KR100409168B1 - 약제의결정변체 - Google Patents

약제의결정변체 Download PDF

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Publication number
KR100409168B1
KR100409168B1 KR10-1998-0708149A KR19980708149A KR100409168B1 KR 100409168 B1 KR100409168 B1 KR 100409168B1 KR 19980708149 A KR19980708149 A KR 19980708149A KR 100409168 B1 KR100409168 B1 KR 100409168B1
Authority
KR
South Korea
Prior art keywords
variant
weak
medium
difluorobenzyl
triazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR10-1998-0708149A
Other languages
English (en)
Korean (ko)
Other versions
KR19990087835A (ko
Inventor
로베르트 포르트만
우르스 크리스토프 호프마이어
안드레아스 브루크하르트
발터 쉐러
마르틴 스첼라기빅츠
Original Assignee
노파르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100409168(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR19990087835A publication Critical patent/KR19990087835A/ko
Application granted granted Critical
Publication of KR100409168B1 publication Critical patent/KR100409168B1/ko
Assigned to 노파르티스 파르마 아게 reassignment 노파르티스 파르마 아게 권리의 전부이전등록 Assignors: 노파르티스 아게
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR10-1998-0708149A 1997-06-10 1998-06-08 약제의결정변체 Expired - Lifetime KR100409168B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1404/97 1997-06-10
CH140497 1997-06-10

Publications (2)

Publication Number Publication Date
KR19990087835A KR19990087835A (ko) 1999-12-27
KR100409168B1 true KR100409168B1 (ko) 2004-01-31

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
KR10-1998-0708149A Expired - Lifetime KR100409168B1 (ko) 1997-06-10 1998-06-08 약제의결정변체
KR10-1998-0708150A Expired - Lifetime KR100425656B1 (ko) 1997-06-10 1998-06-08 약제의결정변체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR10-1998-0708150A Expired - Lifetime KR100425656B1 (ko) 1997-06-10 1998-06-08 약제의결정변체

Country Status (36)

Country Link
US (6) US6740669B1 (https=)
EP (2) EP0994863B1 (https=)
JP (2) JP3672574B2 (https=)
KR (2) KR100409168B1 (https=)
CN (3) CN1298708C (https=)
AR (4) AR012946A1 (https=)
AT (2) ATE237599T1 (https=)
AU (2) AU725517B2 (https=)
BR (2) BR9804946A (https=)
CA (3) CA2256013C (https=)
CO (2) CO4940452A1 (https=)
CY (1) CY2007014I2 (https=)
CZ (2) CZ292260B6 (https=)
DE (3) DE122007000051I2 (https=)
DK (2) DK0994863T3 (https=)
ES (2) ES2197485T3 (https=)
FR (1) FR07C0037I2 (https=)
HU (2) HU226107B1 (https=)
ID (2) ID21014A (https=)
IL (2) IL125733A (https=)
LU (1) LU91345I2 (https=)
MY (2) MY120156A (https=)
NL (1) NL300284I2 (https=)
NO (2) NO329315B1 (https=)
NZ (2) NZ331370A (https=)
PE (2) PE80999A1 (https=)
PL (2) PL192114B1 (https=)
PT (1) PT994864E (https=)
RU (2) RU2194041C2 (https=)
SI (2) SI0994864T1 (https=)
SK (2) SK283734B6 (https=)
TR (2) TR199801631T1 (https=)
TW (2) TW403740B (https=)
UY (1) UY25844A1 (https=)
WO (2) WO1998056772A1 (https=)
ZA (2) ZA984966B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
JP2005529933A (ja) * 2002-05-31 2005-10-06 シェーリング　コーポレイション キサンチンホスホジエステラーゼｖインヒビター多形体
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
NZ591725A (en) 2008-10-13 2012-09-28 Cipla Ltd PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
NZ598482A (en) * 2009-09-04 2014-05-30 Tactical Therapeutics Inc Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
ES2498267T3 (es) 2010-04-30 2014-09-24 Laboratorios Lesvi, S.L. Procedimiento mejorado para la preparación de un intermedio de rufinamida
ITMI20110718A1 (it) * 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
WO2014013511A2 (en) * 2012-07-20 2014-01-23 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (23)

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US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
FI834666A7 (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
PH22568A (en) * 1985-04-18 1988-10-17 Ciba Geigy Ag Fluorinated benzyl triazoles and pharmaceutical compositions containing the same
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
WO1991001724A1 (en) 1989-07-27 1991-02-21 G.D. Searle & Co. Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
HU221425B (en) 1990-11-06 2002-10-28 Yamanouchi Pharma Co Ltd Condensed pyrazine derivatives, process for their production and pharmaceutical preparations containing these compounds
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
DK0812320T3 (da) 1995-02-22 2003-04-14 Aventis Pharma Ltd Amorft piretanid, polymorfe former deraf, fremgangsmåde til fremstilling deraf og deres anvendelse
IL127665A (en) * 1996-07-11 2004-03-28 Novartis Ag Process for the preparation of 4 cyano - 3,2,1 converted triazoles in position 1
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Also Published As

Publication number Publication date
CN1132820C (zh) 2003-12-31
US7750028B2 (en) 2010-07-06
CZ253398A3 (cs) 1999-04-14
LU91345I9 (https=) 2018-12-31
CA2256015C (en) 2008-06-03
US6740669B1 (en) 2004-05-25
DK0994864T3 (da) 2003-07-21
PL191943B1 (pl) 2006-07-31
CY2007014I1 (el) 2009-11-04
ATE232852T1 (de) 2003-03-15
NO329314B1 (no) 2010-09-27
NO983667L (no) 1998-12-17
HUP0002113A3 (en) 2002-09-30
ATE237599T1 (de) 2003-05-15
MY120156A (en) 2005-09-30
DE69813560D1 (de) 2003-05-22
KR100425656B1 (ko) 2004-05-17
FR07C0037I1 (https=) 2007-08-17
US20100310655A1 (en) 2010-12-09
PE80999A1 (es) 1999-09-06
EP0994864A1 (en) 2000-04-26
CN1259127A (zh) 2000-07-05
CN1298708C (zh) 2007-02-07
CO4940448A1 (es) 2000-07-24
SK283685B6 (sk) 2003-12-02
CN1572789A (zh) 2005-02-02
SK109498A3 (en) 1998-12-02
CN1159300C (zh) 2004-07-28
NL300284I2 (nl) 2007-11-01
JP2000516259A (ja) 2000-12-05
PL192114B1 (pl) 2006-08-31
ID21014A (id) 1999-04-08
CA2614926C (en) 2010-02-09
TR199801631T1 (xx) 1999-06-21
RU2194041C2 (ru) 2002-12-10
PT994864E (pt) 2003-07-31
AU725517B2 (en) 2000-10-12
AR012945A1 (es) 2000-11-22
US20030125568A1 (en) 2003-07-03
ES2197485T3 (es) 2004-01-01
DE69811500D1 (de) 2003-03-27
HUP0000798A2 (hu) 2000-10-30
AR061005A2 (es) 2008-07-30
FR07C0037I2 (https=) 2008-05-16
HUP0000798A3 (en) 2000-10-30
SK283734B6 (sk) 2003-12-02
IL125732A (en) 2002-12-01
EP0994863A1 (en) 2000-04-26
UY25844A1 (es) 2001-08-27
IL125733A0 (en) 1999-04-11
PE79799A1 (es) 1999-09-03
HU226107B1 (en) 2008-04-28
PL330798A1 (en) 1999-06-07
TR199801630T1 (xx) 1999-06-21
NO329315B1 (no) 2010-09-27
RU2198167C2 (ru) 2003-02-10
MY125854A (en) 2006-08-30
AR061004A2 (es) 2008-07-30
NO983666L (no) 1998-12-17
CO4940452A1 (es) 2000-07-24
CZ292260B6 (cs) 2003-08-13
CA2256015A1 (en) 1998-12-17
ZA984967B (en) 1999-01-11
BR9804946A (pt) 1999-08-24
EP0994863B1 (en) 2003-02-19
LU91345I2 (fr) 2007-09-04
HUP0002113A2 (hu) 2001-02-28
KR19990087835A (ko) 1999-12-27
ID27660A (id) 2001-04-19
DK0994863T3 (da) 2003-05-26
WO1998056773A1 (en) 1998-12-17
US8076362B2 (en) 2011-12-13
DE122007000051I2 (de) 2009-02-19
CA2256013C (en) 2007-10-16
HK1028242A1 (en) 2001-02-09
CN1217716A (zh) 1999-05-26
CZ292481B6 (cs) 2003-09-17
ZA984966B (en) 1999-01-11
DE122007000051I1 (de) 2007-11-08
AU8437198A (en) 1998-12-30
JP3672575B2 (ja) 2005-07-20
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
CZ253498A3 (cs) 1999-04-14
NZ331370A (en) 2000-08-25
TW403740B (en) 2000-09-01
DE69811500T2 (de) 2004-04-01
HK1028031A1 (en) 2001-02-02
US20060116520A1 (en) 2006-06-01
US6455556B2 (en) 2002-09-24
HK1028241A1 (en) 2001-02-09
AU8437298A (en) 1998-12-30
AU725528B2 (en) 2000-10-12
SI0994863T1 (en) 2003-08-31
IL125733A (en) 2002-12-01
AR012946A1 (es) 2000-11-22
KR19990087836A (ko) 1999-12-27
JP3672574B2 (ja) 2005-07-20
TW526195B (en) 2003-04-01
SK109398A3 (en) 1998-12-02
US20040167186A1 (en) 2004-08-26
DE69813560T2 (de) 2004-02-05
NZ331371A (en) 2000-08-25
NO983666D0 (no) 1998-08-11
JP2000516258A (ja) 2000-12-05
US20010037029A1 (en) 2001-11-01
HU225153B1 (en) 2006-07-28
CY2007014I2 (el) 2009-11-04
SI0994864T1 (en) 2003-10-31
EP0994864B1 (en) 2003-04-16
IL125732A0 (en) 1999-04-11
CA2256013A1 (en) 1998-12-17
BR9804947A (pt) 1999-08-24
ES2192779T3 (es) 2003-10-16
CA2614926A1 (en) 1998-12-17
WO1998056772A1 (en) 1998-12-17
PL330764A1 (en) 1999-05-24

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