US20020016351A1 - New crystals of celecoxib - Google Patents
New crystals of celecoxib Download PDFInfo
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- US20020016351A1 US20020016351A1 US09/887,354 US88735401A US2002016351A1 US 20020016351 A1 US20020016351 A1 US 20020016351A1 US 88735401 A US88735401 A US 88735401A US 2002016351 A1 US2002016351 A1 US 2002016351A1
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- methylphenyl
- pyrazol
- trifluoromethyl
- benzenesulfonamide
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- XEWGUQOGDSXTCN-UHFFFAOYSA-N CC1=CC=C(C2=CC(C)=NN2C2=CC=C(S(N)(=O)=O)C=C2)C=C1 Chemical compound CC1=CC=C(C2=CC(C)=NN2C2=CC=C(S(N)(=O)=O)C=C2)C=C1 XEWGUQOGDSXTCN-UHFFFAOYSA-N 0.000 description 2
- HCKFGSCIKVPTSP-UHFFFAOYSA-N CC1=CC=C(C(=O)CC(=O)C(F)(F)F)C=C1.II Chemical compound CC1=CC=C(C(=O)CC(=O)C(F)(F)F)C=C1.II HCKFGSCIKVPTSP-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Definitions
- This invention relates to the pharmaceutical therapeutic agent 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (celecoxib) of formula I
- NSAIDs non-steroidal anti-inflammatory drugs
- celecoxib may exist at least in two crystalline forms, hereinafter designated as Form I and Form II, having different properties.
- the object of the present invention is to provide a new crystalline form of celecoxib which avoids the problems produced by the known, needle-like crystalline form.
- the solution of this object is provided by the new crystalline form of celecoxib as disclosed herein, which we have called “Form I” of celecoxib, and by the corresponding production method, as also described herein.
- the invention accordingly comprises a composition of matter possessing the characteristics, properties, and the relation of constituents which will be exemplified in the composition hereinafter described, and the scope of the invention will be indicated in the claims.
- FIG. 1 is an x-ray diffraction pattern of the crystal of Form I of celecoxib prepared in accordancne with the inventions;
- FIG. 2 is an x-ray diffraction pattern for the known Form II of Celecoxib
- FIG. 3 is a SEM image of the crystallites of Form I described in FIG. 1;
- FIG. 4 is a SEM image of the crystallites of Form II described in FIG. 2.
- Crystalline forms are characterised by means of X-ray powder diffraction patterns.
- X-ray diffraction data are provided in terms of 2 ⁇ values and corresponding intensities.
- the crystalline form of celecoxib designated as Form I is characterised by at least the X-ray powder diffractogram data given in table I: TABLE I X-ray Diffraction data of Form I: Angle [°2 ⁇ ] Rel.int [%] 14.800 69.0 16.050 78.9 17.875 63.7 19.615 100.0 21.455 96.6 22.080 68.1 22.385 65.4 23.425 62.5 25.330 64.5 29.355 60.8
- said crystalline form of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide of Form I is further characterised by at least the following further X-ray powder diffractogram data given in table II: TABLE II Further X-ray Diffraction data Form I: Angle [°2 ⁇ ] Rel.int [%] 10.670 33.4 10.970 34.0 12.985 32.4 13.855 17.5 18.340 40.4 18.685 40.0 20.425 19.1 20.670 19.0 23.185 48.7 24.510 37.8 24.930 34.5 25.730 22.8 26.915 23.1 27.630 31.5 28.185 26.2 29.955 32.7 30.375 9.9 31.405 9.6 34.915 15.7 35.585 10.9 37.895 17.9 44.070 9.4 45.250 14.5
- FIG. 1 An example of the X-ray diffraction pattern of Form I is shown in FIG. 1.
- the alternative disadvantageous, needle-like crystal form (designated herein as Form II) which is provided by the methods described in the prior art differs significantly from Form I according to the present invention.
- Form I is denser than the crystals of Form II, providing improved filtration and drying characteristics. Due to its increased density, better flow properties and lower electrostatic charge, Form I provides further advantages in formulation and capsule preparation.
- the present invention further relates to a method for the production of the crystals of Form I of celecoxib by reacting 1-(4-methylphenyl)-4,4,4-trifluorobutane-1,3-dione of formula II
- the preparation of celecoxib, according to the present invention differs from the production described in WO 95/15316 mainly by the crystallization system used.
- the dione is preferably reacted with 4-sulphonamidophenylhydrazine hydrochloride in isopropanol, instead of absolute ethanol, at reflux temperature.
- the reaction mixture is treated with activated carbon; after filtering, the product is preferably obtained by crystallizing it by the addition of a non-solvent, especially water (instead of by concentration of the reaction mixture).
- the substance is preferably recrystallized from isopropanol and water, instead of methylenechloride/hexane.
- the present invention provides further advantages for the preparation of celecoxib by eliminating methylene chloride, a risk for the environment and human health. In addition, it also eliminates the use of n-hexane which causes an ignition and fire risk due to its electrostatic charge accumulation property. Further, according to the present invention, water replaces n-hexane.
- isopropanol is a further advantage, since it is commercially available and widely used in chemical industry compared to absolute ethanol. Isopropanol should be anhydrous and may be combined with other hydroxylic solvents. Finally, by precipitating the product from the reaction mixture instead of concentrating the reaction mixture to dryness, a higher purity is achieved.
- celecoxib is most preferably prepared by dissolving celecoxib in a suitable solvent system comprising at least one amide solvent, preferably selected from the group comprising N,N-dimethylformamide, NN-dimethylacetamide and/or mixtures thereof, N,N-dimethylformamide being most preferred, from which solution the crystals of Form I are obtained by the addition of a non-solvent, especially water.
- a suitable solvent system comprising at least one amide solvent, preferably selected from the group comprising N,N-dimethylformamide, NN-dimethylacetamide and/or mixtures thereof, N,N-dimethylformamide being most preferred, from which solution the crystals of Form I are obtained by the addition of a non-solvent, especially water.
- This recrystallization is generally carried out at temperatures of 0 to 80° C., particularly of 5 to 70° C., preferably of 10 to 60° C., more preferably of 15 to 50° C., most preferably of 20 to 40° C., e.g., of 25 to 30° C. and/or ambient temperature.
- the present invention further includes crystalline celecoxib of Form I crystallography, obtainable by the above described method of production.
- the present invention includes pharmaceutical preparations, comprising crystalline celecoxib according to the present invention.
- Pharmaceutical preparations according to the present invention may be adapted for oral administration and are conveniently presented in the form of, e.g., tablets, capsules, dragees or the like.
- the formulations may contain ingredients like pharmaceutically acceptable carriers, excipients, adjuvants, etc. as they are known in the art.
- Step a 1-(4-methylphenyl)-4,4,4-trifluorobutane-1,3-dione
- Step b 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
- Step c Isolation of Form I
- the product corresponds to FIG. 3 and showed the X-ray diffraction data presented in FIG. 1 and tables I and II.
- ingredients or compounds recited in the singular are intended to include compatible mixtures of such ingredients wherever the sense permits.
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
Description
-
- specifically to a new crystalline form of celecoxib with improved properties. This invention further relates to a method for the production of this crystalline form of the agent.
- Since prostaglandins play a major role in the inflammation process, the discovery of non-steroidal anti-inflammatory drugs (NSAIDs) has focused on the inhibition of prostaglandin production, especially PGG2, PGH2 and PGC2 production. The use of NSAIDs in the treatment of pain and swelling associated with the inflammation tends to cause side effects by affecting other prostaglandin regulated processes. Thus NSAIDs tend to cause significant side effects including ulcers.
- Previous NSAIDs have been found to inhibit some enzymes including cyclooxygenase. Recently, an inducible form of cyclooxygenase associated with inflammation known as cyclooxygenase II (COX-2) or prostaglandin G/M synthase II has been found to exist. This enzyme is more effective in reducing inflammation, causing fewer and less drastic side effects.
- Several compounds selectively inhibiting cyclooxygenase II are described in U.S. Pat. Nos. 5,380,738, 5,344,991, 5,393,790, 5,466,823, 5,434,178, 5,474,995, 5,510,368, and International Applications WO 96/06840, 96/03388, 96/03387, 95/15316, 94/15932, 94/27980, 95/00501, 94/13635, 94/20480 and 94/26731.
- Certain substituted pyrazolylbenzenesulfonamides, specifically celecoxib (4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) as selective COX-2 inhibitor and their preparation have been described in International Application WO 95/15316. In addition, an efficient preparation of 3-haloalkyl-1H-pyrazoles in a one-pot synthesis which is suitable for large-scale process has been described in International Application WO 96/37476.
- International Application No. WO 00/32189 discloses specific celecoxib compositions. In this document a number of problems concerning the formulation of this agent, inter alia, its cohesiveness, low bulk density, low compressibility, poor solubility, etc., are described. According to this document, these disadvantages are caused by the crystal structure of celecoxib. Unformulated celecoxib, which has a crystal morphology that tends to form long cohesive needles, typically fuses into a monolith mass upon compression in a tablet die, which leads to problems in blending the agent uniformly. Further, low bulk density causes problems in processing the small quantities required in the formulation of pharmaceutical compositions.
- It has now surprisingly been discovered that celecoxib may exist at least in two crystalline forms, hereinafter designated as Form I and Form II, having different properties.
- Certain organic compounds can exist in several different crystal forms, which can have different chemical and physical properties, such as density, hardness, flow properties, etc. Therefore, new crystal forms of existing compounds are of great interest. The new crystal form of celecoxib reported herein provides improved properties, making it possible to overcome the problems described in the prior art. Since the new crystal form does not have the disadvantages of the known needle-like crystals, it overcomes the problems disclosed e.g. in WO 00/32189.
- The object of the present invention, therefore, is to provide a new crystalline form of celecoxib which avoids the problems produced by the known, needle-like crystalline form. The solution of this object is provided by the new crystalline form of celecoxib as disclosed herein, which we have called “Form I” of celecoxib, and by the corresponding production method, as also described herein.
- Still other objects and advantages of the invention will in part be obvious and will in part be apparent from the specification.
- The invention accordingly comprises a composition of matter possessing the characteristics, properties, and the relation of constituents which will be exemplified in the composition hereinafter described, and the scope of the invention will be indicated in the claims.
- For a fuller understanding of the invention, reference is had to the following description taken in connection with the accompanying drawing(s), in which:
- FIG. 1 is an x-ray diffraction pattern of the crystal of Form I of celecoxib prepared in accordancne with the inventions;
- FIG. 2 is an x-ray diffraction pattern for the known Form II of Celecoxib;
- FIG. 3 is a SEM image of the crystallites of Form I described in FIG. 1; and
- FIG. 4 is a SEM image of the crystallites of Form II described in FIG. 2.
- Crystalline forms are characterised by means of X-ray powder diffraction patterns. For this purpose a PHILIPS PW 1710 based diffractometer was used and Cu—K60 -radiation (λ(Cu—Kα1)=1.54056 Å; λ(Cu—Kα2)=1.54439 Å) was applied. X-ray diffraction data are provided in terms of 2θ values and corresponding intensities.
- The crystalline form of celecoxib designated as Form I according to the present invention is characterised by at least the X-ray powder diffractogram data given in table I:
TABLE I X-ray Diffraction data of Form I: Angle [°2θ] Rel.int [%] 14.800 69.0 16.050 78.9 17.875 63.7 19.615 100.0 21.455 96.6 22.080 68.1 22.385 65.4 23.425 62.5 25.330 64.5 29.355 60.8 - In a preferred embodiment of the present invention said crystalline form of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide of Form I is further characterised by at least the following further X-ray powder diffractogram data given in table II:
TABLE II Further X-ray Diffraction data Form I: Angle [°2θ] Rel.int [%] 10.670 33.4 10.970 34.0 12.985 32.4 13.855 17.5 18.340 40.4 18.685 40.0 20.425 19.1 20.670 19.0 23.185 48.7 24.510 37.8 24.930 34.5 25.730 22.8 26.915 23.1 27.630 31.5 28.185 26.2 29.955 32.7 30.375 9.9 31.405 9.6 34.915 15.7 35.585 10.9 37.895 17.9 44.070 9.4 45.250 14.5 - (in addition to the dominant reflexes of table I).
- An example of the X-ray diffraction pattern of Form I is shown in FIG. 1. The alternative disadvantageous, needle-like crystal form (designated herein as Form II) which is provided by the methods described in the prior art differs significantly from Form I according to the present invention.
- An example of the X-ray diffraction pattern for the known Form II is shown in FIG. 2 and the corresponding data are given in Table III.
TABLE III X-ray Diffraction data of Form II Angle [°2θ] Rel.int [%] 11.025 27.5 13.285 5.9 15.115 16.5 16.415 91.4 17.625 3.2 18.265 3.6 19.785 5.6 21.820 100.00 22.440 16.9 23.500 2.7 24.620 3.0 25.460 2.7 27.280 21.0 29.885 15.6 31.580 1.5 32.815 9.0 35.185 7.4 38.205 5.8 38.415 4.2 39.695 2.5 40.740 3.7 41.285 0.8 42.960 2.4 43.810 2.7 44.820 4.5 45.415 5.0 46.300 4.9 - Further, SEM images of the crystallites of Form I according to the invention and Form II obtained by the production methods known in the prior art clearly illustrate the plate like habit of the crystals of Form I in contrast to the needle like habit of the crystals of Form II; as is illustrated by attached FIG. 3 and FIG. 4.
- One of the main disadvantages of the needle-like crystals of Form II mentioned in WO 00/32189 is their low bulk density. It was found, that the crystals of the invention's Form I are distinctly denser in comparison to the crystals of Form II prepared according to the methods as given in International Applications WO 95/15316 and WO 96/37476. The following densities are typical and characteristic for the crystals of Form I and II, respectively:
Form I Form II bulk density ≧about 0.270 g/ml about 0.130 g/ml tap density ≧about 0.360 g/ml about 0.180 g/ml - Consequently, the crystals of Form I are denser than the crystals of Form II, providing improved filtration and drying characteristics. Due to its increased density, better flow properties and lower electrostatic charge, Form I provides further advantages in formulation and capsule preparation.
-
- with 4-sulphonamidophenylhydrazine hydrochloride in a suitable solvent, crystallizing the resulting 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide from the reaction mixture and recrystallizing it from a suitable solvent. 1-(4-methylphenyl)-4,4,4-trifluorobutane-1,3-dione may be prepared according to Example 2 Step 1 in International Application WO 95/15316.
- The preparation of celecoxib, according to the present invention, differs from the production described in WO 95/15316 mainly by the crystallization system used.
- Thus, the dione is preferably reacted with 4-sulphonamidophenylhydrazine hydrochloride in isopropanol, instead of absolute ethanol, at reflux temperature. The reaction mixture is treated with activated carbon; after filtering, the product is preferably obtained by crystallizing it by the addition of a non-solvent, especially water (instead of by concentration of the reaction mixture). Finally, the substance is preferably recrystallized from isopropanol and water, instead of methylenechloride/hexane.
- Accordingly, the present invention provides further advantages for the preparation of celecoxib by eliminating methylene chloride, a risk for the environment and human health. In addition, it also eliminates the use of n-hexane which causes an ignition and fire risk due to its electrostatic charge accumulation property. Further, according to the present invention, water replaces n-hexane. The use of isopropanol is a further advantage, since it is commercially available and widely used in chemical industry compared to absolute ethanol. Isopropanol should be anhydrous and may be combined with other hydroxylic solvents. Finally, by precipitating the product from the reaction mixture instead of concentrating the reaction mixture to dryness, a higher purity is achieved.
- In order to obtain crystals of Form I, celecoxib is most preferably prepared by dissolving celecoxib in a suitable solvent system comprising at least one amide solvent, preferably selected from the group comprising N,N-dimethylformamide, NN-dimethylacetamide and/or mixtures thereof, N,N-dimethylformamide being most preferred, from which solution the crystals of Form I are obtained by the addition of a non-solvent, especially water.
- This recrystallization is generally carried out at temperatures of 0 to 80° C., particularly of 5 to 70° C., preferably of 10 to 60° C., more preferably of 15 to 50° C., most preferably of 20 to 40° C., e.g., of 25 to 30° C. and/or ambient temperature.
- The present invention further includes crystalline celecoxib of Form I crystallography, obtainable by the above described method of production. Further, the present invention includes pharmaceutical preparations, comprising crystalline celecoxib according to the present invention. Pharmaceutical preparations according to the present invention may be adapted for oral administration and are conveniently presented in the form of, e.g., tablets, capsules, dragees or the like. The formulations may contain ingredients like pharmaceutically acceptable carriers, excipients, adjuvants, etc. as they are known in the art.
- Step a: 1-(4-methylphenyl)-4,4,4-trifluorobutane-1,3-dione
- 4′-Methylacetophenone was dissolved in methanol (25 ml) under nitrogen atmosphere. To the stirred solution was added 25% sodium methoxide in methanol (12 ml). The reaction mixture was stirred for 5 minutes and ethyltrifluoroacetate (5.5 ml) was added. After refluxing under nitrogen atmosphere for 24 hours the mixture was cooled to room temperature and concentrated. 10% hydrochloric acid (100 ml) was added. The mixture was extracted with ethyl acetate (4×75 ml). The combined organic layer was dried over MgSO4, filtered and concentrated. The product was obtained as an oily residue.
- Step b: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
- 1-(4-Methylphenyl)-4,4,4-trifluorobutane-1,3-dione (4.14 g) from step a was stirred in isopropanol (75 ml). 4-sulphonamidophenylhydrazine hydrochloride (4.25 g) was added. The reaction mixture was refluxed under nitrogen atmosphere for 24 hours, cooled to room temperature and filtered, The filtrate was treated with activated carbon at 40-45° C. The product was crystallized by adding water (150 ml). The product was recrystallized from isopropanol and water.
- Step c: Isolation of Form I
- 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (20 g) from step b was dissolved in N,N-dimethylformamide (80 ml) at room temperature. The product was crystallized by addition of water (200 ml). The reaction mixture was stirred for 30 minutes. The product was isolated by filtration, washed with water (3×40 ml) and dried. Yield: 18 g.
- The product corresponds to FIG. 3 and showed the X-ray diffraction data presented in FIG. 1 and tables I and II.
- It will thus be seen that the objects set forth above, among those made apparent from the preceding description, are efficiently attained and, since certain changes may be made in carrying out the above method (process) and in the composition set forth without departing from the spirit and scope of the invention, it is intended that all matter contained in the above description and shown in the accompanying drawing(s) shall be interpreted as illustrative and not in a limiting sense.
- It is also to be understood that the following claims are intended to cover all of the generic and specific features of the invention herein described and all statements of the scope of the invention which, as a matter of language, might be said to fall therebetween.
- Particularly it is to be understood that in said claims, ingredients or compounds recited in the singular are intended to include compatible mixtures of such ingredients wherever the sense permits.
Claims (13)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2000/01872A TR200001872A3 (en) | 2000-06-26 | 2000-06-26 | The new crystal form "Form I" of 4- [5- (4-Methylphenyl-3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide and the method for producing this product. |
TR2000/01872 | 2000-06-26 |
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US20020016351A1 true US20020016351A1 (en) | 2002-02-07 |
US6391906B2 US6391906B2 (en) | 2002-05-21 |
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US09/887,354 Expired - Fee Related US6391906B2 (en) | 2000-06-26 | 2001-06-22 | Crystals of celecoxib |
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EP (1) | EP1167355B1 (en) |
AT (1) | ATE251142T1 (en) |
AU (1) | AU2001276808A1 (en) |
CA (1) | CA2350956C (en) |
DE (1) | DE60100873T2 (en) |
EA (1) | EA004470B1 (en) |
ES (1) | ES2206360T3 (en) |
HK (1) | HK1045155B (en) |
IL (1) | IL153615A0 (en) |
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WO2003091221A1 (en) * | 2002-04-25 | 2003-11-06 | Generics [Uk] Limited | Celecoxib forms |
EP1507766A4 (en) * | 2002-05-24 | 2006-06-14 | Pharmacia Corp | Synthesis of diaryl pyrazoles |
JP2006500377A (en) | 2002-06-21 | 2006-01-05 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | Pharmaceutical composition having improved solubility |
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WO2005095349A1 (en) | 2004-04-01 | 2005-10-13 | Pharmacia & Upjohn Company Llc | Crystalline pyrazole derivative |
WO2006024930A1 (en) * | 2004-09-01 | 2006-03-09 | Pharmacia & Upjohn Company Llc | Novel co-crystals between polyethylene glycols and 5-phenylpyrazolyl-1-benzenesulfonamides |
EP2374897B1 (en) * | 2004-10-28 | 2014-10-15 | DSM IP Assets B.V. | Stable needle-shaped crystals of natamycin |
WO2006079923A2 (en) * | 2005-01-31 | 2006-08-03 | Pharmacia & Upjohn Company Llc | Form iv crystalline celecoxib |
WO2008153697A1 (en) * | 2007-05-25 | 2008-12-18 | Exxonmobil Upstream Research Company | A process for producing hydrocarbon fluids combining in situ heating, a power plant and a gas plant |
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US20110213159A1 (en) | 2010-03-01 | 2011-09-01 | Vamsee Krishna Muppidi | Process for preparation of celecoxib crystalline form |
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CN103539739B (en) * | 2013-10-30 | 2016-02-10 | 中美华世通生物医药科技(武汉)有限公司 | A kind of Novel celecoxib crystal form B and preparation method thereof |
CN103508958A (en) * | 2013-10-30 | 2014-01-15 | 中美华世通生物医药科技(武汉)有限公司 | Novel celecoxib crystal form C and preparation method thereof |
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JP3996638B2 (en) * | 1995-05-25 | 2007-10-24 | ジー.ディー.サール アンド カンパニー | Method for producing 3-haloalkyl-1H-pyrazole |
WO2000042021A1 (en) * | 1999-01-14 | 2000-07-20 | Merck Frosst Canada & Co. | Synthesis of 4-[(5-substituted or unsubstituted phenyl) -3-substituted -1h-pyrazol -1-yl] benzenesulfonamides |
UA74539C2 (en) * | 1999-12-08 | 2006-01-16 | Pharmacia Corp | Crystalline polymorphous forms of celecoxib (variants), a method for the preparation thereof (variants), a pharmaceutical composition (variants) |
-
2000
- 2000-06-26 TR TR2000/01872A patent/TR200001872A3/en unknown
-
2001
- 2001-03-15 DE DE60100873T patent/DE60100873T2/en not_active Expired - Lifetime
- 2001-03-15 ES ES01106333T patent/ES2206360T3/en not_active Expired - Lifetime
- 2001-03-15 PT PT01106333T patent/PT1167355E/en unknown
- 2001-03-15 AT AT01106333T patent/ATE251142T1/en not_active IP Right Cessation
- 2001-03-15 EP EP01106333A patent/EP1167355B1/en not_active Expired - Lifetime
- 2001-06-18 CA CA002350956A patent/CA2350956C/en not_active Expired - Fee Related
- 2001-06-22 US US09/887,354 patent/US6391906B2/en not_active Expired - Fee Related
- 2001-06-26 AU AU2001276808A patent/AU2001276808A1/en not_active Abandoned
- 2001-06-26 WO PCT/TR2001/000025 patent/WO2002000627A1/en active Application Filing
- 2001-06-26 EA EA200300067A patent/EA004470B1/en not_active IP Right Cessation
- 2001-06-26 IL IL15361501A patent/IL153615A0/en unknown
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2002
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Also Published As
Publication number | Publication date |
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EA004470B1 (en) | 2004-04-29 |
CA2350956C (en) | 2005-08-23 |
TR200001872A2 (en) | 2002-01-21 |
HK1045155A1 (en) | 2002-11-15 |
WO2002000627A1 (en) | 2002-01-03 |
ATE251142T1 (en) | 2003-10-15 |
CA2350956A1 (en) | 2001-12-26 |
PT1167355E (en) | 2004-02-27 |
EA200300067A1 (en) | 2003-06-26 |
EP1167355B1 (en) | 2003-10-01 |
US6391906B2 (en) | 2002-05-21 |
EP1167355A1 (en) | 2002-01-02 |
DE60100873T2 (en) | 2004-07-22 |
AU2001276808A1 (en) | 2002-01-08 |
TR200001872A3 (en) | 2002-01-21 |
DE60100873D1 (en) | 2003-11-06 |
HK1045155B (en) | 2004-05-28 |
IL153615A0 (en) | 2003-07-06 |
ES2206360T3 (en) | 2004-05-16 |
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