KR100435611B1 - 에피나스틴을포함하는동통치료용약제학적조성물 - Google Patents

에피나스틴을포함하는동통치료용약제학적조성물 Download PDF

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Publication number
KR100435611B1
KR100435611B1 KR10-1998-0703549A KR19980703549A KR100435611B1 KR 100435611 B1 KR100435611 B1 KR 100435611B1 KR 19980703549 A KR19980703549 A KR 19980703549A KR 100435611 B1 KR100435611 B1 KR 100435611B1
Authority
KR
South Korea
Prior art keywords
epinastine
pain
treatment
migraine
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR10-1998-0703549A
Other languages
English (en)
Korean (ko)
Other versions
KR19990067527A (ko
Inventor
비르기트 융
크리스토퍼 존 몬테규 미드
미쉘 파이레
Original Assignee
뵈링거 인겔하임 카게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 뵈링거 인겔하임 카게 filed Critical 뵈링거 인겔하임 카게
Publication of KR19990067527A publication Critical patent/KR19990067527A/ko
Application granted granted Critical
Publication of KR100435611B1 publication Critical patent/KR100435611B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
KR10-1998-0703549A 1995-11-14 1996-11-13 에피나스틴을포함하는동통치료용약제학적조성물 Expired - Fee Related KR100435611B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19542281A DE19542281C2 (de) 1995-11-14 1995-11-14 Verwendung von Epinastin für die Behandlung der Migräne
DE19542281.3 1995-11-14

Publications (2)

Publication Number Publication Date
KR19990067527A KR19990067527A (ko) 1999-08-25
KR100435611B1 true KR100435611B1 (ko) 2005-01-13

Family

ID=7777343

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1998-0703549A Expired - Fee Related KR100435611B1 (ko) 1995-11-14 1996-11-13 에피나스틴을포함하는동통치료용약제학적조성물

Country Status (31)

Country Link
US (1) US5942503A (enExample)
EP (1) EP0861081B1 (enExample)
JP (2) JP4264850B2 (enExample)
KR (1) KR100435611B1 (enExample)
CN (1) CN1104242C (enExample)
AR (1) AR004321A1 (enExample)
AT (1) ATE213160T1 (enExample)
AU (1) AU706112B2 (enExample)
BG (1) BG62511B1 (enExample)
BR (1) BR9611502A (enExample)
CA (1) CA2232008C (enExample)
CO (1) CO4770978A1 (enExample)
CZ (1) CZ290115B6 (enExample)
DE (2) DE19542281C2 (enExample)
DK (1) DK0861081T3 (enExample)
EE (1) EE03512B1 (enExample)
ES (1) ES2171746T3 (enExample)
HU (1) HU225759B1 (enExample)
IL (1) IL123601A (enExample)
NO (1) NO982172L (enExample)
NZ (1) NZ322467A (enExample)
PL (1) PL186615B1 (enExample)
PT (1) PT861081E (enExample)
RO (1) RO118373B1 (enExample)
RU (2) RU2238733C2 (enExample)
SK (1) SK61398A3 (enExample)
TR (1) TR199800853T2 (enExample)
TW (1) TW575423B (enExample)
UY (1) UY24354A1 (enExample)
WO (1) WO1997017971A1 (enExample)
ZA (1) ZA969520B (enExample)

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US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
RS49982B (sr) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
DE69922688T2 (de) * 1998-11-02 2005-12-01 Merck & Co. Inc. Zusammensetzungen aus einem 5ht1b/1d agonisten und einem selektiven cox-2 hemmer zur behandlung von migräne
WO2000048583A2 (en) * 1999-02-19 2000-08-24 Pozen Inc. Formulation of 5-ht agonists with nsaids, especially cox-2 inhibitors, for treating migraine
DE19954516A1 (de) * 1999-11-12 2001-05-17 Boehringer Ingelheim Int Epinastin-haltige Lösungen
DE19958460A1 (de) * 1999-12-03 2001-06-07 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Epinastine-Hydrochlorid in der hochschmelzenden Kristallmodifikation
JP2002087963A (ja) * 2000-09-08 2002-03-27 Nippon Boehringer Ingelheim Co Ltd 直接打錠により製造されたエピナスチン含有錠剤
US20030104017A1 (en) * 2001-10-26 2003-06-05 Boehringer Ingelheim International Gmbh Epinastine formulation for oral administration
DE10152973A1 (de) * 2001-10-26 2003-05-08 Boehringer Ingelheim Int Neue trockene und wässrige Epinastin-Sirup-Formulierung
EP1531802A1 (en) * 2002-08-02 2005-05-25 Boehringer Ingelheim International GmbH Pharmaceutical formulations comprising combinations of epinastine, pseudoephedrine and methylephedrine
US7332183B2 (en) 2002-12-26 2008-02-19 Pozen Inc. Multilayer dosage forms containing NSAIDs and triptans
EP1452177A1 (en) * 2003-02-27 2004-09-01 Boehringer Ingelheim International GmbH Pharmaceutical formulations comprising sodium laurylsulfate as bitterness masking agent
CN101217948A (zh) * 2005-07-08 2008-07-09 千寿制药株式会社 包含依匹那丁的透皮吸收眼科制剂
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
RU2283112C1 (ru) * 2005-10-04 2006-09-10 Открытое акционерное общество "Нижегородский химико-фармацевтический завод" Противовоспалительное лекарственное средство
RU2311179C1 (ru) * 2006-02-20 2007-11-27 Дмитрий Владимирович Зимин Лекарственное средство, обладающее противовоспалительным, анальгезирующим и жаропонижающим действием, и способ его получения
WO2007110380A1 (en) * 2006-03-25 2007-10-04 Boehringer Ingelheim International Gmbh Insect bite relief preparation comprising epinastine
US8536445B2 (en) * 2006-06-02 2013-09-17 Emcore Solar Power, Inc. Inverted metamorphic multijunction solar cells
EP1875899A1 (en) * 2006-06-29 2008-01-09 Laboratorios Del Dr. Esteve, S.A. Use of 5HT7 receptor agonists for the treatment of pain
US20080102097A1 (en) * 2006-10-31 2008-05-01 Zanella John M Device and method for treating osteolysis using a drug depot to deliver an anti-inflammatory agent
US8470360B2 (en) * 2008-04-18 2013-06-25 Warsaw Orthopedic, Inc. Drug depots having different release profiles for reducing, preventing or treating pain and inflammation
RU2464984C2 (ru) * 2007-11-22 2012-10-27 Общество с ограниченной ответственностью "МС-Вита" Нестероидное противовоспалительное лекарственное средство
US9072727B2 (en) 2008-04-18 2015-07-07 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of degenerative disc disease
US8722079B2 (en) 2008-04-18 2014-05-13 Warsaw Orthopedic, Inc. Methods for treating conditions such as dystonia and post-stroke spasticity with clonidine
US8889173B2 (en) * 2008-04-18 2014-11-18 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
US20090264477A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc., An Indiana Corporation Beta adrenergic receptor agonists for treatment of pain and/or inflammation
US20090263489A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Analgesic and anti-inflammatory compositions and methods for reducing, preventing or treating pain and inflammation
US8883768B2 (en) * 2008-04-18 2014-11-11 Warsaw Orthopedic, Inc. Fluocinolone implants to protect against undesirable bone and cartilage destruction
US20090263451A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Anti-Inflammatory and/or Analgesic Agents for Treatment of Myofascial Pain
US8420114B2 (en) * 2008-04-18 2013-04-16 Warsaw Orthopedic, Inc. Alpha and beta adrenergic receptor agonists for treatment of pain and / or inflammation
US8956641B2 (en) * 2008-04-18 2015-02-17 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of inflammatory diseases
US9610243B2 (en) 2008-04-18 2017-04-04 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US9132119B2 (en) * 2008-04-18 2015-09-15 Medtronic, Inc. Clonidine formulation in a polyorthoester carrier
US8946277B2 (en) 2008-04-18 2015-02-03 Warsaw Orthopedic, Inc. Clonidine formulations in a biodegradable polymer carrier
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US8629172B2 (en) 2008-04-18 2014-01-14 Warsaw Orthopedic, Inc. Methods and compositions for treating post-operative pain comprising clonidine
US20090264489A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Method for Treating Acute Pain with a Formulated Drug Depot in Combination with a Liquid Formulation
US8557273B2 (en) 2008-04-18 2013-10-15 Medtronic, Inc. Medical devices and methods including polymers having biologically active agents therein
US9132085B2 (en) 2008-04-18 2015-09-15 Warsaw Orthopedic, Inc. Compositions and methods for treating post-operative pain using clonidine and bupivacaine
US20100098746A1 (en) * 2008-10-20 2010-04-22 Warsaw Orthopedic, Inc. Compositions and methods for treating periodontal disease comprising clonidine, sulindac and/or fluocinolone
US8822546B2 (en) * 2008-12-01 2014-09-02 Medtronic, Inc. Flowable pharmaceutical depot
US20100228097A1 (en) * 2009-03-04 2010-09-09 Warsaw Orthopedic, Inc. Methods and compositions to diagnose pain
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
US8617583B2 (en) * 2009-07-17 2013-12-31 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for prevention or treatment of a hematoma, edema, and/or deep vein thrombosis
US8231891B2 (en) * 2009-07-31 2012-07-31 Warsaw Orthopedic, Inc. Implantable drug depot for weight control
US20110097375A1 (en) 2009-10-26 2011-04-28 Warsaw Orthopedic, Inc. Formulation for preventing or reducing bleeding at a surgical site
DK3041506T3 (da) * 2013-09-02 2023-02-27 Univ Melbourne Behandlingsfremgangsmåde
CN105708840A (zh) * 2014-12-01 2016-06-29 重庆安格龙翔医药科技有限公司 一种盐酸依匹斯汀组合物
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
KR102041389B1 (ko) 2017-12-12 2019-11-27 (주)프론트바이오 N-(9,13b-디하이드로-1H-디벤조[c,f]이미다조[1,5-a]아제핀-3-일)-2-하이드록시벤즈아미드 및 2-((9,13b-디하이드로-1H-디벤조[c,f]이미다조[1,5-a]아제핀-3-일) 카바모일)페닐 아세테이트의 화합물, 이의 제조방법 및 이를 포함하는 항염증 및 진통제 조성물
CN113993523A (zh) 2019-04-17 2022-01-28 指南针探路者有限公司 用赛洛西宾治疗抑郁症和其他各种病症
JP7118579B1 (ja) 2020-04-16 2022-08-16 参天製薬株式会社 エピナスチン又はその塩を含有する水性組成物
JP6963651B2 (ja) * 2020-04-16 2021-11-10 参天製薬株式会社 エピナスチン又はその塩を含有する水性組成物
KR20230124625A (ko) * 2020-12-24 2023-08-25 산텐 세이야꾸 가부시키가이샤 에피나스틴 또는 그의 염과 황계 항산화제를 함유하는경피 투여용 의약 조성물
CN115448927A (zh) * 2022-10-20 2022-12-09 重庆瑞泊莱医药科技有限公司 一种氢溴酸依匹斯汀晶型ii及其制备方法

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Also Published As

Publication number Publication date
DE19542281A1 (de) 1997-05-15
TR199800853T2 (xx) 1998-09-21
AU7623096A (en) 1997-06-05
CN1202111A (zh) 1998-12-16
PL186615B1 (pl) 2004-02-27
AR004321A1 (es) 1998-11-04
ES2171746T3 (es) 2002-09-16
BG102408A (en) 1998-12-30
CZ290115B6 (cs) 2002-06-12
US5942503A (en) 1999-08-24
PL326653A1 (en) 1998-10-12
CO4770978A1 (es) 1999-04-30
IL123601A (en) 2002-12-01
KR19990067527A (ko) 1999-08-25
CN1104242C (zh) 2003-04-02
EE9800158A (et) 1998-12-15
JP4850880B2 (ja) 2012-01-11
JP4264850B2 (ja) 2009-05-20
PT861081E (pt) 2002-06-28
NZ322467A (en) 2000-01-28
RU2217144C2 (ru) 2003-11-27
NO982172D0 (no) 1998-05-13
MX9803206A (es) 1998-09-30
AU706112B2 (en) 1999-06-10
BG62511B1 (bg) 2000-01-31
EE03512B1 (et) 2001-10-15
HUP9903489A2 (hu) 2000-03-28
DE59608738D1 (de) 2002-03-21
HK1015280A1 (en) 1999-10-15
ATE213160T1 (de) 2002-02-15
TW575423B (en) 2004-02-11
SK61398A3 (en) 1998-09-09
RO118373B1 (ro) 2003-05-30
CA2232008C (en) 2004-01-06
HU225759B1 (en) 2007-08-28
HUP9903489A3 (en) 2001-12-28
CZ149898A3 (cs) 1998-10-14
UY24354A1 (es) 2001-10-25
DK0861081T3 (da) 2002-05-27
ZA969520B (en) 1997-05-14
JP2000500446A (ja) 2000-01-18
DE19542281C2 (de) 1997-12-04
JP2009019050A (ja) 2009-01-29
CA2232008A1 (en) 1997-05-22
IL123601A0 (en) 1998-10-30
NO982172L (no) 1998-05-13
BR9611502A (pt) 1999-03-02
EP0861081A1 (de) 1998-09-02
RU2238733C2 (ru) 2004-10-27
WO1997017971A1 (de) 1997-05-22
EP0861081B1 (de) 2002-02-13

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