KR100538669B1 - 리간드 쌍의 결합 검출에 사용되는 화합물, 이를 포함하는조성물 및 키트 - Google Patents

리간드 쌍의 결합 검출에 사용되는 화합물, 이를 포함하는조성물 및 키트 Download PDF

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Publication number
KR100538669B1
KR100538669B1 KR10-2004-7013511A KR20047013511A KR100538669B1 KR 100538669 B1 KR100538669 B1 KR 100538669B1 KR 20047013511 A KR20047013511 A KR 20047013511A KR 100538669 B1 KR100538669 B1 KR 100538669B1
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acid
formula
tag
group
moi
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Korean (ko)
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KR20040081811A (ko
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반네스제프리
테이본존씨
하우버트제이제프리
멀리건존티
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퀴아진 지노믹스, 인코포레이티드
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Publication of KR20040081811A publication Critical patent/KR20040081811A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/167—Mass label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/627—Detection means characterised by use of a special device being a mass spectrometer

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Saccharide Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR10-2004-7013511A 1996-01-23 1997-01-23 리간드 쌍의 결합 검출에 사용되는 화합물, 이를 포함하는조성물 및 키트 Expired - Fee Related KR100538669B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1043696P 1996-01-23 1996-01-23
US60/010,436 1996-01-23
US1540296P 1996-03-21 1996-03-21
US60/015,402 1996-03-21
PCT/US1997/001070 WO1997027327A2 (en) 1996-01-23 1997-01-23 Methods and compositions for detecting binding of ligand pair using non-fluorescent label

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR10-1998-0705636A Division KR100473903B1 (ko) 1996-01-23 1997-01-23 리간드쌍의결합을검출하는방법

Publications (2)

Publication Number Publication Date
KR20040081811A KR20040081811A (ko) 2004-09-22
KR100538669B1 true KR100538669B1 (ko) 2005-12-26

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KR10-2004-7013511A Expired - Fee Related KR100538669B1 (ko) 1996-01-23 1997-01-23 리간드 쌍의 결합 검출에 사용되는 화합물, 이를 포함하는조성물 및 키트
KR10-1998-0705636A Expired - Fee Related KR100473903B1 (ko) 1996-01-23 1997-01-23 리간드쌍의결합을검출하는방법

Family Applications After (1)

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KR10-1998-0705636A Expired - Fee Related KR100473903B1 (ko) 1996-01-23 1997-01-23 리간드쌍의결합을검출하는방법

Country Status (17)

Country Link
EP (1) EP0850320B1 (enExample)
JP (2) JP2000507091A (enExample)
KR (2) KR100538669B1 (enExample)
CN (2) CN1159452C (enExample)
AT (1) ATE187501T1 (enExample)
AU (1) AU717330B2 (enExample)
BR (1) BR9707060A (enExample)
CA (1) CA2243989A1 (enExample)
CZ (1) CZ218398A3 (enExample)
DE (1) DE69700902T2 (enExample)
ES (1) ES2143848T3 (enExample)
GR (1) GR3032843T3 (enExample)
HU (1) HUP9900459A3 (enExample)
NZ (1) NZ331042A (enExample)
PL (1) PL328272A1 (enExample)
PT (1) PT850320E (enExample)
WO (1) WO1997027327A2 (enExample)

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Publication number Publication date
CN1159452C (zh) 2004-07-28
AU717330B2 (en) 2000-03-23
PL328272A1 (en) 1999-01-18
EP0850320A2 (en) 1998-07-01
BR9707060A (pt) 1999-12-28
CZ218398A3 (cs) 1998-12-16
DE69700902D1 (de) 2000-01-13
HUP9900459A2 (hu) 1999-06-28
PT850320E (pt) 2000-05-31
ES2143848T3 (es) 2000-05-16
KR100473903B1 (ko) 2005-09-30
KR19990081923A (ko) 1999-11-15
JP2000507091A (ja) 2000-06-13
HUP9900459A3 (en) 1999-11-29
AU1707997A (en) 1997-08-20
CN1515541A (zh) 2004-07-28
ATE187501T1 (de) 1999-12-15
DE69700902T2 (de) 2000-07-20
JP2008220370A (ja) 2008-09-25
WO1997027327A2 (en) 1997-07-31
EP0850320B1 (en) 1999-12-08
CA2243989A1 (en) 1997-07-31
WO1997027327A3 (en) 1997-11-20
CN1212019A (zh) 1999-03-24
GR3032843T3 (en) 2000-07-31
NZ331042A (en) 1999-10-28
KR20040081811A (ko) 2004-09-22

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