ATE192736T1 - (2,4-disulfophenyl) n-tertiär butyl nitron, seine salze und ihre verwendung als pharmazeutische radikalfänger - Google Patents

(2,4-disulfophenyl) n-tertiär butyl nitron, seine salze und ihre verwendung als pharmazeutische radikalfänger

Info

Publication number
ATE192736T1
ATE192736T1 AT95907224T AT95907224T ATE192736T1 AT E192736 T1 ATE192736 T1 AT E192736T1 AT 95907224 T AT95907224 T AT 95907224T AT 95907224 T AT95907224 T AT 95907224T AT E192736 T1 ATE192736 T1 AT E192736T1
Authority
AT
Austria
Prior art keywords
pharmaceutical
salts
disulfophenyl
tertiary butyl
butyl nitrone
Prior art date
Application number
AT95907224T
Other languages
German (de)
English (en)
Inventor
John M Carney
Original Assignee
Oklahoma Med Res Found
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found, Univ Kentucky Res Found filed Critical Oklahoma Med Res Found
Application granted granted Critical
Publication of ATE192736T1 publication Critical patent/ATE192736T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT95907224T 1993-12-23 1994-12-22 (2,4-disulfophenyl) n-tertiär butyl nitron, seine salze und ihre verwendung als pharmazeutische radikalfänger ATE192736T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/173,579 US5488145A (en) 1993-12-23 1993-12-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
PCT/US1994/014545 WO1995017876A2 (en) 1993-12-23 1994-12-22 2,4-disulphophenyl butylnitrone, its salts, and their use as pharmaceutical spintraps

Publications (1)

Publication Number Publication Date
ATE192736T1 true ATE192736T1 (de) 2000-05-15

Family

ID=22632663

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95907224T ATE192736T1 (de) 1993-12-23 1994-12-22 (2,4-disulfophenyl) n-tertiär butyl nitron, seine salze und ihre verwendung als pharmazeutische radikalfänger

Country Status (28)

Country Link
US (4) US5488145A (https=)
EP (1) EP0736004B1 (https=)
JP (3) JP3412821B2 (https=)
KR (1) KR100370522B1 (https=)
CN (1) CN1070176C (https=)
AT (1) ATE192736T1 (https=)
AU (1) AU679835B2 (https=)
BR (2) BR9408378A (https=)
CA (1) CA2179521C (https=)
CZ (1) CZ289629B6 (https=)
DE (1) DE69424441T2 (https=)
DK (1) DK0736004T3 (https=)
ES (1) ES2145264T3 (https=)
FI (1) FI111718B (https=)
GR (1) GR3034134T3 (https=)
HR (1) HRP950358B1 (https=)
HU (1) HU221167B1 (https=)
MY (1) MY114178A (https=)
NO (1) NO306457B1 (https=)
NZ (1) NZ279025A (https=)
PL (1) PL185189B1 (https=)
PT (1) PT736004E (https=)
RU (1) RU2159231C2 (https=)
SG (1) SG64903A1 (https=)
SK (1) SK282403B6 (https=)
TW (1) TW299315B (https=)
UA (1) UA45964C2 (https=)
WO (1) WO1995017876A2 (https=)

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US5622994A (en) * 1989-10-17 1997-04-22 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
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US20040208875A1 (en) * 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
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AU725432B2 (en) * 1996-04-17 2000-10-12 Centaur Pharmaceuticals, Inc. Nitrone free radical trap treatment of dementia associated with AIDS virus (HIV-1) infection
US6376540B1 (en) * 1996-07-19 2002-04-23 Centaur Pharmaceuticals, Inc. Furan nitrone compounds
TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) * 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
AU2226999A (en) * 1998-01-16 1999-08-02 Renovis, Inc. Thiophene nitrone compounds
JP2002509143A (ja) * 1998-01-16 2002-03-26 センター ファーマシューティカルズ， インコーポレイテッド チオエーテルフランニトロン化合物
JP2002506022A (ja) * 1998-03-13 2002-02-26 センター ファーマシューティカルズ， インコーポレイテッド 新脈管形成の阻害
US6083989A (en) * 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
AU3985799A (en) * 1998-05-19 1999-12-06 Centaur Pharmaceuticals, Inc. Furan nitrone therapeutics for the treatment of inflammatory bowel disease
US6730700B2 (en) * 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
ATE312103T1 (de) 1999-01-25 2005-12-15 Nat Jewish Med & Res Center Substituierte porphyrine und deren therapeutische verwendungen
IL146143A0 (en) * 1999-04-28 2002-07-25 Univ Kingston Compositions and methods for treating amyloidosis
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
AU1574701A (en) * 1999-10-22 2001-04-30 Wrair Walter Reed Army Institute Of Research A pharmaceutical composition containing pglu-glu-pro-nh2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
US6815425B1 (en) 1999-10-22 2004-11-09 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
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SE0000056D0 (sv) * 2000-01-10 2000-01-10 Astrazeneca Ab Novel process
SE0000055D0 (sv) * 2000-01-10 2000-01-10 Centaur Pharmaceuticals Inc Novel process
SE0001916D0 (sv) * 2000-05-23 2000-05-23 Astrazeneca Ab Novel formulation
US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
AU2002253857A1 (en) 2001-01-08 2002-09-04 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
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FR2846968B1 (fr) * 2002-11-08 2005-02-04 Salles Jean Pierre Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone
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BRPI0519243A2 (pt) * 2004-12-22 2009-01-06 Neurochem Int Ltd mÉtodos e composiÇÕes para tratar doenÇas relacionadas a amilàide
US20060235370A1 (en) * 2005-04-04 2006-10-19 Oblong John E Method of regulating mammalian keratinous tissue
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WO2007013843A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate n-oxide against myocardial ischaemia
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CA2069961C (en) * 1989-10-17 2000-05-02 John M. Carney Method and compositions for inhibition of disorders associated with oxidative damage
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Also Published As

Publication number Publication date
NO962637D0 (no) 1996-06-20
US5475032A (en) 1995-12-12
HU221167B1 (en) 2002-08-28
SG64903A1 (en) 1999-05-25
CZ289629B6 (cs) 2002-03-13
FI111718B (fi) 2003-09-15
BR1100626A (pt) 1999-11-23
HK1001768A1 (en) 1998-07-10
CA2179521A1 (en) 1995-07-06
JPH09507232A (ja) 1997-07-22
SK282403B6 (sk) 2002-01-07
ES2145264T3 (es) 2000-07-01
CN1070176C (zh) 2001-08-29
US5780510A (en) 1998-07-14
JP2001010953A (ja) 2001-01-16
PL185189B1 (pl) 2003-03-31
CA2179521C (en) 2002-03-19
EP0736004A1 (en) 1996-10-09
HRP950358B1 (en) 2001-04-30
JP2004075696A (ja) 2004-03-11
FI962589L (fi) 1996-08-20
CZ177596A3 (en) 1996-12-11
NO306457B1 (no) 1999-11-08
KR100370522B1 (ko) 2003-05-16
GR3034134T3 (en) 2000-11-30
RU2159231C2 (ru) 2000-11-20
HU9601739D0 (en) 1996-08-28
AU679835B2 (en) 1997-07-10
WO1995017876A3 (en) 1995-08-10
PT736004E (pt) 2000-09-29
WO1995017876A2 (en) 1995-07-06
AU1552795A (en) 1995-07-17
PL315154A1 (en) 1996-10-14
NZ279025A (en) 1998-02-26
SK78896A3 (en) 1997-09-10
DE69424441T2 (de) 2000-10-12
UA45964C2 (uk) 2002-05-15
HK1008294A1 (en) 1999-05-07
FI962589A0 (fi) 1996-06-20
US5488145A (en) 1996-01-30
US5508305A (en) 1996-04-16
HUT76788A (en) 1997-11-28
DE69424441D1 (de) 2000-06-15
JP3412821B2 (ja) 2003-06-03
BR9408378A (pt) 1997-08-19
NO962637L (no) 1996-08-13
DK0736004T3 (da) 2000-10-09
EP0736004B1 (en) 2000-05-10
HRP950358A2 (en) 1997-08-31
CN1156447A (zh) 1997-08-06
TW299315B (https=) 1997-03-01
MY114178A (en) 2002-08-30

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