DK1690536T3 - Anvendelse af R-( )-2-(3-diisopropylamino-1-phenylpropyl)4-4-hydroxy-methyl-phenylsobutyrat hydrogenfumarat til behandling af urininkontinens og andre spasmogene lidelser - Google Patents

Anvendelse af R-( )-2-(3-diisopropylamino-1-phenylpropyl)4-4-hydroxy-methyl-phenylsobutyrat hydrogenfumarat til behandling af urininkontinens og andre spasmogene lidelser

Info

Publication number
DK1690536T3
DK1690536T3 DK06011207T DK06011207T DK1690536T3 DK 1690536 T3 DK1690536 T3 DK 1690536T3 DK 06011207 T DK06011207 T DK 06011207T DK 06011207 T DK06011207 T DK 06011207T DK 1690536 T3 DK1690536 T3 DK 1690536T3
Authority
DK
Denmark
Prior art keywords
phenylsobutyrate
spasmogenic
diisopropylamino
phenylpropyl
disorders
Prior art date
Application number
DK06011207T
Other languages
Danish (da)
English (en)
Inventor
Claus Meese
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7929277&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1690536(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Application granted granted Critical
Publication of DK1690536T3 publication Critical patent/DK1690536T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Luminescent Compositions (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK06011207T 1999-11-16 2000-11-15 Anvendelse af R-( )-2-(3-diisopropylamino-1-phenylpropyl)4-4-hydroxy-methyl-phenylsobutyrat hydrogenfumarat til behandling af urininkontinens og andre spasmogene lidelser DK1690536T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19955190A DE19955190A1 (de) 1999-11-16 1999-11-16 Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen
PCT/EP2000/011309 WO2001035957A1 (de) 1999-11-16 2000-11-15 Stabile salze neuartiger derivate von 3,3-diphenylpropylaminen

Publications (1)

Publication Number Publication Date
DK1690536T3 true DK1690536T3 (da) 2008-09-01

Family

ID=7929277

Family Applications (3)

Application Number Title Priority Date Filing Date
DK06011207T DK1690536T3 (da) 1999-11-16 2000-11-15 Anvendelse af R-( )-2-(3-diisopropylamino-1-phenylpropyl)4-4-hydroxy-methyl-phenylsobutyrat hydrogenfumarat til behandling af urininkontinens og andre spasmogene lidelser
DK04018487T DK1481964T3 (da) 1999-11-16 2000-11-15 Stabile salte af hidtil ukendte derivater af 3,3-diphenylpropylaminer
DK00989857T DK1230209T3 (da) 1999-11-16 2000-11-15 Stabile salte af hidtil ukendte derivater af 3,3-diphenylpropylaminer

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK04018487T DK1481964T3 (da) 1999-11-16 2000-11-15 Stabile salte af hidtil ukendte derivater af 3,3-diphenylpropylaminer
DK00989857T DK1230209T3 (da) 1999-11-16 2000-11-15 Stabile salte af hidtil ukendte derivater af 3,3-diphenylpropylaminer

Country Status (30)

Country Link
US (1) US6858650B1 (enExample)
EP (3) EP1481964B1 (enExample)
JP (6) JP4083431B2 (enExample)
KR (2) KR100536095B1 (enExample)
CN (1) CN1215045C (enExample)
AT (3) ATE395056T1 (enExample)
AU (1) AU778132B2 (enExample)
BR (1) BRPI0015610C1 (enExample)
CA (1) CA2389749C (enExample)
CY (2) CY1106204T1 (enExample)
CZ (2) CZ302497B6 (enExample)
DE (5) DE29923134U1 (enExample)
DK (3) DK1690536T3 (enExample)
EA (1) EA005588B1 (enExample)
ES (3) ES2236032T7 (enExample)
GE (1) GEP20084430B (enExample)
HK (1) HK1045148B (enExample)
HU (2) HU227608B1 (enExample)
IL (2) IL149567A0 (enExample)
IS (2) IS2124B (enExample)
MX (1) MXPA02004603A (enExample)
NO (2) NO323920B1 (enExample)
NZ (1) NZ519230A (enExample)
PL (1) PL201422B1 (enExample)
PT (3) PT1690536E (enExample)
SI (3) SI1230209T1 (enExample)
SK (3) SK287430B6 (enExample)
UA (2) UA73324C2 (enExample)
WO (1) WO2001035957A1 (enExample)
ZA (1) ZA200203315B (enExample)

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EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
DE29923134U1 (de) * 1999-11-16 2000-06-29 Schwarz Pharma Ag, 40789 Monheim Stabile Salze neuartiger Derviate von 3,3-Diphenylpropylaminen
DE10028443C1 (de) * 2000-06-14 2002-05-29 Sanol Arznei Schwarz Gmbh Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
DE10315878B4 (de) * 2003-04-08 2009-06-04 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Fesoterodin und Verwendung
WO2005012227A2 (en) * 2003-08-05 2005-02-10 Ranbaxy Laboratories Limited Process for preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, a metabolite of tolterodine
ES2235648B1 (es) * 2003-12-22 2006-11-01 Ragactives, S.L. Procedimiento para la obtencion de tolterodina.
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PE20080331A1 (es) * 2006-06-09 2008-06-19 Sanol Arznei Schwarz Gmbh Composiciones farmaceuticas estabilizadas que comprenden fesoterodina
ATE477234T1 (de) 2006-06-09 2010-08-15 Schwarz Pharma Ltd Synthese von phenolischen estern von hydroxymethylphenolen
BRPI0712842A2 (pt) * 2006-06-12 2012-07-24 Sanol Arznei Schwarz Gmbh internediÁrio quiral, processo para produÇço do mesmo e seu emprego na fabricaÇço da tolterodina, fesoterodina ou o metabàlito ativo das mesmas.
IES20060435A2 (en) 2006-06-12 2007-12-12 Schwarz Pharma Ltd Shortened synthesis using paraformaldehyde or trioxane
WO2009037569A2 (en) * 2007-09-21 2009-03-26 Actavis Group Ptc Ehf An improved process for the preparation of fesoterodine
US20100297241A1 (en) * 2007-10-01 2010-11-25 Actavis Group Ptc Ehf Amorphous Fesoterodine Fumarate
EP2294047A2 (en) * 2008-04-04 2011-03-16 Actavis Group PTC EHF Novel mandelate salt of fesoterodine
EP2323967A2 (en) * 2008-07-21 2011-05-25 Actavis Group PTC EHF Fesoterodine comprising a reduced amount of dehydroxyfesoterodine
IT1392082B1 (it) * 2008-12-10 2012-02-09 Chemi Spa Nuove forme solide della fesoterodina fumarato
MX2011011937A (es) 2009-05-11 2012-01-27 Ratiopharm Gmbh Desfesoterodina en la forma de una sal del acido tartarico.
IT1394219B1 (it) * 2009-05-15 2012-06-01 Chemi Spa Metodo di preparazione di fesoterodina fumarato di elevata purezza.
IT1394217B1 (it) * 2009-05-15 2012-06-01 Chemi Spa Metodo di preparazione di fesoterodina e/o fesoterodina fumarato.
US20120220655A1 (en) 2009-09-03 2012-08-30 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Crystalline forms of fesoterodine fumarate and fesoterodine base
IT1396373B1 (it) * 2009-10-29 2012-11-19 Dipharma Francis Srl Procedimento per la preparazione di fesoterodina.
EP2316432A1 (de) 2009-10-30 2011-05-04 ratiopharm GmbH Zusammensetzung enthaltend Fesoterodin und Ballaststoffe
US20110124903A1 (en) * 2009-11-20 2011-05-26 Actavis Group Ptc Ehf Solid state forms of fesoterodine intermediates
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IT1397920B1 (it) * 2010-02-08 2013-02-04 Dipharma Francis Srl Forma cristallina di fesoterodina fumarato e procedimento per la sua preparazione
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WO2011145019A1 (en) * 2010-05-17 2011-11-24 Orchid Chemicals And Pharmaceuticals Limited Improved process for diphenylpropylamine derivatives
IT1401451B1 (it) 2010-06-10 2013-07-26 Chemi Spa Nuovo processo di preparazione di 2-idrossi-4-fenil-3,4-diidro-2h-cromen-6-il-metanolo e (r)-2-[3-(diisopropilammino)-1-fenilpropil]-4-(idrossimetil)fenolo.
WO2011158257A1 (en) 2010-06-18 2011-12-22 Panacea Biotec Ltd Preparation process of fesoterodine and intermediates
WO2012025941A2 (en) 2010-08-25 2012-03-01 Cadila Healthcare Limited Processes for the preparation of fesoterodine
IT1403094B1 (it) * 2010-12-09 2013-10-04 Dipharma Francis Srl Procedimento per la preparazione di fesoterodina o un suo sale
WO2012098560A2 (en) * 2011-01-17 2012-07-26 Msn Laboratories Limited Process for the preparation of muscarinic receptor antagonist
TWI520732B (zh) 2011-01-18 2016-02-11 輝瑞有限公司 固體分子分散液
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EP2508175A1 (en) 2011-04-08 2012-10-10 LEK Pharmaceuticals d.d. Pharmaceutical composition comprising fesoterodine or a salt or a solvate thereof
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DE29923134U1 (de) * 1999-11-16 2000-06-29 Schwarz Pharma Ag, 40789 Monheim Stabile Salze neuartiger Derviate von 3,3-Diphenylpropylaminen

Also Published As

Publication number Publication date
DK1230209T3 (da) 2005-05-30
KR100536095B1 (ko) 2005-12-12
JP2003514018A (ja) 2003-04-15
EA005588B1 (ru) 2005-04-28
JP2011148824A (ja) 2011-08-04
DE50009239D1 (de) 2005-02-17
DE50013365D1 (de) 2006-10-05
EP1481964B1 (de) 2006-08-23
JP2010180243A (ja) 2010-08-19
CY1106204T1 (el) 2011-06-08
ES2270240T3 (es) 2007-04-01
NO323920B1 (no) 2007-07-23
PL356766A1 (en) 2004-07-12
PT1230209E (pt) 2005-05-31
EP1690536B1 (de) 2008-05-14
IS8382A (is) 2006-03-29
WO2001035957A1 (de) 2001-05-25
SK288384B6 (sk) 2016-08-01
UA73324C2 (uk) 2005-07-15
MXPA02004603A (es) 2004-09-10
BR0015610A (pt) 2002-07-30
PT1690536E (pt) 2008-07-14
SI1481964T1 (sl) 2006-12-31
CA2389749C (en) 2009-03-31
EP1230209B3 (de) 2011-10-05
ATE395056T1 (de) 2008-05-15
CN1390194A (zh) 2003-01-08
HUP0204034A3 (en) 2004-12-28
JP2010180242A (ja) 2010-08-19
EA200200511A1 (ru) 2002-10-31
AU2666701A (en) 2001-05-30
SK288185B6 (sk) 2014-04-02
ZA200203315B (en) 2003-09-23
SI1690536T1 (sl) 2008-08-31
IS6351A (is) 2002-04-19
HUP0204034A2 (hu) 2003-03-28
DE19955190A1 (de) 2001-06-21
CZ20021343A3 (cs) 2002-09-11
WO2001035957A8 (de) 2001-06-21
DE50015163D1 (de) 2008-06-26
IS2673B (is) 2010-09-15
IL149567A0 (en) 2002-11-10
HU228197B1 (en) 2013-01-28
JP5503393B2 (ja) 2014-05-28
HK1045148A1 (en) 2002-11-15
US6858650B1 (en) 2005-02-22
JP5290351B2 (ja) 2013-09-18
DE29923134U1 (de) 2000-06-29
CY1110389T1 (el) 2015-04-29
EP1230209B1 (de) 2005-01-12
EP1481964A1 (de) 2004-12-01
CA2389749A1 (en) 2001-05-25
UA77322C2 (en) 2006-11-15
KR20050100711A (ko) 2005-10-19
ATE337293T1 (de) 2006-09-15
JP4083431B2 (ja) 2008-04-30
BR0015610B8 (pt) 2017-10-31
BRPI0015610B1 (pt) 2016-04-19
CZ302967B6 (cs) 2012-01-25
NZ519230A (en) 2004-11-26
HK1067114A1 (en) 2005-04-01
SI1230209T1 (en) 2005-06-30
JP2014111589A (ja) 2014-06-19
IS2124B (is) 2006-07-14
HU227608B1 (en) 2011-09-28
WO2001035957A3 (de) 2001-12-27
DK1481964T3 (da) 2006-11-27
KR20020059744A (ko) 2002-07-13
AU778132B2 (en) 2004-11-18
EP1230209A2 (de) 2002-08-14
HU0900587D0 (en) 2009-11-30
IL149567A (en) 2007-08-19
HK1095736A1 (en) 2007-05-18
NO20065380L (no) 2002-05-15
EP1690536A3 (de) 2006-08-23
PT1481964E (pt) 2006-12-29
SK6572002A3 (en) 2002-12-03
GEP20084430B (enExample) 2008-07-25
HK1045148B (zh) 2005-05-06
HUP0900587A3 (en) 2010-04-28
JP5650924B2 (ja) 2015-01-07
BRPI0015610C1 (pt) 2021-05-25
PL201422B1 (pl) 2009-04-30
KR100563149B1 (ko) 2006-03-21
ES2236032T3 (es) 2005-07-16
CN1215045C (zh) 2005-08-17
JP5717824B2 (ja) 2015-05-13
EP1690536A2 (de) 2006-08-16
ES2236032T7 (es) 2012-06-14
ATE286872T1 (de) 2005-01-15
NO20022314D0 (no) 2002-05-15
NO332637B1 (no) 2012-11-26
NO20022314L (no) 2002-05-15
ES2303708T3 (es) 2008-08-16
SK287430B6 (sk) 2010-09-07
JP2007137895A (ja) 2007-06-07
CZ302497B6 (cs) 2011-06-15

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