KR100533477B1 - 핵이식용 세포질 수용체로서의 불활성화 난모세포 - Google Patents
핵이식용 세포질 수용체로서의 불활성화 난모세포 Download PDFInfo
- Publication number
- KR100533477B1 KR100533477B1 KR1019980701382A KR19980701382A KR100533477B1 KR 100533477 B1 KR100533477 B1 KR 100533477B1 KR 1019980701382 A KR1019980701382 A KR 1019980701382A KR 19980701382 A KR19980701382 A KR 19980701382A KR 100533477 B1 KR100533477 B1 KR 100533477B1
- Authority
- KR
- South Korea
- Prior art keywords
- oocytes
- activation
- nucleus
- cells
- embryos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8773—Ovine embryos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8771—Bovine embryos
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9517779.6A GB9517779D0 (en) | 1995-08-31 | 1995-08-31 | Biological manipulation |
| GB9517779.6 | 1995-08-31 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057014691A Division KR100743006B1 (ko) | 1995-08-31 | 1996-08-30 | 핵이식용 세포질 수용체로서의 불활성화 난모 세포 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR19990044149A KR19990044149A (ko) | 1999-06-25 |
| KR100533477B1 true KR100533477B1 (ko) | 2006-04-28 |
Family
ID=10779997
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019980701382A Expired - Lifetime KR100533477B1 (ko) | 1995-08-31 | 1996-08-30 | 핵이식용 세포질 수용체로서의 불활성화 난모세포 |
| KR1020067006296A Ceased KR20060057638A (ko) | 1995-08-31 | 1996-08-30 | 핵이식용 세포질 수용체로서의 불활성화 난모 세포 |
| KR1020057014691A Expired - Lifetime KR100743006B1 (ko) | 1995-08-31 | 1996-08-30 | 핵이식용 세포질 수용체로서의 불활성화 난모 세포 |
| KR1020077007531A Withdrawn KR20070041793A (ko) | 1995-08-31 | 1996-08-30 | 핵이식용 세포질 수용체로서의 불활성화 난모 세포 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067006296A Ceased KR20060057638A (ko) | 1995-08-31 | 1996-08-30 | 핵이식용 세포질 수용체로서의 불활성화 난모 세포 |
| KR1020057014691A Expired - Lifetime KR100743006B1 (ko) | 1995-08-31 | 1996-08-30 | 핵이식용 세포질 수용체로서의 불활성화 난모 세포 |
| KR1020077007531A Withdrawn KR20070041793A (ko) | 1995-08-31 | 1996-08-30 | 핵이식용 세포질 수용체로서의 불활성화 난모 세포 |
Country Status (22)
| Country | Link |
|---|---|
| US (12) | US6252133B1 (enExample) |
| EP (1) | EP0847237B1 (enExample) |
| JP (3) | JP2000506721A (enExample) |
| KR (4) | KR100533477B1 (enExample) |
| CN (3) | CN1250715C (enExample) |
| AT (1) | ATE400176T1 (enExample) |
| AU (1) | AU728809B2 (enExample) |
| BR (1) | BR9610013A (enExample) |
| CA (1) | CA2229657A1 (enExample) |
| CZ (1) | CZ60498A3 (enExample) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101352641B1 (ko) | 2010-11-08 | 2014-01-17 | 광주과학기술원 | 골격근-유래된 다능성 세포의 화학적 제조방법 및 이의 용도 |
Families Citing this family (191)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5480772A (en) | 1993-02-03 | 1996-01-02 | Brandeis University | In vitro activation of a nucleus |
| GB9517780D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| GB9517779D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| US7304204B2 (en) | 1995-08-31 | 2007-12-04 | Roslin Institute | Ungulates produced by nuclear transfer of G1 cells |
| US6025155A (en) * | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US6077697A (en) * | 1996-04-10 | 2000-06-20 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| EP0941310A1 (en) | 1996-10-11 | 1999-09-15 | THE TEXAS A&M UNIVERSITY SYSTEM | Methods for the generation of primordial germ cells and transgenic animal species |
| US6235969B1 (en) * | 1997-01-10 | 2001-05-22 | University Of Massachusetts | Cloning pigs using donor nuclei from non-quiescent differentiated cells |
| US5945577A (en) * | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US20090092588A1 (en) * | 1997-01-10 | 2009-04-09 | University Of Massachusetts As Represented By Its Amherst Campus | Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease |
| US6011197A (en) | 1997-03-06 | 2000-01-04 | Infigen, Inc. | Method of cloning bovines using reprogrammed non-embryonic bovine cells |
| ES2513043T3 (es) | 1997-03-26 | 2014-10-24 | Imperial Innovations Limited | Proteína de fusión anticoagulante anclada a membrana de la célula |
| IL133786A0 (en) | 1997-07-03 | 2001-04-30 | Univ Massachusetts | Cloning using donor nuclei from non-serum starved, differentiated cells |
| US7923216B2 (en) | 1997-08-14 | 2011-04-12 | Institut Pasteur | In vivo modulation of neuronal transport |
| US7923015B2 (en) | 1997-08-14 | 2011-04-12 | Institut Pasteur | Methods for direct visualization of active synapses |
| JPH11127852A (ja) * | 1997-10-28 | 1999-05-18 | Snow Brand Milk Prod Co Ltd | 上皮細胞のg0期同調方法 |
| AU739902B2 (en) * | 1998-01-16 | 2001-10-25 | Agrobiogen Gmbh | Efficient nuclear transfer using fetal fibroblasts |
| US7351876B2 (en) | 1998-01-16 | 2008-04-01 | Agrobiogen Gmbh Biotechnologie | Efficient nuclear transfer with primordial gametes |
| CA2318117A1 (en) * | 1998-01-16 | 1999-07-22 | Agrobiogen Gmbh | Efficient nuclear transfer using primordial germ cells |
| US6331659B1 (en) * | 1998-01-21 | 2001-12-18 | University Of Hawaii | Cumulus cells as nuclear donors |
| JP2002511234A (ja) * | 1998-03-16 | 2002-04-16 | リレグ ピーティーワイ リミテッド | ブタの核移植 |
| AUPP294898A0 (en) * | 1998-04-15 | 1998-05-07 | Monash University | Method of nuclear transfer |
| GB9808325D0 (en) * | 1998-04-20 | 1998-06-17 | Ltr Ciz Di Associazione Italia | Source of nuclei for nuclear transfer |
| US6143564A (en) * | 1998-07-07 | 2000-11-07 | University Of Hawaii | Use of the polar body chromosomes for the production of embryos and normal offspring |
| GB9820988D0 (en) * | 1998-09-25 | 1998-11-18 | Biotech & Biolog Scien Res | Screening method |
| GB2365445A (en) * | 1998-10-12 | 2002-02-20 | Geron Bio Med Ltd | Porcine occcytes with improved developmental competence |
| EP1818397A1 (en) * | 1998-11-02 | 2007-08-15 | Trustees Of Tufts College | Methods for cloning animals |
| US6781030B1 (en) | 1998-11-02 | 2004-08-24 | Trustee Of Tufts College, Ballou Hall | Methods for cloning mammals using telophase oocytes |
| ATE427653T1 (de) | 1998-11-19 | 2009-04-15 | Pharming Intellectual Pty Bv | Stabilisierung der milch transgener tieren |
| US6700037B2 (en) | 1998-11-24 | 2004-03-02 | Infigen, Inc. | Method of cloning porcine animals |
| US6258998B1 (en) | 1998-11-24 | 2001-07-10 | Infigen, Inc. | Method of cloning porcine animals |
| CA2360549C (en) * | 1999-01-13 | 2013-04-09 | Ppl Therapeutics (Scotland) Limited | Double nuclear transfer method and results thereof |
| US7531715B1 (en) * | 1999-01-13 | 2009-05-12 | Ppl Therapeutics (Scotland) | Double nuclear transfer method and results thereof |
| WO2000044914A1 (en) | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
| EP1179000A4 (en) | 1999-02-26 | 2005-10-12 | Millennium Pharm Inc | DECISION PROTEINS AND THEIR USE |
| US20020012660A1 (en) * | 1999-03-04 | 2002-01-31 | Alan Colman | Method of preparing a somatic cells for nuclear transfer |
| AU780754B2 (en) * | 1999-03-04 | 2005-04-14 | Revivicor Inc | Genetic modification of somatic cells and uses thereof |
| WO2001000855A1 (en) | 1999-06-23 | 2001-01-04 | Ppl Therapeutics (Scotland) Ltd. | Fusion proteins incorporating lysozyme |
| KR100368435B1 (ko) * | 1999-06-30 | 2003-01-24 | 황우석 | 체세포 복제동물의 생산을 위한 세포융합방법 |
| WO2001000794A1 (en) * | 1999-06-30 | 2001-01-04 | Hwang, Woo-Suk | Method for producing cloned tigers by employing inter-species nuclear transplantation technique |
| JP2003503044A (ja) * | 1999-06-30 | 2003-01-28 | ワン,ウー−サク | 種間核移植技術を用いたヒトクローン胚の作製方法 |
| US6590139B1 (en) | 1999-06-30 | 2003-07-08 | Woo-Suk Hwang | Method for producing cloned cows |
| KR100414043B1 (ko) * | 1999-06-30 | 2004-01-13 | 황우석 | 체세포 복제동물 및 그 생산방법 |
| US7291714B1 (en) | 1999-06-30 | 2007-11-06 | Millennium Pharmaceuticals, Inc. | Glycoprotein VI and uses thereof |
| EP1210428B1 (en) | 1999-08-23 | 2015-03-18 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
| EP2275559A3 (en) | 1999-09-28 | 2011-03-23 | Shire Human Genetic Therapies, Inc. | Optimized messenger RNA |
| WO2002064799A2 (en) | 1999-09-28 | 2002-08-22 | Transkaryotic Therapies, Inc. | Optimized messenger rna |
| GB9927444D0 (en) * | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| KR100417566B1 (ko) * | 1999-11-19 | 2004-02-05 | 한국생명공학연구원 | 체세포 핵치환 복제수정란의 대량생산방법 |
| US7074983B2 (en) * | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
| US7820878B2 (en) * | 1999-11-19 | 2010-10-26 | Kyowa Hakko Kirin Co., Ltd. | Production of ungulates, preferably bovines that produce human immunoglobulins |
| US7414170B2 (en) * | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
| AU1777301A (en) * | 1999-11-19 | 2001-05-30 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
| US7071372B2 (en) | 2000-01-04 | 2006-07-04 | University Of Connecticut | Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells |
| US6635802B1 (en) * | 2000-01-10 | 2003-10-21 | The Texas A&M University System | Nuclear transfer using cells cultured in serum starvation media containing apoptosis inhibitors |
| EP1248640B1 (en) | 2000-01-20 | 2006-10-04 | Diabcell Pty Limited | Preparation and xenotransplantation of porcine islets |
| AU2001236919A1 (en) * | 2000-02-09 | 2001-08-20 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Premeiotic and postmeiotic origin of teratomas: isolated teratoma stem cells for therapeutic uses |
| CA2403344C (en) | 2000-03-15 | 2013-05-21 | The University Of Georgia Research Foundation, Inc. | Effective nuclear reprogramming in mammals |
| GB2360522A (en) | 2000-03-24 | 2001-09-26 | Geron Corp | A strategy for maintaining pregnancy |
| WO2001088096A2 (en) * | 2000-05-15 | 2001-11-22 | Geron Corporation | Ovine tissue for xenotransplantation |
| JP2004501624A (ja) | 2000-06-28 | 2004-01-22 | ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー | Pd−l2分子:新規pd−1リガンドおよびその使用 |
| CA2634294A1 (en) | 2000-08-03 | 2002-02-14 | Therapeutic Human Polyclonals, Inc. | Production of humanized antibodies in transgenic animals |
| WO2002014473A2 (en) | 2000-08-15 | 2002-02-21 | Board Of Trustees Of The University Of Illinois | Animals expressing exogenous igf-i in their milk |
| US7049480B1 (en) * | 2000-09-01 | 2006-05-23 | Avigenics, Inc. | Methods of enucleating an avian oocyte or zygote using two-photon laser scanning microscopy |
| FR2814642B1 (fr) | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
| US20040031069A1 (en) * | 2000-10-06 | 2004-02-12 | Philip Damiani | Cloning endangered and extinct species |
| PL362606A1 (en) | 2000-11-28 | 2004-11-02 | Wyeth | Expression analysis of kiaa nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
| EP1356108A2 (en) | 2000-11-28 | 2003-10-29 | Wyeth | Expression analysis of fkbp nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
| US20020168763A1 (en) * | 2000-11-30 | 2002-11-14 | Yan Wen Liang | Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same |
| US20020142397A1 (en) * | 2000-12-22 | 2002-10-03 | Philippe Collas | Methods for altering cell fate |
| US7491534B2 (en) | 2000-12-22 | 2009-02-17 | Kirin Holdings Kabushiki Kaisha | Methods for altering cell fate to generate T-cells specific for an antigen of interest |
| EP1217071B1 (en) | 2000-12-22 | 2010-04-28 | Institut National De La Recherche Agronomique | Position-independent and tissue specific expression of a transgene in milk of transgenic animals |
| AU2002232858B2 (en) * | 2000-12-22 | 2007-01-11 | Sab, Llc | Methods for cloning mammals using reprogrammed donor chromatin or donor cells |
| EP1860199B1 (en) | 2001-01-12 | 2014-03-05 | Exelixis, Inc. | Modulating insulin receptor signaling |
| WO2002074078A2 (en) | 2001-01-30 | 2002-09-26 | Rebholtz, Amy, K. | Method for embryo after impregnation of the recipient female |
| EP1229134A3 (en) | 2001-01-31 | 2004-01-28 | Nucleonics, Inc | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
| JP2002262716A (ja) * | 2001-03-07 | 2002-09-17 | National Agricultural Research Organization | 株化細胞を用いて家畜個体を作出する方法 |
| US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
| US7126039B2 (en) * | 2001-03-21 | 2006-10-24 | Geron Corporation | Animal tissue with carbohydrate antigens compatible for human transplantation |
| AU2002242854A1 (en) * | 2001-03-21 | 2002-10-03 | Geron Corporation | Use of telomerase reverse transcriptase to create homozygous knockout animals |
| EP2388590A1 (en) | 2001-04-02 | 2011-11-23 | Dana Farber Cancer Institute | PD-1, a receptor for B7-4, and uses thereof |
| KR100886095B1 (ko) | 2001-04-16 | 2009-02-27 | 와이어쓰 홀딩스 코포레이션 | 폴리펩티드 항원을 암호화하는 신규한 스트렙토코쿠스 뉴모니애 개방형 판독 프레임 및 이를 포함하는 조성물 |
| WO2002103350A1 (en) * | 2001-06-14 | 2002-12-27 | Infigen, Inc. | Methods for cloning mammals using remodeling factors |
| US6949691B2 (en) * | 2001-06-15 | 2005-09-27 | New Century Pharmaceuticals Inc. | Human albumin animal models for drug evaluation, toxicology and immunogenicity studies |
| EP1900815B1 (en) | 2001-07-12 | 2016-09-07 | University of Massachusetts | In vivo production of small interfering RNAs that mediate gene silencing |
| ES2566561T3 (es) | 2001-07-12 | 2016-04-13 | University Of Massachusetts | Producción in vivo de ARN pequeños de interferencia que median el silenciamiento génico |
| US20030211603A1 (en) * | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| US20030170678A1 (en) * | 2001-10-25 | 2003-09-11 | Neurogenetics, Inc. | Genetic markers for Alzheimer's disease and methods using the same |
| US20030224380A1 (en) * | 2001-10-25 | 2003-12-04 | The General Hospital Corporation | Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases |
| AU2002364945A1 (en) * | 2001-10-25 | 2003-07-09 | Neurogenetics, Inc. | Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases |
| EP1525323B1 (en) | 2001-11-09 | 2015-01-21 | Dana-Farber Cancer Institute, Inc. | Pgc-1beta, a novel pgc-1 homologue and uses therefor |
| US7704736B2 (en) * | 2001-11-09 | 2010-04-27 | Trustees Of The University Of Pennsylvania | Compositions for the derivation of germ cells from stem cells and methods of use thereof |
| WO2003060083A2 (en) * | 2002-01-15 | 2003-07-24 | Advanced Cell Technology, Inc. | Cloning b and t lymphocytes |
| US20050170506A1 (en) * | 2002-01-16 | 2005-08-04 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
| US20050090004A1 (en) * | 2003-01-16 | 2005-04-28 | Sayre Chauncey B. | Stem cell maturation for all tissue lines |
| US20030134422A1 (en) * | 2002-01-16 | 2003-07-17 | Sayre Chauncey Bigelow | Stem cell maturation for all tissue lines |
| AU2003230725A1 (en) * | 2002-04-01 | 2003-10-20 | Gtc Biotherapeutics, Inc. | A method for selecting cell lines to be used for nuclear transfer in mammalian species |
| US20030217378A1 (en) * | 2002-04-05 | 2003-11-20 | The University Of Georgia Research Foundation, Inc | Cloning using rapidly matured oocytes |
| US7612250B2 (en) * | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
| KR20050058407A (ko) | 2002-08-20 | 2005-06-16 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 자궁경부암의 확인, 평가, 예방 및 요법을 위한 조성물, 키트 및 방법 |
| AU2003300027A1 (en) | 2002-10-10 | 2004-05-04 | Wyeth | Compositions, organisms and methodologies employing a novel human kinase |
| EP1581636A4 (en) * | 2002-10-16 | 2006-09-20 | Advanced Cell Tech Inc | METHOD OF USE OF STEM CELLS TREATED BY DERGENVALENTECHNIK (GENE TRAP) FOR MARKING STRAIN CELL DIFFERENTIATION PATHS, AND THE PREPARATION AND ISOLATION OF DIFFERENTIATED CELLS |
| US7208306B2 (en) | 2002-10-24 | 2007-04-24 | Wyeth | Compositions employing a novel human protein phosphatase |
| AU2003290689A1 (en) | 2002-11-08 | 2004-06-03 | Kyowa Hakko Kirin Co., Ltd. | Transgenic ungulates having reduced prion protein activity and uses thereof |
| JP2006514554A (ja) | 2002-11-21 | 2006-05-11 | ワイス | 腎細胞癌および他の固形腫瘍の診断法 |
| AU2003290664A1 (en) | 2002-11-27 | 2004-06-23 | Wei Liu | Compositions, organisms and methodologies employing a novel human kinase |
| EP2474630B1 (en) | 2002-12-20 | 2016-04-27 | Celera Corporation | Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof |
| DE602004015064D1 (de) | 2003-01-06 | 2008-08-28 | Wyeth Corp | Zusammensetzungen und verfahren zur diagnose und behandlung von kolonkrebs |
| AU2004248136B2 (en) | 2003-06-02 | 2011-09-15 | University Of Massachusetts | Methods and compositions for controlling efficacy of RNA silencing |
| ATE485394T1 (de) | 2003-06-02 | 2010-11-15 | Univ Massachusetts | Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai |
| JP2007502119A (ja) | 2003-08-14 | 2007-02-08 | エクセリクシス, インク. | βカテニン経路のモディファイヤーとしてのUPs及び使用方法 |
| MXPA06003402A (es) | 2003-10-07 | 2006-06-27 | Millennium Pharm Inc | Moleculas de acidos nucleicos y proteinas para la identificacion, evaluacion, prevencion y tratamiento de cancer de ovario. |
| EP1681988B1 (en) | 2003-11-12 | 2015-04-08 | The Children's Hospital Medical Center | Method for diagnosis and treatment of pulmonary disorders |
| EP2186913B1 (en) | 2003-11-26 | 2016-02-10 | Celera Corporation | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| CA2563064A1 (en) | 2004-04-22 | 2005-11-10 | Kirin Beer Kabushiki Kaisha | Transgenic animals and uses thereof |
| CA2566256C (en) | 2004-05-07 | 2015-07-07 | Applera Corporation | Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof |
| JP2008517931A (ja) | 2004-10-22 | 2008-05-29 | ダナ−ファーバー キャンサー インスティチュート,インコーポレイテッド | 脂質関連疾患および障害を処置するための、PGC−1βを調節するための方法および組成物 |
| GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
| CN1274829C (zh) | 2004-12-10 | 2006-09-13 | 四川大学华西医院 | 抗eb病毒所致肿瘤多肽及其应用与制备方法 |
| EP1856296A2 (en) | 2005-03-11 | 2007-11-21 | Applera Corporation | Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof |
| US20070011603A1 (en) * | 2005-07-06 | 2007-01-11 | Mikko Makela | Method, system, device and software product for showing tooltips for page segments and generating content for the page segments |
| CA2617930A1 (en) | 2005-08-09 | 2007-03-29 | Revivicor, Inc. | Transgenic ungulates expressing ctla4-ig and uses thereof |
| CA2621992C (en) | 2005-09-09 | 2020-08-04 | The Johns Hopkins University | Manipulation of regulatory t cell and dc function by targeting neuritin gene using antibodies, agonists and antagonists |
| US8921109B2 (en) | 2005-09-19 | 2014-12-30 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
| US7799530B2 (en) | 2005-09-23 | 2010-09-21 | Celera Corporation | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
| US7695911B2 (en) | 2005-10-26 | 2010-04-13 | Celera Corporation | Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof |
| WO2008027986A2 (en) | 2006-09-01 | 2008-03-06 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| WO2008033239A2 (en) | 2006-09-11 | 2008-03-20 | Applera | Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof |
| CA2666346C (en) | 2006-10-20 | 2016-02-23 | Celera Corporation | Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof |
| KR101398220B1 (ko) * | 2006-10-30 | 2014-05-22 | 건국대학교 산학협력단 | 형질전환 배아 생성방법 |
| WO2008085891A1 (en) * | 2007-01-05 | 2008-07-17 | Worcester Polytechnic Institute | Oocyte spindle-associated factors improve somatic cell cloning |
| CN105861443A (zh) * | 2007-04-07 | 2016-08-17 | 怀特黑德生物医学研究所 | 体细胞重编程 |
| WO2008134522A1 (en) * | 2007-04-26 | 2008-11-06 | President And Fellows Of Harvard College | Deriving embryonic stem cells |
| WO2008144580A2 (en) * | 2007-05-17 | 2008-11-27 | Oregon Health & Science University | Primate stem cells produced by somatic cell nuclear transfer |
| US20090111764A1 (en) * | 2007-10-25 | 2009-04-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Mitochondrial selection |
| EP2214708A4 (en) | 2007-10-26 | 2011-01-12 | Centocor Ortho Biotech Inc | VECTORS, HOST CELLS, METHODS OF PRODUCTION AND USES |
| US8039212B2 (en) | 2007-11-05 | 2011-10-18 | Celera Corporation | Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof |
| US20090221620A1 (en) | 2008-02-20 | 2009-09-03 | Celera Corporation | Gentic polymorphisms associated with stroke, methods of detection and uses thereof |
| KR100915397B1 (ko) * | 2008-02-22 | 2009-09-03 | 삼성전자주식회사 | 커버부재, 현상 카트리지 및 화상형성장치의 현상유닛 |
| WO2009114185A2 (en) | 2008-03-12 | 2009-09-17 | The Rockefeller University | Methods and compositions for translational profiling and molecular phenotyping |
| US8288094B2 (en) | 2008-04-09 | 2012-10-16 | Institut Pasteur | APOBEC3 mediated DNA editing |
| CN105671065A (zh) | 2008-06-13 | 2016-06-15 | 怀特黑德生物医学研究所 | 细胞编程和重编程 |
| US8216786B2 (en) | 2008-07-09 | 2012-07-10 | Celera Corporation | Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof |
| US9181315B2 (en) | 2009-01-08 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for induced brown fat differentiation |
| US8722964B2 (en) | 2009-04-23 | 2014-05-13 | Transposagen Biopharmaceuticals, Inc. | Genetically engineered or transgenic rats exhibiting a cancer phenotype due to a disruption of germline tumor suppressor genes |
| WO2010124123A1 (en) | 2009-04-24 | 2010-10-28 | Oregon Health & Science University | Methods for mitochondrial dna replacement in oocytes |
| EP2267153A1 (en) | 2009-05-26 | 2010-12-29 | Université Claude Bernard Lyon 1 | Identification of netrin-1 receptor unc5c gene mutation in solid cancers |
| WO2011002988A1 (en) | 2009-07-01 | 2011-01-06 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for severe combined immunodeficiency (scid) |
| EP2456876A2 (en) | 2009-07-24 | 2012-05-30 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for cytokine-cytokine signaling pathways |
| EP2460016A2 (en) | 2009-07-30 | 2012-06-06 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for pharmacokinetics |
| EP2461672A2 (en) | 2009-08-05 | 2012-06-13 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for drug metabolism |
| EP2467013A2 (en) | 2009-08-20 | 2012-06-27 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for pain |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| JP2013520162A (ja) | 2010-01-22 | 2013-06-06 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 代謝障害の同定、査定、予防および治療のための組成物、キットおよび方法 |
| TWI518325B (zh) | 2010-02-04 | 2016-01-21 | 自治醫科大學 | 對alk抑制劑具有先抗性或後抗性癌症的識別、判斷和治療 |
| US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
| US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
| CA2794483C (en) | 2010-03-26 | 2020-07-07 | Trustees Of Dartmouth College | Vista regulatory t cell mediator protein, vista binding agents and use thereof |
| US8383793B2 (en) | 2010-04-15 | 2013-02-26 | St. Jude Children's Research Hospital | Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors |
| US20110269735A1 (en) | 2010-04-19 | 2011-11-03 | Celera Corporation | Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof |
| US9497964B2 (en) | 2010-10-22 | 2016-11-22 | Agri-Neo Inc. | Synergistic activity of peracetic acid and at least one SAR inducer for the control of pathogens in and onto growing plants |
| US20120108651A1 (en) | 2010-11-02 | 2012-05-03 | Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) | Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof |
| NZ759163A (en) | 2011-02-14 | 2023-03-31 | Revivicor Inc | Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof |
| WO2012129198A1 (en) | 2011-03-23 | 2012-09-27 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for obesity and diabetes |
| PT2709445T (pt) | 2011-05-16 | 2018-11-27 | Univ Missouri | Animais resistentes ao vírus da síntese reprodutiva e respiratória porcino |
| WO2013039996A1 (en) | 2011-09-13 | 2013-03-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for brown fat induction and activity using fndc5 |
| PL2814844T3 (pl) | 2012-02-15 | 2017-12-29 | Novo Nordisk A/S | Przeciwciała wiążące i blokujące receptor aktywujący wykazujący ekspresję na komórkach szpikowych -1 (trem-1) |
| EP3456742A1 (en) | 2012-02-15 | 2019-03-20 | Novo Nordisk A/S | Antibodies that bind peptidoglycan recognition protein 1 |
| US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
| US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
| TWI677507B (zh) | 2012-06-22 | 2019-11-21 | 達特茅斯學院基金會 | 新穎之vista-ig構築體及vista-ig用於治療自體免疫、過敏及發炎病症之用途 |
| EP2892558B1 (en) | 2012-09-07 | 2019-04-10 | The Trustees Of Dartmouth College | Vista modulators for diagnosis and treatment of cancer |
| CN119775416A (zh) | 2013-12-24 | 2025-04-08 | 杨森制药公司 | 抗vista抗体及片段 |
| US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| EP3094736A4 (en) | 2014-01-14 | 2017-10-25 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms |
| JP6997619B2 (ja) | 2014-06-11 | 2022-01-17 | キャシー・エイ・グリーン | 液性免疫の抑制または増進のための、vistaアゴニスト及びvistaアンタゴニストの使用 |
| KR20250110365A (ko) | 2014-07-17 | 2025-07-18 | 노보 노르디스크 에이/에스 | 점도를 감소시키기 위한 trem-1 항체의 부위 지정 돌연변이유발 |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| AU2015357463B2 (en) | 2014-12-05 | 2021-10-07 | Immunext, Inc. | Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators |
| EP4399969A3 (en) | 2014-12-09 | 2024-10-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| WO2016131133A1 (en) | 2015-02-19 | 2016-08-25 | Agri-Neo Inc. | Composition of peracetic acid and at least one organic fungicide for the control of pathogens in and onto growing plants |
| EP3722314A1 (en) | 2015-06-24 | 2020-10-14 | Janssen Pharmaceutica NV | Anti-vista antibodies and fragments |
| BR112018002417A2 (pt) | 2015-08-06 | 2018-09-18 | Univ Missouri | animal não humano ou descendente do mesmo ou uma célula de animal, animal suíno, descendente ou célula, célula, descendente, método de reprodução, população de animais, método para aumentar uma resistência de animal, molécula de ácido nucleico, ácido nucleico e ácido nucleico isolado |
| EP3368157B1 (en) | 2015-10-29 | 2022-06-29 | Dana-Farber Cancer Institute, Inc. | Methods for identification, assessment, prevention, and treatment of metabolic disorders using pm20d1 and n-lipidated amino acids |
| MX2018009800A (es) | 2016-02-12 | 2018-11-09 | Janssen Pharmaceutica Nv | Anticuerpos y fragmentos anti-vista, usos de los mismos y procedimientos de identificacion de los mismos. |
| EP3448412A4 (en) | 2016-04-15 | 2020-03-25 | Immunext Inc. | ANTI-HUMAN-VISTA ANTIBODIES AND USE THEREOF |
| CR20250022A (es) | 2018-04-02 | 2025-02-25 | Bristol Myers Squibb Co | Anticuerpos anti-trem-1, ácidos nucleicos y vectores de los mismos (divisional 2020-0450) |
| US11160260B2 (en) | 2018-04-17 | 2021-11-02 | The Curators Of The University Of Missouri | Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV) |
| KR20230107335A (ko) | 2020-11-20 | 2023-07-14 | 레비비코르 인코포레이션 | 이종이식을 위한 성장 호르몬 수용체 녹아웃을 갖는 다중-전이유전자 돼지 |
| JP2024534702A (ja) | 2021-09-20 | 2024-09-20 | レバイビコア,インコーポレイティド | 異種移植のための10個の遺伝子改変を含むマルチトランスジェニックブタ |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ224241A (en) * | 1987-04-14 | 1991-03-26 | Bresatec Ltd | Method of producing new animal breeds using plasmid expression vectors; plasmid expression vectors |
| US5057420A (en) * | 1987-06-05 | 1991-10-15 | Granada Biosciences, Inc. | Bovine nuclear transplantation |
| CA2059199A1 (en) | 1992-01-10 | 1993-07-11 | Steen Willadsen | Method for producing mature reconstituted mammalian eggs by nuclear transplantation |
| GB2265909B (en) | 1992-04-01 | 1996-03-20 | Inst Of Animal Physiology And | Fusion of donor nucleus with recipient cytoplast in the absence of calcium ion |
| CA2145190A1 (en) * | 1992-09-22 | 1994-03-31 | The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services | Use of taxol for treating lymphomas and breast cancer |
| CA2092258A1 (en) | 1992-12-30 | 1994-07-01 | Steven L. Stice | Synchronized donor cells for bovine nuclear transfer |
| US5480772A (en) | 1993-02-03 | 1996-01-02 | Brandeis University | In vitro activation of a nucleus |
| US5496720A (en) | 1993-02-10 | 1996-03-05 | Susko-Parrish; Joan L. | Parthenogenic oocyte activation |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US5333948A (en) | 1993-06-22 | 1994-08-02 | Tekonsha Engineering Company | Multiple-gain electronic brake actuator with trigger point inertial sensor |
| AU7476894A (en) * | 1993-07-29 | 1995-02-28 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Method of treating atherosclerosis or restenosis using microtubule stabilizing agent |
| EP0739412B1 (en) | 1993-12-23 | 2002-02-27 | Infigen, Inc. | ungulate EMBRYONIC STEM CELLS AS NUCLEAR DONORS AND NUCLEAR TRANSFER TECHNIQUES TO PRODUCE CHIMERIC AND TRANSGENIC ANIMALS |
| GB9417831D0 (en) | 1994-09-05 | 1994-10-26 | Biotech & Biolog Scien Res | Biological manipulation |
| GB9517779D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| GB9517780D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| US7304204B2 (en) * | 1995-08-31 | 2007-12-04 | Roslin Institute | Ungulates produced by nuclear transfer of G1 cells |
| US6215041B1 (en) * | 1997-01-10 | 2001-04-10 | University Of Mmassachusetts | Cloning using donor nuclei from a non-quiesecent somatic cells |
| US6235969B1 (en) * | 1997-01-10 | 2001-05-22 | University Of Massachusetts | Cloning pigs using donor nuclei from non-quiescent differentiated cells |
| US5945577A (en) * | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US7291764B1 (en) * | 1997-01-10 | 2007-11-06 | University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of Massachusetts, as Represented by its Amherst Campus, Office of Vice Chancellor for Research at Amherst | Cloning pigs using non-quiescent differentiated donor cells or nuclei |
| US7361804B1 (en) * | 1997-02-19 | 2008-04-22 | Roslin Institute (Edinburgh) | Unactivated oocytes in nuclear transfer to produce ungulates |
| US6011197A (en) * | 1997-03-06 | 2000-01-04 | Infigen, Inc. | Method of cloning bovines using reprogrammed non-embryonic bovine cells |
| AU739902B2 (en) | 1998-01-16 | 2001-10-25 | Agrobiogen Gmbh | Efficient nuclear transfer using fetal fibroblasts |
| JP3573964B2 (ja) * | 1998-06-17 | 2004-10-06 | 三洋電機株式会社 | アルカリ電池用水素吸蔵合金電極及びアルカリ蓄電池用水素吸蔵合金電極の製造方法 |
| GB2365445A (en) * | 1998-10-12 | 2002-02-20 | Geron Bio Med Ltd | Porcine occcytes with improved developmental competence |
| US6700037B2 (en) * | 1998-11-24 | 2004-03-02 | Infigen, Inc. | Method of cloning porcine animals |
| US20050156424A1 (en) * | 2000-02-29 | 2005-07-21 | Thyssenkrupp Presta Ag | Steering column and manufacturing method thereof |
| US8302202B2 (en) * | 2005-08-03 | 2012-10-30 | International Business Machines Corporation | Transportable computing environment apparatus system and method |
-
1995
- 1995-08-31 GB GBGB9517779.6A patent/GB9517779D0/en active Pending
-
1996
- 1996-08-30 CA CA002229657A patent/CA2229657A1/en not_active Abandoned
- 1996-08-30 CN CNB961978929A patent/CN1250715C/zh not_active Expired - Lifetime
- 1996-08-30 KR KR1019980701382A patent/KR100533477B1/ko not_active Expired - Lifetime
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- 1996-08-30 NZ NZ316148A patent/NZ316148A/xx not_active IP Right Cessation
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- 1996-08-30 ES ES96928586T patent/ES2309989T3/es not_active Expired - Lifetime
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- 1996-08-30 JP JP9509995A patent/JP2000506721A/ja active Pending
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- 1996-08-30 DE DE69637591T patent/DE69637591D1/de not_active Expired - Lifetime
- 1996-08-30 DK DK96928586T patent/DK0847237T3/da active
- 1996-08-30 KR KR1020077007531A patent/KR20070041793A/ko not_active Withdrawn
- 1996-08-30 HU HU9802485A patent/HUP9802485A3/hu unknown
- 1996-08-30 CZ CZ98604A patent/CZ60498A3/cs unknown
- 1996-08-30 WO PCT/GB1996/002098 patent/WO1997007668A1/en not_active Ceased
- 1996-08-30 ZA ZA9607383A patent/ZA967383B/xx unknown
- 1996-08-30 CN CNA2005101270278A patent/CN1772891A/zh active Pending
- 1996-08-30 BR BR9610013-3A patent/BR9610013A/pt not_active Application Discontinuation
- 1996-08-30 CN CN2006100037660A patent/CN1813642B/zh not_active Expired - Lifetime
- 1996-08-30 AU AU68309/96A patent/AU728809B2/en not_active Expired
- 1996-08-30 PL PL96325336A patent/PL325336A1/xx unknown
- 1996-08-30 NZ NZ335407A patent/NZ335407A/en not_active IP Right Cessation
-
1997
- 1997-02-19 US US08/803,165 patent/US6252133B1/en not_active Expired - Lifetime
-
1998
- 1998-02-27 NO NO980846A patent/NO980846L/no unknown
-
2000
- 2000-08-29 US US09/650,285 patent/US6525243B1/en not_active Expired - Lifetime
-
2001
- 2001-10-11 US US09/973,701 patent/US20030037352A1/en not_active Abandoned
-
2002
- 2002-07-09 US US10/190,617 patent/US7326824B2/en not_active Expired - Fee Related
- 2002-09-05 US US10/234,854 patent/US7321075B2/en not_active Expired - Fee Related
-
2004
- 2004-08-03 US US10/909,845 patent/US7329796B2/en not_active Expired - Fee Related
- 2004-08-10 US US10/914,161 patent/US7321076B2/en not_active Expired - Fee Related
-
2005
- 2005-03-02 US US11/068,903 patent/US7432415B2/en not_active Expired - Fee Related
- 2005-11-03 US US11/265,114 patent/US7524677B2/en not_active Expired - Fee Related
- 2005-11-30 JP JP2005345998A patent/JP2006340710A/ja active Pending
-
2006
- 2006-10-06 US US11/544,038 patent/US20070028312A1/en not_active Abandoned
- 2006-10-06 US US11/543,881 patent/US7326825B2/en not_active Expired - Fee Related
-
2008
- 2008-04-22 JP JP2008111492A patent/JP2008194053A/ja active Pending
-
2009
- 2009-12-24 US US12/647,316 patent/US20100146654A1/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| Biology of Reproduction, vol.49, pp.933-942 (1993) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101352641B1 (ko) | 2010-11-08 | 2014-01-17 | 광주과학기술원 | 골격근-유래된 다능성 세포의 화학적 제조방법 및 이의 용도 |
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