KR100499655B1 - 헤테로 이작용성 폴리(에틸렌 글리콜) 유도체 및 그의제조 방법 - Google Patents

헤테로 이작용성 폴리(에틸렌 글리콜) 유도체 및 그의제조 방법 Download PDF

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Publication number
KR100499655B1
KR100499655B1 KR10-2002-7004507A KR20027004507A KR100499655B1 KR 100499655 B1 KR100499655 B1 KR 100499655B1 KR 20027004507 A KR20027004507 A KR 20027004507A KR 100499655 B1 KR100499655 B1 KR 100499655B1
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KR
South Korea
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poly
group
peg
alkyl
aryl
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Expired - Lifetime
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KR10-2002-7004507A
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English (en)
Korean (ko)
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KR20020040841A (ko
Inventor
벤틀리마이클데이비드
해리스제이.밀톤
코즐로우스키안토니
Original Assignee
넥타르 테라퓨틱스 에이엘, 코포레이션
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Publication of KR20020040841A publication Critical patent/KR20020040841A/ko
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Publication of KR100499655B1 publication Critical patent/KR100499655B1/ko
Assigned to 넥타르 테라퓨틱스 reassignment 넥타르 테라퓨틱스 권리의 전부이전등록 Assignors: 넥타르 테라퓨틱스 에이엘, 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR10-2002-7004507A 1999-10-08 1999-10-08 헤테로 이작용성 폴리(에틸렌 글리콜) 유도체 및 그의제조 방법 Expired - Lifetime KR100499655B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1999/023536 WO2001026692A1 (en) 1999-10-08 1999-10-08 Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation

Publications (2)

Publication Number Publication Date
KR20020040841A KR20020040841A (ko) 2002-05-30
KR100499655B1 true KR100499655B1 (ko) 2005-07-07

Family

ID=22273776

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2002-7004507A Expired - Lifetime KR100499655B1 (ko) 1999-10-08 1999-10-08 헤테로 이작용성 폴리(에틸렌 글리콜) 유도체 및 그의제조 방법

Country Status (17)

Country Link
EP (1) EP1455839B1 (https=)
JP (1) JP4344110B2 (https=)
KR (1) KR100499655B1 (https=)
CN (1) CN1284603C (https=)
AU (1) AU781336B2 (https=)
BR (1) BR9917517A (https=)
CA (1) CA2386762C (https=)
CY (1) CY1114128T1 (https=)
DK (1) DK1455839T3 (https=)
ES (1) ES2404685T3 (https=)
HU (1) HU228491B1 (https=)
IL (2) IL148890A0 (https=)
MX (1) MXPA02003540A (https=)
NO (1) NO331781B1 (https=)
NZ (1) NZ518143A (https=)
PT (1) PT1455839E (https=)
WO (1) WO2001026692A1 (https=)

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US20050214250A1 (en) * 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
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CA2619709C (en) * 2005-08-26 2012-05-01 Novo Nordisk A/S A method of modifying a macromolecular system
ATE425204T1 (de) * 2005-08-26 2009-03-15 Novo Nordisk As Verfahren zur modifizierung eines makromolekularen systems
BRPI0621841B8 (pt) 2006-07-06 2021-05-25 Daewoong Co Ltd formulação líquida
US7985783B2 (en) 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
CN102612362A (zh) 2009-08-05 2012-07-25 皮里斯股份公司 脂质运载蛋白突变蛋白的控制释放制剂
EP2494073B1 (de) 2009-10-26 2017-11-29 AGCT GmbH Konjugate von nukleotiden und methoden zu deren anwendung
CN103747807B (zh) 2011-07-05 2016-12-07 比奥阿赛斯技术有限公司 P97‑抗体缀合物和使用方法
CA3140358A1 (en) 2012-07-31 2014-02-06 Bioasis Technologies, Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
AU2013341711A1 (en) 2012-11-12 2015-05-21 Redwood Bioscience, Inc. Compounds and methods for producing a conjugate
US9310374B2 (en) 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
WO2014078733A1 (en) 2012-11-16 2014-05-22 The Regents Of The University Of California Pictet-spengler ligation for protein chemical modification
CN103044677A (zh) * 2012-12-28 2013-04-17 上海景宇生物科技有限公司 一种异端基遥爪聚乙二醇及其制备方法
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Publication number Publication date
MXPA02003540A (es) 2003-09-12
KR20020040841A (ko) 2002-05-30
HU228491B1 (en) 2013-03-28
NZ518143A (en) 2004-04-30
EP1455839A1 (en) 2004-09-15
BR9917517A (pt) 2002-07-30
CA2386762A1 (en) 2001-04-19
IL148890A0 (en) 2002-09-12
AU6423099A (en) 2001-04-23
JP2003511422A (ja) 2003-03-25
NO331781B1 (no) 2012-03-26
ES2404685T3 (es) 2013-05-28
PT1455839E (pt) 2013-04-24
CY1114128T1 (el) 2016-07-27
CN1374875A (zh) 2002-10-16
DK1455839T3 (da) 2013-05-06
CA2386762C (en) 2009-06-16
AU781336B2 (en) 2005-05-19
NO20021555D0 (no) 2002-04-02
NO20021555L (no) 2002-06-04
WO2001026692A1 (en) 2001-04-19
CN1284603C (zh) 2006-11-15
IL148890A (en) 2007-09-20
HUP0203149A2 (en) 2002-12-28
EP1455839B1 (en) 2013-01-23
JP4344110B2 (ja) 2009-10-14

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