KR100536095B1 - 3,3-디페닐-프로필아민의 신규한 유도체의 안정한 염 - Google Patents

3,3-디페닐-프로필아민의 신규한 유도체의 안정한 염 Download PDF

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Publication number
KR100536095B1
KR100536095B1 KR10-2002-7006306A KR20027006306A KR100536095B1 KR 100536095 B1 KR100536095 B1 KR 100536095B1 KR 20027006306 A KR20027006306 A KR 20027006306A KR 100536095 B1 KR100536095 B1 KR 100536095B1
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South Korea
Prior art keywords
acid
phenyl
propyl
diisopropylamino
formula
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Expired - Fee Related
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KR10-2002-7006306A
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English (en)
Korean (ko)
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KR20020059744A (ko
Inventor
클라우스 미세
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쉬바르츠파르마에이지
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7929277&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100536095(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 쉬바르츠파르마에이지 filed Critical 쉬바르츠파르마에이지
Publication of KR20020059744A publication Critical patent/KR20020059744A/ko
Application granted granted Critical
Publication of KR100536095B1 publication Critical patent/KR100536095B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Luminescent Compositions (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR10-2002-7006306A 1999-11-16 2000-11-15 3,3-디페닐-프로필아민의 신규한 유도체의 안정한 염 Expired - Fee Related KR100536095B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19955190A DE19955190A1 (de) 1999-11-16 1999-11-16 Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen
DE19955190.1 1999-11-16

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020057018318A Division KR100563149B1 (ko) 1999-11-16 2000-11-15 3,3-디페닐-프로필아민의 신규한 유도체의 안정한 염
KR10-2005-7001429A Division KR100486394B1 (ko) 1999-11-16 2000-11-15 3,3-디페닐-프로필아민의 신규한 유도체의 안정한 염

Publications (2)

Publication Number Publication Date
KR20020059744A KR20020059744A (ko) 2002-07-13
KR100536095B1 true KR100536095B1 (ko) 2005-12-12

Family

ID=7929277

Family Applications (2)

Application Number Title Priority Date Filing Date
KR10-2002-7006306A Expired - Fee Related KR100536095B1 (ko) 1999-11-16 2000-11-15 3,3-디페닐-프로필아민의 신규한 유도체의 안정한 염
KR1020057018318A Expired - Lifetime KR100563149B1 (ko) 1999-11-16 2000-11-15 3,3-디페닐-프로필아민의 신규한 유도체의 안정한 염

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020057018318A Expired - Lifetime KR100563149B1 (ko) 1999-11-16 2000-11-15 3,3-디페닐-프로필아민의 신규한 유도체의 안정한 염

Country Status (30)

Country Link
US (1) US6858650B1 (enExample)
EP (3) EP1481964B1 (enExample)
JP (6) JP4083431B2 (enExample)
KR (2) KR100536095B1 (enExample)
CN (1) CN1215045C (enExample)
AT (3) ATE395056T1 (enExample)
AU (1) AU778132B2 (enExample)
BR (1) BRPI0015610C1 (enExample)
CA (1) CA2389749C (enExample)
CY (2) CY1106204T1 (enExample)
CZ (2) CZ302497B6 (enExample)
DE (5) DE29923134U1 (enExample)
DK (3) DK1690536T3 (enExample)
EA (1) EA005588B1 (enExample)
ES (3) ES2236032T7 (enExample)
GE (1) GEP20084430B (enExample)
HK (1) HK1045148B (enExample)
HU (2) HU227608B1 (enExample)
IL (2) IL149567A0 (enExample)
IS (2) IS2124B (enExample)
MX (1) MXPA02004603A (enExample)
NO (2) NO323920B1 (enExample)
NZ (1) NZ519230A (enExample)
PL (1) PL201422B1 (enExample)
PT (3) PT1690536E (enExample)
SI (3) SI1230209T1 (enExample)
SK (3) SK287430B6 (enExample)
UA (2) UA73324C2 (enExample)
WO (1) WO2001035957A1 (enExample)
ZA (1) ZA200203315B (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
DE29923134U1 (de) * 1999-11-16 2000-06-29 Schwarz Pharma Ag, 40789 Monheim Stabile Salze neuartiger Derviate von 3,3-Diphenylpropylaminen
DE10028443C1 (de) * 2000-06-14 2002-05-29 Sanol Arznei Schwarz Gmbh Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
DE10315878B4 (de) * 2003-04-08 2009-06-04 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Fesoterodin und Verwendung
WO2005012227A2 (en) * 2003-08-05 2005-02-10 Ranbaxy Laboratories Limited Process for preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, a metabolite of tolterodine
ES2235648B1 (es) * 2003-12-22 2006-11-01 Ragactives, S.L. Procedimiento para la obtencion de tolterodina.
US8034823B2 (en) 2005-02-22 2011-10-11 Savvipharm Inc Method of increasing drug oral bioavailability and compositions of less toxic orotate salts
KR100647068B1 (ko) 2005-09-15 2006-11-23 하나제약 주식회사 라세믹ｎ,ｎ-디이소프로필-3-(2-히드록시-5-메틸페닐)-3-페닐프로판아민의 제조방법
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EP1940774B1 (en) * 2006-05-31 2014-03-05 Schwarz Pharma Ltd. New synthesis of substituted hydroxymethyl phenols
IES20060424A2 (en) * 2006-06-08 2007-10-31 Schwarz Pharma Ltd Accelerated synthesis of (3-Diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)phenol and its phenolic monoesters
US7807715B2 (en) 2006-06-09 2010-10-05 Ucb Pharma Gmbh Pharmaceutical compositions comprising fesoterodine
PE20080331A1 (es) * 2006-06-09 2008-06-19 Sanol Arznei Schwarz Gmbh Composiciones farmaceuticas estabilizadas que comprenden fesoterodina
ATE477234T1 (de) 2006-06-09 2010-08-15 Schwarz Pharma Ltd Synthese von phenolischen estern von hydroxymethylphenolen
BRPI0712842A2 (pt) * 2006-06-12 2012-07-24 Sanol Arznei Schwarz Gmbh internediÁrio quiral, processo para produÇço do mesmo e seu emprego na fabricaÇço da tolterodina, fesoterodina ou o metabàlito ativo das mesmas.
IES20060435A2 (en) 2006-06-12 2007-12-12 Schwarz Pharma Ltd Shortened synthesis using paraformaldehyde or trioxane
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US20100297241A1 (en) * 2007-10-01 2010-11-25 Actavis Group Ptc Ehf Amorphous Fesoterodine Fumarate
EP2294047A2 (en) * 2008-04-04 2011-03-16 Actavis Group PTC EHF Novel mandelate salt of fesoterodine
EP2323967A2 (en) * 2008-07-21 2011-05-25 Actavis Group PTC EHF Fesoterodine comprising a reduced amount of dehydroxyfesoterodine
IT1392082B1 (it) * 2008-12-10 2012-02-09 Chemi Spa Nuove forme solide della fesoterodina fumarato
MX2011011937A (es) 2009-05-11 2012-01-27 Ratiopharm Gmbh Desfesoterodina en la forma de una sal del acido tartarico.
IT1394219B1 (it) * 2009-05-15 2012-06-01 Chemi Spa Metodo di preparazione di fesoterodina fumarato di elevata purezza.
IT1394217B1 (it) * 2009-05-15 2012-06-01 Chemi Spa Metodo di preparazione di fesoterodina e/o fesoterodina fumarato.
US20120220655A1 (en) 2009-09-03 2012-08-30 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Crystalline forms of fesoterodine fumarate and fesoterodine base
IT1396373B1 (it) * 2009-10-29 2012-11-19 Dipharma Francis Srl Procedimento per la preparazione di fesoterodina.
EP2316432A1 (de) 2009-10-30 2011-05-04 ratiopharm GmbH Zusammensetzung enthaltend Fesoterodin und Ballaststoffe
US20110124903A1 (en) * 2009-11-20 2011-05-26 Actavis Group Ptc Ehf Solid state forms of fesoterodine intermediates
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IT1397920B1 (it) * 2010-02-08 2013-02-04 Dipharma Francis Srl Forma cristallina di fesoterodina fumarato e procedimento per la sua preparazione
EP2549985A1 (en) 2010-03-22 2013-01-30 Cadila Healthcare Limited Stable pharmaceutical compositions comprising fesoterodine
US8748433B2 (en) 2010-04-30 2014-06-10 Merck Sharp & Dohme Corp. β3 adrenergic receptor agonists
WO2011141932A2 (en) 2010-05-11 2011-11-17 Intas Pharmaceuticals Limited Process for preparation of phenolic monoesters of hydroxymethyl phenols
WO2011145019A1 (en) * 2010-05-17 2011-11-24 Orchid Chemicals And Pharmaceuticals Limited Improved process for diphenylpropylamine derivatives
IT1401451B1 (it) 2010-06-10 2013-07-26 Chemi Spa Nuovo processo di preparazione di 2-idrossi-4-fenil-3,4-diidro-2h-cromen-6-il-metanolo e (r)-2-[3-(diisopropilammino)-1-fenilpropil]-4-(idrossimetil)fenolo.
WO2011158257A1 (en) 2010-06-18 2011-12-22 Panacea Biotec Ltd Preparation process of fesoterodine and intermediates
WO2012025941A2 (en) 2010-08-25 2012-03-01 Cadila Healthcare Limited Processes for the preparation of fesoterodine
IT1403094B1 (it) * 2010-12-09 2013-10-04 Dipharma Francis Srl Procedimento per la preparazione di fesoterodina o un suo sale
WO2012098560A2 (en) * 2011-01-17 2012-07-26 Msn Laboratories Limited Process for the preparation of muscarinic receptor antagonist
TWI520732B (zh) 2011-01-18 2016-02-11 輝瑞有限公司 固體分子分散液
EP2508173A1 (en) 2011-04-08 2012-10-10 LEK Pharmaceuticals d.d. Stabilized pharmaceutical composition comprising fesoterodine
EP2508175A1 (en) 2011-04-08 2012-10-10 LEK Pharmaceuticals d.d. Pharmaceutical composition comprising fesoterodine or a salt or a solvate thereof
US9422228B2 (en) 2012-05-04 2016-08-23 Crystal Pharma, S.A.U. Process for the preparation of optically pure fesoterodine derivatives
ITMI20121232A1 (it) 2012-07-16 2014-01-17 Cambrex Profarmaco Milano Srl Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati
TR201721437A2 (tr) 2017-12-25 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Fesoterodi̇ni̇n modi̇fi̇ye salim sağlayan formülasyonlari
CN116472262A (zh) * 2020-10-27 2023-07-21 威娜德国有限责任公司 化妆品级品质的2-甲氧基甲基-对苯二胺

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DE29923134U1 (de) * 1999-11-16 2000-06-29 Schwarz Pharma Ag, 40789 Monheim Stabile Salze neuartiger Derviate von 3,3-Diphenylpropylaminen

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DK1230209T3 (da) 2005-05-30
JP2003514018A (ja) 2003-04-15
EA005588B1 (ru) 2005-04-28
JP2011148824A (ja) 2011-08-04
DE50009239D1 (de) 2005-02-17
DE50013365D1 (de) 2006-10-05
EP1481964B1 (de) 2006-08-23
JP2010180243A (ja) 2010-08-19
CY1106204T1 (el) 2011-06-08
ES2270240T3 (es) 2007-04-01
NO323920B1 (no) 2007-07-23
PL356766A1 (en) 2004-07-12
PT1230209E (pt) 2005-05-31
EP1690536B1 (de) 2008-05-14
IS8382A (is) 2006-03-29
WO2001035957A1 (de) 2001-05-25
SK288384B6 (sk) 2016-08-01
UA73324C2 (uk) 2005-07-15
MXPA02004603A (es) 2004-09-10
BR0015610A (pt) 2002-07-30
PT1690536E (pt) 2008-07-14
SI1481964T1 (sl) 2006-12-31
CA2389749C (en) 2009-03-31
EP1230209B3 (de) 2011-10-05
ATE395056T1 (de) 2008-05-15
CN1390194A (zh) 2003-01-08
HUP0204034A3 (en) 2004-12-28
JP2010180242A (ja) 2010-08-19
EA200200511A1 (ru) 2002-10-31
AU2666701A (en) 2001-05-30
SK288185B6 (sk) 2014-04-02
ZA200203315B (en) 2003-09-23
SI1690536T1 (sl) 2008-08-31
IS6351A (is) 2002-04-19
HUP0204034A2 (hu) 2003-03-28
DE19955190A1 (de) 2001-06-21
CZ20021343A3 (cs) 2002-09-11
WO2001035957A8 (de) 2001-06-21
DE50015163D1 (de) 2008-06-26
IS2673B (is) 2010-09-15
IL149567A0 (en) 2002-11-10
HU228197B1 (en) 2013-01-28
JP5503393B2 (ja) 2014-05-28
HK1045148A1 (en) 2002-11-15
US6858650B1 (en) 2005-02-22
JP5290351B2 (ja) 2013-09-18
DE29923134U1 (de) 2000-06-29
CY1110389T1 (el) 2015-04-29
EP1230209B1 (de) 2005-01-12
EP1481964A1 (de) 2004-12-01
CA2389749A1 (en) 2001-05-25
UA77322C2 (en) 2006-11-15
KR20050100711A (ko) 2005-10-19
ATE337293T1 (de) 2006-09-15
JP4083431B2 (ja) 2008-04-30
BR0015610B8 (pt) 2017-10-31
BRPI0015610B1 (pt) 2016-04-19
CZ302967B6 (cs) 2012-01-25
NZ519230A (en) 2004-11-26
HK1067114A1 (en) 2005-04-01
SI1230209T1 (en) 2005-06-30
JP2014111589A (ja) 2014-06-19
IS2124B (is) 2006-07-14
HU227608B1 (en) 2011-09-28
DK1690536T3 (da) 2008-09-01
WO2001035957A3 (de) 2001-12-27
DK1481964T3 (da) 2006-11-27
KR20020059744A (ko) 2002-07-13
AU778132B2 (en) 2004-11-18
EP1230209A2 (de) 2002-08-14
HU0900587D0 (en) 2009-11-30
IL149567A (en) 2007-08-19
HK1095736A1 (en) 2007-05-18
NO20065380L (no) 2002-05-15
EP1690536A3 (de) 2006-08-23
PT1481964E (pt) 2006-12-29
SK6572002A3 (en) 2002-12-03
GEP20084430B (enExample) 2008-07-25
HK1045148B (zh) 2005-05-06
HUP0900587A3 (en) 2010-04-28
JP5650924B2 (ja) 2015-01-07
BRPI0015610C1 (pt) 2021-05-25
PL201422B1 (pl) 2009-04-30
KR100563149B1 (ko) 2006-03-21
ES2236032T3 (es) 2005-07-16
CN1215045C (zh) 2005-08-17
JP5717824B2 (ja) 2015-05-13
EP1690536A2 (de) 2006-08-16
ES2236032T7 (es) 2012-06-14
ATE286872T1 (de) 2005-01-15
NO20022314D0 (no) 2002-05-15
NO332637B1 (no) 2012-11-26
NO20022314L (no) 2002-05-15
ES2303708T3 (es) 2008-08-16
SK287430B6 (sk) 2010-09-07
JP2007137895A (ja) 2007-06-07
CZ302497B6 (cs) 2011-06-15

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