko active IP Right Grant
- 2003-01-06 AT AT08006461T patent/ATE482285T1/de active
- 2003-01-06 JP JP2003558198A patent/JP4045323B2/ja not_active Expired - Lifetime
- 2003-01-06 CA CA002448128A patent/CA2448128C/en not_active Expired - Fee Related
- 2003-01-06 DE DE60334333T patent/DE60334333D1/de not_active Expired - Lifetime
- 2003-01-06 EP EP03700461A patent/EP1457572B1/en not_active Expired - Lifetime
- 2003-01-06 EP EP08006461A patent/EP1942195B1/en not_active Expired - Lifetime
- 2003-01-06 ES ES03700461T patent/ES2322990T3/es not_active Expired - Lifetime
- 2003-01-06 CN CNB038006049A patent/CN1261588C/zh not_active Expired - Lifetime
- 2003-01-06 KR KR1020067001158A patent/KR100693899B1/ko active IP Right Grant
- 2003-01-06 AU AU2003201901A patent/AU2003201901B2/en not_active Ceased
- 2003-01-06 WO PCT/JP2003/000027 patent/WO2003057905A1/ja active Application Filing
- 2003-01-06 NZ NZ529279A patent/NZ529279A/en not_active IP Right Cessation
- 2003-10-31 ZA ZA200308519A patent/ZA200308519B/en unknown
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2009
- 2009-05-20 US US12/469,403 patent/US8574896B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP1942195A1 (en) | 2008-07-09 |
JP4045323B2 (ja) | 2008-02-13 |
KR20060010872A (ko) | 2006-02-02 |
US20040142406A1 (en) | 2004-07-22 |
EP1457572B1 (en) | 2009-03-25 |
EP1457572A1 (en) | 2004-09-15 |
US7550273B2 (en) | 2009-06-23 |
CA2448128C (en) | 2009-07-14 |
CN1522302A (zh) | 2004-08-18 |
AU2003201901A1 (en) | 2003-07-24 |
PL213316B1 (pl) | 2013-02-28 |
NZ529279A (en) | 2005-12-23 |
ES2322990T3 (es) | 2009-07-03 |
ZA200308519B (en) | 2004-11-04 |
KR20040010671A (ko) | 2004-01-31 |
EP1942195B1 (en) | 2010-09-22 |
ATE482285T1 (de) | 2010-10-15 |
EP1457572A4 (en) | 2006-04-05 |
US20090233322A1 (en) | 2009-09-17 |
AU2003201901B2 (en) | 2006-09-21 |
CN1261588C (zh) | 2006-06-28 |
WO2003057905A1 (fr) | 2003-07-17 |
ATE426676T1 (de) | 2009-04-15 |
CA2448128A1 (en) | 2003-06-28 |
JPWO2003057905A1 (ja) | 2005-05-19 |
KR100693899B1 (ko) | 2007-03-12 |
DE60334333D1 (de) | 2010-11-04 |
PL369143A1 (en) | 2005-04-18 |
US8574896B2 (en) | 2013-11-05 |
DE60326814D1 (de) | 2009-05-07 |
ES2350507T3 (es) | 2011-01-24 |
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