KR100370522B1 - 2,4-디술포페닐부틸니트론,그의염및이들의제약스핀트랩으로서의용도 - Google Patents

2,4-디술포페닐부틸니트론,그의염및이들의제약스핀트랩으로서의용도 Download PDF

Info

Publication number
KR100370522B1
KR100370522B1 KR1019960703367A KR19960703367A KR100370522B1 KR 100370522 B1 KR100370522 B1 KR 100370522B1 KR 1019960703367 A KR1019960703367 A KR 1019960703367A KR 19960703367 A KR19960703367 A KR 19960703367A KR 100370522 B1 KR100370522 B1 KR 100370522B1
Authority
KR
South Korea
Prior art keywords
disease
ataxia
compound
pharmaceutically acceptable
side effects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019960703367A
Other languages
English (en)
Korean (ko)
Inventor
존 엠. 카니
Original Assignee
오클라호마 메디컬 리써치 화운데이션
유니버시티 오브 켄터키 리서치 화운데이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오클라호마 메디컬 리써치 화운데이션, 유니버시티 오브 켄터키 리서치 화운데이션 filed Critical 오클라호마 메디컬 리써치 화운데이션
Application granted granted Critical
Publication of KR100370522B1 publication Critical patent/KR100370522B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019960703367A 1993-12-23 1994-12-22 2,4-디술포페닐부틸니트론,그의염및이들의제약스핀트랩으로서의용도 Expired - Fee Related KR100370522B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/173,579 1993-12-23
US08/173,579 US5488145A (en) 1993-12-23 1993-12-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Publications (1)

Publication Number Publication Date
KR100370522B1 true KR100370522B1 (ko) 2003-05-16

Family

ID=22632663

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960703367A Expired - Fee Related KR100370522B1 (ko) 1993-12-23 1994-12-22 2,4-디술포페닐부틸니트론,그의염및이들의제약스핀트랩으로서의용도

Country Status (28)

Country Link
US (4) US5488145A (https=)
EP (1) EP0736004B1 (https=)
JP (3) JP3412821B2 (https=)
KR (1) KR100370522B1 (https=)
CN (1) CN1070176C (https=)
AT (1) ATE192736T1 (https=)
AU (1) AU679835B2 (https=)
BR (2) BR9408378A (https=)
CA (1) CA2179521C (https=)
CZ (1) CZ289629B6 (https=)
DE (1) DE69424441T2 (https=)
DK (1) DK0736004T3 (https=)
ES (1) ES2145264T3 (https=)
FI (1) FI111718B (https=)
GR (1) GR3034134T3 (https=)
HR (1) HRP950358B1 (https=)
HU (1) HU221167B1 (https=)
MY (1) MY114178A (https=)
NO (1) NO306457B1 (https=)
NZ (1) NZ279025A (https=)
PL (1) PL185189B1 (https=)
PT (1) PT736004E (https=)
RU (1) RU2159231C2 (https=)
SG (1) SG64903A1 (https=)
SK (1) SK282403B6 (https=)
TW (1) TW299315B (https=)
UA (1) UA45964C2 (https=)
WO (1) WO1995017876A2 (https=)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
CA2069961C (en) * 1989-10-17 2000-05-02 John M. Carney Method and compositions for inhibition of disorders associated with oxidative damage
US5622994A (en) * 1989-10-17 1997-04-22 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
US20050107366A1 (en) * 1991-06-18 2005-05-19 Carney John M. Spin trapping pharmaceutical compositions and methods for use thereof
US6002001A (en) * 1991-06-18 1999-12-14 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
US20040208875A1 (en) * 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
DK1288203T3 (da) * 1995-09-11 2005-07-11 Aventis Pharma Inc Cykliske nitroner og farmaceutiske præparater, der indeholder dem
CA2235765C (en) * 1995-11-17 2006-04-04 David A. Becker Azulenyl nitrone spin trapping agents, methods of making and using same
AU725432B2 (en) * 1996-04-17 2000-10-12 Centaur Pharmaceuticals, Inc. Nitrone free radical trap treatment of dementia associated with AIDS virus (HIV-1) infection
US6376540B1 (en) * 1996-07-19 2002-04-23 Centaur Pharmaceuticals, Inc. Furan nitrone compounds
TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) * 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
AU2226999A (en) * 1998-01-16 1999-08-02 Renovis, Inc. Thiophene nitrone compounds
JP2002509143A (ja) * 1998-01-16 2002-03-26 センター ファーマシューティカルズ， インコーポレイテッド チオエーテルフランニトロン化合物
JP2002506022A (ja) * 1998-03-13 2002-02-26 センター ファーマシューティカルズ， インコーポレイテッド 新脈管形成の阻害
US6083989A (en) * 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
AU3985799A (en) * 1998-05-19 1999-12-06 Centaur Pharmaceuticals, Inc. Furan nitrone therapeutics for the treatment of inflammatory bowel disease
US6730700B2 (en) * 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
ATE312103T1 (de) 1999-01-25 2005-12-15 Nat Jewish Med & Res Center Substituierte porphyrine und deren therapeutische verwendungen
IL146143A0 (en) * 1999-04-28 2002-07-25 Univ Kingston Compositions and methods for treating amyloidosis
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
AU1574701A (en) * 1999-10-22 2001-04-30 Wrair Walter Reed Army Institute Of Research A pharmaceutical composition containing pglu-glu-pro-nh2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
US6815425B1 (en) 1999-10-22 2004-11-09 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
US20020022743A1 (en) * 2000-01-10 2002-02-21 Sergei Pouhov Method for the purification of aryl sulfonic acids and salts
SE0000056D0 (sv) * 2000-01-10 2000-01-10 Astrazeneca Ab Novel process
SE0000055D0 (sv) * 2000-01-10 2000-01-10 Centaur Pharmaceuticals Inc Novel process
SE0001916D0 (sv) * 2000-05-23 2000-05-23 Astrazeneca Ab Novel formulation
US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
AU2002253857A1 (en) 2001-01-08 2002-09-04 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
US20030045461A1 (en) * 2001-09-06 2003-03-06 Jen-Chang Hsia Composition and methods of esterified nitroxides gated with carboxylic acids
FR2846968B1 (fr) * 2002-11-08 2005-02-04 Salles Jean Pierre Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) * 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) * 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
EP1828111A2 (en) * 2004-11-12 2007-09-05 Neurochem (International) Limited Methods and fluorinated compositions for treating amyloid-related diseases
CN101103018A (zh) * 2004-11-16 2008-01-09 神经化学（国际）有限公司 治疗cns和淀粉样蛋白-相关疾病的化合物
BRPI0519243A2 (pt) * 2004-12-22 2009-01-06 Neurochem Int Ltd mÉtodos e composiÇÕes para tratar doenÇas relacionadas a amilàide
US20060235370A1 (en) * 2005-04-04 2006-10-19 Oblong John E Method of regulating mammalian keratinous tissue
TW200716088A (en) * 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
WO2007013843A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate n-oxide against myocardial ischaemia
WO2007013842A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimino)methyl) benzene-1,3-disulfonate n-oxide against maemorrhagic changes in the brain
WO2007013844A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea
WO2007013841A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimine)methyl) benzene-1,3-disulfonate n-oxide against cerebral oedema
MX2008008213A (es) * 2005-12-22 2008-09-03 Neurochem Int Ltd Tratamiento de trastornos renales, nefropatia diabetica y dislipidemias.
JP5236641B2 (ja) * 2006-07-25 2013-07-17 ハフ イヤ インスティテュート 急性音響外傷の治療方法
DK2089417T3 (en) 2006-10-12 2015-03-23 Bhi Ltd Partnership Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid
CN101730529A (zh) * 2006-12-22 2010-06-09 贝鲁斯健康(国际)有限公司 用于治疗代谢疾病和糖尿病的方法、化合物和组合物
US20090082454A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched disufenton
US8425593B2 (en) 2007-09-26 2013-04-23 St. Jude Medical, Inc. Collapsible prosthetic heart valves
WO2009102808A2 (en) 2008-02-12 2009-08-20 Tosk, Incorporated Doxorubicin adjuvants to reduce toxicity and methods for using the same
CN102105146A (zh) 2008-05-23 2011-06-22 国立犹太保健医院 用于治疗与暴露于烷化物质有关的损伤的方法
AU2009288057B2 (en) 2008-09-02 2014-07-03 Oklahoma Medical Research Foundation 2, 4-disulfonyl pheny tert-butyl nitrone for the treatment of gliomas
EP2470015B1 (en) * 2009-08-24 2016-01-13 Hough Ear Institute Nitrone compounds for treating sensorineural hearing loss
ES2893825T3 (es) 2011-02-04 2022-02-10 Hough Ear Inst Métodos de tratamiento de lesiones cerebrales
US10576125B2 (en) * 2016-10-31 2020-03-03 Hough Ear Institute Methods for enhancing synaptogenesis and neuritogenesis
EP3570826A4 (en) 2017-01-19 2020-09-23 Otologic Pharmaceutics, Inc. N-ACETYLCYSTEIN FORMULATIONS AND THEIR USES
ES3063479T3 (en) * 2017-09-20 2026-04-16 Oklahoma Med Res Found Treatment of drug resistant gliomas
US10829441B2 (en) 2017-11-14 2020-11-10 The University Of Toledo Reactive oxygen species-sensitive nitric oxide synthase inhibitors for the treatment of ischemic stroke
EP3787750A1 (en) * 2018-05-03 2021-03-10 Hough Ear Institute Methods for reducing accumulated pathologic tau protein
US12121501B2 (en) 2018-09-12 2024-10-22 Hough Ear Institute Methods for treating hearing loss incident to cochlear implant surgery
KR20220145861A (ko) * 2020-02-24 2022-10-31 오블라토 인코포레이티드 암 및 종양을 치료하기 위한 조성물 및 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3914650A1 (de) * 1989-05-03 1990-11-08 Basf Ag Neue phenylendiamine sowie ein verfahren zur herstellung von phenylendiaminen
CA2069961C (en) * 1989-10-17 2000-05-02 John M. Carney Method and compositions for inhibition of disorders associated with oxidative damage
US5025032A (en) * 1989-10-17 1991-06-18 Oklahoma Medical Research Foundation Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
US5036097A (en) * 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
DE3937342A1 (de) * 1989-11-09 1991-05-16 Bayer Ag Verfahren zur herstellung von 2-aminobenzol-disulfonsaeuren-(1,4) und die neue verbindung 6-chlor-2-aminobenzol-disulfonsaeure-(1,4)
WO1992022290A1 (en) * 1991-06-18 1992-12-23 Oklahoma Medical Research Foundation Use of spin trapping for the treatment of diseases associated with oxidation of lipids and proteins
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Also Published As

Publication number Publication date
NO962637D0 (no) 1996-06-20
US5475032A (en) 1995-12-12
HU221167B1 (en) 2002-08-28
SG64903A1 (en) 1999-05-25
CZ289629B6 (cs) 2002-03-13
FI111718B (fi) 2003-09-15
BR1100626A (pt) 1999-11-23
HK1001768A1 (en) 1998-07-10
CA2179521A1 (en) 1995-07-06
JPH09507232A (ja) 1997-07-22
SK282403B6 (sk) 2002-01-07
ES2145264T3 (es) 2000-07-01
CN1070176C (zh) 2001-08-29
US5780510A (en) 1998-07-14
JP2001010953A (ja) 2001-01-16
PL185189B1 (pl) 2003-03-31
CA2179521C (en) 2002-03-19
EP0736004A1 (en) 1996-10-09
HRP950358B1 (en) 2001-04-30
JP2004075696A (ja) 2004-03-11
FI962589L (fi) 1996-08-20
CZ177596A3 (en) 1996-12-11
NO306457B1 (no) 1999-11-08
GR3034134T3 (en) 2000-11-30
RU2159231C2 (ru) 2000-11-20
HU9601739D0 (en) 1996-08-28
AU679835B2 (en) 1997-07-10
ATE192736T1 (de) 2000-05-15
WO1995017876A3 (en) 1995-08-10
PT736004E (pt) 2000-09-29
WO1995017876A2 (en) 1995-07-06
AU1552795A (en) 1995-07-17
PL315154A1 (en) 1996-10-14
NZ279025A (en) 1998-02-26
SK78896A3 (en) 1997-09-10
DE69424441T2 (de) 2000-10-12
UA45964C2 (uk) 2002-05-15
HK1008294A1 (en) 1999-05-07
FI962589A0 (fi) 1996-06-20
US5488145A (en) 1996-01-30
US5508305A (en) 1996-04-16
HUT76788A (en) 1997-11-28
DE69424441D1 (de) 2000-06-15
JP3412821B2 (ja) 2003-06-03
BR9408378A (pt) 1997-08-19
NO962637L (no) 1996-08-13
DK0736004T3 (da) 2000-10-09
EP0736004B1 (en) 2000-05-10
HRP950358A2 (en) 1997-08-31
CN1156447A (zh) 1997-08-06
TW299315B (https=) 1997-03-01
MY114178A (en) 2002-08-30

Similar Documents

Publication Publication Date Title
KR100370522B1 (ko) 2,4-디술포페닐부틸니트론,그의염및이들의제약스핀트랩으로서의용도
JP7030093B2 (ja) オキサチアジン様化合物を作製する方法
BRPI0715745A2 (pt) compostos e mÉtodos para inibir a interaÇço de proteÍnas bcl com parceiros ligantes
BR112019020691A2 (pt) Composição farmacêutica contendo agonista do mor e agonista do kor, e usos da mesma
WO2022105852A1 (zh) 三嗪二酮类衍生物、其制备方法及其在医药上的应用
AU2006329879B2 (en) Compounds and methods for inhibiting the interaction of Bcl proteins with binding partners
JP6952911B2 (ja) ２−（αヒドロキシペンチル）安息香酸の有機アミンエステル誘導体薬物
WO2025116822A1 (en) Near infrared fluorescence compounds and methods thereof
JP7007746B2 (ja) １，２－ナフトキノン誘導体化合物を含む固形癌または血液癌の予防または治療用薬学組成物
HK1008294B (en) (2-4-disulfophenyl) n-tertiary butyl nitrone its salts, and their use as pharmaceutical radical trapping agents
CN105439889A (zh) 一种香兰素胺类新化合物、其制备方法及医药用途
BRPI0611096A2 (pt) (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)a mino]-1,3-tiazol-4(5h)-ona
DE69006187T2 (de) Verwendung von Chinolyl- und Isochinolyloxazol-2-onen zur Herstellung eines Arzneimittels zur Verhinderung der Ansteckungsfähigkeit von mit Glykoproteinen umhüllten Viren.
EA050218B1 (ru) Производные 6-метилурацила, обладающие антихолинэстеразной активностью, и их применение
CN120398835A (zh) 一种激酶抑制剂化合物及其制备方法和用途
Rakoczy et al. Salts of α-Amino-p-toluenesulfonamide
JPWO2003087091A1 (ja) キノキサリンジオン誘導体無水物の新規結晶
CN112118840A (zh) 用于预防或治疗实体癌或血癌的包含1,2-萘醌衍生化合物的药物组合物
WO1997032579A1 (en) Neural differentiation inducer

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20060116

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20070118

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20070118

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000